| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Edward J Robinson, Sebastian Aguiar, Marten P Smidt, Lars P van der Heid. MCL1 as a Therapeutic Target in Parkinson's Disease? Trends in molecular medicine. vol 25. issue 12. 2020-07-21. PMID:31706839. |
recent work performed on the role of the bcl2 family (highly specialized proteins which control cellular survival and death) in midbrain dopamine neurons has led to the identification of the bcl2 factor mcl1 as a weak link in the survival of these neurons. |
2020-07-21 |
2023-08-13 |
Not clear |
| Alicia J Avelar, Austin T Akers, Zachary J Baumgard, Skylar Y Cooper, Gabriella P Casinelli, Brandon J Henderso. Why flavored vape products may be attractive: Green apple tobacco flavor elicits reward-related behavior, upregulates nAChRs on VTA dopamine neurons, and alters midbrain dopamine and GABA neuron function. Neuropharmacology. vol 158. 2020-07-20. PMID:31369741. |
why flavored vape products may be attractive: green apple tobacco flavor elicits reward-related behavior, upregulates nachrs on vta dopamine neurons, and alters midbrain dopamine and gaba neuron function. |
2020-07-20 |
2023-08-13 |
mouse |
| D M Bortz, K L Gazo, A A Grac. The medial septum enhances reversal learning via opposing actions on ventral tegmental area and substantia nigra dopamine neurons. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 44. issue 13. 2020-07-08. PMID:31261368. |
taken together, these data suggest a key role for the ms in cognitive flexibility, and suggest that ms-mediated changes in midbrain dopamine neuron population activity could be one mechanism by which this occurs. |
2020-07-08 |
2023-08-13 |
rat |
| Elizabeth J Glover, E Margaret Starr, Ying Chao, Thomas C Jhou, L Judson Chandle. Inhibition of the rostromedial tegmental nucleus reverses alcohol withdrawal-induced anxiety-like behavior. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 44. issue 11. 2020-07-06. PMID:31060041. |
in addition, rmtg neurons exert inhibitory control over midbrain dopamine neurons, the activity of which are suppressed during acute withdrawal. |
2020-07-06 |
2023-08-13 |
rat |
| Anna K Radke, Adrina Kocharian, Dan P Covey, David M Lovinger, Joseph F Cheer, Yolanda Mateo, Andrew Holme. Contributions of nucleus accumbens dopamine to cognitive flexibility. The European journal of neuroscience. vol 50. issue 3. 2020-06-30. PMID:30218623. |
there is a compelling evidence that midbrain dopamine (da) neurons and their projections to the ventral striatum provide a mechanism for motivating reward-seeking behavior, and for utilizing information about unexpected reward prediction errors (rpes) to guide behavior based on current, rather than historical, outcomes. |
2020-06-30 |
2023-08-13 |
mouse |
| Paul Bernard Fole. Dopamine in psychiatry: a historical perspective. Journal of neural transmission (Vienna, Austria : 1996). vol 126. issue 4. 2020-06-26. PMID:30758785. |
dopamine is the principal transmitter of several central nervous system pathways originating in the midbrain and critically involved in motor activity, learning and motivation, disruptions of which have been implicated in a number of disorders, including parkinson disease and schizophrenia. |
2020-06-26 |
2023-08-13 |
Not clear |
| Niamh Moriarty, Clare L Parish, Eilís Dow. Primary tissue for cellular brain repair in Parkinson's disease: Promise, problems and the potential of biomaterials. The European journal of neuroscience. vol 49. issue 4. 2020-06-22. PMID:29923311. |
to date, this approach has been developed, validated and clinically assessed using dopamine neuron-rich foetal ventral mesencephalon grafts which have been shown to survive and reinnervate the denervated brain after transplantation, and to restore motor function. |
2020-06-22 |
2023-08-13 |
Not clear |
| Christopher R Bye, Valeria Rytova, Walaa F Alsanie, Clare L Parish, Lachlan H Thompso. Axonal Growth of Midbrain Dopamine Neurons is Modulated by the Cell Adhesion Molecule ALCAM Through The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 34. 2020-06-19. PMID:31300520. |
axonal growth of midbrain dopamine neurons is modulated by the cell adhesion molecule alcam through the growth of axons corresponding to different neuronal subtypes is governed by unique expression profiles of molecules on the growth cone. |
2020-06-19 |
2023-08-13 |
Not clear |
| Christopher R Bye, Valeria Rytova, Walaa F Alsanie, Clare L Parish, Lachlan H Thompso. Axonal Growth of Midbrain Dopamine Neurons is Modulated by the Cell Adhesion Molecule ALCAM Through The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 34. 2020-06-19. PMID:31300520. |
here, we report that that the cell adhesion molecule alcam (cd166) can act as an extracellular substrate to selectively promote the growth of murine midbrain dopamine (mda) neuron axons through a |
2020-06-19 |
2023-08-13 |
Not clear |
| Nobuhito Nakajima, Masayuki Ued. Striatal dopamine transporter abnormalities associated with midbrain hemiatrophy. Journal of the neurological sciences. vol 399. 2020-06-18. PMID:30782529. |
striatal dopamine transporter abnormalities associated with midbrain hemiatrophy. |
2020-06-18 |
2023-08-13 |
Not clear |
| Qian Zhang, Changpeng Hu, Jingbin Huang, Wuyi Liu, Wenjing Lai, Faning Leng, Qin Tang, Yali Liu, Qing Wang, Min Zhou, Fangfang Sheng, Guobing Li, Rong Zhan. ROCK1 induces dopaminergic nerve cell apoptosis via the activation of Drp1-mediated aberrant mitochondrial fission in Parkinson's disease. Experimental & molecular medicine. vol 51. issue 10. 2020-06-15. PMID:31578315. |
dopamine deficiency is mainly caused by apoptosis of dopaminergic nerve cells in the substantia nigra of the midbrain and the striatum and is an important pathologic basis of parkinson's disease (pd). |
2020-06-15 |
2023-08-13 |
Not clear |
| Layal Maatouk, Chenju Yi, Maria-Angeles Carrillo-de Sauvage, Anne-Claire Compagnion, Stéphane Hunot, Pascal Ezan, Etienne C Hirsch, Annette Koulakoff, Frank W Pfrieger, François Tronche, Luc Leybaert, Christian Giaume, Sheela Vya. Glucocorticoid receptor in astrocytes regulates midbrain dopamine neurodegeneration through connexin hemichannel activity. Cell death and differentiation. vol 26. issue 3. 2020-06-03. PMID:30006609. |
glucocorticoid receptor in astrocytes regulates midbrain dopamine neurodegeneration through connexin hemichannel activity. |
2020-06-03 |
2023-08-13 |
Not clear |
| Akanksha Mishra, Sonu Singh, Virendra Tiwari, Swati Chaturvedi, M Wahajuddin, Shubha Shukl. Dopamine receptor activation mitigates mitochondrial dysfunction and oxidative stress to enhance dopaminergic neurogenesis in 6-OHDA lesioned rats: A role of Wnt signalling. Neurochemistry international. vol 129. 2020-06-01. PMID:31078578. |
nigral dopaminergic (daergic) cell degeneration and depletion of dopamine neurotransmitter in the midbrain are cardinal features of parkinson's disease (pd). |
2020-06-01 |
2023-08-13 |
rat |
| Brónagh McCoy, Sara Jahfari, Gwenda Engels, Tomas Knapen, Jan Theeuwe. Dopaminergic medication reduces striatal sensitivity to negative outcomes in Parkinson's disease. Brain : a journal of neurology. vol 142. issue 11. 2020-05-26. PMID:31603493. |
reduced levels of dopamine in parkinson's disease contribute to changes in learning, resulting from the loss of midbrain neurons that transmit a dopaminergic teaching signal to the striatum. |
2020-05-26 |
2023-08-13 |
human |
| Olga Trubetckaia, Ariana E Lane, Liping Qian, Ping Zhou, Diane A Lan. Alpha-synuclein is strategically positioned for afferent modulation of midbrain dopamine neurons and is essential for cocaine preference. Communications biology. vol 2. 2020-05-18. PMID:31754648. |
alpha-synuclein is strategically positioned for afferent modulation of midbrain dopamine neurons and is essential for cocaine preference. |
2020-05-18 |
2023-08-13 |
Not clear |
| Akinyinka O Alabi, Abayomi M Ajayi, Benneth Ben-Azu, Osarume Omorobge, Solomon Umukor. Methyl jasmonate ameliorates rotenone-induced motor deficits in rats through its neuroprotective activity and increased expression of tyrosine hydroxylase immunopositive cells. Metabolic brain disease. vol 34. issue 6. 2020-05-14. PMID:31463866. |
rot impaired locomotion and rearing behavior, and decreased dopamine content in the striatum, prefrontal cortex and midbrain. |
2020-05-14 |
2023-08-13 |
rat |
| Ada Ledonne, Nicola B Mercur. On the Modulatory Roles of Neuregulins/ErbB Signaling on Synaptic Plasticity. International journal of molecular sciences. vol 21. issue 1. 2020-05-13. PMID:31906113. |
here, we provide a review of the literature documenting the roles of nrgs/erbb signaling in the modulation of synaptic plasticity, focusing on evidence reported in the hippocampus and midbrain dopamine (da) nuclei. |
2020-05-13 |
2023-08-13 |
Not clear |
| Tsuyoshi Ishikawa, Hideyuki Matsumoto, Keiji Miur. Identification of midbrain dopamine neurons using features from spontaneous spike activity patterns Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. vol 2019. 2020-05-07. PMID:31946517. |
identification of midbrain dopamine neurons using features from spontaneous spike activity patterns although dopamine neurons are considered essential in various brain functions, their specific roles are under debate, partially due to the difficulty to identify dopamine neurons among surrounding neurons deep in the brain based only on the extracellularly recorded electric activities. |
2020-05-07 |
2023-08-13 |
Not clear |
| Yoki Nakamura, Dilyan I Dryanovski, Yuriko Kimura, Shelley N Jackson, Amina S Woods, Yuko Yasui, Shang-Yi Tsai, Sachin Patel, Daniel P Covey, Tsung-Ping Su, Carl R Lupic. Cocaine-induced endocannabinoid signaling mediated by sigma-1 receptors and extracellular vesicle secretion. eLife. vol 8. 2020-05-05. PMID:31596232. |
recent evidence suggests that cocaine stimulates synthesis of the endocannabinoid 2-arachidonoylglycerol (2-ag) in midbrain, increasing dopamine neuron activity via disinhibition. |
2020-05-05 |
2023-08-13 |
mouse |
| Yuan-Hao Chen, Vicki Wang, Eagle Yi-Kung Huang, Yu-Ching Chou, Tung-Tai Kuo, Lars Olson, Barry J Hoffe. Delayed Dopamine Dysfunction and Motor Deficits in Female Parkinson Model Mice. International journal of molecular sciences. vol 20. issue 24. 2020-04-22. PMID:31835787. |
this study analyzed gender differences in the progressive dopamine (da) deficiency phenotype in the mitopark (mp) mouse model of parkinson's disease (pd) with progressive loss of da release and reuptake in midbrain da pathways. |
2020-04-22 |
2023-08-13 |
mouse |