| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zachary A Grieb, Joseph S Lonstei. Oxytocin receptor expression in the midbrain dorsal raphe is dynamic across female reproduction in rats. Journal of neuroendocrinology. vol 33. issue 2. 2021-06-15. PMID:33427399. |
overall, these results suggest that the rostral subregion of the midbrain dr is uniquely sensitive to oxytocin around the time of parturition, with subpopulations of cells that become more sensitive (i.e., dopamine), less sensitive (i.e., gaba) and show no change (i.e., serotonin) to this neuropeptide. |
2021-06-15 |
2023-08-13 |
rat |
| Yun Tang, Xiao-Ke Yang, Xin-Wei Zhang, Wen-Tao Wu, Fu-Li Zhang, Hong Jiang, Yan-Ling Liu, Christian Amatore, Wei-Hua Huan. Harpagide, a natural product, promotes synaptic vesicle release as measured by nanoelectrode amperometry. Chemical science. vol 11. issue 3. 2021-06-15. PMID:34123052. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by progressive loss of dopaminergic (daergic) neurons and low level of dopamine (da) in the midbrain. |
2021-06-15 |
2023-08-13 |
Not clear |
| Cameron S Carte. Further evidence that MRI based measurement of midbrain neuromelanin may serve as a proxy measure of brain dopamine activity in psychiatric disorders. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 7. 2021-06-11. PMID:33526833. |
further evidence that mri based measurement of midbrain neuromelanin may serve as a proxy measure of brain dopamine activity in psychiatric disorders. |
2021-06-11 |
2023-08-13 |
Not clear |
| Francisco Arencibia-Albite, Carlos A Jiménez-River. Computational and theoretical insights into the homeostatic response to the decreased cell size of midbrain dopamine neurons. Physiological reports. vol 9. issue 2. 2021-06-03. PMID:33484235. |
computational and theoretical insights into the homeostatic response to the decreased cell size of midbrain dopamine neurons. |
2021-06-03 |
2023-08-13 |
human |
| Francisco Arencibia-Albite, Carlos A Jiménez-River. Computational and theoretical insights into the homeostatic response to the decreased cell size of midbrain dopamine neurons. Physiological reports. vol 9. issue 2. 2021-06-03. PMID:33484235. |
midbrain dopamine neurons communicate signals of reward anticipation and attribution of salience. |
2021-06-03 |
2023-08-13 |
human |
| Jingyi He, Guofu Zhu, Guoqing Wang, Feng Zhan. Oxidative Stress and Neuroinflammation Potentiate Each Other to Promote Progression of Dopamine Neurodegeneration. Oxidative medicine and cellular longevity. vol 2020. 2021-05-28. PMID:32714488. |
progressive loss of dopamine (da) neurons in midbrain substantia nigra is considered to be the main cause of pd. |
2021-05-28 |
2023-08-13 |
Not clear |
| Shuibing Chen, Yuling Han, Liuliu Yang, Tae Kim, Manoj Nair, Oliver Harschnitz, Pengfei Wang, Jiajun Zhu, So Yeon Koo, Xuming Tang, Lauretta Lacko, Vasuretha Chandar, Yaron Bram, Tuo Zhang, Wei Zhang, Feng He, James Caicedo, Yaoxing Huang, Todd Evans, Paul van der Valk, Maarten J Titulaer, Jochem K H Spoor, Robert L Furler, Peter Canoll, James Goldman, Serge Przedborski, Robert Schwartz, David Ho, Lorenz Stude. SARS-CoV-2 Infection Causes Dopaminergic Neuron Senescence. Research square. 2021-05-28. PMID:34031650. |
here, we show that midbrain dopamine (da) neurons derived from human pluripotent stem cells (hpscs) are selectively permissive to sars-cov-2 infection both in vitro and upon transplantation in vivo, and that sars-cov-2 infection triggers a da neuron inflammatory and cellular senescence response. |
2021-05-28 |
2023-08-13 |
human |
| Tae Wan Kim, So Yeon Koo, Lorenz Stude. Pluripotent Stem Cell Therapies for Parkinson Disease: Present Challenges and Future Opportunities. Frontiers in cell and developmental biology. vol 8. 2021-05-27. PMID:32903681. |
progress in establishing protocols for the direct differentiation to midbrain dopamine (mda) neurons from hpsc have catalyzed the development of cell-based therapies for pd. |
2021-05-27 |
2023-08-13 |
human |
| Gabriela Rodríguez-Manzo, Estefanía González-Morale. Endocannabinoids mediate long-lasting behavioural and physiological changes in male rats induced by the repeated activation of the mesolimbic system by copulation to satiety. Behavioural brain research. vol 383. 2021-05-25. PMID:31987931. |
copulation activates the mesolimbic circuit increasing dopamine (da) release in the nucleus accumbens (nacc) and, enhanced midbrain da neuron activity promotes endocannabinoid (ecb) release in the ventral tegmental area (vta). |
2021-05-25 |
2023-08-13 |
rat |
| Julian L Goggi, Lifeng Qiu, Mei Chih Liao, Shivashankar Khanapur, Lingfan Jiang, Ramasamy Boominathan, Siddesh V Hartimath, Peter Cheng, Fui Fong Yong, Vanessa Soh, Xiaozhou Deng, Youshan Melissa Lin, Anna Haslop, Peng Wen Tan, Xiaoxia Zeng, Jolene W L Lee, Zhiwei Zhang, Pragalath Sadasivam, Eng King Tan, Sajinder K Luthra, William D Shingleton, Steve K W Oh, Li Zeng, Edward G Robin. Dopamine transporter neuroimaging accurately assesses the maturation of dopamine neurons in a preclinical model of Parkinson's disease. Stem cell research & therapy. vol 11. issue 1. 2021-05-24. PMID:32771055. |
the current study examines the utility of neuroimaging to characterise the in vivo maturation, innervation and functional dopamine release of transplanted human embryonic stem cell-derived midbrain dopaminergic neurons (hesc-mdas) in a preclinical model of pd. |
2021-05-24 |
2023-08-13 |
human |
| Ewa Galaj, Zheng-Xiong X. Progress in opioid reward research: From a canonical two-neuron hypothesis to two neural circuits. Pharmacology, biochemistry, and behavior. vol 200. 2021-05-24. PMID:33227308. |
based on recent findings that activation of dopamine neurons in the ventral tegmental area (vta) and substantia nigra pars compacta (snc) is equally rewarding and that gaba neurons in the rostromedial tegmental nucleus (rmtg) and the substantia nigra pars reticula (snr) are rich in mu opioid receptors and directly synapse onto midbrain da neurons, we proposed that the rtmg→vta → ventrostriatal and snr → snc → dorsostriatal pathways may act as the two major neural substrates underlying opioid reward and abuse. |
2021-05-24 |
2023-08-13 |
Not clear |
| Tertia D Purves-Tyson, Kate Robinson, Amelia M Brown, Danny Boerrigter, Helen Q Cai, Christin Weissleder, Samantha J Owens, Debora A Rothmond, Cynthia Shannon Weicker. Increased Macrophages and C1qA, C3, C4 Transcripts in the Midbrain of People With Schizophrenia. Frontiers in immunology. vol 11. 2021-05-20. PMID:33133060. |
increased cytokine and inflammatory-related transcripts are found in the ventral midbrain, a dopamine neuron-rich region associated with schizophrenia symptoms. |
2021-05-20 |
2023-08-13 |
Not clear |
| Tertia D Purves-Tyson, Kate Robinson, Amelia M Brown, Danny Boerrigter, Helen Q Cai, Christin Weissleder, Samantha J Owens, Debora A Rothmond, Cynthia Shannon Weicker. Increased Macrophages and C1qA, C3, C4 Transcripts in the Midbrain of People With Schizophrenia. Frontiers in immunology. vol 11. 2021-05-20. PMID:33133060. |
our study is the first to suggest that more circulating macrophages may be attracted to the midbrain in schizophrenia, and that increased macrophages are linked to increased complement pathway activation in tissue and may contribute to dopamine dysregulation in schizophrenia. |
2021-05-20 |
2023-08-13 |
Not clear |
| Man Xiong, Yezheng Tao, Qinqin Gao, Ban Feng, Wei Yan, Yingying Zhou, Thomas A Kotsonis, Tingli Yuan, Zhiwen You, Ziyan Wu, Jiajie Xi, Alexander Haberman, Julia Graham, Jasper Block, Wenhao Zhou, Yuejun Chen, Su-Chun Zhan. Human Stem Cell-Derived Neurons Repair Circuits and Restore Neural Function. Cell stem cell. vol 28. issue 1. 2021-05-19. PMID:32966778. |
we transplanted hesc-derived midbrain dopamine (mda) or cortical glutamate neurons into the substantia nigra or striatum of a mouse pd model and found extensive graft integration with host circuitry. |
2021-05-19 |
2023-08-13 |
mouse |
| Jinghua Piao, Susan Zabierowski, Brittany N Dubose, Ellen J Hill, Monalisa Navare, Nidia Claros, Siera Rosen, Kiran Ramnarine, Callie Horn, Craig Fredrickson, Karen Wong, Brent Safford, Sonja Kriks, Abderrahman El Maarouf, Urs Rutishauser, Claire Henchcliffe, Yongzeng Wang, Isabelle Riviere, Shannon Mann, Vladimir Bermudez, Stefan Irion, Lorenz Studer, Mark Tomishima, Viviane Taba. Preclinical Efficacy and Safety of a Human Embryonic Stem Cell-Derived Midbrain Dopamine Progenitor Product, MSK-DA01. Cell stem cell. vol 28. issue 2. 2021-05-19. PMID:33545080. |
preclinical efficacy and safety of a human embryonic stem cell-derived midbrain dopamine progenitor product, msk-da01. |
2021-05-19 |
2023-08-13 |
mouse |
| Jinghua Piao, Susan Zabierowski, Brittany N Dubose, Ellen J Hill, Monalisa Navare, Nidia Claros, Siera Rosen, Kiran Ramnarine, Callie Horn, Craig Fredrickson, Karen Wong, Brent Safford, Sonja Kriks, Abderrahman El Maarouf, Urs Rutishauser, Claire Henchcliffe, Yongzeng Wang, Isabelle Riviere, Shannon Mann, Vladimir Bermudez, Stefan Irion, Lorenz Studer, Mark Tomishima, Viviane Taba. Preclinical Efficacy and Safety of a Human Embryonic Stem Cell-Derived Midbrain Dopamine Progenitor Product, MSK-DA01. Cell stem cell. vol 28. issue 2. 2021-05-19. PMID:33545080. |
we have generated midbrain dopamine neurons from human embryonic stem cells and manufactured large-scale cryopreserved dopamine progenitors for clinical use. |
2021-05-19 |
2023-08-13 |
mouse |
| Tae Wan Kim, Jinghua Piao, So Yeon Koo, Sonja Kriks, Sun Young Chung, Doron Betel, Nicholas D Socci, Se Joon Choi, Susan Zabierowski, Brittany N Dubose, Ellen J Hill, Eugene V Mosharov, Stefan Irion, Mark J Tomishima, Viviane Tabar, Lorenz Stude. Biphasic Activation of WNT Signaling Facilitates the Derivation of Midbrain Dopamine Neurons from hESCs for Translational Use. Cell stem cell. vol 28. issue 2. 2021-05-19. PMID:33545081. |
biphasic activation of wnt signaling facilitates the derivation of midbrain dopamine neurons from hescs for translational use. |
2021-05-19 |
2023-08-13 |
human |
| Tae Wan Kim, Jinghua Piao, So Yeon Koo, Sonja Kriks, Sun Young Chung, Doron Betel, Nicholas D Socci, Se Joon Choi, Susan Zabierowski, Brittany N Dubose, Ellen J Hill, Eugene V Mosharov, Stefan Irion, Mark J Tomishima, Viviane Tabar, Lorenz Stude. Biphasic Activation of WNT Signaling Facilitates the Derivation of Midbrain Dopamine Neurons from hESCs for Translational Use. Cell stem cell. vol 28. issue 2. 2021-05-19. PMID:33545081. |
protocols have been developed to generate authentic midbrain dopamine (mda) neurons capable of reversing dopamine-related deficits in animal models of parkinson's disease. |
2021-05-19 |
2023-08-13 |
human |
| HyungGoo R Kim, Athar N Malik, John G Mikhael, Pol Bech, Iku Tsutsui-Kimura, Fangmiao Sun, Yajun Zhang, Yulong Li, Mitsuko Watabe-Uchida, Samuel J Gershman, Naoshige Uchid. A Unified Framework for Dopamine Signals across Timescales. Cell. vol 183. issue 6. 2021-05-18. PMID:33248024. |
rapid phasic activity of midbrain dopamine neurons is thought to signal reward prediction errors (rpes), resembling temporal difference errors used in machine learning. |
2021-05-18 |
2023-08-13 |
Not clear |
| Tertia D Purves-Tyson, Ulrike Weber-Stadlbauer, Juliet Richetto, Debora A Rothmond, Marie A Labouesse, Marcello Polesel, Kate Robinson, Cynthia Shannon Weickert, Urs Meye. Increased levels of midbrain immune-related transcripts in schizophrenia and in murine offspring after maternal immune activation. Molecular psychiatry. vol 26. issue 3. 2021-05-14. PMID:31168068. |
the pathophysiology of dopamine dysregulation in schizophrenia involves alterations at the ventral midbrain level. |
2021-05-14 |
2023-08-13 |
mouse |