| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mateja Rybiczka-Tešulov, Oxana Garritsen, Morten T Venø, Laura Wieg, Roland van Dijk, Karim Rahimi, Andreia Gomes-Duarte, Marina de Wit, Lieke L van de Haar, Lars Michels, Nicky C H van Kronenburg, Christiaan van der Meer, Jørgen Kjems, Vamshidhar R Vangoor, R Jeroen Pasterkam. Circular RNAs regulate neuron size and migration of midbrain dopamine neurons during development. Nature communications. vol 15. issue 1. 2024-08-08. PMID:39117691. |
midbrain dopamine (mda) neurons play an essential role in cognitive and motor behaviours and are linked to different brain disorders. |
2024-08-08 |
2024-08-12 |
mouse |
| Hirotoshi Iguchi, Takumi Katsuzawa, Chihiro Saruta, Tetsushi Sadakata, Shota Kobayashi, Yumi Sato, Akira Sato, Yoshitake Sano, So Maezawa, Yo Shinoda, Teiichi Furuich. Calcium-dependent activator protein for secretion 2 is involved in dopamine release in mouse midbrain neurons. Frontiers in molecular neuroscience. vol 17. 2024-08-02. PMID:39092202. |
calcium-dependent activator protein for secretion 2 is involved in dopamine release in mouse midbrain neurons. |
2024-08-02 |
2024-08-05 |
mouse |
| Yusuke Ichikawa, Bunpei Sato, Shin-Ichi Hirano, Yoshiyasu Takefuji, Fumitake Sato. Realizing brain therapy with "smart medicine": mechanism and case report of molecular hydrogen inhalation for Parkinson's disease. Medical gas research. vol 14. issue 3. 2024-07-29. PMID:39073335. |
in the midbrain of parkinson's disease patients, hydroxyl radicals generated by the fenton reaction cause a chain reaction of oxidation of dopamine, but hydrogen entering the midbrain can convert the hydroxyl radicals into water molecules and inhibit the oxidation of dopamine. |
2024-07-29 |
2024-08-02 |
Not clear |
| Christina A Nelson, James N Brundage, Benjamin M Williams, Jared K Baldridge, Alyssa L Stockard, Charlton H Bassett, Brandon J Burger, Bridger T Gunter, Andrew J Payne, Jordan T Yorgason, Scott C Steffensen, Kyle B Bill. Voluntary Exercise Ameliorates Chronic Ethanol Withdrawal-Induced Adaptations of Opioid Receptor Expression in the Nucleus Accumbens, Dopamine Release, and Ethanol Consumption. Biomedicines. vol 12. issue 7. 2024-07-27. PMID:39062166. |
chronic ethanol (etoh) exposure has been shown to upregulate and sensitize kappa opioid receptors (kors) in the nucleus accumbens (nac), which is innervated by dopamine (da) neurons in the midbrain ventral tegmental area (vta), which may contribute to aud-related behaviors. |
2024-07-27 |
2024-07-29 |
mouse |
| Roger A Barker, Anders Björklund, Malin Parma. The history and status of dopamine cell therapies for Parkinson's disease. BioEssays : news and reviews in molecular, cellular and developmental biology. 2024-07-26. PMID:39058892. |
the results of these trials are eagerly awaited although proof of principle data has already come from trials using human fetal midbrain dopamine cell transplants. |
2024-07-26 |
2024-07-29 |
human |
| Jingjing Yang, Hongjuan Wang, Huan Chen, Hongwei Hou, Qingyuan H. The association of genetic polymorphisms within the dopaminergic system with nicotine dependence: A narrative review. Heliyon. vol 10. issue 12. 2024-07-18. PMID:39021905. |
nicotine acts on the limbic dopamine reward loop in the midbrain by binding to nicotinic acetylcholine receptors, promoting the release of dopamine, and resulting in a rewarding effect or satisfaction. |
2024-07-18 |
2024-07-20 |
Not clear |
| Nina Rouhani, David Clewett, James W Anton. Building and Breaking the Chain: A Model of Reward Prediction Error Integration and Segmentation of Memory. Journal of cognitive neuroscience. 2024-07-11. PMID:38991138. |
here, we review the roles of midbrain dopamine, the locus coeruleus, and the hippocampus in event cognition to propose and simulate the theoretical influence of two prediction error signals in integrating versus segmenting events in memory. |
2024-07-11 |
2024-07-14 |
Not clear |
| Matthew H Higgs, Michael J Beckstea. Impact of unitary synaptic inhibition on spike timing in ventral tegmental area dopamine neurons. eNeuro. 2024-07-05. PMID:38969500. |
midbrain dopamine neurons receive convergent synaptic input from multiple brain areas, which perturbs rhythmic pacemaking to produce the complex firing patterns observed in vivo. |
2024-07-05 |
2024-07-08 |
mouse |
| Rachel S Lee, Yotam Sagiv, Ben Engelhard, Ilana B Witten, Nathaniel D Da. A feature-specific prediction error model explains dopaminergic heterogeneity. Nature neuroscience. 2024-07-03. PMID:38961229. |
the hypothesis that midbrain dopamine (da) neurons broadcast a reward prediction error (rpe) is among the great successes of computational neuroscience. |
2024-07-03 |
2024-07-10 |
Not clear |
| Joohyun An, Minkyu Shin, Geunyoung Beak, Jinho Yoon, Seewoo Kim, Hyeon-Yeol Cho, Jeong-Woo Cho. Drug Evaluation of Parkinson's Disease Patient-Derived Midbrain Organoids Using Mesoporous Au Nanodot-Patterned 3D Concave Electrode. ACS sensors. 2024-07-02. PMID:38954790. |
and the dopamine secreted from normal midbrain organoids or pd midbrain organoids on the 3d concave electrode could be detected electrochemically. |
2024-07-02 |
2024-07-06 |
human |
| Joohyun An, Minkyu Shin, Geunyoung Beak, Jinho Yoon, Seewoo Kim, Hyeon-Yeol Cho, Jeong-Woo Cho. Drug Evaluation of Parkinson's Disease Patient-Derived Midbrain Organoids Using Mesoporous Au Nanodot-Patterned 3D Concave Electrode. ACS sensors. 2024-07-02. PMID:38954790. |
after the treatment of pd midbrain organoids with levodopa, the drug for pd, the increase in dopamine level was detected due to the activation of dopaminergic neurons by the drug. |
2024-07-02 |
2024-07-06 |
human |
| Luke J Vano, Robert A McCutcheon, Grazia Rutigliano, Stephen J Kaar, Valeria Finelli, Giovanna Nordio, George Wellby, Jan Sedlacik, Ben Statton, Eugenii A Rabiner, Rong Ye, Mattia Veronese, Seth C Hopkins, Kenneth S Koblan, Ian P Everall, Oliver D Howe. Mesostriatal Dopaminergic Circuit Dysfunction in Schizophrenia: A Multimodal Neuromelanin-sensitive MRI and [18F]-DOPA PET Study. Biological psychiatry. 2024-06-28. PMID:38942349. |
we examined if midbrain nm-mri contrast-to-noise ratio (nm-cnr) was higher in people with schizophrenia relative to controls and if this correlated with dopamine synthesis capacity. |
2024-06-28 |
2024-07-01 |
Not clear |
| Benjamin R Fry, Victoria Fex, Akira Sawa, Minae Niwa, Alexander W Johnso. The role of midbrain dopamine cells projecting to the insular cortex in mediated performance: Implications for animal models of reality testing. Behavioral neuroscience. vol 138. issue 3. 2024-06-27. PMID:38934920. |
the role of midbrain dopamine cells projecting to the insular cortex in mediated performance: implications for animal models of reality testing. |
2024-06-27 |
2024-06-29 |
mouse |
| Zachary Gaertner, Cameron Oram, Amanda Schneeweis, Elan Schonfeld, Cyril Bolduc, Chuyu Chen, Daniel Dombeck, Loukia Parisiadou, Jean Francois Poulin, Rajeshwar Awatraman. Molecular and spatial transcriptomic classification of midbrain dopamine neurons and their alterations in a LRRK2 bioRxiv : the preprint server for biology. 2024-06-19. PMID:38895448. |
molecular and spatial transcriptomic classification of midbrain dopamine neurons and their alterations in a lrrk2 several studies have revealed that midbrain dopamine (da) neurons, even within a single neuroanatomical area, display heterogeneous properties. |
2024-06-19 |
2024-06-21 |
mouse |
| Pingping Song, Dimitri Krain. Diverse Functions of Parkin in Midbrain Dopaminergic Neurons. Movement disorders : official journal of the Movement Disorder Society. 2024-06-11. PMID:38858837. |
in pd patient neurons, disruption of this pathway on loss of parkin leads to defective recycling of synaptic vesicles and accumulation of toxic oxidized dopamine that at least in part explains preferential vulnerability of midbrain dopaminergic neurons. |
2024-06-11 |
2024-06-14 |
human |
| Tania Arora, Gaurav Sharma, Vikash Prashar, Randeep Singh, Arti Sharma, Harish Changotra, Jyoti Parkas. Mechanistic Evaluation of miRNAs and Their Targeted Genes in the Pathogenesis and Therapeutics of Parkinson's Disease. Molecular neurobiology. 2024-06-01. PMID:38823001. |
pd is mainly caused by the demolition of the primary dopamine neurotransmitter secretory cells and dopaminergic or dopamine secretory neurons in the substantia nigra pars compacta of the midbrain, which are majorly responsible for motor functions. |
2024-06-01 |
2024-06-03 |
Not clear |
| Eric Garr, Yifeng Cheng, Huijeong Jeong, Sara Brooke, Laia Castell, Aneesh Bal, Robin Magnard, Vijay Mohan K Namboodiri, Patricia H Jana. Mesostriatal dopamine is sensitive to changes in specific cue-reward contingencies. Science advances. vol 10. issue 22. 2024-05-29. PMID:38809978. |
conditioned responding was attenuated for the cue-reward contingency that was degraded, as was dopamine neuron activity in the midbrain and dopamine release in the ventral striatum in response to the cue and subsequent reward. |
2024-05-29 |
2024-06-02 |
rat |
| Minryung R Song, Sang Wan Le. Rethinking dopamine-guided action sequence learning. The European journal of neuroscience. 2024-05-27. PMID:38798086. |
previous research has demonstrated that midbrain dopamine and its major projection target, the striatum, play crucial roles in these processes. |
2024-05-27 |
2024-05-31 |
Not clear |
| Tae-Yoon Park, Jeha Jeon, Young Cha, Kwang-Soo Ki. Past, present, and future of cell replacement therapy for parkinson's disease: a novel emphasis on host immune responses. Cell research. 2024-05-22. PMID:38777859. |
central to the pathophysiology of pd is the specific degeneration of midbrain dopamine neurons (mdans) in the substantia nigra. |
2024-05-22 |
2024-05-27 |
human |
| Fares J P Sayegh, Lionel Mouledous, Catherine Macri, Juliana Pi Macedo, Camille Lejards, Claire Rampon, Laure Verret, Lionel Daha. Ventral tegmental area dopamine projections to the hippocampus trigger long-term potentiation and contextual learning. Nature communications. vol 15. issue 1. 2024-05-21. PMID:38773091. |
here, we used optogenetic manipulation of midbrain dopamine neurons in male dat::cre mice, and discovered that stimulating the schaffer collaterals - the glutamatergic axons connecting ca3 and ca1 regions - of the dorsal hippocampus concomitantly with midbrain dopamine terminals within a 200 millisecond time-window triggers ltp at glutamatergic synapses. |
2024-05-21 |
2024-05-27 |
mouse |