| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nina Rouhani, Yael Ni. Signed and unsigned reward prediction errors dynamically enhance learning and memory. eLife. vol 10. 2021-04-16. PMID:33661094. |
we further characterize the effects of these rpe signals on memory and show that both signed and unsigned rpes enhance memory, in line with midbrain dopamine and locus-coeruleus modulation of hippocampal plasticity, thereby reconciling separate findings in the literature. |
2021-04-16 |
2023-08-13 |
Not clear |
| Déborah Le Nogue, Jérémie Lavaur, Aude Milet, Juan Fernando Ramirez-Gil, Ira Katz, Marc Lemaire, Géraldine Farjot, Etienne C Hirsch, Patrick Pierre Miche. Neuroprotection of dopamine neurons by xenon against low-level excitotoxic insults is not reproduced by other noble gases. Journal of neural transmission (Vienna, Austria : 1996). vol 127. issue 1. 2021-03-26. PMID:31807953. |
using midbrain cultures, we previously demonstrated that the noble gas xenon is robustly protective for dopamine (da) neurons exposed to l-trans-pyrrolidine-2,4-dicarboxylate (pdc), an inhibitor of glutamate uptake used to generate sustained, low-level excitotoxic insults. |
2021-03-26 |
2023-08-13 |
Not clear |
| Chaya Shor, Wanhong Zuo, Jean D Eloy, Jiang-Hong Y. The Emerging Role of LHb CaMKII in the Comorbidity of Depressive and Alcohol Use Disorders. International journal of molecular sciences. vol 21. issue 21. 2021-03-26. PMID:33143210. |
recently, interest in the lateral habenula, a small epithalamic brain structure, has increased because it becomes hyperactive in depression and alcohol use disorders, and can inhibit dopamine and serotonin neurons in the midbrain reward center, the hypofunction of which is believed to be a critical contributor to the etiology of depressive disorders and alcohol use disorders as well as their comorbidities. |
2021-03-26 |
2023-08-13 |
Not clear |
| Nadja Mannal, Katharina Kleiner, Michael Fauler, Antonios Dougalis, Christina Poetschke, Birgit Lis. Multi-Electrode Array Analysis Identifies Complex Dopamine Responses and Glucose Sensing Properties of Substantia Nigra Neurons in Mouse Brain Slices. Frontiers in synaptic neuroscience. vol 13. 2021-03-16. PMID:33716704. |
dopaminergic (da) midbrain neurons within the substantia nigra (sn) display an autonomous pacemaker activity that is crucial for dopamine release and voluntary movement control. |
2021-03-16 |
2023-08-13 |
mouse |
| Yawei Wang, Osamu Toyoshima, Jun Kunimatsu, Hiroshi Yamada, Masayuki Matsumot. Tonic firing mode of midbrain dopamine neurons continuously tracks reward values changing moment-by-moment. eLife. vol 10. 2021-03-13. PMID:33689680. |
tonic firing mode of midbrain dopamine neurons continuously tracks reward values changing moment-by-moment. |
2021-03-13 |
2023-08-13 |
monkey |
| Yawei Wang, Osamu Toyoshima, Jun Kunimatsu, Hiroshi Yamada, Masayuki Matsumot. Tonic firing mode of midbrain dopamine neurons continuously tracks reward values changing moment-by-moment. eLife. vol 10. 2021-03-13. PMID:33689680. |
the phasic activity of midbrain dopamine neurons signals these values. |
2021-03-13 |
2023-08-13 |
monkey |
| Joanes Grandjean, David Buehlmann, Michaela Buerge, Hannes Sigrist, Erich Seifritz, Franz X Vollenweider, Christopher R Pryce, Markus Rudi. Psilocybin exerts distinct effects on resting state networks associated with serotonin and dopamine in mice. NeuroImage. vol 225. 2021-03-10. PMID:33069863. |
refinement of the analysis using spatial references derived from both gene expression maps and viral tracer projection fields revealed two distinct effects of psilocybin: it increased fc between 5-ht-associated networks and cortical areas, including elements of the murine dmn, thalamus, and midbrain; it decreased fc within dopamine (da)-associated striatal networks. |
2021-03-10 |
2023-08-13 |
mouse |
| Jessica A Mollick, Luke J Chang, Anjali Krishnan, Thomas E Hazy, Kai A Krueger, Guido K W Frank, Tor D Wager, Randall C O'Reill. The Neural Correlates of Cued Reward Omission. Frontiers in human neuroscience. vol 15. 2021-03-10. PMID:33679345. |
both reward presentation and the reward-predictive cue activated midbrain dopamine regions, insula and orbitofrontal cortex. |
2021-03-10 |
2023-08-13 |
human |
| Steven R DeGroot, Rubing Zhao-Shea, Leeyup Chung, Paul M Klenowski, Fangmiao Sun, Susanna Molas, Paul D Gardner, Yulong Li, Andrew R Tappe. Midbrain Dopamine Controls Anxiety-like Behavior by Engaging Unique Interpeduncular Nucleus Microcircuitry. Biological psychiatry. vol 88. issue 11. 2021-03-08. PMID:32800629. |
midbrain dopamine controls anxiety-like behavior by engaging unique interpeduncular nucleus microcircuitry. |
2021-03-08 |
2023-08-13 |
Not clear |
| Erin S Calipar. Dopamine Release in the Midbrain Promotes Anxiety. Biological psychiatry. vol 88. issue 11. 2021-03-08. PMID:33153526. |
dopamine release in the midbrain promotes anxiety. |
2021-03-08 |
2023-08-13 |
Not clear |
| Yanfei Sun, Jing Cao, Chunpeng Xu, Xiaofeng Liu, Zicheng Wang, Hua Zha. Rostromedial tegmental nucleus-substantia nigra pars compacta circuit mediates aversive and despair behavior in mice. Experimental neurology. vol 333. 2021-03-05. PMID:32791155. |
gabaergic neurons in the rostromedial tegmental nucleus (rmtg) receive major input from the lateral habenula (lhb), which conveys negative reward and motivation related information, and project intensively to midbrain dopamine neurons, including those in the ventral tegmental area (vta) and substantia nigra pars compacta (snc). |
2021-03-05 |
2023-08-13 |
mouse |
| Suzanne O Nolan, Jennifer E Zachry, Amy R Johnson, Lillian J Brady, Cody A Siciliano, Erin S Calipar. Direct dopamine terminal regulation by local striatal microcircuitry. Journal of neurochemistry. vol 155. issue 5. 2021-03-02. PMID:32356315. |
here we review how these mechanisms work in concert to influence the timing and magnitude of striatal dopamine signaling, independent of action potential activity at the level of dopaminergic cell bodies in the midbrain, thereby providing a parallel pathway by which dopamine can be modulated. |
2021-03-02 |
2023-08-13 |
Not clear |
| Mengmeng Wang, King-Hwa Ling, Jun Jie Tan, Cheng-Biao L. Development and Differentiation of Midbrain Dopaminergic Neuron: From Bench to Bedside. Cells. vol 9. issue 6. 2021-03-01. PMID:32570916. |
it is primarily due to substantial loss of midbrain dopamine (mda) neurons in the substantia nigra pars compacta and to decreased innervation to the striatum. |
2021-03-01 |
2023-08-13 |
human |
| Annelies J van Nuland, Rick C Helmich, Michiel F Dirkx, Heidemarie Zach, Ivan Toni, Roshan Cools, Hanneke E M den Oude. Effects of dopamine on reinforcement learning in Parkinson's disease depend on motor phenotype. Brain : a journal of neurology. vol 143. issue 11. 2021-03-01. PMID:33147621. |
this variability in tremor relates to variation in cognitive/motivational impairment, as well as the spatial distribution of neurodegeneration in the midbrain and dopamine depletion in the striatum. |
2021-03-01 |
2023-08-13 |
human |
| Yue Lang, Yu Li, Haojia Yu, Lulu Lin, Xingchi Chen, Sainan Wang, Hui Zhan. HOTAIR drives autophagy in midbrain dopaminergic neurons in the substantia nigra compacta in a mouse model of Parkinson's disease by elevating NPTX2 Aging. vol 12. issue 9. 2021-02-25. PMID:32396526. |
hotair drives autophagy in midbrain dopaminergic neurons in the substantia nigra compacta in a mouse model of parkinson's disease by elevating nptx2 parkinson's disease (pd) is a neurodegenerative disorder characterized by progressive cell loss, largely confined to mesencephalic dopamine neurons of the substantia nigra. |
2021-02-25 |
2023-08-13 |
mouse |
| Federica Murgia, Luigi Atzori, Ezio Carboni, Maria Laura Santoru, Aran Hendren, Augusta Pisanu, Pierluigi Caboni, Laura Boi, Giuliana Fusco, Anna R Cart. Metabolomics Fingerprint Induced by the Intranigral Inoculation of Exogenous Human Alpha-Synuclein Oligomers in a Rat Model of Parkinson's Disease. International journal of molecular sciences. vol 21. issue 18. 2021-02-24. PMID:32937957. |
three months postinfusion, the striatum was dissected for striatal dopamine (da) measurements via high pressure liquid chromatography (hplc) analysis and mesencephalon and serum samples were collected for the evaluation of metabolite content via gas chromatography mass spectrometry analysis. |
2021-02-24 |
2023-08-13 |
human |
| Helena Alicart, David Cucurell, Josep Marco-Pallaré. Gossip information increases reward-related oscillatory activity. NeuroImage. vol 210. 2021-02-19. PMID:31917324. |
previous research has described the process by which the interaction between the firing in midbrain dopamine neurons and the hippocampus results in promoting memory for high-value motivational and rewarding events, both extrinsically and intrinsically driven (i.e. |
2021-02-19 |
2023-08-13 |
human |
| May-Jywan Tsai, Shih-Chieh Hung, Ching-Feng Weng, Su-Fen Fan, Dann-Ying Liou, Wen-Cheng Huang, Kang-Du Liu, Henrich Chen. Stem cell transplantation and/or adenoviral glial cell line-derived neurotrophic factor promote functional recovery in hemiparkinsonian rats. World journal of stem cells. vol 13. issue 1. 2021-02-16. PMID:33584981. |
parkinson's disease (pd) is a neurological disorder characterized by the progressive loss of midbrain dopamine (da) neurons. |
2021-02-16 |
2023-08-13 |
human |
| Benjamin M Hiller, David J Marmion, Rachel M Gross, Cayla A Thompson, Carrie A Chavez, Patrik Brundin, Dustin R Wakeman, Christopher W McMahon, Jeffrey H Kordowe. Mitomycin-C treatment during differentiation of induced pluripotent stem cell-derived dopamine neurons reduces proliferation without compromising survival or function in vivo. Stem cells translational medicine. vol 10. issue 2. 2021-02-06. PMID:32997443. |
to this end, we modified an established method for controlled differentiation of human induced pluripotent stem cells (ipscs) into midbrain dopamine neurons using two distinct methods: omission of fgf8 or the in-process use of the dna cross-linker mitomycin-c (mmc). |
2021-02-06 |
2023-08-13 |
human |
| Jun-Hwan Byun, Ji-Yeon Hyeon, Eun-Su Kim, Shin-Kwon Kim, Sung-Pyo Hur, Se-Jae Kim, Akihiro Takemur. Daily variation of D2 dopamine receptor transcription in the brain of the Japanese eel Anguilla japonica and its regulation with dopamine and melatonin. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. vol 240. 2021-02-02. PMID:31634572. |
intraperitoneal injection of dopamine downregulated d2b receptor transcription significantly in the midbrain and moderately in the pituitary within 1 h, but upregulated its transcription in the forebrain. |
2021-02-02 |
2023-08-13 |
Not clear |