| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michele Salemi, Giuseppe Lanza, Maria Paola Mogavero, Filomena I I Cosentino, Eugenia Borgione, Roberta Iorio, Giovanna Maria Ventola, Giovanna Marchese, Maria Grazia Salluzzo, Maria Ravo, Raffaele Ferr. A Transcriptome Analysis of mRNAs and Long Non-Coding RNAs in Patients with Parkinson's Disease. International journal of molecular sciences. vol 23. issue 3. 2022-02-15. PMID:35163455. |
clinical symptoms include the progressive loss of dopaminergic neurons in the substantia nigra of the midbrain, which leads to striatal dopamine deficiency and, subsequently, causes motor dysfunction. |
2022-02-15 |
2023-08-13 |
human |
| Rubén Pavia-Collado, Raquel Rodríguez-Aller, Diana Alarcón-Arís, Lluís Miquel-Rio, Esther Ruiz-Bronchal, Verónica Paz, Leticia Campa, Mireia Galofré, Véronique Sgambato, Analia Bortolozz. Up and Down γ-Synuclein Transcription in Dopamine Neurons Translates into Changes in Dopamine Neurotransmission and Behavioral Performance in Mice. International journal of molecular sciences. vol 23. issue 3. 2022-02-15. PMID:35163729. |
the current study aimed at investigating the biological role of γ-syn controlling the midbrain dopamine (da) function. |
2022-02-15 |
2023-08-13 |
mouse |
| Pieter Derdeyn, May Hui, Desiree Macchia, Kevin T Beie. Uncovering the Connectivity Logic of the Ventral Tegmental Area. Frontiers in neural circuits. vol 15. 2022-02-14. PMID:35153681. |
decades of research have revealed the remarkable complexity of the midbrain dopamine (da) system, which comprises cells principally located in the ventral tegmental area (vta) and substantia nigra pars compacta (snc). |
2022-02-14 |
2023-08-13 |
Not clear |
| Olga Skiteva, Ning Yao, Giacomo Sitzia, Karima Chergu. LRRK2-G2019S mice display alterations in glutamatergic synaptic transmission in midbrain dopamine neurons. Journal of neurochemistry. 2022-02-13. PMID:35152441. |
lrrk2-g2019s mice display alterations in glutamatergic synaptic transmission in midbrain dopamine neurons. |
2022-02-13 |
2023-08-13 |
mouse |
| Jisun Kim, Jeha Jeon, Bin Song, Nayeon Lee, Sanghyeok Ko, Young Cha, Pierre Leblanc, Hyemyung Seo, Kwang-Soo Ki. Spotting-based differentiation of functional dopaminergic progenitors from human pluripotent stem cells. Nature protocols. 2022-02-10. PMID:35140411. |
this highly reproducible protocol describes how to grow hpscs such as human induced pluripotent and embryonic stem cells in a physically confined area ('spot') and efficiently differentiate them into a highly enriched population of healthy and functional midbrain dopamine progenitors (mdaps) and midbrain dopamine neurons (mdans). |
2022-02-10 |
2023-08-13 |
human |
| Qi Hu, Mei Hong, Mengyang Huang, Quan Gong, Xiaofan Zhang, Vladimir N Uversky, Francisco Pan-Montojo, Teng Huang, Honglian Zhou, Suiqiang Zh. Age-dependent aggregation of α-synuclein in the nervous system of gut-brain axis is associated with caspase-1 activation. Metabolic brain disease. 2022-01-28. PMID:35089485. |
whereas, the expression of tyrosine hydroxylase (th), the rate-limiting enzyme for dopamine synthesis, was decreased with aging in the midbrain. |
2022-01-28 |
2023-08-13 |
mouse |
| Javed Ahmed Ujjan, William Morani, Naz Memon, Sugumar Mohanasundaram, Shibili Nuhmani, Bhupesh Kumar Sing. Force Platform-Based Intervention Program for Individuals Suffering with Neurodegenerative Diseases like Parkinson. Computational and mathematical methods in medicine. vol 2022. 2022-01-27. PMID:35082910. |
substantia nigra (a midbrain dopaminergic nucleus) with lack of hormone called dopamine causes parkinson's disease (pd), a neurological disorder. |
2022-01-27 |
2023-08-13 |
human |
| Erwan Bezard, Benjamin Deha. [Aggregation and spread of synuclein in Parkinson's disease]. Medecine sciences : M/S. vol 38. issue 1. 2022-01-21. PMID:35060886. |
the neuropathological features of parkinson's disease are the progressive loss of dopamine neurons in the midbrain and the formation of aggregates composed mainly of a-synuclein protein. |
2022-01-21 |
2023-08-13 |
Not clear |
| Benjamin D Hobson, Linghao Kong, Maria Florencia Angelo, Ori J Lieberman, Eugene V Mosharov, Etienne Herzog, David Sulzer, Peter A Sim. Subcellular and regional localization of mRNA translation in midbrain dopamine neurons. Cell reports. vol 38. issue 2. 2022-01-12. PMID:35021090. |
subcellular and regional localization of mrna translation in midbrain dopamine neurons. |
2022-01-12 |
2023-08-13 |
Not clear |
| Emmanuel Vazquez-Mayorga, Mariana Grigoruta, Raul Dagda, Bridget Martinez, Ruben K Dagd. Intraperitoneal Administration of Forskolin Reverses Motor Symptoms and Loss of Midbrain Dopamine Neurons in PINK1 Knockout Rats. Journal of Parkinson's disease. 2021-12-27. PMID:34957950. |
intraperitoneal administration of forskolin reverses motor symptoms and loss of midbrain dopamine neurons in pink1 knockout rats. |
2021-12-27 |
2023-08-13 |
rat |
| Hao Yu, Xiaojie Liu, Bixuan Chen, Casey R Vickstrom, Vladislav Friedman, Thomas J Kelly, Xiaowen Bai, Li Zhao, Cecilia J Hillard, Qing-Song Li. The Neuroprotective Effects of the CB2 Agonist GW842166x in the 6-OHDA Mouse Model of Parkinson's Disease. Cells. vol 10. issue 12. 2021-12-24. PMID:34944056. |
to investigate potential mechanisms for the neuroprotective effects of gw842166x, we performed electrophysiological recordings from substantia nigra pars compacta (snc) dopamine neurons in ex vivo midbrain slices prepared from drug-naïve mice. |
2021-12-24 |
2023-08-13 |
mouse |
| Alexander K Song, Kaitlyn R Hay, Paula Trujillo, Megan Aumann, Adam J Stark, Yan Yan, Hakmook Kang, Manus J Donahue, David H Zald, Daniel O Claasse. Amphetamine-induced dopamine release and impulsivity in Parkinson disease. Brain : a journal of neurology. 2021-12-24. PMID:34951464. |
prior studies of impulsivity suggest that midbrain d2 autoreceptors regulate striatal dopamine release in a feedback inhibitory manner, and in healthy populations, greater impulsivity is linked to poor proficiency of this inhibition. |
2021-12-24 |
2023-08-13 |
human |
| Alexander K Song, Kaitlyn R Hay, Paula Trujillo, Megan Aumann, Adam J Stark, Yan Yan, Hakmook Kang, Manus J Donahue, David H Zald, Daniel O Claasse. Amphetamine-induced dopamine release and impulsivity in Parkinson disease. Brain : a journal of neurology. 2021-12-24. PMID:34951464. |
we hypothesized that parkinson disease patients with impulsive-compulsive behaviors would have greater ventral striatal dopaminergic response to dextroamphetamine, and that an inability to attenuate ventral striatal dopamine release via midbrain d2 autoreceptors would underlie this response. |
2021-12-24 |
2023-08-13 |
human |
| Alexander K Song, Kaitlyn R Hay, Paula Trujillo, Megan Aumann, Adam J Stark, Yan Yan, Hakmook Kang, Manus J Donahue, David H Zald, Daniel O Claasse. Amphetamine-induced dopamine release and impulsivity in Parkinson disease. Brain : a journal of neurology. 2021-12-24. PMID:34951464. |
in participants without impulsive-compulsive behaviors, baseline midbrain d2 receptor availability negatively correlated with ventral striatal dopamine release; however, this relationship was absent in those with impulsive-compulsive behaviors. |
2021-12-24 |
2023-08-13 |
human |
| Alexander K Song, Kaitlyn R Hay, Paula Trujillo, Megan Aumann, Adam J Stark, Yan Yan, Hakmook Kang, Manus J Donahue, David H Zald, Daniel O Claasse. Amphetamine-induced dopamine release and impulsivity in Parkinson disease. Brain : a journal of neurology. 2021-12-24. PMID:34951464. |
these findings emphasize that reward-based behaviors in pd are regulated by ventral striatal dopamine release, and suggest that loss of inhibitory feedback from midbrain autoreceptors may underlie the manifestation of impulsive-compulsive behaviors. |
2021-12-24 |
2023-08-13 |
human |
| Anne-Emilie Allain, Oceane Aribo, Maria-Carmen Medrano, Marie-Line Fournier, Sandrine S Bertrand, Stephanie Caill. Impact of acute and chronic nicotine administration on midbrain dopaminergic neuron activity and related behaviors in TRPV1 knock-out juvenile mice. The European journal of neuroscience. 2021-12-23. PMID:34939238. |
the addictive properties of nicotine, the main alkaloid in tobacco and tobacco-derived products, largely depend on its action on the activity of midbrain dopamine (da) neurons. |
2021-12-23 |
2023-08-13 |
mouse |
| Xiaodan Li, Jian Xiong, Baojian Zhang, Dongting Zhangsun, Sulan Lu. α-Conotoxin TxIB Inhibits Development of Morphine-Induced Conditioned Place Preference in Mice Frontiers in pharmacology. vol 12. 2021-12-20. PMID:34925031. |
previous studies have showed that α6β2* (* designated other subunits) nachrs are mainly distributed in dopaminergic neurons in the midbrain area, which regulates the release of dopamine. |
2021-12-20 |
2023-08-13 |
mouse |
| Kenan Steidel, Marina C Ruppert, Irina Palaghia, Andrea Greuel, Masoud Tahmasian, Franziska Maier, Jochen Hammes, Thilo van Eimeren, Lars Timmermann, Marc Tittgemeyer, Alexander Drzezga, David Pedrosa, Carsten Egger. Dopaminergic pathways and resting-state functional connectivity in Parkinson's disease with freezing of gait. NeuroImage. Clinical. vol 32. 2021-12-16. PMID:34911202. |
seed-to-voxel resting-state functional connectivity maps of the resulting dopamine depleted structures and dopaminergic midbrain regions were created and compared between both groups. |
2021-12-16 |
2023-08-13 |
Not clear |
| Alessandro Fiorenzano, Edoardo Sozzi, Marcella Birtele, Janko Kajtez, Jessica Giacomoni, Fredrik Nilsson, Andreas Bruzelius, Yogita Sharma, Yu Zhang, Bengt Mattsson, Jenny Emnéus, Daniella Rylander Ottosson, Petter Storm, Malin Parma. Single-cell transcriptomics captures features of human midbrain development and dopamine neuron diversity in brain organoids. Nature communications. vol 12. issue 1. 2021-12-16. PMID:34911939. |
single-cell transcriptomics captures features of human midbrain development and dopamine neuron diversity in brain organoids. |
2021-12-16 |
2023-08-13 |
human |
| Alessandro Fiorenzano, Edoardo Sozzi, Marcella Birtele, Janko Kajtez, Jessica Giacomoni, Fredrik Nilsson, Andreas Bruzelius, Yogita Sharma, Yu Zhang, Bengt Mattsson, Jenny Emnéus, Daniella Rylander Ottosson, Petter Storm, Malin Parma. Single-cell transcriptomics captures features of human midbrain development and dopamine neuron diversity in brain organoids. Nature communications. vol 12. issue 1. 2021-12-16. PMID:34911939. |
here we establish a midbrain organoid culture system to study the developmental trajectory from pluripotent stem cells to mature dopamine neurons. |
2021-12-16 |
2023-08-13 |
human |