| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tate A Pollock, Alexander V Margetts, Samara J Vilca, Luis M Tuest. Cocaine taking and craving produce distinct transcriptional profiles in dopamine neurons. bioRxiv : the preprint server for biology. 2024-10-17. PMID:39416214. |
the adaptive responses from midbrain dopamine neurons to artificial rewards such as drugs of abuse are therefore important for understanding the development of substance use disorders. |
2024-10-17 |
2024-10-19 |
mouse |
| Huifang Wu, Minghao Yan, Tong Wu, Xiaodong Ha. MC-LR disrupts dopamine synthesis in the substantia nigra of midbrain by enhancing the chaperone-mediated autophagy pathway through direct binding to ERK2. Journal of hazardous materials. vol 480. 2024-10-16. PMID:39413523. |
mc-lr disrupts dopamine synthesis in the substantia nigra of midbrain by enhancing the chaperone-mediated autophagy pathway through direct binding to erk2. |
2024-10-16 |
2024-10-19 |
mouse |
| Huifang Wu, Minghao Yan, Tong Wu, Xiaodong Ha. MC-LR disrupts dopamine synthesis in the substantia nigra of midbrain by enhancing the chaperone-mediated autophagy pathway through direct binding to ERK2. Journal of hazardous materials. vol 480. 2024-10-16. PMID:39413523. |
mc-lr could penetrate the blood-brain barrier of mice and accumulate in the substantia nigra (sn) of the midbrain, leading to a reduction in dopamine levels and parkinson's disease (pd)-like motor dysfunction in mice. |
2024-10-16 |
2024-10-19 |
mouse |
| Zhewei Zhang, Yuji K Takahashi, Marlian Montesinos-Cartegena, Thorsten Kahnt, Angela J Langdon, Geoffrey Schoenbau. Expectancy-related changes in firing of dopamine neurons depend on hippocampus. Nature communications. vol 15. issue 1. 2024-10-16. PMID:39414794. |
we recorded midbrain dopamine neurons as rats performed an odor-based choice task, in which expected rewards were manipulated across blocks. |
2024-10-16 |
2024-10-19 |
rat |
| Xóchitl Flores-Ponce, Iván Velasc. Dopaminergic neuron metabolism: relevance for understanding Parkinson's disease. Metabolomics : Official journal of the Metabolomic Society. vol 20. issue 6. 2024-10-13. PMID:39397188. |
dopaminergic neurons from the substantia nigra pars compacta (snc) have a higher susceptibility to aging-related degeneration, compared to midbrain dopaminergic cells present in the ventral tegmental area (vta); the death of dopamine neurons in the snc results in parkinson´s disease (pd). |
2024-10-13 |
2024-10-16 |
Not clear |
| Greg Perlman, Kenneth Wengler, Scott J Moeller, Roman Kotov, Daniel N Klein, Jodi J Weinstein, Guillermo Horga, Anissa Abi-Dargha. Association of Neuromelanin-Sensitive MRI Signal With Lifetime Substance Use in Young Women. The American journal of psychiatry. 2024-10-09. PMID:39380373. |
midbrain dopamine function plays a key role in translational models of substance use disorders. |
2024-10-09 |
2024-10-11 |
Not clear |
| Greg Perlman, Kenneth Wengler, Scott J Moeller, Roman Kotov, Daniel N Klein, Jodi J Weinstein, Guillermo Horga, Anissa Abi-Dargha. Association of Neuromelanin-Sensitive MRI Signal With Lifetime Substance Use in Young Women. The American journal of psychiatry. 2024-10-09. PMID:39380373. |
whether midbrain dopamine function is associated with substance use frequency and severity or reward function in 20-24 year-olds remains a critical gap in knowledge. |
2024-10-09 |
2024-10-11 |
Not clear |
| Samuel J Gershman, Armin La. Policy complexity suppresses dopamine responses. bioRxiv : the preprint server for biology. 2024-09-30. PMID:39345642. |
in support of this hypothesis, we find that policy complexity suppresses midbrain dopamine responses to reward outcomes, thereby reducing behavioral sensitivity to these outcomes. |
2024-09-30 |
2024-10-02 |
Not clear |
| Valentina Basso, Máté D Döbrössy, Lachlan H Thompson, Deniz Kirik, Heidi R Fuller, Monte A Gate. State of the Art in Sub-Phenotyping Midbrain Dopamine Neurons. Biology. vol 13. issue 9. 2024-09-28. PMID:39336117. |
state of the art in sub-phenotyping midbrain dopamine neurons. |
2024-09-28 |
2024-10-01 |
human |
| Daria S Gorina, Anastasiya V Lastovka, Artem D Rogachev, Alexandra V Podturkina, Alla V Pavlova, Oleg V Ardashov, Nikolai S Li-Zhulanov, Tatyana G Tolstikova, Konstantin P Volcho, Nariman F Salakhutdino. Pharmacokinetics and Dose Proportionality Study of a Novel Antiparkinsonian Agent, a 1 Molecules (Basel, Switzerland). vol 29. issue 18. 2024-09-28. PMID:39339493. |
pa-96 supported the survival of cultured naïve dopamine neurons, alleviated motor deficits in mptp and haloperidol-based mice models of parkinson's disease, and increased the density of tyrosine hydroxylase positive neurons and dopamine concentration in the midbrain of an mptp-damaged brain. |
2024-09-28 |
2024-10-01 |
mouse |
| Zhe Chen, Naiyan Lu, Xu Li, Qingrun Liu, Yujie Li, Xiyue Li, Ximiao Yu, Haotian Zhao, Chang Liu, Xue Tang, Xun Wang, Weisun Huan. The Effect of a Caffeine and Nicotine Combination on Nicotine Withdrawal Syndrome in Mice. Nutrients. vol 16. issue 18. 2024-09-28. PMID:39339647. |
the changes in dopamine release in the prefrontal cortex (pfc) and ventral tegmental area (vta) in the midbrain were analyzed using elisa. |
2024-09-28 |
2024-10-01 |
mouse |
| Alain Rios, Kyohei Fujita, Yoshikazu Isomura, Nobuya Sat. Adaptive circuits for action and value information in rodent operant learning. Neuroscience research. 2024-09-28. PMID:39341460. |
we include insights from recent studies, which reveals the intricate roles of midbrain dopamine neurons in integrating action initiation and reward feedback, thereby enhancing movement-related activities in the dorsal striatum. |
2024-09-28 |
2024-10-01 |
Not clear |
| Christopher A Guevara, Kumayl Alloo, Swati Gupta, Romario Thomas, Pamela Del Valle, Alexandra R Magee, Deanna L Benson, George W Huntle. Parkinson's LRRK2-G2019S risk gene mutation drives sex-specific behavioral and cellular adaptations to chronic variable stress. Frontiers in behavioral neuroscience. vol 18. 2024-09-27. PMID:39328984. |
anxiety is a psychiatric non-motor symptom of parkinson's that can appear in the prodromal period, prior to significant loss of midbrain dopamine neurons and motor symptoms. |
2024-09-27 |
2024-09-29 |
mouse |
| Mingxin Ding, Porter L Tomsick, Ryan A Young, Shantanu P Jadha. Ventral tegmental area dopamine neural activity switches simultaneously with rule representations in the prefrontal cortex and hippocampus. bioRxiv : the preprint server for biology. 2024-09-24. PMID:39314328. |
midbrain dopamine (da) activity is key in reward seeking behavior and learning. |
2024-09-24 |
2024-09-26 |
rat |
| Lidia Miguel Telega, Danesh Ashouri Vajari, Chockalingam Ramanathan, Volker A Coenen, Máté D Döbröss. Chronic in vivo sequelae of repetitive acute mfb-DBS on accumbal dopamine and midbrain neuronal activity. Journal of neurochemistry. 2024-09-23. PMID:39308085. |
chronic in vivo sequelae of repetitive acute mfb-dbs on accumbal dopamine and midbrain neuronal activity. |
2024-09-23 |
2024-09-26 |
Not clear |
| Yi-Ming Li, Xiao-Hu Xu, Li-Na Ren, Xiao-Fan Xu, Yi-Long Dai, Rui-Rui Yang, Cheng-Qiang Ji. The diagnostic value of neutrophil to lymphocyte ratio, albumin to fibrinogen ratio, and lymphocyte to monocyte ratio in Parkinson's disease: a retrospective study. Frontiers in neurology. vol 15. 2024-09-18. PMID:39286804. |
parkinson's disease (pd) is a prevalent disorder of the central nervous system, marked by the degeneration of dopamine (da) neurons in the ventral midbrain. |
2024-09-18 |
2024-09-20 |
Not clear |
| Sofia Ines Garcia Moreno, Fabian Limani, Iina Ludwig, Catherine Gilbert, Christian Pifl, Thomas S Hnasko, Thomas Steinkellne. Viral overexpression of human alpha-synuclein in mouse substantia nigra dopamine neurons results in hyperdopaminergia but no neurodegeneration. Experimental neurology. 2024-09-17. PMID:39288832. |
loss of select neuronal populations such as midbrain dopamine (da) neurons is a pathological hallmark of parkinson's disease (pd). |
2024-09-17 |
2024-09-20 |
mouse |
| Daniel F Hill, Robert W Hickman, Alaa Al-Mohammad, Arkadiusz Stasiak, Wolfram Schult. Dopamine neurons encode trial-by-trial subjective reward value in an auction-like task. Nature communications. vol 15. issue 1. 2024-09-17. PMID:39289338. |
in these highly experienced animals, responses of midbrain dopamine neurons followed the trial-by-trial variations of bids despite constant, explicitly predicted reward amounts. |
2024-09-17 |
2024-09-20 |
human |
| Fanshi Zhang, Zhuofan Ye, Yuanyang Xie, Mei Liu, Li Zhang, Jun Zhang, Zucai X. Levodopa-induced dyskinesia: brain iron deposition as a new hypothesis. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 2024-08-30. PMID:39212870. |
the main pathological change in pd is the degenerative death of dopamine (da) neurons in the midbrain substantia nigra, which causes a significant decrease in the da content of the striatum. |
2024-08-30 |
2024-09-04 |
Not clear |
| Jordan E Elum, Eric R Szelenyi, Barbara Juarez, Alexandria D Murry, Grigory Loginov, Catalina A Zamorano, Pan Gao, Ginny Wu, Scott Ng-Evans, Joshua X Yee, Xiangmin Xu, Sam A Golden, Larry S Zweife. Distinct dynamics and intrinsic properties in ventral tegmental area populations mediate reward association and motivation. Cell reports. vol 43. issue 9. 2024-08-29. PMID:39207900. |
here, we compare the contribution of two primarily dopaminergic and largely non-overlapping vta subpopulations, all vta dopamine neurons and vta gabaergic neurons of the mouse midbrain, to these processes. |
2024-08-29 |
2024-09-04 |
mouse |