| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shingo Tanaka, John P O'Doherty, Masamichi Sakagam. The cost of obtaining rewards enhances the reward prediction error signal of midbrain dopamine neurons. Nature communications. vol 10. issue 1. 2019-12-10. PMID:31417077. |
midbrain dopamine neurons are known to encode reward prediction errors (rpe) used to update value predictions. |
2019-12-10 |
2023-08-13 |
monkey |
| Shingo Tanaka, John P O'Doherty, Masamichi Sakagam. The cost of obtaining rewards enhances the reward prediction error signal of midbrain dopamine neurons. Nature communications. vol 10. issue 1. 2019-12-10. PMID:31417077. |
here, we examine whether rpe signals coded by midbrain dopamine neurons are modulated by the cost paid to obtain rewards, by recording from dopamine neurons in awake behaving monkeys during performance of an effortful saccade task. |
2019-12-10 |
2023-08-13 |
monkey |
| Yuan Cai, Christopher P For. Dopamine Cells Differentially Regulate Striatal Cholinergic Transmission across Regions through Corelease of Dopamine and Glutamate. Cell reports. vol 25. issue 11. 2019-12-03. PMID:30540946. |
midbrain dopamine cells and local cholinergic interneurons (chis) densely innervate the striatum and have strong reciprocal actions on each other. |
2019-12-03 |
2023-08-13 |
Not clear |
| Yuan Cai, Christopher P For. Dopamine Cells Differentially Regulate Striatal Cholinergic Transmission across Regions through Corelease of Dopamine and Glutamate. Cell reports. vol 25. issue 11. 2019-12-03. PMID:30540946. |
here, we find that midbrain dopamine neurons drive pauses in the firing of dorsomedial chis but robust bursts in dorsolateral chis. |
2019-12-03 |
2023-08-13 |
Not clear |
| Caleb Pitcairn, Willayat Yousuf Wani, Joseph R Mazzull. Dysregulation of the autophagic-lysosomal pathway in Gaucher and Parkinson's disease. Neurobiology of disease. vol 122. 2019-12-02. PMID:29550539. |
translational application of these findings may be accelerated by the use of midbrain dopamine neuronal models derived from induced pluripotent stem cells (ipscs) that recapitulate several pathological features of gd and pd. |
2019-12-02 |
2023-08-13 |
Not clear |
| Bo Pan, Chao Den. Modulation by chronic antipsychotic administration of PKA- and GSK3β-mediated pathways and the NMDA receptor in rat ventral midbrain. Psychopharmacology. vol 236. issue 9. 2019-12-02. PMID:31053935. |
the ventral midbrain, mainly containing the ventral tegmental area (vta) and substantia nigra (sn), are the nuclei with dopamine origins in the brain, which are also involved in the actions of antipsychotics. |
2019-12-02 |
2023-08-13 |
rat |
| Jennifer M Wenzel, Erik B Oleson, Willard N Gove, Anthony B Cole, Utsav Gyawali, Hannah M Dantrassy, Rebecca J Bluett, Dilyan I Dryanovski, Garret D Stuber, Karl Deisseroth, Brian N Mathur, Sachin Patel, Carl R Lupica, Joseph F Chee. Phasic Dopamine Signals in the Nucleus Accumbens that Cause Active Avoidance Require Endocannabinoid Mobilization in the Midbrain. Current biology : CB. vol 28. issue 9. 2019-11-25. PMID:29681476. |
phasic dopamine signals in the nucleus accumbens that cause active avoidance require endocannabinoid mobilization in the midbrain. |
2019-11-25 |
2023-08-13 |
Not clear |
| Sawaguch. The role of D1-dopamine receptors in working memory-guided movements mediated by frontal cortical areas. Parkinsonism & related disorders. vol 7. issue 1. 2019-11-20. PMID:11008191. |
like the striatum, the frontal motor cortices receive dopaminergic fibers from midbrain dopamine cells and contain high levels of dopamine receptors. |
2019-11-20 |
2023-08-12 |
monkey |
| S.D. Iverse. Interactions between excitatory amino acids and dopamine systems in the forebrain: implications for schizophrenia and Parkinson's disease. Behavioural pharmacology. vol 6. issue 5 And 6. 2019-11-20. PMID:11224356. |
the midbrain dopamine neurones innervate not only the dorsal and ventral sectors of the striatum but also limbic structures and fronto-temporal association cortex. |
2019-11-20 |
2023-08-12 |
Not clear |
| S Raypor. Glutamate is a cotransmitter in ventral midbrain dopamine neurons. Parkinsonism & related disorders. vol 7. issue 3. 2019-11-20. PMID:11331197. |
glutamate is a cotransmitter in ventral midbrain dopamine neurons. |
2019-11-20 |
2023-08-12 |
rat |
| S Raypor. Glutamate is a cotransmitter in ventral midbrain dopamine neurons. Parkinsonism & related disorders. vol 7. issue 3. 2019-11-20. PMID:11331197. |
so it is surprising that the ventral midbrain dopamine neurons, which give rise to the dopaminergic pathway, may themselves also be glutamatergic. |
2019-11-20 |
2023-08-12 |
rat |
| S Raypor. Glutamate is a cotransmitter in ventral midbrain dopamine neurons. Parkinsonism & related disorders. vol 7. issue 3. 2019-11-20. PMID:11331197. |
we have addressed this idea in both rat and monkey brain and found that most ventral midbrain dopamine neurons exhibit glutamate immunoreactivity. |
2019-11-20 |
2023-08-12 |
rat |
| S Raypor. Glutamate is a cotransmitter in ventral midbrain dopamine neurons. Parkinsonism & related disorders. vol 7. issue 3. 2019-11-20. PMID:11331197. |
we used postnatal cell culture to examine ventral midbrain dopamine neurons more closely. |
2019-11-20 |
2023-08-12 |
rat |
| Wolfram Schult. The Reward Signal of Midbrain Dopamine Neurons. News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society. vol 14. 2019-11-20. PMID:11390860. |
the reward signal of midbrain dopamine neurons. |
2019-11-20 |
2023-08-12 |
Not clear |
| Wolfram Schult. The Reward Signal of Midbrain Dopamine Neurons. News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society. vol 14. 2019-11-20. PMID:11390860. |
dopamine projections from the midbrain to striatum and frontal cortex play a major role in behavioral reactions controlled by rewards. |
2019-11-20 |
2023-08-12 |
Not clear |
| Ronald J. Mandel, Patrik Brundin, Anders Björklun. The Importance of Graft Placement and Task Complexity for Transplant-Induced Recovery of Simple and Complex Sensorimotor Deficits in Dopamine Denervated Rats. The European journal of neuroscience. vol 2. issue 10. 2019-11-20. PMID:12106096. |
the present study examined the role of graft placement and behavioural task complexity in determining the functional efficacy of intrastriatal grafts of dopamine-rich fetal ventral mesencephalon (vm) placed in the dopamine (da) depleted striatum. |
2019-11-20 |
2023-08-12 |
rat |
| Jian-Da Wang, Yu-Lan Cao, Qian Li, Ya-Ping Yang, Mengmeng Jin, Dong Chen, Fen Wang, Guang-Hui Wang, Zheng-Hong Qin, Li-Fang Hu, Chun-Feng Li. A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in dopamine D2 and D3 receptor agonist-induced autophagy activation. Autophagy. vol 11. issue 11. 2019-11-20. PMID:26649942. |
in this study, we report that dopamine d2 and d3 receptor (drd2 and drd3) activation by pramipexole and quinpirole could enhance becn1 transcription and promote autophagy activation in several cell lines, including pc12, mes23.5 and differentiated sh-sy5y cells, and also in tyrosine hydroxylase positive primary midbrain neurons. |
2019-11-20 |
2023-08-13 |
human |
| Yong-Hee Rhee, Tae-Ho Kim, A-Young Jo, Mi-Yoon Chang, Chang-Hwan Park, Sang-Mi Kim, Jae-Jin Song, Sang-Min Oh, Sang-Hoon Yi, Hyeon Ho Kim, Bo-Hyun You, Jin-Wu Nam, Sang-Hun Le. LIN28A enhances the therapeutic potential of cultured neural stem cells in a Parkinson's disease model. Brain : a journal of neurology. vol 139. issue Pt 10. 2019-11-20. PMID:27538419. |
specifically, neural stem cells derived from the ventral midbrain lose their dopamine neurogenic potential, ventral midbrain-specific phenotypes, and repair capacity during in vitro cell expansion, all of which are critical concerns in using the cultured neural stem cells in therapeutic approaches for parkinson's disease. |
2019-11-20 |
2023-08-13 |
rat |
| Yong-Hee Rhee, Tae-Ho Kim, A-Young Jo, Mi-Yoon Chang, Chang-Hwan Park, Sang-Mi Kim, Jae-Jin Song, Sang-Min Oh, Sang-Hoon Yi, Hyeon Ho Kim, Bo-Hyun You, Jin-Wu Nam, Sang-Hun Le. LIN28A enhances the therapeutic potential of cultured neural stem cells in a Parkinson's disease model. Brain : a journal of neurology. vol 139. issue Pt 10. 2019-11-20. PMID:27538419. |
when lin28a expression was forced and sustained during neural stem cell expansion using an inducible expression-vector system, loss of dopamine neurogenic potential and midbrain phenotypes after long-term culturing was blocked. |
2019-11-20 |
2023-08-13 |
rat |
| Jana Drgonova, Donna Walther, G Luke Hartstein, Mohammad O Bukhari, Michael H Baumann, Jonathan Katz, Frank Scott Hall, Elizabeth R Arnold, Shaun Flax, Anthony Riley, Olga Rivero-Martin, Klaus-Peter Lesch, Juan Troncoso, Barbara Ranscht, George R Uh. Cadherin 13: human Molecular medicine (Cambridge, Mass.). vol 22. 2019-11-20. PMID:27579475. |
cadherin 13: human the cadherin 13 (cdh13) gene encodes a cell adhesion molecule likely to influence development and connections of brain circuits that modulate addiction, locomotion and cognition, including those that involve midbrain dopamine neurons. |
2019-11-20 |
2023-08-13 |
mouse |