| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zuzana Bacova, Tomas Havranek, Denisa Mihalj, Veronika Borbelyova, Kristina Kostrubanicova, Michaela Kramarova, Daniela Ostatnikova, Jan Bako. Reduced Neurite Arborization in Primary Dopaminergic Neurons in Autism-Like Shank3B-Deficient Mice. Molecular neurobiology. 2024-12-09. PMID:39654001. |
despite many studies on dopamine changes in autism, specific alterations in midbrain dopamine neurons projecting to the striatum and cortex remain unclear. |
2024-12-09 |
2024-12-12 |
mouse |
| Yuma Sato, Masayuki Matsumoto, Tadachika Koganezaw. The dopaminergic system mediates the lateral habenula-induced autonomic cardiovascular responses. Frontiers in physiology. vol 15. 2024-12-06. PMID:39640253. |
the lhb regulates the midbrain system of monoamine neurotransmitters such as dopamine, serotonin, and noradrenaline. |
2024-12-06 |
2024-12-08 |
rat |
| Joyce Woo, Ajay Uprety, Daniel Reid, Irene Chang, Aelon Ketema Samuel, Helena de Carvalho Schuch, Caroline C Swain, Alexey Ostroumo. Dynamic Changes in Chloride Homeostasis Coordinate Midbrain Inhibitory Network Activity during Reward Learning. bioRxiv : the preprint server for biology. 2024-11-28. PMID:39605586. |
while extensive research has focused on the response profiles of midbrain dopamine neurons during associative learning, less is known about learning-mediated changes in the afferents that shape their responses. |
2024-11-28 |
2024-11-30 |
Not clear |
| Joyce Woo, Ajay Uprety, Daniel Reid, Irene Chang, Aelon Ketema Samuel, Helena de Carvalho Schuch, Caroline C Swain, Alexey Ostroumo. Dynamic Changes in Chloride Homeostasis Coordinate Midbrain Inhibitory Network Activity during Reward Learning. bioRxiv : the preprint server for biology. 2024-11-28. PMID:39605586. |
we demonstrate that during critical phases of learning, anion homeostasis in midbrain gaba neurons - a primary source of input to dopamine neurons - is disrupted due to downregulation of the chloride transporter kcc2. |
2024-11-28 |
2024-11-30 |
Not clear |
| Sara Nolbrant, Jenelle L Wallace, Jingwen Ding, Tianjia Zhu, Jess L Sevetson, Janko Kajtez, Isabella A Baldacci, Emily K Corrigan, Kaylynn Hoglin, Reed McMullen, Matthew T Schmitz, Arnar Breevoort, Dani Swope, Fengxia Wu, Bryan J Pavlovic, Sofie R Salama, Agnete Kirkeby, Hao Huang, Nathan K Schaefer, Alex A Polle. Interspecies Organoids Reveal Human-Specific Molecular Features of Dopaminergic Neuron Development and Vulnerability. bioRxiv : the preprint server for biology. 2024-11-28. PMID:39605599. |
here, we establish a phylogeny-in-a-dish approach to examine gene regulatory evolution by differentiating pools of human, chimpanzee, orangutan, and macaque pluripotent stem cells into ventral midbrain organoids capable of forming long-range projections, spontaneous activity, and dopamine release. |
2024-11-28 |
2024-11-30 |
human |
| Min Gi Jo, Junyoung Hong, Jiyeon Kim, Seon-Hee Kim, Bina Lee, Ha Nyeoung Choi, So Eun Lee, Young Jin Kim, Heejung Park, Dong-Ho Park, Gu Seob Roh, Chang Sun Kim, Seung Pil Yu. Physiological change of striatum and ventral midbrain's glia cell in response to different exercise modalities. Behavioural brain research. 2024-11-21. PMID:39571940. |
both hie and combined exercises (ce) increased the expression of dopamine transporter (dat) in the str without damaging dopamine neurons in the ventral midbrain (vm). |
2024-11-21 |
2024-11-24 |
Not clear |
| Jun Xue, Dongyan Wu, Yuting Bao, Yifan Wu, Xin Zhang, Liang Che. The Abnormal Proliferation of Midbrain Dopamine Cells From Human Pluripotent Stem Cells Is Induced by Exposure to the Tumor Microenvironment. CNS neuroscience & therapeutics. vol 30. issue 11. 2024-11-20. PMID:39563017. |
the abnormal proliferation of midbrain dopamine cells from human pluripotent stem cells is induced by exposure to the tumor microenvironment. |
2024-11-20 |
2024-11-23 |
human |
| Willa G Kerkhoff, William R Stauffe. Basal ganglia: Uniting circuit logic between matrix and striosome. Current biology : CB. vol 34. issue 22. 2024-11-19. PMID:39561711. |
a new study has identified a novel direct-indirect circuit architecture connecting the striosome compartment of the striatum with midbrain dopamine neurons. |
2024-11-19 |
2024-11-23 |
Not clear |
| Xiaowen Zhuang, Julia Lemak, Sadhana Sridhar, Alexandra B Nelso. Inhibition of Indirect Pathway Activity Causes Abnormal Decision-Making In a Mouse Model of Impulse Control Disorder in Parkinson's Disease. bioRxiv : the preprint server for biology. 2024-11-18. PMID:39554037. |
in parkinson's disease (pd), in which loss of midbrain dopamine neurons is associated with progressive motor and cognitive deficits, this coordination is disrupted. |
2024-11-18 |
2024-11-22 |
mouse |
| Chengxue Du, Jiachen Wang, Huihui Tan, Nannan Han, Xiaobo Li, Baihua Sun, Gejuan Zhang, Mingze Chan. Dopamine D Brain research bulletin. vol 219. 2024-11-13. PMID:39521183. |
dopamine d although the output of the lateral habenula (lhb) controls the activity of midbrain dopamine (da) and 5-hydroxytryptamine (5-ht) containing systems, which are implicated in the pathophysiology of anxiety, it is not clear how activation and blockade of lhb d |
2024-11-13 |
2024-11-17 |
Not clear |
| Tomohiko Yoshizawa, Makoto Funahash. Dopamine release in striatal striosome compartments in response to rewards and aversive outcomes during classical conditioning in mice. Neuroscience research. 2024-11-09. PMID:39515479. |
the striatum consists of two anatomically and neurochemically distinct compartments, striosomes and the matrix, which receive dopaminergic inputs from the midbrain and exhibit distinct dopamine release dynamics in acute brain slices. |
2024-11-09 |
2024-11-17 |
mouse |
| Sonia Aroni, Claudia Sagheddu, Marco Pistis, Anna Lisa Munton. Functional Adaptation in the Brain Habenulo-Mesencephalic Pathway During Cannabinoid Withdrawal. Cells. vol 13. issue 21. 2024-11-08. PMID:39513916. |
the mesolimbic reward system originating from dopamine neurons in the ventral tegmental area (vta) of the midbrain shows a profound reduction in function during cannabinoid withdrawal. |
2024-11-08 |
2024-11-16 |
Not clear |
| Harris E Blankenship, Kelsey A Carter, Kevin D Pham, Nina T Cassidy, Andrea N Markiewicz, Michael I Thellmann, Amanda L Sharpe, Willard M Freeman, Michael J Beckstea. VTA dopamine neurons are hyperexcitable in 3xTg-AD mice due to casein kinase 2-dependent SK channel dysfunction. Nature communications. vol 15. issue 1. 2024-11-08. PMID:39516200. |
here, we investigated the role of midbrain dopamine (da) neurons in ad using the amyloid + tau-driven 3xtg-ad mouse model. |
2024-11-08 |
2024-11-17 |
mouse |
| Wisberty J Gordián-Vélez, Kevin D Browne, Jonathan H Galarraga, Dimple Chouhan, John E Duda, Rodrigo A España, H Isaac Chen, Jason A Burdick, D Kacy Culle. Dopaminergic Axon Tracts Within a Hyaluronic Acid Hydrogel Encasement to Restore the Nigrostriatal Pathway. Advanced healthcare materials. 2024-11-04. PMID:39494983. |
using rat ventral midbrain neurons, it is found that te-nsps exhibited improved neurite growth with ha relative to agarose, with no differences in electrically-evoked dopamine release. |
2024-11-04 |
2024-11-06 |
rat |
| Mohd Yaseen Malik, Fei Guo, Aman Asif-Malik, Vasileios Eftychidis, Nikolaos Barkas, Elena Eliseeva, Kerstin N Timm, Aleksandra Wolska, David Bergin, Barbara Zonta, Veronika Ratz-Wirsching, Stephan von Hörsten, Mark E Walton, Peter J Magill, Claus Nerlov, Liliana Minichiell. Impaired striatal glutathione-ascorbate metabolism induces transient dopamine increase and motor dysfunction. Nature metabolism. 2024-10-29. PMID:39468205. |
here, we demonstrate that genetic disruption of ispns function by ntrk2/trkb deletion in mice results in increased striatal dopamine and midbrain dopaminergic neurons, preceding hyperkinetic dysfunction. |
2024-10-29 |
2024-10-31 |
mouse |
| Jasmine L Carter, Julian A N M Halmai, Jennifer J Waldo, Paula A Vij, Maribel Anguiano, Isaac J Villegas, Yu Xin Du, Jan Nolta, Kyle D Fin. A de novo Missense Mutation in PPP2R5D Alters Dopamine Pathways and Morphology of iPSC-derived Midbrain Neurons. Stem cells (Dayton, Ohio). 2024-10-26. PMID:39460716. |
a de novo missense mutation in ppp2r5d alters dopamine pathways and morphology of ipsc-derived midbrain neurons. |
2024-10-26 |
2024-10-29 |
human |
| Tate A Pollock, Alexander V Margetts, Samara J Vilca, Luis M Tuest. Cocaine taking and craving produce distinct transcriptional profiles in dopamine neurons. bioRxiv : the preprint server for biology. 2024-10-17. PMID:39416214. |
the adaptive responses from midbrain dopamine neurons to artificial rewards such as drugs of abuse are therefore important for understanding the development of substance use disorders. |
2024-10-17 |
2024-10-19 |
mouse |
| Huifang Wu, Minghao Yan, Tong Wu, Xiaodong Ha. MC-LR disrupts dopamine synthesis in the substantia nigra of midbrain by enhancing the chaperone-mediated autophagy pathway through direct binding to ERK2. Journal of hazardous materials. vol 480. 2024-10-16. PMID:39413523. |
mc-lr disrupts dopamine synthesis in the substantia nigra of midbrain by enhancing the chaperone-mediated autophagy pathway through direct binding to erk2. |
2024-10-16 |
2024-10-19 |
mouse |
| Huifang Wu, Minghao Yan, Tong Wu, Xiaodong Ha. MC-LR disrupts dopamine synthesis in the substantia nigra of midbrain by enhancing the chaperone-mediated autophagy pathway through direct binding to ERK2. Journal of hazardous materials. vol 480. 2024-10-16. PMID:39413523. |
mc-lr could penetrate the blood-brain barrier of mice and accumulate in the substantia nigra (sn) of the midbrain, leading to a reduction in dopamine levels and parkinson's disease (pd)-like motor dysfunction in mice. |
2024-10-16 |
2024-10-19 |
mouse |
| Zhewei Zhang, Yuji K Takahashi, Marlian Montesinos-Cartegena, Thorsten Kahnt, Angela J Langdon, Geoffrey Schoenbau. Expectancy-related changes in firing of dopamine neurons depend on hippocampus. Nature communications. vol 15. issue 1. 2024-10-16. PMID:39414794. |
we recorded midbrain dopamine neurons as rats performed an odor-based choice task, in which expected rewards were manipulated across blocks. |
2024-10-16 |
2024-10-19 |
rat |