| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jun-Hwan Byun, Ji-Yeon Hyeon, Eun-Su Kim, Shin-Kwon Kim, Sung-Pyo Hur, Se-Jae Kim, Akihiro Takemur. Daily variation of D2 dopamine receptor transcription in the brain of the Japanese eel Anguilla japonica and its regulation with dopamine and melatonin. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. vol 240. 2021-02-02. PMID:31634572. |
co-injection of dopamine with its antagonist (domperidone) reversed the effect of dopamine in the pituitary and forebrain, but not in the midbrain, suggesting that the effect of dopamine on d2b receptor transcription differs among brain regions. |
2021-02-02 |
2023-08-13 |
Not clear |
| R N Lippert, S Hess, P Klemm, L M Burgeno, T Jahans-Price, M E Walton, P Kloppenburg, J C Brünin. Maternal high-fat diet during lactation reprograms the dopaminergic circuitry in mice. The Journal of clinical investigation. vol 130. issue 7. 2021-02-02. PMID:32510473. |
this translated into silencing of dopaminergic midbrain neurons, reduced connectivity to their downstream targets, and reduced stimulus-evoked dopamine (da) release in the striatum. |
2021-02-02 |
2023-08-13 |
mouse |
| Yuki Yasumoto, Tamas L Horvat. Crosstalk between maternal perinatal obesity and offspring dopaminergic circuitry. The Journal of clinical investigation. vol 130. issue 7. 2021-01-27. PMID:32510474. |
showed that feeding maternal mice a high-fat diet (hfd) during lactation attenuated the activity of dopamine (da) midbrain neurons and altered the da-related behavioral phenotype seen in the offspring. |
2021-01-27 |
2023-08-13 |
mouse |
| Manon Dubol, Christian Trichard, Claire Leroy, Bernard Granger, Eleni T Tzavara, Jean-Luc Martinot, Eric Artige. Lower midbrain dopamine transporter availability in depressed patients: Report from high-resolution PET imaging. Journal of affective disorders. vol 262. 2021-01-25. PMID:31732277. |
lower midbrain dopamine transporter availability in depressed patients: report from high-resolution pet imaging. |
2021-01-25 |
2023-08-13 |
Not clear |
| F M Corrigan, J Christie-Sand. An innate brainstem self-other system involving orienting, affective responding, and polyvalent relational seeking: Some clinical implications for a "Deep Brain Reorienting" trauma psychotherapy approach. Medical hypotheses. vol 136. 2021-01-25. PMID:31794877. |
the hypothesis set out here is that this most basic urge to connect is dependent on circuits based in three main components: the midbrain superior colliculi (sc), the midbrain periaqueductal gray (pag), and the mesolimbic and mesocortical dopamine systems originating in the midbrain ventral tegmental area. |
2021-01-25 |
2023-08-13 |
Not clear |
| Wanpeng Cui, Tomomi Aida, Hikaru Ito, Kenta Kobayashi, Yusaku Wada, Shigeki Kato, Takashi Nakano, Meina Zhu, Kaoru Isa, Kazuto Kobayashi, Tadashi Isa, Kohichi Tanaka, Hidenori Aizaw. Dopaminergic Signaling in the Nucleus Accumbens Modulates Stress-Coping Strategies during Inescapable Stress. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 38. 2021-01-15. PMID:32847967. |
to investigate how dopamine signaling modulates stress-coping behavior, we measured the subsecond fluctuation of extracellular dopamine concentration and ph using fast scanning cyclic voltammetry (fscv) in the nac, a postsynaptic target of midbrain dopaminergic neurons, in male mice engaged in a tail suspension test (tst). |
2021-01-15 |
2023-08-13 |
mouse |
| Joseph J Lebowitz, Habibeh Khoshboue. Heterogeneity of dopamine release sites in health and degeneration. Neurobiology of disease. vol 134. 2021-01-13. PMID:31698055. |
despite comprising only ~ 0.001% of all neurons in the human brain, ventral midbrain dopamine neurons exert a profound influence on human behavior and cognition. |
2021-01-13 |
2023-08-13 |
human |
| Fabin Han, Baoyang H. Stem Cell Therapy for Parkinson's Disease. Advances in experimental medicine and biology. vol 1266. 2021-01-08. PMID:33105493. |
parkinson's disease (pd) is one of the most common neurodegenerative diseases caused by specific degeneration and loss of dopamine neurons in substantia nigra of the midbrain. |
2021-01-08 |
2023-08-13 |
human |
| Kanako Otomo, Jessica Perkins, Anand Kulkarni, Strahinja Stojanovic, Jochen Roeper, Carlos A Paladin. In vivo patch-clamp recordings reveal distinct subthreshold signatures and threshold dynamics of midbrain dopamine neurons. Nature communications. vol 11. issue 1. 2021-01-07. PMID:33293613. |
in vivo patch-clamp recordings reveal distinct subthreshold signatures and threshold dynamics of midbrain dopamine neurons. |
2021-01-07 |
2023-08-13 |
mouse |
| Kanako Otomo, Jessica Perkins, Anand Kulkarni, Strahinja Stojanovic, Jochen Roeper, Carlos A Paladin. In vivo patch-clamp recordings reveal distinct subthreshold signatures and threshold dynamics of midbrain dopamine neurons. Nature communications. vol 11. issue 1. 2021-01-07. PMID:33293613. |
the in vivo firing patterns of ventral midbrain dopamine neurons are controlled by afferent and intrinsic activity to generate sensory cue and prediction error signals that are essential for reward-based learning. |
2021-01-07 |
2023-08-13 |
mouse |
| Kanako Otomo, Jessica Perkins, Anand Kulkarni, Strahinja Stojanovic, Jochen Roeper, Carlos A Paladin. In vivo patch-clamp recordings reveal distinct subthreshold signatures and threshold dynamics of midbrain dopamine neurons. Nature communications. vol 11. issue 1. 2021-01-07. PMID:33293613. |
to address this, we established in vivo whole-cell recordings and obtained over 100 spontaneously active, immunocytochemically-defined midbrain dopamine neurons in isoflurane-anaesthetized adult mice. |
2021-01-07 |
2023-08-13 |
mouse |
| Ioannis Mantas, Yunting Yang, Clotilde Mannoury-la-Cour, Mark J Millan, Xiaoqun Zhang, Per Svenningsso. Genetic deletion of GPR88 enhances the locomotor response to L-DOPA in experimental parkinsonism while counteracting the induction of dyskinesia. Neuropharmacology. vol 162. 2021-01-06. PMID:31666199. |
parkinson's disease (pd) is characterized by progressive loss of midbrain dopaminergic neurons and treated with the dopamine precursor, 3,4-dihydroxy-l-phenylalanine (l-dopa). |
2021-01-06 |
2023-08-13 |
mouse |
| Mizuho Gotoh, Kazuaki Nagasaka, Mariko Nakata, Ichiro Takashima, Shinya Yamamot. Brain Temperature Alters Contributions of Excitatory and Inhibitory Inputs to Evoked Field Potentials in the Rat Frontal Cortex. Frontiers in cellular neuroscience. vol 14. 2020-12-31. PMID:33364923. |
we delivered electrical stimulations to the midbrain dopamine area and measured the evoked potentials in the frontal cortex, the temperature of which was locally altered using a thermal control device. |
2020-12-31 |
2023-08-13 |
rat |
| Justin K Siemann, Piper Williams, Turnee N Malik, Chad R Jackson, Noah H Green, Ronald B Emeson, Pat Levitt, Douglas G McMaho. Photoperiodic effects on monoamine signaling and gene expression throughout development in the serotonin and dopamine systems. Scientific reports. vol 10. issue 1. 2020-12-15. PMID:32963273. |
mice that developed under short photoperiods demonstrated elevated midbrain th expression levels, specifically during perinatal development compared to mice raised under long photoperiods, and significantly decreased serotonin and dopamine content throughout the course of development. |
2020-12-15 |
2023-08-13 |
mouse |
| Anouk Pierre, Andries Van Schuerbeek, Wissal Allaoui, Sven Van Laere, Nicolas Singewald, Ann Van Eeckhaut, Ilse Smolders, Dimitri De Bunde. Effects of ghrelin receptor activation on forebrain dopamine release, conditioned fear and fear extinction in C57BL/6J mice. Journal of neurochemistry. vol 154. issue 4. 2020-12-07. PMID:32128814. |
interestingly, the ghrelin system was also shown to control the activity of midbrain dopamine neurons. |
2020-12-07 |
2023-08-13 |
mouse |
| Anouk Pierre, Andries Van Schuerbeek, Wissal Allaoui, Sven Van Laere, Nicolas Singewald, Ann Van Eeckhaut, Ilse Smolders, Dimitri De Bunde. Effects of ghrelin receptor activation on forebrain dopamine release, conditioned fear and fear extinction in C57BL/6J mice. Journal of neurochemistry. vol 154. issue 4. 2020-12-07. PMID:32128814. |
our data indicate that pharmacological activation of midbrain dopamine neurons using a ghrelin receptor agonist does not affect auditory fear extinction. |
2020-12-07 |
2023-08-13 |
mouse |
| Safak Er, Irena Hlushchuk, Mikko Airavaara, Piotr Chmielarz, Andrii Domansky. Studying Pre-formed Fibril Induced α-Synuclein Accumulation in Primary Embryonic Mouse Midbrain Dopamine Neurons. Journal of visualized experiments : JoVE. issue 162. 2020-11-18. PMID:32865527. |
studying pre-formed fibril induced α-synuclein accumulation in primary embryonic mouse midbrain dopamine neurons. |
2020-11-18 |
2023-08-13 |
mouse |
| Safak Er, Irena Hlushchuk, Mikko Airavaara, Piotr Chmielarz, Andrii Domansky. Studying Pre-formed Fibril Induced α-Synuclein Accumulation in Primary Embryonic Mouse Midbrain Dopamine Neurons. Journal of visualized experiments : JoVE. issue 162. 2020-11-18. PMID:32865527. |
primary midbrain cultures provide a reliable source of bona fide embryonic dopamine neurons. |
2020-11-18 |
2023-08-13 |
mouse |
| Dai-di Li, Guo-Qing Wang, Qin Wu, Jing-Shan Shi, Feng Zhan. Dendrobium nobile Lindl alkaloid attenuates 6-OHDA-induced dopamine neurotoxicity. Biotechnology and applied biochemistry. 2020-11-18. PMID:33146428. |
parkinson's disease (pd) is one of the most common central nervous system (cns) degenerative disease and is characterized by a progressive loss of midbrain substantia nigra dopamine (da) neurons. |
2020-11-18 |
2023-08-13 |
human |
| Francesco Napolitano, Arianna De Rosa, Rosita Russo, Anna Di Maio, Martina Garofalo, Mauro Federici, Sara Migliarini, Ada Ledonne, Francesca Romana Rizzo, Luigi Avallone, Tommaso Nuzzo, Tommaso Biagini, Massimo Pasqualetti, Nicola Biagio Mercuri, Tommaso Mazza, Angela Chambery, Alessandro Usiell. The striatal-enriched protein Rhes is a critical modulator of cocaine-induced molecular and behavioral responses. Scientific reports. vol 9. issue 1. 2020-11-05. PMID:31653935. |
despite dramatic striatal alterations associated to cocaine exposure, our data did not reveal any significant changes in midbrain dopaminergic neurons as a lack of rhes did not affect: (i) dat activity; (ii) d2r-dependent regulation of girk; and (iii) d2r-dependent regulation of dopamine release. |
2020-11-05 |
2023-08-13 |
mouse |