| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrew R Tapper, Susanna Mola. Midbrain circuits of novelty processing. Neurobiology of learning and memory. vol 176. 2021-09-27. PMID:33053429. |
accumulating evidence indicate that midbrain circuits, the majority of which linked to dopamine transmission, promote exploratory assessments and guide approach/avoidance behaviors to different types of novelty via specific projection sites. |
2021-09-27 |
2023-08-13 |
Not clear |
| Samuel K Powell, Callan O'Shea, Kayla Townsley, Iya Prytkova, Kristina Dobrindt, Rahat Elahi, Marina Iskhakova, Tova Lambert, Aditi Valada, Will Liao, Seok-Man Ho, Paul A Slesinger, Laura M Huckins, Schahram Akbarian, Kristen J Brennan. Induction of dopaminergic neurons for neuronal subtype-specific modeling of psychiatric disease risk. Molecular psychiatry. 2021-09-26. PMID:34493831. |
we observe maturation-dependent increase in dopamine synthesis and electrophysiological properties consistent with midbrain dopaminergic neuron identity, such as slow-rising after- hyperpolarization potentials, an action potential duration of ~3 ms, tonic sub-threshold oscillatory activity, and spontaneous burst firing at a frequency of ~1.0-1.75 hz. |
2021-09-26 |
2023-08-13 |
human |
| Yong-Xia Xu, Guo-Ying Liu, Qian Jiang, Han-Qi Bi, Shi-Chan Wang, Ping-Ping Zhang, Chao-Bing Gao, Gui-Hai Chen, Wen-Hui Cheng, Guan-Jun Chen, De-Fa Zhu, Ming-Kui Zhong, Qi X. Effect of Restricted Feeding on Metabolic Health and Sleep-Wake Rhythms in Aging Mice. Frontiers in neuroscience. vol 15. 2021-09-25. PMID:34557073. |
during the rf regime, dopamine levels in the midbrain increased in the rf group, pointing to its potential as the mechanism mediating metabolic symptoms and sleep-wake regulation during rf. |
2021-09-25 |
2023-08-13 |
mouse |
| Alexander Woolrych, Nicolas Vautrelle, John N J Reynolds, Louise C Parr-Brownli. Throwing open the doors of perception: The role of dopamine in visual processing. The European journal of neuroscience. vol 54. issue 6. 2021-09-24. PMID:34340265. |
however, such signals primarily originate in cortical and basal ganglia circuits, and evidence of direct signalling from midbrain dopamine neurons to superior colliculus is lacking. |
2021-09-24 |
2023-08-13 |
Not clear |
| Jing Jiang, Xiujuan Hu, Lihua Liu, Zhicheng He, Qingjie Wu, Qunchao Li, Xianwei Hu, Nan Jiang, Chao Li. Age-related changes in expression of lysine48 and lysine63 ubiquitin linkages in dopamine neurons of midbrain in mice. Neuroreport. vol 32. issue 7. 2021-09-17. PMID:33657079. |
age-related changes in expression of lysine48 and lysine63 ubiquitin linkages in dopamine neurons of midbrain in mice. |
2021-09-17 |
2023-08-13 |
mouse |
| Jing Jiang, Xiujuan Hu, Lihua Liu, Zhicheng He, Qingjie Wu, Qunchao Li, Xianwei Hu, Nan Jiang, Chao Li. Age-related changes in expression of lysine48 and lysine63 ubiquitin linkages in dopamine neurons of midbrain in mice. Neuroreport. vol 32. issue 7. 2021-09-17. PMID:33657079. |
these results suggest the first time that expression of k48 and k63 ubiquitin lysine linkages in midbrain dopamine neurons is age-related and may be involved in the loss of dopamine neurons. |
2021-09-17 |
2023-08-13 |
mouse |
| Dominic P Isaacs, Ryan P Leman, Thomas J Everett, Hendrick Lopez-Beltran, Lindsey R Hamilton, Erik B Oleso. Buprenorphine is a weak dopamine releaser relative to heroin, but its pretreatment attenuates heroin-evoked dopamine release in rats. Neuropsychopharmacology reports. vol 40. issue 4. 2021-09-07. PMID:32935483. |
by activating gi/o-coupled μ-opioid receptors, opioids are thought to indirectly excite midbrain dopamine neurons by removing an inhibitory gabaergic tone. |
2021-09-07 |
2023-08-13 |
rat |
| Vasilisa Skvortsova, Stefano Palminteri, Anne Buot, Carine Karachi, Marie-Laure Welter, David Grabli, Mathias Pessiglion. A Causal Role for the Pedunculopontine Nucleus in Human Instrumental Learning. Current biology : CB. vol 31. issue 5. 2021-09-07. PMID:33352119. |
a wealth of evidence across species and experimental techniques has established that rpes are signaled by midbrain dopamine neurons. |
2021-09-07 |
2023-08-13 |
human |
| Juliann D Jaumotte, Mart Saarma, Michael J Zigmon. Protection of dopamine neurons by CDNF and neurturin variant N4 against MPP+ in dissociated cultures from rat mesencephalon. PloS one. vol 16. issue 2. 2021-09-07. PMID:33534843. |
protection of dopamine neurons by cdnf and neurturin variant n4 against mpp+ in dissociated cultures from rat mesencephalon. |
2021-09-07 |
2023-08-13 |
rat |
| Juliann D Jaumotte, Mart Saarma, Michael J Zigmon. Protection of dopamine neurons by CDNF and neurturin variant N4 against MPP+ in dissociated cultures from rat mesencephalon. PloS one. vol 16. issue 2. 2021-09-07. PMID:33534843. |
parkinson's disease is associated with the loss of dopamine (da) neurons in ventral mesencephalon. |
2021-09-07 |
2023-08-13 |
rat |
| Rahul, Yasir Siddiqu. Neurodegenerative disorders and the current state, pathophysiology and management of Parkinson's disease. CNS & neurological disorders drug targets. 2021-09-03. PMID:34477534. |
based on neurotoxicological studies and postmortem investigations, now there is a general concept that how environmental toxicants (neurotoxins, pesticides insecticides) and genetic factors (genetic mutations in pd-associated proteins) cause depletion of dopamine from substantia nigra pars compacta region of midbrain and modulate cellular processes leading to pathogenesis of pd. |
2021-09-03 |
2023-08-13 |
Not clear |
| Jian Fen. Modeling the pathophysiology of Parkinson's disease in patient-specific neurons. Experimental biology and medicine (Maywood, N.J.). vol 246. issue 3. 2021-09-02. PMID:32972199. |
using midbrain neuronal cultures differentiated from ipscs of parkinson's disease patients with parkin mutations, we find that parkin mutations cause oscillatory neuronal activities when dopamine d1-class receptors are activated. |
2021-09-02 |
2023-08-13 |
human |
| Jessica A Mollick, Thomas E Hazy, Kai A Krueger, Ananta Nair, Prescott Mackie, Seth A Herd, Randall C O'Reill. A systems-neuroscience model of phasic dopamine. Psychological review. vol 127. issue 6. 2021-08-31. PMID:32525345. |
the lv system represents the amygdala, which drives phasic bursting in midbrain dopamine areas, while the pv system represents the ventral striatum, which drives shunting inhibition of dopamine for expected uss (via direct inhibitory projections) and phasic pausing for expected uss (via the lateral habenula). |
2021-08-31 |
2023-08-13 |
Not clear |
| Ave Eesmaa, Li-Ying Yu, Helka Göös, Kristofer Nõges, Vera Kovaleva, Maarit Hellman, Richard Zimmermann, Martin Jung, Perttu Permi, Markku Varjosalo, Päivi Lindholm, Mart Saarm. The cytoprotective protein MANF promotes neuronal survival independently from its role as a GRP78 cofactor. The Journal of biological chemistry. vol 296. 2021-08-31. PMID:33460650. |
although initially characterized as a secreted neurotrophic factor for midbrain dopamine neurons, manf has recently gained more interest for its intracellular role in regulating the er homeostasis, including serving as a cofactor of the chaperone glucose-regulated protein 78 (grp78). |
2021-08-31 |
2023-08-13 |
Not clear |
| Susana Mingote, Nao Chuhma, Stephen Raypor. Optogenetic Mapping of Synaptic Connections in Mouse Brain Slices to Definethe Functional Connectome of Identified Neuronal Populations. Bio-protocol. vol 7. issue 1. 2021-08-31. PMID:34458420. |
here we describe the experimental protocol used to investigate the excitatory functional connectome of ventral midbrain dopamine neurons, mediated by glutamate cotransmission ( mingote |
2021-08-31 |
2023-08-13 |
mouse |
| Denis Pavăl, Ioana Valentina Micluți. The Dopamine Hypothesis of Autism Spectrum Disorder Revisited: Current Status and Future Prospects. Developmental neuroscience. vol 43. issue 2. 2021-08-25. PMID:34010842. |
in 2017, we provided a theoretical framework for a "dopamine hypothesis of asd" which proposed that autistic behavior arises from a dysfunctional midbrain dopaminergic system. |
2021-08-25 |
2023-08-13 |
Not clear |
| Nii A Add. An ongoing saga of nicotine complexity and dopamine heterogeneity: Nicotine activation and inhibition mediating reward and anxiety. Neuron. vol 109. issue 16. 2021-08-25. PMID:34411537. |
in this issue of neuron, nguyen and colleagues (nguyen et al., 2021) investigate nicotine's effects on diverse midbrain dopamine neurons. |
2021-08-25 |
2023-08-13 |
Not clear |
| Paolo Flace, Paolo Livrea, Gianpaolo Antonio Basile, Diana Galletta, Antonella Bizzoca, Gianfranco Gennarini, Salvatore Bertino, Jacopo Junio Valerio Branca, Massimo Gulisano, Simona Bianconi, Alessia Bramanti, Giuseppe Anastas. The Cerebellar Dopaminergic System. Frontiers in systems neuroscience. vol 15. 2021-08-24. PMID:34421548. |
nevertheless, biochemical studies detected in the mammalians cerebellum high dopamine levels, while chemical neuroanatomy studies revealed the presence of midbrain dopaminergic afferents to the cerebellum as well as wide distribution of the dopaminergic receptor subtypes (drd |
2021-08-24 |
2023-08-13 |
Not clear |
| Aimée I Vester, Karen Hermetz, Amber Burt, Todd Everson, Carmen J Marsit, William M Caudl. Combined neurodevelopmental exposure to deltamethrin and corticosterone is associated with Nr3c1 hypermethylation in the midbrain of male mice. Neurotoxicology and teratology. vol 80. 2021-08-20. PMID:32348866. |
work from our group and that of others indicates that deltamethrin insecticide and stress exposure during neurodevelopment leads to alterations in dopamine function, and we hypothesized that exposure to both of these factors together would lead to synergistic effects on dna methylation of key genes within the midbrain, a highly dopaminergic region, that could contribute to these findings. |
2021-08-20 |
2023-08-13 |
mouse |
| Jean-Francois Poulin, Zachary Gaertner, Oscar Andrés Moreno-Ramos, Rajeshwar Awatraman. Classification of Midbrain Dopamine Neurons Using Single-Cell Gene Expression Profiling Approaches. Trends in neurosciences. vol 43. issue 3. 2021-08-18. PMID:32101709. |
classification of midbrain dopamine neurons using single-cell gene expression profiling approaches. |
2021-08-18 |
2023-08-13 |
Not clear |