| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cian-Fen Jhuo, Chun-Jung Chen, Jason T C Tzen, Wen-Ying Che. Teaghrelin protected dopaminergic neurons in MPTP-induced Parkinson's disease animal model by promoting PINK1/Parkin-mediated mitophagy and AMPK/SIRT1/PGC1-α-mediated mitochondrial biogenesis. Environmental toxicology. 2024-04-16. PMID:38622810. |
tyrosine hydroxylase and dopamine transporter protein were found reduced in the striatum and midbrain of mptp-treated mice, and significantly mitigated by teaghrelin supplementation. |
2024-04-16 |
2024-04-18 |
mouse |
| Cian-Fen Jhuo, Chun-Jung Chen, Jason T C Tzen, Wen-Ying Che. Teaghrelin protected dopaminergic neurons in MPTP-induced Parkinson's disease animal model by promoting PINK1/Parkin-mediated mitophagy and AMPK/SIRT1/PGC1-α-mediated mitochondrial biogenesis. Environmental toxicology. 2024-04-16. PMID:38622810. |
tyrosine hydroxylase and dopamine transporter protein were found reduced in the striatum and midbrain of mptp-treated mice, and significantly mitigated by teaghrelin supplementation. |
2024-04-16 |
2024-04-18 |
mouse |
| Xin Yi Ng, Mian Ca. Dysfunction of synaptic endocytic trafficking in Parkinson's disease. Neural regeneration research. vol 19. issue 12. 2024-04-10. PMID:38595283. |
this suggests that impaired synaptic vesicle recycling might represent an early feature of parkinson's disease, followed by axonal degeneration and the eventual loss of dopamine cell bodies in the midbrain via a "dying back" mechanism. |
2024-04-10 |
2024-04-12 |
mouse |
| Omar Soler-Cedeño, Hannah Alton, Guo-Hua Bi, Emily Linz, Lipin Ji, Alexandros Makriyannis, Zheng-Xiong X. AM6527, a neutral CB1 receptor antagonist, suppresses opioid taking and seeking, as well as cocaine seeking in rodents without aversive effects. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-04-10. PMID:38600154. |
however, in optical intracranial self-stimulation (oicss) maintained by optogenetic stimulation of midbrain dopamine neurons in dat-cre mice, both am6527 and rimonabant dose-dependently inhibited dopamine-dependent oicss behavior. |
2024-04-10 |
2024-04-13 |
mouse |
| Behzad Yaghmaeian Salmani, Laura Lahti, Linda Gillberg, Jesper Kjaer Jacobsen, Ioannis Mantas, Per Svenningsson, Thomas Perlman. Transcriptomic atlas of midbrain dopamine neurons uncovers differential vulnerability in a Parkinsonism lesion model. eLife. vol 12. 2024-04-08. PMID:38587883. |
transcriptomic atlas of midbrain dopamine neurons uncovers differential vulnerability in a parkinsonism lesion model. |
2024-04-08 |
2024-04-10 |
mouse |
| Behzad Yaghmaeian Salmani, Laura Lahti, Linda Gillberg, Jesper Kjaer Jacobsen, Ioannis Mantas, Per Svenningsson, Thomas Perlman. Transcriptomic atlas of midbrain dopamine neurons uncovers differential vulnerability in a Parkinsonism lesion model. eLife. vol 12. 2024-04-08. PMID:38587883. |
midbrain dopamine (mda) neurons comprise diverse cells with unique innervation targets and functions. |
2024-04-08 |
2024-04-10 |
mouse |
| Riccardo Avvisati, Anna-Kristin Kaufmann, Callum J Young, Gabriella E Portlock, Sophie Cancemi, Rui Ponte Costa, Peter J Magill, Paul D Dodso. Distributional coding of associative learning in discrete populations of midbrain dopamine neurons. Cell reports. vol 43. issue 4. 2024-04-06. PMID:38581677. |
distributional coding of associative learning in discrete populations of midbrain dopamine neurons. |
2024-04-06 |
2024-04-10 |
Not clear |
| Riccardo Avvisati, Anna-Kristin Kaufmann, Callum J Young, Gabriella E Portlock, Sophie Cancemi, Rui Ponte Costa, Peter J Magill, Paul D Dodso. Distributional coding of associative learning in discrete populations of midbrain dopamine neurons. Cell reports. vol 43. issue 4. 2024-04-06. PMID:38581677. |
midbrain dopamine neurons are thought to play key roles in learning by conveying the difference between expected and actual outcomes. |
2024-04-06 |
2024-04-10 |
Not clear |
| Riccardo Avvisati, Anna-Kristin Kaufmann, Callum J Young, Gabriella E Portlock, Sophie Cancemi, Rui Ponte Costa, Peter J Magill, Paul D Dodso. Distributional coding of associative learning in discrete populations of midbrain dopamine neurons. Cell reports. vol 43. issue 4. 2024-04-06. PMID:38581677. |
here, we investigated the organizational logic of dopaminergic signaling by recording and labeling individual midbrain dopamine neurons during associative behavior. |
2024-04-06 |
2024-04-10 |
Not clear |
| Harysh Winster Suresh Babu, Sindduja Muthu Kumar, Harsimrat Kaur, Mahalaxmi Iyer, Balachandar Vellingir. Midbrain organoids for Parkinson's disease (PD) - A powerful tool to understand the disease pathogenesis. Life sciences. 2024-04-05. PMID:38580194. |
in the context of parkinson's disease (pd), recent advancements have been made in the development of midbrain organoids (mbos) models that consider key pathophysiological mechanisms such as alpha-synuclein (α-syn), lewy bodies, dopamine loss, and microglia activation. |
2024-04-05 |
2024-04-10 |
human |
| Alice Petty, Anna Garcia-Hidalgo, Els F Halff, Sridhar Natesan, Dominic J Withers, Elaine E Irvine, Michelle Kokkinou, Lisa A Wells, David R Bonsall, Sac-Pham Tang, Mattia Veronese, Oliver D Howe. Correction: Sub-Chronic Ketamine Administration Increases Dopamine Synthesis Capacity in the Mouse Midbrain: a Preclinical In Vivo PET Study. Molecular imaging and biology. 2024-04-03. PMID:38570447. |
correction: sub-chronic ketamine administration increases dopamine synthesis capacity in the mouse midbrain: a preclinical in vivo pet study. |
2024-04-03 |
2024-04-06 |
mouse |
| Jessica M Phillips, Mohsen Afrasiabi, Niranjan A Kambi, Michelle J Redinbaugh, Summer Steely, Emily R Johnson, Xi Cheng, Maath Fayyad, Sounak Mohanta, Asia Carís, Charles B Mikell, Sima Mofakham, Yuri B Saalman. Primate thalamic nuclei select abstract rules and shape prefrontal dynamics. bioRxiv : the preprint server for biology. 2024-04-01. PMID:38559142. |
md, a major recipient of midbrain dopamine input, was first to represent information about behavioral outcomes. |
2024-04-01 |
2024-04-04 |
monkey |
| Zahra Z Farahbakhsh, Katherine M Holleran, Jonathon P Sens, Steve C Fordahl, Madelyn I Mauterer, Alberto J López, Verginia C Cuzon Carlson, Drew D Kiraly, Kathleen A Grant, Sara R Jones, Cody A Sicilian. Synchrony between midbrain gene transcription and dopamine terminal regulation is modulated by chronic alcohol drinking. bioRxiv : the preprint server for biology. 2024-04-01. PMID:38559169. |
synchrony between midbrain gene transcription and dopamine terminal regulation is modulated by chronic alcohol drinking. |
2024-04-01 |
2024-04-04 |
Not clear |
| Vasileios Glykos, Shigeyoshi Fujisaw. Memory-specific encoding activities of the ventral tegmental area dopamine and GABA neurons. eLife. vol 12. 2024-03-21. PMID:38512339. |
although the midbrain dopamine (da) system plays a crucial role in higher cognitive functions, including updating and maintaining short-term memory, the encoding properties of the somatic spiking activity of ventral tegmental area (vta) da neurons for short-term memory computations have not yet been identified. |
2024-03-21 |
2024-03-23 |
mouse |
| Patrick R Melugin, Suzanne O Nolan, Evelyn Kandov, Carson F Ferrara, Zahra Z Farahbakhsh, Cody A Sicilian. Medial prefrontal dopamine dynamics reflect allocation of selective attention. bioRxiv : the preprint server for biology. 2024-03-18. PMID:38496533. |
the mesocortical dopamine system is comprised of midbrain dopamine neurons that predominantly innervate the medial prefrontal cortex (mpfc) and exert a powerful neuromodulatory influence over this region |
2024-03-18 |
2024-03-20 |
Not clear |
| Yixin Fu, Wenfu Li, Yunlin Mai, Junhao Guan, Ruxuan Ding, Jiawei Hou, Bingqing Chen, Guoxin Cao, Shizhu Sun, Ying Tang, Rao F. Association between RMTg Neuropeptide Genes and Negative Effect during Alcohol Withdrawal in Mice. International journal of molecular sciences. vol 25. issue 5. 2024-03-13. PMID:38474180. |
the rostromedial tegmental nucleus (rmtg), which inhibits midbrain dopamine neurons and signals aversion, has been shown to increase ethanol consumption and negative emotional states during abstinence. |
2024-03-13 |
2024-03-15 |
mouse |
| Kelley E Gunther, Xiaoxue Fu, Leigha A MacNeill, Morgan Jones, Briana Ermanni, Koraly Pérez-Edga. Now it's your turn!: Eye blink rate in a Jenga task modulated by interaction of task wait times, effortful control, and internalizing behaviors. PloS one. vol 19. issue 3. 2024-03-08. PMID:38457390. |
eye blink rate is a non-invasive proxy metric of midbrain dopamine activity. |
2024-03-08 |
2024-03-11 |
Not clear |
| Kelley E Gunther, Xiaoxue Fu, Leigha A MacNeill, Morgan Jones, Briana Ermanni, Koraly Pérez-Edga. Now it's your turn!: Eye blink rate in a Jenga task modulated by interaction of task wait times, effortful control, and internalizing behaviors. PloS one. vol 19. issue 3. 2024-03-08. PMID:38457390. |
these findings index task-related changes in midbrain dopamine activity in relation to naturalistic task demands, and that these changes may vary as a function of individual differences in effortful control and internalizing behaviors. |
2024-03-08 |
2024-03-11 |
Not clear |
| Domenic H Cerri, Daniel L Albaugh, Lindsay R Walton, Brittany Katz, Tzu-Wen Wang, Tzu-Hao Harry Chao, Weiting Zhang, Randal J Nonneman, Jing Jiang, Sung-Ho Lee, Amit Etkin, Catherine N Hall, Garret D Stuber, Yen-Yu Ian Shi. Distinct neurochemical influences on fMRI response polarity in the striatum. Nature communications. vol 15. issue 1. 2024-03-01. PMID:38429266. |
in parallel, midbrain dopaminergic neuron optogenetic modulation, coupled with electrochemical measurements, establishes a link between striatal vasodilation and dopamine release. |
2024-03-01 |
2024-03-04 |
rat |
| Mohamed A Eldeeb, Andrew N Bayne, Armaan Fallahi, Thomas Goiran, Emma J MacDougall, Andrea Soumbasis, Cornelia E Zorca, Jace-Jones Tabah, Rhalena A Thomas, Nathan Karpilovsky, Meghna Mathur, Thomas M Durcan, Jean-François Trempe, Edward A Fo. Tom20 gates PINK1 activity and mediates its tethering of the TOM and TIM23 translocases upon mitochondrial stress. Proceedings of the National Academy of Sciences of the United States of America. vol 121. issue 10. 2024-02-28. PMID:38416681. |
herein, we demonstrate that mitochondrial stress induces the formation of a pink1-tom-tim23 supercomplex in human cultured cell lines, dopamine neurons, and midbrain organoids. |
2024-02-28 |
2024-03-02 |
human |