| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shweta Jain, Andrew G Yee, James Maas, Sarah Gierok, Hongfei Xu, Jasmine Stansil, Jacob Eriksen, Alexandra Nelson, Katlin Silm, Christopher P Ford, Robert H Edward. Adaptor Protein-3 Produces Synaptic Vesicles that Release Phasic Dopamine. bioRxiv : the preprint server for biology. 2023-08-23. PMID:37609166. |
the burst firing of midbrain dopamine neurons releases a phasic dopamine signal that mediates reinforcement learning. |
2023-08-23 |
2023-09-07 |
Not clear |
| Adrien T Stanley, Michael R Post, Clay Lacefield, David Sulzer, Maria Concetta Miniac. Norepinephrine release in the cerebellum contributes to aversive learning. Nature communications. vol 14. issue 1. 2023-08-10. PMID:37563141. |
the modulation of dopamine release from midbrain projections to the striatum has long been demonstrated in reward-based learning, but the synaptic basis of aversive learning is far less characterized. |
2023-08-10 |
2023-08-16 |
mouse |
| Jens Devoght, Joris Comhair, Giovanni Morelli, Jean-Michel Rigo, Rudi D'Hooge, Chadi Touma, Rupert Palme, Ilse Dewachter, Martin vandeVen, Robert J Harvey, Serge N Schiffmann, Elisabeth Piccart, Bert Brôn. Dopamine-mediated striatal activity and function is enhanced in GlyRα2 knockout animals. iScience. vol 26. issue 8. 2023-08-09. PMID:37554441. |
we show that depletion of glyrα2 enhances dopamine-induced increases in the activity of putative dopamine d1 receptor-expressing striatal projection neurons, but does not alter midbrain dopamine neuron activity. |
2023-08-09 |
2023-08-16 |
mouse |
| Emmi Pakarinen, Päivi Lindhol. CDNF and MANF in the brain dopamine system and their potential as treatment for Parkinson's disease. Frontiers in psychiatry. vol 14. 2023-08-09. PMID:37555005. |
parkinson's disease (pd) is a progressive neurodegenerative disease characterized by gradual loss of midbrain dopamine neurons, leading to impaired motor function. |
2023-08-09 |
2023-08-16 |
human |
| Mengxi Yun, Masafumi Nejime, Takashi Kawai, Jun Kunimatsu, Hiroshi Yamada, HyungGoo R Kim, Masayuki Matsumot. Distinct roles of the orbitofrontal cortex, ventral striatum, and dopamine neurons in counterfactual thinking of decision outcomes. Science advances. vol 9. issue 32. 2023-08-09. PMID:37556536. |
here we report a clear distinction among the roles of the orbitofrontal cortex, ventral striatum and midbrain dopamine neurons in processing counterfactual outcomes in monkeys. |
2023-08-09 |
2023-08-16 |
monkey |
| Hiroyasu Murasawa, Hitomi Soumiya, Hiroyuki Kobayashi, Jun Imai, Takahiko Nagase, Hidefumi Fukumits. Neonatal bilateral whisker trimming in male mice age-dependently alters brain neurotransmitter levels and causes adolescent onsets of social behavior abnormalities. Biomedical research (Tokyo, Japan). vol 44. issue 4. 2023-08-06. PMID:37544736. |
however, reduced levels of dopamine (da) and their metabolites were more significantly identified at p8w in the nuclear origins of monoamine (midbrain and medulla oblongata) and the limbic system (frontal cortex, amygdala, and hippocampus) than at p4w. |
2023-08-06 |
2023-08-14 |
mouse |
| Emil Wärnberg, Arvind Kuma. Feasibility of dopamine as a vector-valued feedback signal in the basal ganglia. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 32. 2023-08-01. PMID:37527344. |
inspired by the recent observations that besides rpe, the firing rates of midbrain dopaminergic neurons correlate with motor and cognitive variables, we propose a model in which dopamine signal in the striatum carries a vector-valued error feedback signal (a loss gradient) instead of a homogeneous scalar error (a loss). |
2023-08-01 |
2023-08-14 |
Not clear |
| Olivia K Swanson, Priscilla E Yevoo, David Richard, Arianna Maffe. Altered Thalamocortical Signaling in a Mouse Model of Parkinson's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-08-01. PMID:37527923. |
a well-accepted idea in pd research, albeit not tested experimentally, is that the loss of midbrain dopamine leads to decreased activation of m1 by the motor thalamus (mthal). |
2023-08-01 |
2023-08-14 |
mouse |
| Olivia K Swanson, Priscilla E Yevoo, David Richard, Arianna Maffe. Altered Thalamocortical Signaling in a Mouse Model of Parkinson's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-08-01. PMID:37527923. |
here, we report that midbrain dopamine loss altered mthal input in a laminar- and cell type-specific fashion and induced laminar-specific changes in intracortical synaptic transmission. |
2023-08-01 |
2023-08-14 |
mouse |
| Michael B Prit. Nuclei and tracts in the epithalamus of crocodiles. The Journal of comparative neurology. 2023-07-29. PMID:37507852. |
the medial component is related to the limbic system and serotonergic raphe, while the lateral nucleus is more interconnected with the basal ganglia and midbrain dopamine systems. |
2023-07-29 |
2023-08-14 |
Not clear |
| Zizhen Si, Xidi Wang, Zhaoying Yu, Yuer Ruan, Liyin Qian, Shujun Lin, Xinshuang Gong, Longhui Li, Jing Huang, Yu Li. EGCG attenuates METH self-administration and reinstatement of METH seeking in mice. Addiction biology. vol 28. issue 8. 2023-07-27. PMID:37500489. |
in addition, we found that meth sa led to a decrease in inhibitory postsynaptic currents (ipscs) and increase in the ampar/nmdar ratio and excitation/inhibition (e/i) ratio in ex vivo midbrain slices from ventral tegmental area (vta) dopamine neurons. |
2023-07-27 |
2023-08-14 |
mouse |
| Briana Hempel, Madeline Crissman, Sruti Pari, Benjamin Klein, Guo-Hua Bi, Hannah Alton, Zheng-Xiong X. PPARα and PPARγ are expressed in midbrain dopamine neurons and modulate dopamine- and cannabinoid-mediated behavior in mice. Molecular psychiatry. 2023-07-21. PMID:37479780. |
pparα and pparγ are expressed in midbrain dopamine neurons and modulate dopamine- and cannabinoid-mediated behavior in mice. |
2023-07-21 |
2023-08-14 |
mouse |
| Woori Kim, Mohit Tripathi, Chunhyung Kim, Satyapavan Vardhineni, Young Cha, Shamseer Kulangara Kandi, Melissa Feitosa, Rohit Kholiya, Eric Sah, Anuj Thakur, Yehan Kim, Sanghyeok Ko, Kaiya Bhatia, Sunny Manohar, Young-Bin Kong, Gagandeep Sindhu, Yoon-Seong Kim, Bruce Cohen, Diwan S Rawat, Kwang-Soo Ki. An optimized Nurr1 agonist provides disease-modifying effects in Parkinson's disease models. Nature communications. vol 14. issue 1. 2023-07-18. PMID:37463889. |
the nuclear receptor, nurr1, is critical for both the development and maintenance of midbrain dopamine neurons, representing a promising molecular target for parkinson's disease (pd). |
2023-07-18 |
2023-08-14 |
mouse |
| Woori Kim, Mohit Tripathi, Chunhyung Kim, Satyapavan Vardhineni, Young Cha, Shamseer Kulangara Kandi, Melissa Feitosa, Rohit Kholiya, Eric Sah, Anuj Thakur, Yehan Kim, Sanghyeok Ko, Kaiya Bhatia, Sunny Manohar, Young-Bin Kong, Gagandeep Sindhu, Yoon-Seong Kim, Bruce Cohen, Diwan S Rawat, Kwang-Soo Ki. An optimized Nurr1 agonist provides disease-modifying effects in Parkinson's disease models. Nature communications. vol 14. issue 1. 2023-07-18. PMID:37463889. |
in addition, 4a7c-301 protects midbrain dopamine neurons in the mptp-induced male mouse model of pd and improves both motor and non-motor olfactory deficits without dyskinesia-like behaviors. |
2023-07-18 |
2023-08-14 |
mouse |
| M J Corenblum, A McRobbie-Johnson, E Carruth, K Bernard, M Luo, L J Mandarino, S Peterson, M A Sans-Fuentes, D Billheimer, T Maley, E D Eggers, L Madhava. Parallel Neurodegenerative Phenotypes in Sporadic Parkinson's Disease Fibroblasts and Midbrain Dopamine Neurons. Progress in neurobiology. 2023-07-14. PMID:37451330. |
parallel neurodegenerative phenotypes in sporadic parkinson's disease fibroblasts and midbrain dopamine neurons. |
2023-07-14 |
2023-08-14 |
human |
| M J Corenblum, A McRobbie-Johnson, E Carruth, K Bernard, M Luo, L J Mandarino, S Peterson, M A Sans-Fuentes, D Billheimer, T Maley, E D Eggers, L Madhava. Parallel Neurodegenerative Phenotypes in Sporadic Parkinson's Disease Fibroblasts and Midbrain Dopamine Neurons. Progress in neurobiology. 2023-07-14. PMID:37451330. |
here, we report cellular and molecular alterations in skin fibroblasts of late-onset sporadic pd subjects, that were recapitulated in matched induced pluripotent stem cell (ipsc)-derived midbrain dopamine (da) neurons, reprogrammed from the same fibroblasts. |
2023-07-14 |
2023-08-14 |
human |
| Xiao Cui, Qiuping Tong, Hao Xu, Chuantong Xie, Lei Xia. A putative loop connection between VTA dopamine neurons and nucleus accumbens encodes positive valence to compensate for hunger. Progress in neurobiology. 2023-07-14. PMID:37451329. |
dopamine (da) signal play pivotal roles in regulating motivated behaviors, including feeding behavior, but the role of midbrain da neurons in modulating food intake and neural circuitry mechanisms remain largely unknown. |
2023-07-14 |
2023-08-14 |
mouse |
| Tae-Yoon Park, Jeha Jeon, Nayeon Lee, Jisun Kim, Bin Song, Jung-Ho Kim, Sang-Kyou Lee, Dongxin Liu, Young Cha, Minseon Kim, Pierre Leblanc, Todd M Herrington, Bob S Carter, Jeffrey S Schweitzer, Kwang-Soo Ki. Co-transplantation of autologous T Nature. 2023-07-12. PMID:37438521. |
co-transplantation of autologous t the specific loss of midbrain dopamine neurons (mdans) causes major motor dysfunction in parkinson's disease, which makes cell replacement a promising therapeutic approach |
2023-07-12 |
2023-08-14 |
Not clear |
| Virginie J Oberto, Jumpei Matsumoto, Marco N Pompili, Ralitsa Todorova, Francesco Papaleo, Hisao Nishijo, Laurent Venance, Marie Vandecasteele, Sidney I Wiene. Rhythmic oscillations in the midbrain dopaminergic nuclei in mice. Frontiers in cellular neuroscience. vol 17. 2023-07-10. PMID:37426551. |
dopamine release in the forebrain by midbrain ventral tegmental nucleus (vta) and substantia nigra pars compacta (snc) neurons is implicated in reward processing, goal-directed learning, and decision-making. |
2023-07-10 |
2023-08-14 |
mouse |
| Charles Ducrot, Gregory de Carvalho, Benoit Delignat-Lavaud, Constantin V L Delmas, Priyabrata Halder, Nicolas Giguère, Consiglia Pacelli, Sriparna Mukherjee, Marie-Josée Bourque, Martin Parent, LuLu Y Chen, Louis-Eric Trudea. Conditional deletion of neurexins dysregulates neurotransmission from dopamine neurons. eLife. vol 12. 2023-07-06. PMID:37409563. |
midbrain dopamine (da) neurons are key regulators of basal ganglia functions. |
2023-07-06 |
2023-08-14 |
mouse |