| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Meritxell Pons-Espinal, Lucas Blasco-Agell, Irene Fernandez-Carasa, Pol Andrés-Benito, Angelique di Domenico, Yvonne Richaud-Patin, Valentina Baruffi, Laura Marruecos, Lluís Espinosa, Alicia Garrido, Eduardo Tolosa, Michael J Edel, Manel Juan Otero, José Luis Mosquera, Isidre Ferrer, Angel Raya, Antonella Consigli. Blocking IL-6 signaling prevents astrocyte-induced neurodegeneration in an iPSC-based model of Parkinson's disease. JCI insight. vol 9. issue 3. 2024-02-08. PMID:38329129. |
parkinson's disease (pd) is a neurodegenerative disease associated with progressive death of midbrain dopamine (dan) neurons in the substantia nigra (sn). |
2024-02-08 |
2024-02-10 |
human |
| Yu-Ting Li, Yi-Ling Huang, Jia-Jin Jason Chen, Brian Ian Hyland, Jeffery R Wicken. Phasic dopamine signals are reduced in the spontaneously hypertensive rat and increased by methylphenidate. The European journal of neuroscience. 2024-02-05. PMID:38314648. |
phasic dopamine signals during the pairing of a sensory cue with electrical stimulation of midbrain dopamine neurons were significantly smaller in the shrs than in the sd rats. |
2024-02-05 |
2024-02-07 |
rat |
| Elizabeth N Holly, Jamie Galanaugh, Marc V Fuccill. Local regulation of striatal dopamine: A diversity of circuit mechanisms for a diversity of behavioral functions? Current opinion in neurobiology. vol 85. 2024-02-03. PMID:38309106. |
we first look at historical and recent work demonstrating that striatal circuits interact with dopaminergic terminals to either initiate the release of dopamine or modulate the release of dopamine initiated by spiking in midbrain dopamine neurons, with particular attention to gabaergic and cholinergic local circuit mechanisms. |
2024-02-03 |
2024-02-06 |
Not clear |
| Elizabeth N Holly, Jamie Galanaugh, Marc V Fuccill. Local regulation of striatal dopamine: A diversity of circuit mechanisms for a diversity of behavioral functions? Current opinion in neurobiology. vol 85. 2024-02-03. PMID:38309106. |
then we discuss some of the first in vivo studies of acetylcholine-dopamine interactions in striatum and broadly discuss necessary future work in understanding the roles of midbrain versus striatal dopamine regulation. |
2024-02-03 |
2024-02-06 |
Not clear |
| Arianna R S Lark, Sara R Nass, Yun K Hahn, Benlian Gao, Ginger L Milne, Pamela E Knapp, Kurt F Hause. HIV-1 Tat and morphine interactions dynamically shift striatal monoamine levels and exploratory behaviors over time. Journal of neurochemistry. 2024-02-03. PMID:38308495. |
the combination of tat and morphine altered dopamine, dopac, and hva concentrations differently depending on the neurotransmitter/metabolite and duration of exposure but did not affect the numbers of tyrosine hydroxylase-positive neurons in the mesencephalon. |
2024-02-03 |
2024-02-05 |
mouse |
| Ryunosuke Amo, Naoshige Uchida, Mitsuko Watabe-Uchid. Glutamate inputs send prediction error of reward, but not negative value of aversive stimuli, to dopamine neurons. Neuron. 2024-01-26. PMID:38278147. |
midbrain dopamine neurons are thought to signal reward prediction errors (rpes), but the mechanisms underlying rpe computation, particularly the contributions of different neurotransmitters, remain poorly understood. |
2024-01-26 |
2024-01-29 |
mouse |
| Zhifang Wang, Menglin Kou, Qiyue Deng, Haotian Yu, Jilin Mei, Jing Gao, Wen Fu, Baile Nin. Acupuncture Activates IRE1/XBP1 Endoplasmic Reticulum Stress Pathway in Parkinson's Disease Model Rats. Behavioural brain research. 2024-01-24. PMID:38266778. |
firstly, we assessed the behavioral changes in pd rats, the modulation of dopamine (da) and 5-hydroxytryptamine (5-ht) levels in the striatum, as well as the alteration in α-synuclein (α-syn) levels in the midbrain, aiming to evaluate the efficacy of acupuncture in pd treatment. |
2024-01-24 |
2024-01-27 |
rat |
| Bahareh Tolooshams, Sara Matias, Hao Wu, Simona Temereanca, Naoshige Uchida, Venkatesh N Murthy, Paul Masset, Demba B. Interpretable deep learning for deconvolutional analysis of neural signals. bioRxiv : the preprint server for biology. 2024-01-23. PMID:38260512. |
to exemplify use cases of our decomposition method, we uncover multiplexed salience and reward prediction error signals from midbrain dopamine neurons in an unbiased manner, perform simultaneous event detection and characterization in somatosensory thalamus recordings, and characterize the responses of neurons in piriform cortex. |
2024-01-23 |
2024-01-25 |
Not clear |
| Liuliu Yang, Tae Wan Kim, Yuling Han, Manoj S Nair, Oliver Harschnitz, Jiajun Zhu, Pengfei Wang, So Yeon Koo, Lauretta A Lacko, Vasuretha Chandar, Yaron Bram, Tuo Zhang, Wei Zhang, Feng He, Chendong Pan, Junjie Wu, Yaoxing Huang, Todd Evans, Paul van der Valk, Maarten J Titulaer, Jochem K H Spoor, Robert L Furler O'Brien, Marianna Bugiani, Wilma D J Van de Berg, Robert E Schwartz, David D Ho, Lorenz Studer, Shuibing Che. SARS-CoV-2 infection causes dopaminergic neuron senescence. Cell stem cell. 2024-01-18. PMID:38237586. |
here, we show that midbrain dopamine (da) neurons derived from human pluripotent stem cells (hpscs) are selectively susceptible and permissive to severe acute respiratory syndrome coronavirus 2 (sars-cov-2) infection. |
2024-01-18 |
2024-01-21 |
human |
| Xiahai Zheng, Jing Lin, Zhenzhen Wang, Zhenming Zeng, Haoxiong Che. Research of the analgesic effects and central nervous system impact of electroacupuncture therapy in rats with knee osteoarthritis. Heliyon. vol 10. issue 1. 2024-01-16. PMID:38226224. |
dopamine (da), norepinephrine (ne), 5-hydroxytryptamine (5-ht), β-endorphin (β-ep), and leucine-enkephalin (l-enk) were detected in the midbrain and spinal cord of lumbar enlargement. |
2024-01-16 |
2024-01-18 |
rat |
| Maggy Yu Hei Lau, Sana Gadiwalla, Susan Jones, Elisa Gallian. Different electrophysiological profiles of genetically labelled dopaminergic neurons in the mouse midbrain and olfactory bulb. The European journal of neuroscience. 2024-01-03. PMID:38169095. |
after confirming the penetrance and specificity of the dopamine transporter (dat) cre line, we compared soma shape, passive membrane properties, voltage sags and action potential (ap) firing across midbrain and forebrain bulbar da subtypes. |
2024-01-03 |
2024-01-06 |
mouse |
| Giovanni Mirabella, Andrea Pilotto, Andrea Rizzardi, Martina Montalti, Enrica Olivola, Cinzia Zatti, Veronica Di Caprio, Elisabetta Ferrari, Nicola Modugno, Alessandro Padovan. Effects of dopaminergic treatment on inhibitory control differ across Hoehn and Yahr stages of Parkinson's disease. Brain communications. vol 6. issue 1. 2024-01-01. PMID:38162902. |
a progressive loss of the midbrain's dopamine neurons characterizes parkinson's disease and causes motor features responsive to dopaminergic treatments. |
2024-01-01 |
2024-01-05 |
Not clear |
| Duncan J Noble, Aida Mohammadkhani, Min Qiao, Stephanie L Borglan. Characterization of dopaminergic projections from the ventral tegmental area and the dorsal raphe nucleus to the orbital frontal cortex. The European journal of neuroscience. 2023-12-28. PMID:38155094. |
midbrain dopamine from either the ventral tegmental area (vta) or the dorsal raphe nucleus (drn) has the potential to modulate ofc neurons; however, it is unknown at what concentrations these terminals release dopamine. |
2023-12-28 |
2023-12-31 |
Not clear |
| Pedro Rifes, Marc Isaksson, Charlotte Rusimbi, Adrián Ramón Santonja, Jenny Nelander, Thomas Laurell, Agnete Kirkeb. Identifying secreted biomarkers of dopaminergic ventral midbrain progenitor cells. Stem cell research & therapy. vol 14. issue 1. 2023-12-10. PMID:38072935. |
ventral midbrain (vm) dopaminergic progenitor cells derived from human pluripotent stem cells have the potential to replace endogenously lost dopamine neurons and are currently in preclinical and clinical development for treatment of parkinson's disease (pd). |
2023-12-10 |
2023-12-17 |
human |
| Niklas Hammer, Pascal Vogel, Sanghun Lee, Jochen Roepe. Optogenetic action potentials and intrinsic pacemaker interplay in retrogradely identified midbrain dopamine neurons. The European journal of neuroscience. 2023-12-06. PMID:38056070. |
optogenetic action potentials and intrinsic pacemaker interplay in retrogradely identified midbrain dopamine neurons. |
2023-12-06 |
2023-12-10 |
mouse |
| Niklas Hammer, Pascal Vogel, Sanghun Lee, Jochen Roepe. Optogenetic action potentials and intrinsic pacemaker interplay in retrogradely identified midbrain dopamine neurons. The European journal of neuroscience. 2023-12-06. PMID:38056070. |
dissecting the diversity of midbrain dopamine (da) neurons by optotagging is a promising addition to better identify their functional properties and contribution to motivated behavior. |
2023-12-06 |
2023-12-10 |
mouse |
| Malika S Datta, Yannan Chen, Shradha Chauhan, Jing Zhang, Estanislao Daniel De La Cruz, Cheng Gong, Raju Tome. Whole-brain mapping reveals the divergent impact of ketamine on the dopamine system. Cell reports. 2023-12-05. PMID:38052211. |
here, we develop a sub-cellular resolution whole-brain phenotyping approach and utilize it in male mice to show that repeated ketamine administration leads to a dose-dependent decrease in dopamine neurons in midbrain regions linked to behavioral states, alongside an increase in the hypothalamus. |
2023-12-05 |
2023-12-10 |
mouse |
| Francis Carter, Marie-Pierre Cossette, Ivan Trujillo-Pisanty, Vasilios Pallikaras, Yannick-André Breton, Kent Conover, Jill Caplan, Pavel Solis, Jacques Voisard, Alexandra Yaksich, Peter Shizga. Does phasic dopamine release cause policy updates? The European journal of neuroscience. 2023-12-01. PMID:38039083. |
here, we challenge this view by demonstrating stable, non-maximal work rates in the face of repeated optogenetic stimulation of midbrain dopamine neurons. |
2023-12-01 |
2023-12-10 |
rat |
| L Paul Sands, Angela Jiang, Brittany Liebenow, Emily DiMarco, Adrian W Laxton, Stephen B Tatter, P Read Montague, Kenneth T Kishid. Subsecond fluctuations in extracellular dopamine encode reward and punishment prediction errors in humans. Science advances. vol 9. issue 48. 2023-12-01. PMID:38039368. |
in the mammalian brain, midbrain dopamine neuron activity is hypothesized to encode reward prediction errors that promote learning and guide behavior by causing rapid changes in dopamine levels in target brain regions. |
2023-12-01 |
2023-12-10 |
human |
| Dana Bell, Vaughn J Waldron, P Leon Brow. Quantitative and qualitative sex difference in habenula-induced inhibition of midbrain dopamine neurons in the rat. Frontiers in behavioral neuroscience. vol 17. 2023-12-01. PMID:38025387. |
quantitative and qualitative sex difference in habenula-induced inhibition of midbrain dopamine neurons in the rat. |
2023-12-01 |
2023-12-07 |
rat |