| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lieneke Katharina Janssen, Annette Horstman. Molecular Imaging of Central Dopamine in Obesity: A Qualitative Review across Substrates and Radiotracers. Brain sciences. vol 12. issue 4. 2022-04-21. PMID:35448017. |
the aim of the current review is to give a comprehensive overview of molecular neuroimaging studies that investigated the relation between bmi or weight status and any dopamine target in the striatal and midbrain regions of the human brain. |
2022-04-21 |
2023-08-13 |
human |
| Riccardo Melani, Nicolas X Tritsc. Inhibitory co-transmission from midbrain dopamine neurons relies on presynaptic GABA uptake. Cell reports. vol 39. issue 3. 2022-04-20. PMID:35443174. |
inhibitory co-transmission from midbrain dopamine neurons relies on presynaptic gaba uptake. |
2022-04-20 |
2023-08-13 |
Not clear |
| Vasilios Pallikaras, Peter Shizga. The Convergence Model of Brain Reward Circuitry: Implications for Relief of Treatment-Resistant Depression by Deep-Brain Stimulation of the Medial Forebrain Bundle. Frontiers in behavioral neuroscience. vol 16. 2022-04-18. PMID:35431828. |
panksepp attributed intracranial self-stimulation to excitation of the seeking system in which the ascending projections of midbrain dopamine neurons are an essential component. |
2022-04-18 |
2023-08-13 |
rat |
| Vasilios Pallikaras, Peter Shizga. The Convergence Model of Brain Reward Circuitry: Implications for Relief of Treatment-Resistant Depression by Deep-Brain Stimulation of the Medial Forebrain Bundle. Frontiers in behavioral neuroscience. vol 16. 2022-04-18. PMID:35431828. |
that work argues that the predominant directly stimulated substrate for mfb self-stimulation are myelinated, non-dopaminergic fibers, more readily excited by brief electrical current pulses than the thin, unmyelinated axons of the midbrain dopamine neurons. |
2022-04-18 |
2023-08-13 |
rat |
| Vasilios Pallikaras, Peter Shizga. The Convergence Model of Brain Reward Circuitry: Implications for Relief of Treatment-Resistant Depression by Deep-Brain Stimulation of the Medial Forebrain Bundle. Frontiers in behavioral neuroscience. vol 16. 2022-04-18. PMID:35431828. |
the series-circuit hypothesis reconciles this view with the evidence implicating dopamine in mfb self-stimulation as follows: direct activation of myelinated mfb fibers is rewarding due to their trans-synaptic activation of midbrain dopamine neurons. |
2022-04-18 |
2023-08-13 |
rat |
| Vasilios Pallikaras, Peter Shizga. The Convergence Model of Brain Reward Circuitry: Implications for Relief of Treatment-Resistant Depression by Deep-Brain Stimulation of the Medial Forebrain Bundle. Frontiers in behavioral neuroscience. vol 16. 2022-04-18. PMID:35431828. |
a recent study in which rats worked for optogenetic stimulation of midbrain dopamine neurons challenges the series-circuit hypothesis and provides a new model of intracranial self-stimulation in which the myelinated non-dopaminergic neurons and the midbrain dopamine projections access the behavioral final common path for reward seeking via separate, converging routes. |
2022-04-18 |
2023-08-13 |
rat |
| Abdallah Zayed, Camille Baranowski, Anne-Claire Compagnion, Cécile Vernochet, Samah Karaki, Romain Durand-de Cuttoli, Estefani Saint-Jour, Soumee Bhattacharya, Fabio Marti, Peter Vanhoutte, Moshe Yaniv, Philippe Faure, Jacques Barik, Laurence Amar, François Tronche, Sébastien Parnaudea. SWI/SNF chromatin remodeler complex within the reward pathway is required for behavioral adaptations to stress. Nature communications. vol 13. issue 1. 2022-04-05. PMID:35379786. |
the inactivation of the brg1/smarca4 gene within dopamine-innervated regions or the constitutive inactivation of the brm/smarca2 gene leads to resilience to repeated social defeat and decreases the behavioral responses to cocaine without impacting midbrain dopamine neurons activity. |
2022-04-05 |
2023-08-13 |
mouse |
| Divya Yadav, Pravir Kuma. Restoration and targeting of aberrant neurotransmitters in Parkinson's disease therapeutics. Neurochemistry international. 2022-03-25. PMID:35331828. |
parkinson's disease (pd) occurs due to extensive damage of dopamine-producing neurons; this causes dopamine deficits in the midbrain, followed by the alternation of various other neurotransmitters (glutamate, gaba, serotonin, etc.). |
2022-03-25 |
2023-08-13 |
Not clear |
| Adrianne F Pike, Ildikò Szabò, Robert Veerhuis, Luigi Bubacc. The potential convergence of NLRP3 inflammasome, potassium, and dopamine mechanisms in Parkinson's disease. NPJ Parkinson's disease. vol 8. issue 1. 2022-03-25. PMID:35332154. |
potassium conductance also influences dopamine release from midbrain dopaminergic neurons. |
2022-03-25 |
2023-08-13 |
Not clear |
| Merel Dagher, Katie A Perrotta, Sara A Erwin, Ayaka Hachisuka, Rahul Iyer, Sotiris C Masmanidis, Hongyan Yang, Anne M Andrew. Optogenetic Stimulation of Midbrain Dopamine Neurons Produces Striatal Serotonin Release. ACS chemical neuroscience. 2022-03-21. PMID:35312275. |
optogenetic stimulation of midbrain dopamine neurons produces striatal serotonin release. |
2022-03-21 |
2023-08-13 |
mouse |
| Merel Dagher, Katie A Perrotta, Sara A Erwin, Ayaka Hachisuka, Rahul Iyer, Sotiris C Masmanidis, Hongyan Yang, Anne M Andrew. Optogenetic Stimulation of Midbrain Dopamine Neurons Produces Striatal Serotonin Release. ACS chemical neuroscience. 2022-03-21. PMID:35312275. |
we transfected midbrain dopamine neurons with the excitatory opsin chrimson. |
2022-03-21 |
2023-08-13 |
mouse |
| Edward J Robinson, Sebastian P Aguiar, Willemieke M Kouwenhoven, Dorinde S Starmans, Lars von Oerthel, Marten P Smidt, Lars P van der Heid. Correction to: Survival of midbrain dopamine neurons depends on the Bcl2 factor Mcl1. Cell death discovery. vol 8. issue 1. 2022-03-08. PMID:35256597. |
correction to: survival of midbrain dopamine neurons depends on the bcl2 factor mcl1. |
2022-03-08 |
2023-08-13 |
Not clear |
| Thomas Steinkellner, William S Conrad, Imre Kovacs, Robert A Rissman, Edward B Lee, John Q Trojanowski, Zachary Freyberg, Subhojit Roy, Kelvin C Luk, Virginia M Lee, Thomas S Hnask. Dopamine neurons exhibit emergent glutamatergic identity in Parkinson's disease. Brain : a journal of neurology. 2022-03-08. PMID:35258081. |
loss of midbrain dopamine neurons causes the cardinal symptoms of parkinson's disease. |
2022-03-08 |
2023-08-13 |
Not clear |
| Thomas Steinkellner, William S Conrad, Imre Kovacs, Robert A Rissman, Edward B Lee, John Q Trojanowski, Zachary Freyberg, Subhojit Roy, Kelvin C Luk, Virginia M Lee, Thomas S Hnask. Dopamine neurons exhibit emergent glutamatergic identity in Parkinson's disease. Brain : a journal of neurology. 2022-03-08. PMID:35258081. |
most midbrain dopamine neurons express the vesicular glutamate transporter vglut2 during development and a subset continue to express low levels of vglut2 in adulthood, enabling the co-release of glutamate. |
2022-03-08 |
2023-08-13 |
Not clear |
| María-José Sánchez-Catalán, Michel Barro. Fos response of the tail of the ventral tegmental area to food restriction entails a prediction error processing. Behavioural brain research. 2022-03-05. PMID:35247487. |
the tail of the ventral tegmental area (tvta) or rostromedial tegmental nucleus (rmtg) receives lateral habenula inputs and projects heavily to midbrain dopamine neurons. |
2022-03-05 |
2023-08-13 |
rat |
| María-José Sánchez-Catalán, Michel Barro. Fos response of the tail of the ventral tegmental area to food restriction entails a prediction error processing. Behavioural brain research. 2022-03-05. PMID:35247487. |
midbrain dopamine and lateral habenula neurons participate in learning processes predicting the outcomes of actions, placing the tvta in a critical location into prediction error pathways. |
2022-03-05 |
2023-08-13 |
rat |
| Benoît Delignat-Lavaud, Charles Ducrot, Willemieke Kouwenhoven, Nina Feller, Louis-Éric Trudea. Implication of synaptotagmins 4 and 7 in activity-dependent somatodendritic dopamine release in the ventral midbrain. Open biology. vol 12. issue 3. 2022-03-02. PMID:35232250. |
implication of synaptotagmins 4 and 7 in activity-dependent somatodendritic dopamine release in the ventral midbrain. |
2022-03-02 |
2023-08-13 |
mouse |
| Andrew J Kesner, Coleman B Calva, Satoshi Ikemot. Seeking motivation and reward: roles of dopamine, hippocampus and supramammillo-septal pathway. Progress in neurobiology. 2022-03-01. PMID:35227866. |
extensive research suggests that reinforcement learning and goal-seeking behavior are mediated by midbrain dopamine neurons. |
2022-03-01 |
2023-08-13 |
Not clear |
| Niamh Moriarty, Carlos W Gantner, Cameron P J Hunt, Charlotte M Ermine, Stefano Frausin, Serena Viventi, Dmitry A Ovchinnikov, Deniz Kirik, Clare L Parish, Lachlan H Thompso. A combined cell and gene therapy approach for homotopic reconstruction of midbrain dopamine pathways using human pluripotent stem cells. Cell stem cell. 2022-02-18. PMID:35180398. |
a combined cell and gene therapy approach for homotopic reconstruction of midbrain dopamine pathways using human pluripotent stem cells. |
2022-02-18 |
2023-08-13 |
human |
| Niamh Moriarty, Carlos W Gantner, Cameron P J Hunt, Charlotte M Ermine, Stefano Frausin, Serena Viventi, Dmitry A Ovchinnikov, Deniz Kirik, Clare L Parish, Lachlan H Thompso. A combined cell and gene therapy approach for homotopic reconstruction of midbrain dopamine pathways using human pluripotent stem cells. Cell stem cell. 2022-02-18. PMID:35180398. |
midbrain dopamine (mda) neurons can be replaced in patients with parkinson's disease (pd) in order to provide long-term improvement in motor functions. |
2022-02-18 |
2023-08-13 |
human |