| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tertia D Purves-Tyson, Ulrike Weber-Stadlbauer, Juliet Richetto, Debora A Rothmond, Marie A Labouesse, Marcello Polesel, Kate Robinson, Cynthia Shannon Weickert, Urs Meye. Increased levels of midbrain immune-related transcripts in schizophrenia and in murine offspring after maternal immune activation. Molecular psychiatry. vol 26. issue 3. 2021-05-14. PMID:31168068. |
given that inflammatory mediators such as cytokines influence the functional properties of midbrain dopamine neurons, midbrain inflammation may play a role in schizophrenia by contributing to presynaptic dopamine abnormalities. |
2021-05-14 |
2023-08-13 |
mouse |
| Felipe V Gomes, Xiyu Zhu, Anthony A Grac. The pathophysiological impact of stress on the dopamine system is dependent on the state of the critical period of vulnerability. Molecular psychiatry. vol 25. issue 12. 2021-05-14. PMID:31488866. |
we evaluated the impact of early adolescent and adult stress exposure (combination of daily footshock for 10 days and 3 restraint sessions) on (1) midbrain dopamine (da) neuron activity, (2) ventral hippocampal (vhipp) pyramidal neuron activity, and (3) the number of parvalbumin (pv) interneurons in the vhipp and their associated perineuronal nets (pnns). |
2021-05-14 |
2023-08-13 |
Not clear |
| Gregor Leicht, Christina Andreou, Till Nafe, Felix Nägele, Jonas Rauh, Stjepan Curic, Paul Schauer, Daniel Schöttle, Saskia Steinmann, Christoph Muler. Alterations of oscillatory neuronal activity during reward processing in schizophrenia. Journal of psychiatric research. vol 129. 2021-05-14. PMID:32619750. |
remarkably, midbrain dopaminergic signalling also includes theta and high-beta frequency modes, which have been assumed to reflect tonic and phasic dopamine responses, respectively. |
2021-05-14 |
2023-08-13 |
Not clear |
| Lynn D Selemon, Anita Begovi. Reduced Midbrain Dopamine Neuron Number in the Adult Non-human Primate Brain after Fetal Radiation Exposure. Neuroscience. vol 442. 2021-05-14. PMID:32659340. |
reduced midbrain dopamine neuron number in the adult non-human primate brain after fetal radiation exposure. |
2021-05-14 |
2023-08-13 |
monkey |
| Lynn D Selemon, Anita Begovi. Reduced Midbrain Dopamine Neuron Number in the Adult Non-human Primate Brain after Fetal Radiation Exposure. Neuroscience. vol 442. 2021-05-14. PMID:32659340. |
midbrain dopamine neurons are generated during early gestation and play a key role in the motor, cognitive and reward circuitries implicated in neuropsychiatric disease and addiction. |
2021-05-14 |
2023-08-13 |
monkey |
| Lynn D Selemon, Anita Begovi. Reduced Midbrain Dopamine Neuron Number in the Adult Non-human Primate Brain after Fetal Radiation Exposure. Neuroscience. vol 442. 2021-05-14. PMID:32659340. |
this study examined the impact of curtailing neurogenesis in early gestation on neuron number in the midbrain dopamine group, i.e., the substantia nigra and contiguous ventral tegmental area. |
2021-05-14 |
2023-08-13 |
monkey |
| Lynn D Selemon, Anita Begovi. Reduced Midbrain Dopamine Neuron Number in the Adult Non-human Primate Brain after Fetal Radiation Exposure. Neuroscience. vol 442. 2021-05-14. PMID:32659340. |
stereologic cell counts of tyrosine hydroxylase-positive neurons in the midbrain dopamine group were performed in adult monkeys, as were measurements of somal size. |
2021-05-14 |
2023-08-13 |
monkey |
| Lynn D Selemon, Anita Begovi. Reduced Midbrain Dopamine Neuron Number in the Adult Non-human Primate Brain after Fetal Radiation Exposure. Neuroscience. vol 442. 2021-05-14. PMID:32659340. |
reduced midbrain dopamine neuron number in fetally irradiated, adult monkeys indicates that radiation exposure during the critical period of neurogenesis results in an enduring reduction of this population and underscores the susceptibility of early neurodevelopmental processes to irreversible damage from environmental exposures. |
2021-05-14 |
2023-08-13 |
monkey |
| Li-Ping Liang, Ruth Fulton, Erica L Bradshaw-Pierce, Jennifer Pearson-Smith, Brian J Day, Manisha Pate. Optimization of Lipophilic Metalloporphyrins Modifies Disease Outcomes in a Rat Model of Parkinsonism. The Journal of pharmacology and experimental therapeutics. vol 377. issue 1. 2021-05-14. PMID:33500265. |
in addition, both compounds significantly attenuated 6-hydroxydopamine (6-ohda)-induced neurotoxic damage, including dopamine depletion, cytokine production, and microglial activation in the striata; dopaminergic neuronal loss in the substantia nigra; oxidative/nitrative stress indices (glutathione disulfide and 3-nitrotyrosine) in the ventral midbrain; and rotation behavioral abnormality in rats. |
2021-05-14 |
2023-08-13 |
mouse |
| Jian Han, Pragya Nepal, Anuoluwapo Odelade, Frederick D Freely, Destiny M Belton, Joseph L Graves, Antoniette M Maldonado-Devincc. High-Fat Diet-Induced Weight Gain, Behavioral Deficits, and Dopamine Changes in Young C57BL/6J Mice. Frontiers in nutrition. vol 7. 2021-05-14. PMID:33553228. |
dopamine (da), dopamine receptor d2 (drd2), and dopamine transporter (dt) protein expression levels were measured in the midbrain after 5 months of dietary exposure. |
2021-05-14 |
2023-08-13 |
mouse |
| Cristian Zanetti, Sarah Spitz, Emanuel Berger, Silvia Bolognin, Lisa M Smits, Philipp Crepaz, Mario Rothbauer, Julie M Rosser, Martina Marchetti-Deschmann, Jens C Schwamborn, Peter Ert. Monitoring the neurotransmitter release of human midbrain organoids using a redox cycling microsensor as a novel tool for personalized Parkinson's disease modelling and drug screening. The Analyst. vol 146. issue 7. 2021-05-14. PMID:33625407. |
in this study, we have aimed at developing a novel electrochemical sensing approach capable of detecting dopamine, the main biomarker in parkinson's disease, within the highly complex cell culture matrix of human midbrain organoids in a non-invasive and label-free manner. |
2021-05-14 |
2023-08-13 |
human |
| Cristian Zanetti, Sarah Spitz, Emanuel Berger, Silvia Bolognin, Lisa M Smits, Philipp Crepaz, Mario Rothbauer, Julie M Rosser, Martina Marchetti-Deschmann, Jens C Schwamborn, Peter Ert. Monitoring the neurotransmitter release of human midbrain organoids using a redox cycling microsensor as a novel tool for personalized Parkinson's disease modelling and drug screening. The Analyst. vol 146. issue 7. 2021-05-14. PMID:33625407. |
in this work, we demonstrate the ability to detect and monitor even small differences in dopamine release between healthy and parkinson`s disease-specific midbrain organoids over prolonged cultivation periods, which was additionally verified using liquid chromatography-multiple reaction monitoring mass spectrometry. |
2021-05-14 |
2023-08-13 |
human |
| Yixi Chen, Tilo Kunath, Joanna Simpson, Natalie Homer, Sergiy Sylantye. Synaptic signalling in a network of dopamine neurons: what prevents proper intercellular crosstalk? FEBS letters. vol 594. issue 20. 2021-05-12. PMID:33073864. |
human embryonic stem cell (hesc)-derived midbrain dopamine (da) neurons stand out as a cell source for transplantation with their sustainability and consistency superior to the formerly used fetal tissues. |
2021-05-12 |
2023-08-13 |
human |
| Yunlong Tao, Scott C Vermilyea, Matthew Zammit, Jianfeng Lu, Miles Olsen, Jeanette M Metzger, Lin Yao, Yuejun Chen, Sean Phillips, James E Holden, Viktoriya Bondarenko, Walter F Block, Todd E Barnhart, Nancy Schultz-Darken, Kevin Brunner, Heather Simmons, Bradley T Christian, Marina E Emborg, Su-Chun Zhan. Autologous transplant therapy alleviates motor and depressive behaviors in parkinsonian monkeys. Nature medicine. vol 27. issue 4. 2021-05-11. PMID:33649496. |
degeneration of dopamine (da) neurons in the midbrain underlies the pathogenesis of parkinson's disease (pd). |
2021-05-11 |
2023-08-13 |
monkey |
| Alexandra Bova, Matt Gaidica, Amy Hurst, Yoshiko Iwai, Julia Hunter, Daniel K Leventha. Precisely timed dopamine signals establish distinct kinematic representations of skilled movements. eLife. vol 9. 2021-05-04. PMID:33245045. |
to determine the effects of precisely timed dopamine manipulations on the performance of a complex, finely coordinated dexterous skill, we optogenetically stimulated or inhibited midbrain dopamine neurons as rats performed a skilled reaching task. |
2021-05-04 |
2023-08-13 |
rat |
| Marta Portero-Tresserra, D Rojic-Becker, C Vega-Carbajal, G Guillazo-Blanch, A Vale-Martínez, M Martí-Nicoloviu. Caloric restriction modulates the monoaminergic system and metabolic hormones in aged rats. Scientific reports. vol 10. issue 1. 2021-05-03. PMID:33168891. |
noradrenaline (na), dopamine (da), serotonin (5-ht) and its metabolites were measured by high-performance liquid chromatography with electrochemical detection (hplc-ed) in nine brain regions: cerebellum, pons, midbrain, hypothalamus, thalamus, hippocampus, striatum, frontal cortex, and occipital cortex. |
2021-05-03 |
2023-08-13 |
rat |
| Lukas Meyerolbersleben, Christine Winter, Nadine Bernhard. Dissociation of wanting and liking in the sucrose preference test in dopamine transporter overexpressing rats. Behavioural brain research. vol 378. 2021-04-28. PMID:31629834. |
the predominant theory of mesolimbic dopamine function in recent years has been the incentive salience hypothesis, which describes the role of midbrain dopaminergic circuits as encoding 'wanting', but not 'liking' of rewards, resulting in a dissociation of the two functions. |
2021-04-28 |
2023-08-13 |
rat |
| Hunday Govindasamy, Sivanandam Magudeeswaran, Saravanan Kandasamy, Kumaradhas Pooman. Binding mechanism of naringenin with monoamine oxidase - B enzyme: QM/MM and molecular dynamics perspective. Heliyon. vol 7. issue 4. 2021-04-28. PMID:33898820. |
the reduced level of dopamine at midbrain (substantia nigra) leads to parkinson disease by the influence of monoamine oxidation process of monoamine oxidase b (mao-b) enzyme. |
2021-04-28 |
2023-08-13 |
Not clear |
| Piotr Chmielarz, Şafak Er, Julia Konovalova, Laura Bandres, Irena Hlushchuk, Katrina Albert, Anne Panhelainen, Kelvin Luk, Mikko Airavaara, Andrii Domansky. GDNF/RET Signaling Pathway Activation Eliminates Lewy Body Pathology in Midbrain Dopamine Neurons. Movement disorders : official journal of the Movement Disorder Society. vol 35. issue 12. 2021-04-27. PMID:32964492. |
gdnf/ret signaling pathway activation eliminates lewy body pathology in midbrain dopamine neurons. |
2021-04-27 |
2023-08-13 |
Not clear |
| Vicki Wang, Tung-Tai Kuo, Eagle Yi-Kung Huang, Kuo-Hsing Ma, Yu-Ching Chou, Zhao-Yang Fu, Li-Wen Lai, Jin Jung, Hoi-Ii Choi, Doo-Sup Choi, Yazhou Li, Lars Olson, Nigel H Greig, Barry J Hoffer, Yuan-Hao Che. Sustained Release GLP-1 Agonist PT320 Delays Disease Progression in a Mouse Model of Parkinson's Disease. ACS pharmacology & translational science. vol 4. issue 2. 2021-04-17. PMID:33860208. |
behavioral improvement was correlated with enhanced cellular and molecular indices of dopamine (da) midbrain function. |
2021-04-17 |
2023-08-13 |
mouse |