| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sara Brignani, Divya D A Raj, Ewoud R E Schmidt, Özge Düdükcü, Youri Adolfs, Anna A De Ruiter, Mateja Rybiczka-Tesulov, Marieke G Verhagen, Christiaan van der Meer, Mark H Broekhoven, Juan A Moreno-Bravo, Laurens M Grossouw, Emilie Dumontier, Jean-François Cloutier, Alain Chédotal, R Jeroen Pasterkam. Remotely Produced and Axon-Derived Netrin-1 Instructs GABAergic Neuron Migration and Dopaminergic Substantia Nigra Development. Neuron. vol 107. issue 4. 2020-11-02. PMID:32562661. |
the midbrain dopamine (mda) system is composed of molecularly and functionally distinct neuron subtypes that mediate specific behaviors and show select disease vulnerability, including in parkinson's disease. |
2020-11-02 |
2023-08-13 |
Not clear |
| Alvaro Nuno-Perez, Manuel Mamel. In DA Club of Reinforcement: Glutamate, It's Your Birthday. Neuron. vol 107. issue 5. 2020-11-02. PMID:32910888. |
leverage the genetic ablation of dopamine synthesis from midbrain vglut2 neurons to assess how glutamate shapes positive reinforcement. |
2020-11-02 |
2023-08-13 |
Not clear |
| Matthijs C Dorst, Anna Tokarska, Ming Zhou, Kwang Lee, Stefanos Stagkourakis, Christian Broberger, Sotiris Masmanidis, Gilad Silberber. Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner. Nature communications. vol 11. issue 1. 2020-11-02. PMID:33037215. |
synchronized pauses in the activity of striatal cholinergic interneurons (chins) are correlated with elevated activity of midbrain dopaminergic neurons, whereas synchronous firing of chins induces local release of dopamine. |
2020-11-02 |
2023-08-13 |
Not clear |
| Carlos W Gantner, Agustín Cota-Coronado, Lachlan H Thompson, Clare L Paris. An Optimized Protocol for the Generation of Midbrain Dopamine Neurons under Defined Conditions. STAR protocols. vol 1. issue 2. 2020-10-29. PMID:33111103. |
an optimized protocol for the generation of midbrain dopamine neurons under defined conditions. |
2020-10-29 |
2023-08-13 |
human |
| Teresia M Osborn, Penelope J Hallett, James M Schumacher, Ole Isacso. Advantages and Recent Developments of Autologous Cell Therapy for Parkinson's Disease Patients. Frontiers in cellular neuroscience. vol 14. 2020-10-27. PMID:32317934. |
at the time of diagnosis about 60% of the midbrain dopamine (mda) neurons have already degenerated, resulting in a depletion of roughly 70% of striatal dopamine (da) levels and synapses. |
2020-10-27 |
2023-08-13 |
Not clear |
| Qian Xu, Shasha Yang, Fangzhen Wu, Yao Lin, Jianan Zhong, Lanfang Tang, Xuefeng Hu, Jing Ca. Congrong Shujing Granule-Induced GRP78 Expression Reduced Endoplasmic Reticulum Stress and Neuronal Apoptosis in the Midbrain in a Parkinson's Disease Rat Model. Evidence-based complementary and alternative medicine : eCAM. vol 2020. 2020-10-22. PMID:33062012. |
the main pathological changes inherent in parkinson's disease (pd) are degeneration and loss of dopamine neurons in the midbrain and formation of lewy bodies. |
2020-10-22 |
2023-08-13 |
rat |
| Jimena Monzón-Sandoval, Ilaria Poggiolini, Tobias Ilmer, Richard Wade-Martins, Caleb Webber, Laura Parkkine. Human-Specific Transcriptome of Ventral and Dorsal Midbrain Dopamine Neurons. Annals of neurology. vol 87. issue 6. 2020-10-13. PMID:32167609. |
human-specific transcriptome of ventral and dorsal midbrain dopamine neurons. |
2020-10-13 |
2023-08-13 |
Not clear |
| Debora Bueno, Leandro B Lima, Rudieri Souza, Luciano Gonçalves, Fernanda Leite, Stefani Souza, Isadora C Furigo, Jose Donato, Martin Metzge. Connections of the laterodorsal tegmental nucleus with the habenular-interpeduncular-raphe system. The Journal of comparative neurology. vol 527. issue 18. 2020-10-09. PMID:31199515. |
the laterodorsal tegmental nucleus (ldtg) is a hindbrain cholinergic cell group thought to be involved in mechanisms of arousal and the control of midbrain dopamine cells. |
2020-10-09 |
2023-08-13 |
Not clear |
| David Sulzer, Stephanie J Cragg, Margaret E Ric. Striatal dopamine neurotransmission: regulation of release and uptake. Basal ganglia. vol 6. issue 3. 2020-10-01. PMID:27141430. |
dopamine (da) transmission is governed by processes that regulate release from axonal boutons in the forebrain and the somatodendritic compartment in midbrain, and by clearance by the da transporter, diffusion, and extracellular metabolism. |
2020-10-01 |
2023-08-13 |
Not clear |
| Fanhua Meng, Jianhui Wang, Fuxiang Ding, Yunliang Xie, Yingjie Zhang, Jie Zh. Neuroprotective effect of matrine on MPTP-induced Parkinson's disease and on Nrf2 expression. Oncology letters. vol 13. issue 1. 2020-10-01. PMID:28123558. |
in conclusion, by promoting antioxidant-related nrf2 signaling pathways in the ventral midbrain, matrine can inhibit the oxidative damage of dopamine neurons in pd. |
2020-10-01 |
2023-08-13 |
mouse |
| Kirill S Korshunov, Laura J Blakemore, Paul Q Tromble. Dopamine: A Modulator of Circadian Rhythms in the Central Nervous System. Frontiers in cellular neuroscience. vol 11. 2020-10-01. PMID:28420965. |
dopamine has been shown to have circadian-like activities in the retina, olfactory bulb, striatum, midbrain, and hypothalamus, where it regulates, and is regulated by, clock genes in some of these areas. |
2020-10-01 |
2023-08-13 |
Not clear |
| Katrine Fabricius, Pernille Barkholt, Jacob Jelsing, Henrik H Hanse. Application of the Physical Disector Principle for Quantification of Dopaminergic Neuronal Loss in a Rat 6-Hydroxydopamine Nigral Lesion Model of Parkinson's Disease. Frontiers in neuroanatomy. vol 11. 2020-10-01. PMID:29276478. |
neurodegenerative diseases involve loss of specific neuron types, such as the midbrain tyrosine hydroxylase-positive dopamine neurons in parkinson's disease and in animal models of nigrostriatal degeneration. |
2020-10-01 |
2023-08-13 |
rat |
| Knud Larsen, Jamal Momeni, Leila Farajzadeh, Henrik Callesen, Christian Bendixe. Molecular characterization and analysis of the porcine Biochimie open. vol 3. 2020-10-01. PMID:29450128. |
nurr1 plays an important role in nigrostriatal dopamine neuron development and is therefore implicated in the pathogenesis of neurodegenerative diseases linked to the dopamine system of the midbrain. |
2020-10-01 |
2023-08-13 |
Not clear |
| Rebecca Playne, Kathryn Jones, Bronwen Conno. Generation of dopamine neuronal-like cells from induced neural precursors derived from adult human cells by non-viral expression of lineage factors. Journal of stem cells & regenerative medicine. vol 14. issue 1. 2020-10-01. PMID:30018471. |
reprogramming technology holds great promise for the study and treatment of parkinson's disease (pd) as patient-specific ventral midbrain dopamine (vmda) neurons can be generated. |
2020-10-01 |
2023-08-13 |
human |
| Stefano Di Santo, Hans R Widme. Neurotrophic factor-based strategies to enhance survival and differentiation of neural progenitor cells toward the dopaminergic phenotype. Brain circulation. vol 4. issue 3. 2020-10-01. PMID:30450422. |
using organotypic explant cultures of fetal human ventral mesencephalon, we observed that nt-4/5 and gdnf as single factors, or in combination on daergic neurons, increased survival and number of tyrosine hydroxylase immunoreactive neurons as well as the dopamine content in the culture medium. |
2020-10-01 |
2023-08-13 |
human |
| Giulia Tomagra, Federico Picollo, Alfio Battiato, Barbara Picconi, Silvia De Marchis, Alberto Pasquarelli, Paolo Olivero, Andrea Marcantoni, Paolo Calabresi, Emilio Carbone, Valentina Carabell. Quantal Release of Dopamine and Action Potential Firing Detected in Midbrain Neurons by Multifunctional Diamond-Based Microarrays. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:31024230. |
quantal release of dopamine and action potential firing detected in midbrain neurons by multifunctional diamond-based microarrays. |
2020-10-01 |
2023-08-13 |
Not clear |
| Giulia Tomagra, Federico Picollo, Alfio Battiato, Barbara Picconi, Silvia De Marchis, Alberto Pasquarelli, Paolo Olivero, Andrea Marcantoni, Paolo Calabresi, Emilio Carbone, Valentina Carabell. Quantal Release of Dopamine and Action Potential Firing Detected in Midbrain Neurons by Multifunctional Diamond-Based Microarrays. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:31024230. |
in order to adapt diamond technology to record neuronal activity, the μg-scd-meas in this work have been interfaced with cultured midbrain neurons to detect electrical activity as well as quantal release of dopamine (da). |
2020-10-01 |
2023-08-13 |
Not clear |
| Ashish Kumar Gupta, Gaurav Khunger Kumar, Komal Rani, Ruchika Pokhriyal, Mohd Imran Khan, Domada Ratna Kumar, Vinay Goyal, Manjari Tripathi, Rishab Gupta, Rakesh Kumar Chadda, Perumal Vanamail, Ashok Kumar Mohanty, Gururao Hariprasa. 2D-DIGE as a strategy to identify serum protein biomarkers to monitor pharmacological efficacy in dopamine-dictated states of Parkinson's disease and schizophrenia. Neuropsychiatric disease and treatment. vol 15. 2020-10-01. PMID:31114209. |
current pharmacological interventions for these two diseases therefore aim to restore normal dopamine levels in the midbrain. |
2020-10-01 |
2023-08-13 |
Not clear |
| Cheng Xiao, Chun-Yi Zhou, Jin-Hong Jiang, Cui Yi. Neural circuits and nicotinic acetylcholine receptors mediate the cholinergic regulation of midbrain dopaminergic neurons and nicotine dependence. Acta pharmacologica Sinica. vol 41. issue 1. 2020-10-01. PMID:31554960. |
previous studies have revealed that α4, α6, and β2 subunit-containing nachrs expressed in midbrain da neurons and their terminals in the striatum regulate firings of midbrain da neurons and activity-dependent dopamine release in the striatum. |
2020-10-01 |
2023-08-13 |
Not clear |
| Martina Mazzocchi, Sean L Wyatt, Daniela Mercatelli, Michele Morari, Noelia Morales-Prieto, Louise M Collins, Aideen M Sullivan, Gerard W O'Keeff. Gene Co-expression Analysis Identifies Histone Deacetylase 5 and 9 Expression in Midbrain Dopamine Neurons and as Regulators of Neurite Growth via Bone Morphogenetic Protein Signaling. Frontiers in cell and developmental biology. vol 7. 2020-10-01. PMID:31572723. |
gene co-expression analysis identifies histone deacetylase 5 and 9 expression in midbrain dopamine neurons and as regulators of neurite growth via bone morphogenetic protein signaling. |
2020-10-01 |
2023-08-13 |
human |