| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xi-Biao He, Fang Guo, Kexuan Li, Jiaqing Yan, Sang-Hun Le. Timing of MeCP2 Expression Determines Midbrain Dopamine Neuron Phenotype Specification. Stem cells (Dayton, Ohio). 2022-08-30. PMID:36041430. |
midbrain dopamine (da) neurons are associated with locomotor and psychiatric disorders. |
2022-08-30 |
2023-08-14 |
mouse |
| Vasilios Pallikaras, Peter Shizga. Dopamine and Beyond: Implications of Psychophysical Studies of Intracranial Self-Stimulation for the Treatment of Depression. Brain sciences. vol 12. issue 8. 2022-08-26. PMID:36009115. |
the proposed neural substrate for this promising clinical finding includes midbrain dopamine neurons and a subset of their cortical afferents. |
2022-08-26 |
2023-08-14 |
Not clear |
| Vasilios Pallikaras, Peter Shizga. Dopamine and Beyond: Implications of Psychophysical Studies of Intracranial Self-Stimulation for the Treatment of Depression. Brain sciences. vol 12. issue 8. 2022-08-26. PMID:36009115. |
we chart the evolution of the new model from its predecessors, which held that midbrain dopamine neurons constituted an obligatory stage of the final common path for reward seeking. |
2022-08-26 |
2023-08-14 |
Not clear |
| Xiaojie Liu, Casey R Vickstrom, Hao Yu, Shuai Liu, Shana Terai Snarrenberg, Vladislav Friedman, Lianwei Mu, Bixuan Chen, Thomas J Kelly, David A Baker, Qing-Song Li. Epac2 in midbrain dopamine neurons contributes to cocaine reinforcement via facilitation of dopamine release. eLife. vol 11. 2022-08-22. PMID:35993549. |
epac2 in midbrain dopamine neurons contributes to cocaine reinforcement via facilitation of dopamine release. |
2022-08-22 |
2023-08-14 |
mouse |
| Xiaojie Liu, Casey R Vickstrom, Hao Yu, Shuai Liu, Shana Terai Snarrenberg, Vladislav Friedman, Lianwei Mu, Bixuan Chen, Thomas J Kelly, David A Baker, Qing-Song Li. Epac2 in midbrain dopamine neurons contributes to cocaine reinforcement via facilitation of dopamine release. eLife. vol 11. 2022-08-22. PMID:35993549. |
conditional knockout of epac2 from midbrain dopamine neurons (epac2-cko) and the selective epac2 inhibitor esi-05 decreased cocaine self-administration in mice under both fixed-ratio and progressive-ratio reinforcement schedules and across a broad range of cocaine doses. |
2022-08-22 |
2023-08-14 |
mouse |
| Valentina Martinez Damonte, Matthew B Pomrenze, Claire E Manning, Caroline Casper, Annie L Wolfden, Robert C Malenka, Julie A Kaue. Somatodendritic Release of Cholecystokinin Potentiates GABAergic Synapses Onto Ventral Tegmental Area Dopamine Cells. Biological psychiatry. 2022-08-12. PMID:35961792. |
cholecystokinin (cck), among the most abundant neuropeptides in the brain, is expressed in the majority of midbrain dopamine neurons. |
2022-08-12 |
2023-08-14 |
Not clear |
| Minzhe Yang, Qiangpei Fu, Chaolin Ma, Baoming L. Prefrontal Dopaminergic Regulation of Cue-Guided Risky Decision-Making Performance in Rats. Frontiers in behavioral neuroscience. vol 16. 2022-07-28. PMID:35898651. |
the pfc receives projections from the dopamine (da) system from the ventral tegmental area of the midbrain. |
2022-07-28 |
2023-08-14 |
rat |
| Polina Kosillo, Kamran M Ahmed, Erin E Aisenberg, Vasiliki Karalis, Bradley M Roberts, Stephanie J Cragg, Helen S Bateu. Dopamine neuron morphology and output are differentially controlled by mTORC1 and mTORC2. eLife. vol 11. 2022-07-26. PMID:35881440. |
midbrain dopamine neurons are particularly sensitive to mtor signaling status as activation or inhibition of mtor alters their morphology and physiology. |
2022-07-26 |
2023-08-14 |
mouse |
| Wan Chen Lin, Christine Liu, Polina Kosillo, Lung-Hao Tai, Ezequiel Galarce, Helen S Bateup, Stephan Lammel, Linda Wilbrech. Transient food insecurity during the juvenile-adolescent period affects adult weight, cognitive flexibility, and dopamine neurobiology. Current biology : CB. 2022-07-21. PMID:35863352. |
consistent with these results, in males, we found that the two feeding history groups showed significant differences in the ampar/nmdar ratio of excitatory synapses on nucleus-accumbens-projecting midbrain dopamine neurons and evoked dopamine release in dorsal striatal targets. |
2022-07-21 |
2023-08-14 |
mouse |
| Yunseon Yang, Jae-Jin Song, Yu Ree Choi, Seong-Hoon Kim, Min-Jong Seok, Noviana Wulansari, Wahyu Handoko Wibowo Darsono, Oh-Chan Kwon, Mi-Yoon Chang, Sang Myun Park, Sang-Hun Le. Therapeutic functions of astrocytes to treat α-synuclein pathology in Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 119. issue 29. 2022-07-20. PMID:35858361. |
transplantation of vm astrocytes into the midbrain of pd model mice alleviated α-syn pathology and protected the midbrain dopamine neurons from neurodegeneration. |
2022-07-20 |
2023-08-14 |
mouse |
| Ewa Galaj, Briana Hempel, Allamar Moore, Benjamin Klein, Guo-Hua Bi, Eliot L Gardner, Herbert H Seltzman, Zheng-Xiong X. Therapeutic potential of PIMSR, a novel CB1 receptor neutral antagonist, for cocaine use disorder: evidence from preclinical research. Translational psychiatry. vol 12. issue 1. 2022-07-19. PMID:35851573. |
pimsr itself failed to alter electrical icss, but dose-dependently inhibited icss maintained by optical stimulation of midbrain dopamine neurons in transgenic dat-cre mice, suggesting the involvement of dopamine-dependent mechanisms. |
2022-07-19 |
2023-08-14 |
mouse |
| Rachel Thomas, Adan Hernandez, David R Benavides, Wei Li, Chunfeng Tan, Alan Umfress, Florian Plattner, Ayanabha Chakraborti, Lucas Pozzo-Miller, Susan S Taylor, James A Bib. Integrated regulation of PKA by fast and slow neurotransmission in the nucleus accumbens controls plasticity and stress responses. The Journal of biological chemistry. 2022-07-14. PMID:35835216. |
cortical glutamate and midbrain dopamine neurotransmission converge to mediate striatum-dependent behaviors, while maladaptations in striatal circuitry contribute to mental disorders. |
2022-07-14 |
2023-08-14 |
rat |
| Kamil Pradel, Gniewosz Drwięga, Lukasz Chrobok, Tomasz Błasia. Racing and Pacing in the Reward System: A Multi-Clock Circadian Control Over Dopaminergic Signalling. Frontiers in physiology. vol 13. 2022-07-11. PMID:35812323. |
these processes cause dopamine levels released in structures innervated by midbrain dopaminergic neurons (e.g., the striatum) to oscillate in a circadian fashion. |
2022-07-11 |
2023-08-14 |
human |
| Ryunosuke Amo, Sara Matias, Akihiro Yamanaka, Kenji F Tanaka, Naoshige Uchida, Mitsuko Watabe-Uchid. A gradual temporal shift of dopamine responses mirrors the progression of temporal difference error in machine learning. Nature neuroscience. 2022-07-07. PMID:35798979. |
a large body of evidence has indicated that the phasic responses of midbrain dopamine neurons show a remarkable similarity to a type of teaching signal (temporal difference (td) error) used in machine learning. |
2022-07-07 |
2023-08-14 |
mouse |
| Christopher W Tschumi, Harris E Blankenship, Ramaswamy Sharma, William B Lynch, Michael J Beckstea. Neurotensin Release from Dopamine Neurons Drives Long-Term Depression of Substantia Nigra Dopamine Signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-07-06. PMID:35794014. |
midbrain dopamine neurons play central physiological roles in voluntary movement, reward learning, and motivated behavior. |
2022-07-06 |
2023-08-14 |
Not clear |
| Karim Fifel, Amina El Farissi, Yoan Cherasse, Masashi Yanagisaw. Motivational and Valence-Related Modulation of Sleep/Wake Behavior are Mediated by Midbrain Dopamine and Uncoupled from the Homeostatic and Circadian Processes. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2022-07-06. PMID:35794435. |
motivational and valence-related modulation of sleep/wake behavior are mediated by midbrain dopamine and uncoupled from the homeostatic and circadian processes. |
2022-07-06 |
2023-08-14 |
Not clear |
| Karim Fifel, Amina El Farissi, Yoan Cherasse, Masashi Yanagisaw. Motivational and Valence-Related Modulation of Sleep/Wake Behavior are Mediated by Midbrain Dopamine and Uncoupled from the Homeostatic and Circadian Processes. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2022-07-06. PMID:35794435. |
given the well-established role of midbrain dopamine (mda) neurons in encoding motivation and emotional valence, here, neuronal mechanisms mediating sleep/wake regulation are systematically investigated by da neurotransmission. |
2022-07-06 |
2023-08-14 |
Not clear |
| Francesca Palese, Silvia Pontis, Natalia Realini, Alexa Torrens, Faizy Ahmed, Francesca Assogna, Clelia Pellicano, Paola Bossù, Gianfranco Spalletta, Kim Green, Daniele Piomell. Targeting NAAA counters dopamine neuron loss and symptom progression in mouse models of parkinsonism. Pharmacological research. 2022-07-05. PMID:35781057. |
a similar effect was observed in mouse midbrain dopamine neurons following intra-striatal 6-ohda injection. |
2022-07-05 |
2023-08-14 |
mouse |
| Qiu-Yu Yang, Xian-Wei Li, Rong Yang, Ting-Yang Qin, Hong Long, Shi-Bin Zhang, Feng Zhan. Effects of intraperitoneal injection of lipopolysaccharide-induced peripheral inflammation on dopamine neuron damage in rat midbrain. CNS neuroscience & therapeutics. 2022-07-05. PMID:35789066. |
effects of intraperitoneal injection of lipopolysaccharide-induced peripheral inflammation on dopamine neuron damage in rat midbrain. |
2022-07-05 |
2023-08-14 |
rat |
| Yunting Zhu, Samantha J Owens, Caitlin E Murphy, Kachikwulu Ajulu, Debora Rothmond, Tertia Purves-Tyson, Frank Middleton, Maree J Webster, Cynthia Shannon Weicker. Inflammation-related transcripts define "high" and "low" subgroups of individuals with schizophrenia and bipolar disorder in the midbrain. Brain, behavior, and immunity. 2022-06-28. PMID:35764269. |
dopamine dysregulation in schizophrenia may be associated with midbrain inflammation. |
2022-06-28 |
2023-08-14 |
Not clear |