| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Adaze Bijou Enogieru, Sylvester Ifeanyi Omoruyi, Donavon Charles Hiss, Okobi Eko Ekp. GRP78/BIP/HSPA5 as a Therapeutic Target in Models of Parkinson's Disease: A Mini Review. Advances in pharmacological sciences. vol 2019. 2020-09-30. PMID:30949202. |
parkinson's disease (pd) is a common neurodegenerative disorder characterized by selective loss of dopamine neurons in the substantia nigra pars compacta of the midbrain. |
2020-09-30 |
2023-08-13 |
human |
| Lisa M Smits, Lydia Reinhardt, Peter Reinhardt, Michael Glatza, Anna S Monzel, Nancy Stanslowsky, Marcelo D Rosato-Siri, Alessandra Zanon, Paul M Antony, Jessica Bellmann, Sarah M Nicklas, Kathrin Hemmer, Xiaobing Qing, Emanuel Berger, Norman Kalmbach, Marc Ehrlich, Silvia Bolognin, Andrew A Hicks, Florian Wegner, Jared L Sterneckert, Jens C Schwambor. Modeling Parkinson's disease in midbrain-like organoids. NPJ Parkinson's disease. vol 5. 2020-09-30. PMID:30963107. |
these organoids are composed of midbrain dopaminergic neurons (mdans), which produce and secrete dopamine. |
2020-09-30 |
2023-08-13 |
human |
| Aimée I Vester, Merry Chen, Carmen J Marsit, W Michael Caudl. A Neurodevelopmental Model of Combined Pyrethroid and Chronic Stress Exposure. Toxics. vol 7. issue 2. 2020-09-30. PMID:31052489. |
midbrain rna expression as well as striatal and cortical protein expression of key dopaminergic components were investigated, in addition to adhd-like behavioral tasks and electrochemical dopamine dynamics via fast-scan cyclic voltammetry. |
2020-09-30 |
2023-08-13 |
Not clear |
| Fernanda Vargas-Romero, Rodrigo González-Barrios, Lissania Guerra-Calderas, Itzel Escobedo-Avila, Daniel Cortés-Pérez, Adolfo López-Ornelas, Luisa Rocha, Ernesto Soto-Reyes, Iván Velasc. Histamine Modulates Midbrain Dopamine Neuron Differentiation Through the Regulation of Epigenetic Marks. Frontiers in cellular neuroscience. vol 13. 2020-09-30. PMID:31178697. |
histamine modulates midbrain dopamine neuron differentiation through the regulation of epigenetic marks. |
2020-09-30 |
2023-08-13 |
Not clear |
| Fernanda Vargas-Romero, Rodrigo González-Barrios, Lissania Guerra-Calderas, Itzel Escobedo-Avila, Daniel Cortés-Pérez, Adolfo López-Ornelas, Luisa Rocha, Ernesto Soto-Reyes, Iván Velasc. Histamine Modulates Midbrain Dopamine Neuron Differentiation Through the Regulation of Epigenetic Marks. Frontiers in cellular neuroscience. vol 13. 2020-09-30. PMID:31178697. |
during midbrain development, dopamine neuron differentiation occurs before birth. |
2020-09-30 |
2023-08-13 |
Not clear |
| Emilia Galli, Anu Planken, Liis Kadastik-Eerme, Mart Saarma, Pille Taba, Päivi Lindhol. Increased Serum Levels of Mesencephalic Astrocyte-Derived Neurotrophic Factor in Subjects With Parkinson's Disease. Frontiers in neuroscience. vol 13. 2020-09-30. PMID:31555085. |
mesencephalic astrocyte-derived neurotrophic factor (manf) and cerebral dopamine neurotrophic factor (cdnf) promote the survival of midbrain dopamine neurons in animal models of parkinson's disease (pd). |
2020-09-30 |
2023-08-13 |
human |
| Cui Huang, Jing Ma, Bai-Xiang Li, Yan Su. Wnt1 silencing enhances neurotoxicity induced by paraquat and maneb in SH-SY5Y cells. Experimental and therapeutic medicine. vol 18. issue 5. 2020-09-30. PMID:31602242. |
wingless (wnt) signaling regulates the proliferation and differentiation of midbrain dopamine (da) neurons. |
2020-09-30 |
2023-08-13 |
Not clear |
| Doug J Peterson, Darcy N Marckini, Jordan L Straight, Elizabeth M King, William Johnson, Sarala S Sarah, Puneet K Chowdhary, Merritt K DeLano-Taylo. The Basic Helix-Loop-Helix Gene Nato3 Drives Expression of Dopaminergic Neuron Transcription Factors in Neural Progenitors. Neuroscience. vol 421. 2020-09-30. PMID:31672641. |
neural progenitors of the midbrain floor plate utilize key genes in transcriptional networks to drive dopamine neurogenesis. |
2020-09-30 |
2023-08-13 |
chicken |
| Istvan Mod. The GAD-given Right of Dentate Gyrus Granule Cells to Become GABAergic. Epilepsy currents. vol 2. issue 5. 2020-09-29. PMID:15309121. |
other examples of two fast neurotransmitters released from the same neuron include gaba and glycine in interneurons of the spinal cord (5) and glutamate and dopamine in ventral midbrain dopamine neurons (6). |
2020-09-29 |
2023-08-12 |
Not clear |
| Helen M Nasser, Donna J Calu, Geoffrey Schoenbaum, Melissa J Sharp. The Dopamine Prediction Error: Contributions to Associative Models of Reward Learning. Frontiers in psychology. vol 8. 2020-09-29. PMID:28275359. |
phasic activity of midbrain dopamine neurons is currently thought to encapsulate the prediction-error signal described in sutton and barto's (1981) model-free reinforcement learning algorithm. |
2020-09-29 |
2023-08-13 |
Not clear |
| Yan-Feng Zhang, Stephanie J Crag. Pauses in Striatal Cholinergic Interneurons: What is Revealed by Their Common Themes and Variations? Frontiers in systems neuroscience. vol 11. 2020-09-29. PMID:29163075. |
the respective pause responses observed can demonstrate many commonalities, such as constant latency and duration, synchronous occurrence in a population of cells, and coincidence with phasic activities of midbrain dopamine neurons (dans) that signal reward predictions and errors. |
2020-09-29 |
2023-08-13 |
Not clear |
| Qi Chen, Shurong Li, Yuping Han, Xiaohong Wei, Juan Du, Xiaolin Wang, Bingyin Su, Jun L. Toxicological effects of propofol abuse on the dopaminergic neurons in ventral tegmental area and corpus striatum and its potential mechanisms. The Journal of toxicological sciences. vol 45. issue 7. 2020-09-29. PMID:32612007. |
at the 1st (t1) and 30th (t2) day of drug discontinuance (t2), 15 mice of each group were selected to perform the open field test; then the mice underwent perfusion fixation, and the midbrain and corpus striatum were separated for immunofluorescence assay with anti-tyrosine hydroxylase (th) and anti- dopamine transporter (dat) antibodies. |
2020-09-29 |
2023-08-13 |
mouse |
| David M Bortz, Anthony A Grac. Medial septum activation produces opposite effects on dopamine neuron activity in the ventral tegmental area and substantia nigra in MAM vs. normal rats. NPJ schizophrenia. vol 4. issue 1. 2020-09-28. PMID:30177811. |
the medial septum (ms) differentially impacts midbrain dopamine (da) neuron activity via the ventral hippocampus, a region implicated in da-related disorders. |
2020-09-28 |
2023-08-13 |
rat |
| Angélica Del Pilar Escobar, José Patricio Casanova, María Estela Andrés, José Antonio Fuentealb. Crosstalk Between Kappa Opioid and Dopamine Systems in Compulsive Behaviors. Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32132923. |
the strength of goal-oriented behaviors is regulated by midbrain dopamine neurons. |
2020-09-28 |
2023-08-13 |
Not clear |
| Angélica Del Pilar Escobar, José Patricio Casanova, María Estela Andrés, José Antonio Fuentealb. Crosstalk Between Kappa Opioid and Dopamine Systems in Compulsive Behaviors. Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32132923. |
the activity of midbrain dopamine neurons is principally regulated by the homeostatic action of dopamine through d2 receptors (d2r) that decrease the firing of neurons as well as dopamine synthesis and release. |
2020-09-28 |
2023-08-13 |
Not clear |
| Congcong Jia, Hongqian Qi, Cheng Cheng, Xuefei Wu, Zhaofei Yang, Huaibin Cai, Sheng Chen, Weidong L. α-Synuclein Negatively Regulates Nurr1 Expression Through NF-κB-Related Mechanism. Frontiers in molecular neuroscience. vol 13. 2020-09-28. PMID:32477062. |
the nuclear receptor-related 1 protein (nurr1) is critical for the development and survival of midbrain dopamine neurons that are predominantly affected and progressively degenerated in parkinson's disease (pd). |
2020-09-28 |
2023-08-13 |
Not clear |
| Yanxuan Li, Zili Zhu, Jie Chen, Minming Zhang, Yunjun Yang, Peiyu Huan. Dilated Perivascular Space in the Midbrain May Reflect Dopamine Neuronal Degeneration in Parkinson's Disease. Frontiers in aging neuroscience. vol 12. 2020-09-28. PMID:32581771. |
dilated perivascular space in the midbrain may reflect dopamine neuronal degeneration in parkinson's disease. |
2020-09-28 |
2023-08-13 |
Not clear |
| Tiago Cardoso, Martin Lévesqu. Toward Generating Subtype-Specific Mesencephalic Dopaminergic Neurons Frontiers in cell and developmental biology. vol 8. 2020-09-28. PMID:32626706. |
nonetheless, dopamine neurons residing in the mesencephalon comprise distinct groups of cells within diffusely defined anatomical boundaries and with distinct functional, electrophysiological, and molecular properties. |
2020-09-28 |
2023-08-13 |
Not clear |
| Susan F Sonnenschein, Felipe V Gomes, Anthony A Grac. Dysregulation of Midbrain Dopamine System and the Pathophysiology of Schizophrenia. Frontiers in psychiatry. vol 11. 2020-09-28. PMID:32719622. |
however, emerging evidence suggests that this dysregulation is driven by the disruption of upstream circuits that provide afferent control of midbrain dopamine neurons. |
2020-09-28 |
2023-08-13 |
Not clear |
| Jesse A Mendoza, Christopher K Lafferty, Angela K Yang, Jonathan P Brit. Cue-Evoked Dopamine Neuron Activity Helps Maintain but Does Not Encode Expected Value. Cell reports. vol 29. issue 6. 2020-09-24. PMID:31693885. |
cue-evoked midbrain dopamine (da) neuron activity reflects expected value, but its influence on reward assessment is unclear. |
2020-09-24 |
2023-08-13 |
mouse |