| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N Shashaank, Mahalakshmi Somayaji, Mattia Miotto, Eugene V Mosharov, Emily A Makowicz, David A Knowles, Giancarlo Ruocco, David L Sulze. Computational models of dopamine release measured by fast scan cyclic voltammetry in vivo. PNAS nexus. vol 2. issue 3. 2023-03-13. PMID:36909827. |
ventral midbrain dopamine neurons exhibit ongoing tonic firing that produces low extrasynaptic levels of dopamine below the detection of conventional extrasynaptic cyclic voltammetry (∼10-20 nanomolar), with superimposed bursts that can saturate the dopamine uptake transporter and produce transient micromolar concentrations. |
2023-03-13 |
2023-08-14 |
mouse |
| Baile Ning, Zhifang Wang, Qian Wu, Qiyue Deng, Qing Yang, Jing Gao, Wen Fu, Ying Deng, Bingxin Wu, Xichang Huang, Jilin Mei, Wenbin F. Acupuncture inhibits autophagy and repairs synapses by activating the mTOR pathway in Parkinson's disease depression model rats. Brain research. 2023-03-13. PMID:36914042. |
firstly, observing the behavioral changes of the dpd rat model, the regulation of monoamine neurotransmitters dopamine (da) and 5-hydroxytryptamine (5-ht) in the midbrain, the change of α-synuclein (α-syn) in the striatum, the efficacy of acupuncture in the treatment of dpd was discussed. |
2023-03-13 |
2023-08-14 |
rat |
| William Shao-Tsu Chen, Tzu-Ying Lin, Chia-Hua Kuo, Dennis Jine-Yuan Hsieh, Wei-Wen Kuo, Shih-Chieh Liao, Hui-Chuan Kao, Da-Tong Ju, Yu-Jung Lin, Chih-Yang Huan. Ginkgolide A improves the pleiotropic function and reinforces the neuroprotective effects by mesenchymal stem cell-derived exosomes in 6-OHDA-induced cell model of Parkinson's disease. Aging. vol 15. 2023-03-02. PMID:36863713. |
parkinson's disease (pd) is a common disorder attributed to the loss of midbrain dopamine (mda) neurons and reduced dopamine secretion. |
2023-03-02 |
2023-08-14 |
Not clear |
| M J Corenblum, A McRobbie-Johnson, E Carruth, K Bernard, M Luo, L J Mandarino, S Peterson, D Billheimer, T Maley, E D Eggers, L Madhava. Parallel Neurodegenerative Phenotypes in Sporadic Parkinson's Disease Fibroblasts and Midbrain Dopamine Neurons. bioRxiv : the preprint server for biology. 2023-02-17. PMID:36798207. |
parallel neurodegenerative phenotypes in sporadic parkinson's disease fibroblasts and midbrain dopamine neurons. |
2023-02-17 |
2023-08-14 |
human |
| M J Corenblum, A McRobbie-Johnson, E Carruth, K Bernard, M Luo, L J Mandarino, S Peterson, D Billheimer, T Maley, E D Eggers, L Madhava. Parallel Neurodegenerative Phenotypes in Sporadic Parkinson's Disease Fibroblasts and Midbrain Dopamine Neurons. bioRxiv : the preprint server for biology. 2023-02-17. PMID:36798207. |
here, we report cellular and molecular alterations in skin fibroblasts of late-onset sporadic pd subjects, that were recapitulated in matched induced pluripotent stem cell (ipsc)-derived midbrain dopamine (da) neurons, reprogrammed from the same fibroblasts. |
2023-02-17 |
2023-08-14 |
human |
| Alexander Allen, Elizabeth Heisler, J Matthew Kittelberge. Dopamine Injections to the Midbrain Periaqueductal Gray Inhibit Vocal-Motor Production in a Teleost Fish. Physiology & behavior. 2023-02-16. PMID:36796532. |
dopamine injections to the midbrain periaqueductal gray inhibit vocal-motor production in a teleost fish. |
2023-02-16 |
2023-08-14 |
Not clear |
| Daniel F Hill, Robert W Hickman, Alaa Al-Mohammad, Arkadiusz Stasiak, Wolfram Schult. Dopamine signals encode internally determined subjective value regardless of externally indicated reward attributes. bioRxiv : the preprint server for biology. 2023-01-30. PMID:36711724. |
responses of midbrain dopamine neurons followed the trial-by-trial variation of bids despite constant, explicitly predicted reward amounts; correspondingly, the dopamine responses were similar when the animal placed similar bids for different reward amounts. |
2023-01-30 |
2023-08-14 |
human |
| Jean Paul Selten, Johan Orme. Low status, humiliation, dopamine and risk of schizophrenia. Psychological medicine. 2023-01-25. PMID:36695070. |
since most individuals exposed to low status do not develop schizophrenia, we propose that this risk factor increases the risk of disorder in the presence of a poor homeostatic control of dopamine neurons in midbrain and dorsal striatum. |
2023-01-25 |
2023-08-14 |
human |
| Jean Paul Selten, Johan Orme. Low status, humiliation, dopamine and risk of schizophrenia. Psychological medicine. 2023-01-25. PMID:36695070. |
in this new version of the social defeat hypothesis we propose that the combination of low status, repeated humiliation and poor homeostatic control of dopamine neurons in midbrain and dorsal striatum leads to increased striatal dopamine activity and thereby to an increased risk of schizophrenia. |
2023-01-25 |
2023-08-14 |
human |
| Eva Troyano-Rodriguez, Harris E Blankenship, Kylie Handa, Sarah Y Branch, Michael J Beckstea. Preservation of dendritic D2 receptor transmission in substantia nigra dopamine neurons with age. Scientific reports. vol 13. issue 1. 2023-01-19. PMID:36658269. |
in the midbrain, d2-type dopamine receptors located at dendrodendritic synapses between dopamine neurons control cell firing through g protein-activated potassium (girk) channels. |
2023-01-19 |
2023-08-14 |
mouse |
| Oxana Garritsen, Eljo Y van Battum, Laurens M Grossouw, R Jeroen Pasterkam. Development, wiring and function of dopamine neuron subtypes. Nature reviews. Neuroscience. 2023-01-18. PMID:36653531. |
the midbrain dopamine (mda) system is composed of molecularly and functionally distinct neuron subtypes that mediate specific behaviours and are linked to various brain diseases. |
2023-01-18 |
2023-08-14 |
Not clear |
| Joseph J Lebowitz, Aditi Banerjee, Claire Qiao, James R Bunzow, John T Williams, Pascal S Kaese. Synaptotagmin-1 is a Ca Cell reports. vol 42. issue 1. 2023-01-14. PMID:36640316. |
somatodendritic dopamine secretion in the midbrain leads to d2 receptor-induced modulation of dopamine neurons on the timescale of seconds. |
2023-01-14 |
2023-08-14 |
Not clear |
| Young Cha, Tae-Yoon Park, Pierre Leblanc, Kwang-Soo Ki. Current Status and Future Perspectives on Stem Cell-Based Therapies for Parkinson's Disease. Journal of movement disorders. 2023-01-11. PMID:36628428. |
because the loss of a specific cell type, midbrain dopamine neurons in the substantia nigra, is the main cause of motor dysfunction in pd, it is considered a promising target for cell replacement therapy. |
2023-01-11 |
2023-08-14 |
human |
| Shenjie Wu, Nancy C Hernandez Villegas, Daniel W Sirkis, Iona Thomas-Wright, Richard Wade-Martins, Randy Schekma. Unconventional secretion of α-synuclein mediated by palmitoylated DNAJC5 oligomers. eLife. vol 12. 2023-01-10. PMID:36626307. |
the secretion of endogenous α-syn mediated by dnajc5 is also found in a human neuroblastoma cell line, sh-sy5y, differentiated into neurons in the presence of retinoic acid, and in human induced pluripotent stem cell-derived midbrain dopamine neurons. |
2023-01-10 |
2023-08-14 |
human |
| Ruben K Dagda, Raul Y Dagda, Emmanuel Vazquez-Mayorga, Bridget Martinez, Aine Gallahu. Intranasal Administration of Forskolin and Noopept Reverses Parkinsonian Pathology in PINK1 Knockout Rats. International journal of molecular sciences. vol 24. issue 1. 2023-01-08. PMID:36614135. |
parkinson's disease (pd) is a brain-degenerative disorder characterized by a progressive loss of midbrain dopamine neurons. |
2023-01-08 |
2023-08-14 |
rat |
| Ruben K Dagda, Raul Y Dagda, Emmanuel Vazquez-Mayorga, Bridget Martinez, Aine Gallahu. Intranasal Administration of Forskolin and Noopept Reverses Parkinsonian Pathology in PINK1 Knockout Rats. International journal of molecular sciences. vol 24. issue 1. 2023-01-08. PMID:36614135. |
we previously showed that enhancing pka activity in the brain via intraperitoneal administration of forskolin in parkinsonian rats (pink1 knockout) abrogate motor symptoms and loss of midbrain dopamine neurons. |
2023-01-08 |
2023-08-14 |
rat |
| Ruben K Dagda, Raul Y Dagda, Emmanuel Vazquez-Mayorga, Bridget Martinez, Aine Gallahu. Intranasal Administration of Forskolin and Noopept Reverses Parkinsonian Pathology in PINK1 Knockout Rats. International journal of molecular sciences. vol 24. issue 1. 2023-01-08. PMID:36614135. |
results show that intranasal administration of a formulation (cns/ct-001) containing forskolin (10 µm) and noopept (20 nm) significantly reversed motor symptoms, loss of hind limb strength, and neurodegeneration of midbrain dopamine neurons in pink1-ko rats and is indistinguishable from wild-type (wt) rats; therapeutic effects associated with increased pka activity and levels of bdnf and ngf in the brain. |
2023-01-08 |
2023-08-14 |
rat |
| Sarah Thomas Broome, Alessandro Castorin. Systemic Rotenone Administration Causes Extra-Nigral Alterations in C57BL/6 Mice. Biomedicines. vol 10. issue 12. 2022-12-23. PMID:36551930. |
molecular analyses showed reductions of both th and dat expression in the midbrain, striatum and spinal cord, accompanied by altered expression of dopamine receptors and brain-derived neurotrophic factor (bdnf). |
2022-12-23 |
2023-08-14 |
mouse |
| Pardeep Yadav, Pratik Chakraborty, Niraj Kumar Jha, Saikat Dewanjee, Abhimanyu Kumar Jha, Siva Prasad Panda, Prabhu Chandra Mishra, Abhijit Dey, Saurabh Kumar Jh. Molecular Mechanism and Role of Japanese Encephalitis Virus Infection in Central Nervous System-Mediated Diseases. Viruses. vol 14. issue 12. 2022-12-23. PMID:36560690. |
however, jev enters human brain microvascular endothelial cells via an endocytic pathway mediated by caveolae and the ezrin protein and also targets dopamine-rich areas for infection of the midbrain via altering dopamine levels. |
2022-12-23 |
2023-08-14 |
human |
| Jun Li, Nan Li, Jingkuan Wei, Chun Feng, Yanying Chen, Tingwei Chen, Zongyong Ai, Xiaoqing Zhu, Weizhi Ji, Tianqing L. Genetically engineered mesenchymal stem cells with dopamine synthesis for Parkinson's disease in animal models. NPJ Parkinson's disease. vol 8. issue 1. 2022-12-22. PMID:36550118. |
importantly, after grafting into the caudate and putamen, dopa-mscs provide homotopic reconstruction of midbrain dopamine pathways by restoring striatal dopamine levels, and safely and long-term (up to 51 months) correct motor disorders and nonmotor deficits in acute and chronic pd rhesus monkey models of pd even with advanced pd symptoms. |
2022-12-22 |
2023-08-14 |
rat |