| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Minryung R Song, Sang Wan Le. Dynamic resource allocation during reinforcement learning accounts for ramping and phasic dopamine activity. Neural networks : the official journal of the International Neural Network Society. vol 126. 2020-09-18. PMID:32203877. |
midbrain dopamine neurons are excited by potentially important stimuli, such as reward-predicting or novel stimuli, and allocate resources to these stimuli by modulating how an animal approaches, exploits, explores, and attends. |
2020-09-18 |
2023-08-13 |
Not clear |
| Vasily Vorobyov, Boris Bakharev, Natalia Medvinskaya, Inna Nesterova, Alexander Samokhin, Alexander Deev, Olga Tatarnikova, Aleksey A Ustyugov, Frank Sengpiel, Natalia Bobkov. Loss of Midbrain Dopamine Neurons and Altered Apomorphine EEG Effects in the 5xFAD Mouse Model of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 70. issue 1. 2020-09-16. PMID:31177214. |
loss of midbrain dopamine neurons and altered apomorphine eeg effects in the 5xfad mouse model of alzheimer's disease. |
2020-09-16 |
2023-08-13 |
mouse |
| Jeroen P H Verharen, Theresia J M Roelofs, Shanice Menting-Henry, Mieneke C M Luijendijk, Louk J M J Vanderschuren, Roger A H Ada. Limbic control over the homeostatic need for sodium. Scientific reports. vol 9. issue 1. 2020-09-14. PMID:30705296. |
although the brain regions involved in the sensory detection of sodium levels have been mapped relatively well, data about the neural basis of the motivational properties of salt appetite, including a role for midbrain dopamine cells, have been inconclusive. |
2020-09-14 |
2023-08-13 |
rat |
| Jeroen P H Verharen, Theresia J M Roelofs, Shanice Menting-Henry, Mieneke C M Luijendijk, Louk J M J Vanderschuren, Roger A H Ada. Limbic control over the homeostatic need for sodium. Scientific reports. vol 9. issue 1. 2020-09-14. PMID:30705296. |
we conclude that the nucleus accumbens, but not medial prefrontal cortex, is important for the behavioral expression of salt appetite by mediating its motivational component, but that the switch in salt appreciation after sodium depletion, although detected by midbrain dopamine neurons, must arise from other areas. |
2020-09-14 |
2023-08-13 |
rat |
| Bin Song, Young Cha, Sanghyeok Ko, Jeha Jeon, Nayeon Lee, Hyemyung Seo, Kyung-Joon Park, In-Hee Lee, Claudia Lopes, Melissa Feitosa, María José Luna, Jin Hyuk Jung, Jisun Kim, Dabin Hwang, Bruce M Cohen, Martin H Teicher, Pierre Leblanc, Bob S Carter, Jeffrey H Kordower, Vadim Y Bolshakov, Sek Won Kong, Jeffrey S Schweitzer, Kwang-Soo Ki. Human autologous iPSC-derived dopaminergic progenitors restore motor function in Parkinson's disease models. The Journal of clinical investigation. vol 130. issue 2. 2020-09-14. PMID:31714896. |
parkinson's disease (pd) is a neurodegenerative disorder associated with loss of striatal dopamine, secondary to degeneration of midbrain dopamine (mda) neurons in the substantia nigra, rendering cell transplantation a promising therapeutic strategy. |
2020-09-14 |
2023-08-13 |
human |
| Alessandra Porcu, Megan Vaughan, Anna Nilsson, Natsuko Arimoto, Katja Lamia, David K Wels. Vulnerability to helpless behavior is regulated by the circadian clock component CRYPTOCHROME in the mouse nucleus accumbens. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 24. 2020-09-14. PMID:32487727. |
the nucleus accumbens (nac), a central component of the midbrain dopamine reward circuit, exhibits disturbed circadian rhythms in the postmortem brains of depressed patients. |
2020-09-14 |
2023-08-13 |
mouse |
| Alessandra Porcu, Megan Vaughan, Anna Nilsson, Natsuko Arimoto, Katja Lamia, David K Wels. Vulnerability to helpless behavior is regulated by the circadian clock component CRYPTOCHROME in the mouse nucleus accumbens. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 24. 2020-09-14. PMID:32487727. |
our data reveal a causal role for cry in regulating the midbrain dopamine reward system, and provide a mechanistic link between the nac circadian clock and vulnerability to depression. |
2020-09-14 |
2023-08-13 |
mouse |
| Isela Hernández-Plata, Verónica M Rodríguez, Efraín Tovar-Sánchez, Leticia Carrizalez, Patricia Villalobos, María Soledad Mendoza-Trejo, Patricia Mussali-Galant. Metal brain bioaccumulation and neurobehavioral effects on the wild rodent Liomys irroratus inhabiting mine tailing areas. Environmental science and pollution research international. vol 27. issue 29. 2020-09-03. PMID:32556984. |
the neurochemical evaluation showed higher levels of dopamine and 5-hydroxyindolacetic acid in midbrain, while lower levels of metabolites dihydroxyphenyl acetic acid and homovanillic acid in striatum of exposed rodents. |
2020-09-03 |
2023-08-13 |
Not clear |
| Carol A Gianessi, Thomas L Kas. A Gut Feeling about Dopamine. Neuron. vol 106. issue 5. 2020-08-28. PMID:32497503. |
(2020) compare intra-gastric sugar and non-caloric sweetener to investigate how post-ingestive effects can be reinforcing, revealing a role for the hepatic vagus nerve in transforming sugar sensing by the gut into behavioral reinforcement via midbrain dopamine neuron responses. |
2020-08-28 |
2023-08-13 |
Not clear |
| Eileen L McIver, Jeremy F Atherton, Hong-Yuan Chu, Kathleen E Cosgrove, Jyothisri Kondapalli, David Wokosin, D James Surmeier, Mark D Beva. Maladaptive Downregulation of Autonomous Subthalamic Nucleus Activity following the Loss of Midbrain Dopamine Neurons. Cell reports. vol 28. issue 4. 2020-08-24. PMID:31340159. |
maladaptive downregulation of autonomous subthalamic nucleus activity following the loss of midbrain dopamine neurons. |
2020-08-24 |
2023-08-13 |
mouse |
| Marloes van Hout, Jessica Klein, Philip K Ahring, David T Brown, Siganya Thaneshwaran, Altair B Dos Santos, Anders A Jensen, Kristi A Kohlmeier, Palle Christophersen, Tino Dyhrin. Characterization of AN6001, a positive allosteric modulator of α6β2-containing nicotinic acetylcholine receptors. Biochemical pharmacology. vol 174. 2020-08-24. PMID:31887290. |
α6β2-containing nicotinic acetylcholine receptors (α6β2* nachrs) are predominantly expressed in midbrain dopaminergic neurons, including substantia nigra pars compacta (snc) neurons and their projections to striatal regions, where they regulate dopamine release and nigrostriatal activity. |
2020-08-24 |
2023-08-13 |
human |
| Ivan Trujillo-Pisanty, Kent Conover, Pavel Solis, Daniel Palacios, Peter Shizga. Dopamine neurons do not constitute an obligatory stage in the final common path for the evaluation and pursuit of brain stimulation reward. PloS one. vol 15. issue 6. 2020-08-24. PMID:32502210. |
in rats working for direct, optical activation of midbrain dopamine neurons, we varied the strength and opportunity cost of the stimulation and measured time allocation, the proportion of trial time devoted to reward pursuit. |
2020-08-24 |
2023-08-13 |
rat |
| Ivan Trujillo-Pisanty, Kent Conover, Pavel Solis, Daniel Palacios, Peter Shizga. Dopamine neurons do not constitute an obligatory stage in the final common path for the evaluation and pursuit of brain stimulation reward. PloS one. vol 15. issue 6. 2020-08-24. PMID:32502210. |
we show that dopamine-transporter blockade shifts the mountain along both the strength and cost axes in rats working for optical activation of midbrain dopamine neurons. |
2020-08-24 |
2023-08-13 |
rat |
| Ivan Trujillo-Pisanty, Kent Conover, Pavel Solis, Daniel Palacios, Peter Shizga. Dopamine neurons do not constitute an obligatory stage in the final common path for the evaluation and pursuit of brain stimulation reward. PloS one. vol 15. issue 6. 2020-08-24. PMID:32502210. |
instead, we propose that midbrain dopamine neurons and neurons with non-dopaminergic, mfb axons constitute parallel limbs of brain-reward circuitry that ultimately converge on the final-common path for the evaluation and pursuit of rewards. |
2020-08-24 |
2023-08-13 |
rat |
| Manal H Saad, Matthew Rumschlag, Michael H Guerra, Candace L Savonen, Alaina M Jaster, Philip D Olson, Adnan Alazizi, Francesca Luca, Roger Pique-Regi, Carl J Schmidt, Michael J Banno. Differentially expressed gene networks, biomarkers, long noncoding RNAs, and shared responses with cocaine identified in the midbrains of human opioid abusers. Scientific reports. vol 9. issue 1. 2020-08-18. PMID:30733491. |
although opioids and most other drugs of abuse acutely increase signaling mediated by midbrain dopamine (da)-synthesizing neurons, little is known about long-lasting changes in da cells that may contribute to continued opioid abuse, craving, and relapse. |
2020-08-18 |
2023-08-13 |
human |
| Thiago M Reis-Silva, Thaisa M Sandini, Atilio S Calefi, Bruna C G Orlando, Natalia Moreira, Ana Paula N Lima, Jorge C Florio, Nicolle G T Queiroz-Hazarbassanov, Maria Martha Bernard. Stress resilience evidenced by grooming behaviour and dopamine levels in male mice selected for high and low immobility using the tail suspension test. The European journal of neuroscience. vol 50. issue 6. 2020-08-12. PMID:30888692. |
animals were submitted to an additional day of restraint stress before the hypothalamus, prefrontal cortex and midbrain extraction for dopamine activity analysis. |
2020-08-12 |
2023-08-13 |
mouse |
| Catalina Valdés-Baizabal, Guillermo V Carbajal, David Pérez-González, Manuel S Malmierc. Dopamine modulates subcortical responses to surprising sounds. PLoS biology. vol 18. issue 6. 2020-07-29. PMID:32559190. |
in this study, we tested how dopamine modulates midbrain processing of unexpected tones. |
2020-07-29 |
2023-08-13 |
rat |
| Jocelyn M Breton, Annabelle R Charbit, Benjamin J Snyder, Peter T K Fong, Elayne V Dias, Patricia Himmels, Hagar Lock, Elyssa B Margoli. Relative contributions and mapping of ventral tegmental area dopamine and GABA neurons by projection target in the rat. The Journal of comparative neurology. vol 527. issue 5. 2020-07-28. PMID:30393861. |
the ventral tegmental area (vta) is a heterogeneous midbrain structure that contains dopamine (da), gaba, and glutamate neurons that project to many different brain regions. |
2020-07-28 |
2023-08-13 |
rat |
| Iulia Glovaci, C Andrew Chapma. Dopamine induces release of calcium from internal stores in layer II lateral entorhinal cortex fan cells. Cell calcium. vol 80. 2020-07-27. PMID:30999216. |
interestingly, inputs from midbrain dopamine neurons appear to specifically target clusters of excitatory cells located in the superficial layers of the entorhinal cortex. |
2020-07-27 |
2023-08-13 |
Not clear |
| Lena F Burbulla, Dimitri Krain. The role of dopamine in the pathogenesis of GBA1-linked Parkinson's disease. Neurobiology of disease. vol 132. 2020-07-27. PMID:31351996. |
however, recent emergence of induced pluripotent stem cell technology has highlighted some fundamental differences between human and rodent midbrain dopamine neurons that may at least in part explain relative resistance of rodent neurons to degeneration in genetic models of pd. |
2020-07-27 |
2023-08-13 |
human |