| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anders Björklund, Malin Parma. Dopamine Cell Therapy: From Cell Replacement to Circuitry Repair. Journal of Parkinson's disease. vol 11. issue s2. 2021-11-11. PMID:33814467. |
cell therapy for parkinson's disease (pd) is aimed to replace the degenerated midbrain dopamine (mda) neurons and restore da neurotransmission in the denervated forebrain targets. |
2021-11-11 |
2023-08-13 |
human |
| Seung Won Kim, Hye-Ji Woo, Eun Hee Kim, Hyung Sun Kim, Han Na Suh, Soo-Hyun Kim, Jae-Jin Song, Noviana Wulansari, Minji Kang, Se-Young Choi, Su Jeong Choi, Won Hyuk Jang, Jungbin Lee, Ki Hean Kim, Wongyoung Lee, Sung Hyun Kim, Jinhee Yang, Jangbeen Kyung, Hyun-Seob Lee, Sang Myun Park, Mi-Yoon Chang, Sang-Hun Le. Neural stem cells derived from human midbrain organoids as a stable source for treating Parkinson's disease: Midbrain organoid-NSCs (Og-NSC) as a stable source for PD treatment. Progress in neurobiology. vol 204. 2021-11-11. PMID:34052305. |
neural stem/precursor cells (nscs) isolated from midbrain organoids (og-nscs) expanded stably and differentiated into midbrain-type dopamine(mda) neurons, and an unprecedentedly high proportion expressed midbrain-specific factors, with relatively low cell line and batch-to-batch variations. |
2021-11-11 |
2023-08-13 |
human |
| Mahsa Moaddab, Michael A McDannal. Retrorubral field is a hub for diverse threat and aversive outcome signals. Current biology : CB. vol 31. issue 10. 2021-11-10. PMID:33756109. |
we propose that the retrorubral field (rrf), a midbrain region containing a8 dopamine, is a neural origin of such signals. |
2021-11-10 |
2023-08-13 |
rat |
| Suchan Chang, Yu Fan, Soo Min Lee, Yeonhee Ryu, Bong Hyo Lee, Sang Chan Kim, Kyle B Bills, Scott C Steffensen, Chae Ha Yang, Hee Young Ki. Acupuncture reduces cocaine psychomotor responses by activating the rostromedial tegmental nucleus. Addiction biology. vol 26. issue 6. 2021-11-10. PMID:33969586. |
the rostromedial tegmental nucleus (rmtg), a gabaergic afferent to midbrain dopamine (da) neurons, has emerged as an integral player in both rewarding and nociceptive responses. |
2021-11-10 |
2023-08-13 |
Not clear |
| Morgane M Moss, Peter Zatka-Haas, Kenneth D Harris, Matteo Carandini, Armin La. Dopamine Axons in Dorsal Striatum Encode Contralateral Visual Stimuli and Choices. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 34. 2021-11-09. PMID:34253628. |
the striatum plays critical roles in visually-guided decision-making and receives dense axonal projections from midbrain dopamine neurons. |
2021-11-09 |
2023-08-13 |
mouse |
| Luke D Smillie, Daniel Bennett, Nicholas P Tan, Kiran Sutcliffe, Kirill Fayn, Stefan Bode, Jan Wacke. Does openness/intellect predict sensitivity to the reward value of information? Cognitive, affective & behavioral neuroscience. vol 21. issue 5. 2021-11-05. PMID:33973158. |
this theory draws on evidence that midbrain dopamine neurons respond to unpredicted information gain, mirroring their responses to unpredicted primary rewards. |
2021-11-05 |
2023-08-13 |
human |
| Dong-Hee Kim, Bo-Ryoung Choi, Yong-Jae Jeon, Yoon-Sun Jang, Jung-Soo Ha. Engagement of lateral habenula in the extinction of the appetitive conditioned responses. Behavioural brain research. vol 415. 2021-11-04. PMID:34389424. |
midbrain dopamine neurons are activated by presenting a reward or predictable reward cue, whereas the cue signaling the absence of reward activates the lateral habenula (lhb) neurons. |
2021-11-04 |
2023-08-13 |
rat |
| Andrea N Belovich, Jenny I Aguilar, Samuel J Mabry, Mary H Cheng, Daniele Zanella, Peter J Hamilton, Daniel J Stanislowski, Aparna Shekar, James D Foster, Ivet Bahar, Heinrich J G Matthies, Aurelio Gall. A network of phosphatidylinositol (4,5)-bisphosphate (PIP Molecular psychiatry. vol 26. issue 8. 2021-11-02. PMID:31796894. |
numerous human pet-fmri studies establish a link between midbrain dopamine (da) release, da transporter (dat) availability, and reward responses. |
2021-11-02 |
2023-08-13 |
human |
| K Ushna S Islam, Norisa Meli, Sandra Blaes. The Development of the Mesoprefrontal Dopaminergic System in Health and Disease. Frontiers in neural circuits. vol 15. 2021-10-30. PMID:34712123. |
midbrain dopaminergic neurons located in the substantia nigra and the ventral tegmental area are the main source of dopamine in the brain. |
2021-10-30 |
2023-08-13 |
Not clear |
| Alessandro Fiorenzano, Edoardo Sozzi, Malin Parmar, Petter Stor. Dopamine Neuron Diversity: Recent Advances and Current Challenges in Human Stem Cell Models and Single Cell Sequencing. Cells. vol 10. issue 6. 2021-10-27. PMID:34206038. |
human midbrain dopamine (da) neurons are a heterogeneous group of cells that share a common neurotransmitter phenotype and are in close anatomical proximity but display different functions, sensitivity to degeneration, and axonal innervation targets. |
2021-10-27 |
2023-08-13 |
mouse |
| Oh-Chan Kwon, Jae-Jin Song, Yunseon Yang, Seong-Hoon Kim, Ji Young Kim, Min-Jong Seok, Inhwa Hwang, Je-Wook Yu, Jenisha Karmacharya, Han-Joo Maeng, Jiyoung Kim, Eek-Hoon Jho, Seung Yeon Ko, Hyeon Son, Mi-Yoon Chang, Sang-Hun Le. SGK1 inhibition in glia ameliorates pathologies and symptoms in Parkinson disease animal models. EMBO molecular medicine. vol 13. issue 4. 2021-10-25. PMID:33646633. |
along with those anti-inflammatory/neurotrophic functions, silencing and pharmacological inhibition of sgk1 protected midbrain dopamine neurons from degeneration and cured pathologic synuclein alpha (snca) aggregation and pd-associated behavioral deficits in multiple in vitro and in vivo pd models. |
2021-10-25 |
2023-08-13 |
Not clear |
| Ariana Z Turk, Mahsa Lotfi Marchoubeh, Ingrid Fritsch, Gerald A Maguire, Shahriar SheikhBahae. Dopamine, vocalization, and astrocytes. Brain and language. vol 219. 2021-10-25. PMID:34098250. |
dopamine, the main catecholamine neurotransmitter in the brain, is predominately produced in the basal ganglia and released to various brain regions including the frontal cortex, midbrain and brainstem. |
2021-10-25 |
2023-08-13 |
Not clear |
| Lucy A Crompton, Sarah F McComish, Petros Stathakos, Oscar Cordero-Llana, Jon D Lane, Maeve A Caldwel. Efficient and Scalable Generation of Human Ventral Midbrain Astrocytes from Human-Induced Pluripotent Stem Cells. Journal of visualized experiments : JoVE. issue 176. 2021-10-25. PMID:34661566. |
in parkinson's disease, progressive dysfunction and degeneration of dopamine neurons in the ventral midbrain cause life-changing symptoms. |
2021-10-25 |
2023-08-13 |
human |
| Benjamin M Seitz, Aaron P Blaisdell, Melissa J Sharp. Higher-Order Conditioning and Dopamine: Charting a Path Forward. Frontiers in behavioral neuroscience. vol 15. 2021-10-22. PMID:34671247. |
however, midbrain dopamine, a neurotransmitter long thought to facilitate basic pavlovian conditioning in a relatively simplistic manner, appears critical for both soc and spc. |
2021-10-22 |
2023-08-13 |
human |
| Mikhail U Inyushin, Francisco Arencibia-Albite, Angel de la Cruz, Rafael Vázquez-Torres, Katiria Colon, Priscila Sanabria, Carlos A Jiménez-River. New method to visualize neurons with DAT in slices of rat VTA using fluorescent substrate for DAT, ASP+ Journal of neuroscience and neuroengineering. vol 2. issue 2. 2021-10-21. PMID:24052926. |
new method to visualize neurons with dat in slices of rat vta using fluorescent substrate for dat, asp+ the ventral tegmental area (vta), and in particular dopamine (da) neurons in this region of midbrain, has been shown to play an important role in motivation (goal-directed behavior), reward, and drug addiction. |
2021-10-21 |
2023-08-12 |
rat |
| John J Woodward, Jacob Beckle. Effects of the abused inhalant toluene on the mesolimbic dopamine system. Journal of drug and alcohol research. vol 3. 2021-10-21. PMID:25360326. |
in this review, we focus on the current state of knowledge regarding toluene's action on midbrain dopamine neurons, a key brain region involved in the initial assessment of natural and drug-induced rewards. |
2021-10-21 |
2023-08-13 |
rat |
| Yujie Xiao, Jun Yang, Wenliang Ji, Quansheng He, Lanqun Mao, Yousheng Sh. A- and D-type potassium currents regulate axonal action potential repolarization in midbrain dopamine neurons. Neuropharmacology. vol 185. 2021-10-21. PMID:33400937. |
a- and d-type potassium currents regulate axonal action potential repolarization in midbrain dopamine neurons. |
2021-10-21 |
2023-08-13 |
Not clear |
| Yujie Xiao, Jun Yang, Wenliang Ji, Quansheng He, Lanqun Mao, Yousheng Sh. A- and D-type potassium currents regulate axonal action potential repolarization in midbrain dopamine neurons. Neuropharmacology. vol 185. 2021-10-21. PMID:33400937. |
midbrain dopamine neurons (dans) regulate various brain functions such as motor control and motivation. |
2021-10-21 |
2023-08-13 |
Not clear |
| Heath S Partington, Jennifer Makenzie Nutter, Jeffrey B Eell. Nurr1 deficiency shortens free running period, enhances photoentrainment to phase advance, and disrupts circadian cycling of the dopamine neuron phenotype. Behavioural brain research. vol 411. 2021-10-18. PMID:33991560. |
neurological and neuropsychiatric disorders, including addiction, schizophrenia, and parkinson's disease (pd), involve dysfunction in midbrain dopamine (da) neurotransmission with severity of disease symptoms and progression associated with disrupted circadian rhythms. |
2021-10-18 |
2023-08-13 |
mouse |
| Bo Ning, Gongbo Guo, Chunming Gu, Jiadi Xu, Adnan Bibic, Xiaofei He, Hongshuai Liu, Lin Chen, Zhiliang Wei, Wenzhen Duan, Peiying Liu, Hanzhang Lu, Peter C M van Zijl, Christopher A Ross, Wanli Smith, Jun Hu. Mutant G2019S-LRRK2 Induces Abnormalities in Arteriolar Cerebral Blood Volume in Mouse Brains: An MRI Study. Neuro-degenerative diseases. vol 20. issue 2-3. 2021-10-14. PMID:33152738. |
parkinson's disease (pd) is the second most common neurodegenerative disease and the most common movement disorder characterized by motor impairments resulting from midbrain dopamine neuron loss. |
2021-10-14 |
2023-08-13 |
mouse |