| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jean-Francois Poulin, Zachary Gaertner, Oscar Andrés Moreno-Ramos, Rajeshwar Awatraman. Classification of Midbrain Dopamine Neurons Using Single-Cell Gene Expression Profiling Approaches. Trends in neurosciences. vol 43. issue 3. 2021-08-18. PMID:32101709. |
dysfunctional dopamine (da) signaling has been associated with a broad spectrum of neuropsychiatric disorders, prompting investigations into how midbrain da neuron heterogeneity may underpin this variety of behavioral symptoms. |
2021-08-18 |
2023-08-13 |
Not clear |
| Tapan Behl, Ishnoor Kaur, Arun Kumar, Vineet Mehta, Gokhan Zengin, Sandeep Aror. Gene Therapy in the Management of Parkinson's Disease: Potential of GDNF as a Promising Therapeutic Strategy. Current gene therapy. vol 20. issue 3. 2021-08-18. PMID:32811394. |
viral vector-based dopamine delivery, prodrug approaches, fetal ventral mesencephalon tissue transplantation and dopamine synthesizing enzyme encoding gene delivery are significant therapies evidently supported by numerous trials. |
2021-08-18 |
2023-08-13 |
Not clear |
| Adam S Lowet, Qiao Zheng, Sara Matias, Jan Drugowitsch, Naoshige Uchid. Distributional Reinforcement Learning in the Brain. Trends in neurosciences. vol 43. issue 12. 2021-08-18. PMID:33092893. |
classical studies have demonstrated an impressive correspondence between the firing of dopamine neurons in the mammalian midbrain and the reward prediction errors of reinforcement learning algorithms, which express the difference between actual reward and predicted mean reward. |
2021-08-18 |
2023-08-13 |
Not clear |
| Ruthie E Wittenberg, Shannon L Wolfman, Mariella De Biasi, John A Dan. Nicotinic acetylcholine receptors and nicotine addiction: A brief introduction. Neuropharmacology. vol 177. 2021-08-12. PMID:32738308. |
the nachrs that contain the α4 and β2 subunits, often in combination with the α6 subunit, are particularly important for nicotine's ability to increase midbrain dopamine neuron firing rates and phasic burst firing. |
2021-08-12 |
2023-08-13 |
Not clear |
| Tertia D Purves-Tyson, Amelia M Brown, Christin Weissleder, Debora A Rothmond, Cynthia Shannon Weicker. Reductions in midbrain GABAergic and dopamine neuron markers are linked in schizophrenia. Molecular brain. vol 14. issue 1. 2021-08-12. PMID:34174930. |
reductions in midbrain gabaergic and dopamine neuron markers are linked in schizophrenia. |
2021-08-12 |
2023-08-13 |
Not clear |
| So-Yoon Won, Soon-Tae You, Seung-Won Choi, Catriona McLean, Eun-Young Shin, Eung-Gook Ki. cAMP Response Element Binding-Protein- and Phosphorylation-Dependent Regulation of Tyrosine Hydroxylase by PAK4: Implications for Dopamine Replacement Therapy. Molecules and cells. vol 44. issue 7. 2021-08-12. PMID:34238765. |
parkinson's disease (pd) is characterized by a progressive loss of dopamine-producing neurons in the midbrain, which results in decreased dopamine levels accompanied by movement symptoms. |
2021-08-12 |
2023-08-13 |
Not clear |
| Youri Adolfs, Divya D A Raj, Sara Brignani, R Jeroen Pasterkam. Protocol for tissue clearing and 3D analysis of dopamine neurons in the developing mouse midbrain. STAR protocols. vol 2. issue 3. 2021-08-12. PMID:34377993. |
protocol for tissue clearing and 3d analysis of dopamine neurons in the developing mouse midbrain. |
2021-08-12 |
2023-08-13 |
mouse |
| Youri Adolfs, Divya D A Raj, Sara Brignani, R Jeroen Pasterkam. Protocol for tissue clearing and 3D analysis of dopamine neurons in the developing mouse midbrain. STAR protocols. vol 2. issue 3. 2021-08-12. PMID:34377993. |
here, we implemented a modified version of 3disco to study migration of midbrain dopamine (da) neurons. |
2021-08-12 |
2023-08-13 |
mouse |
| Lisa M Smits, Stefano Magni, Kaoru Kinugawa, Kamil Grzyb, Joachim Luginbühl, Sonia Sabate-Soler, Silvia Bolognin, Jay W Shin, Eiichiro Mori, Alexander Skupin, Jens C Schwambor. Single-cell transcriptomics reveals multiple neuronal cell types in human midbrain-specific organoids. Cell and tissue research. vol 382. issue 3. 2021-08-10. PMID:32737576. |
human midbrain organoids (hmos) have been described to contain midbrain-specific dopaminergic neurons that release the neurotransmitter dopamine. |
2021-08-10 |
2023-08-13 |
human |
| Hui Shen, Kai Chen, Rosa Anna M Marino, Ross A McDevitt, Zheng-Xiong X. Deletion of VGLUT2 in midbrain dopamine neurons attenuates dopamine and glutamate responses to methamphetamine in mice. Pharmacology, biochemistry, and behavior. vol 202. 2021-08-10. PMID:33444596. |
deletion of vglut2 in midbrain dopamine neurons attenuates dopamine and glutamate responses to methamphetamine in mice. |
2021-08-10 |
2023-08-13 |
mouse |
| Yuji Kamikubo, Keiko Wakisaka, Yuzuru Imai, Takashi Sakura. Midbrain Slice Culture as an Ex Vivo Analysis Platform for Parkinson's Disease. Methods in molecular biology (Clifton, N.J.). vol 2322. 2021-08-10. PMID:34043197. |
the motor symptoms of the disease result from the death of cells in the region of the midbrain, leading to a dopamine deficit. |
2021-08-10 |
2023-08-13 |
Not clear |
| Luca Aquili, Eric M Bowman, Robert Schmid. Occasion setters determine responses of putative DA neurons to discriminative stimuli. Neurobiology of learning and memory. vol 173. 2021-07-27. PMID:32565408. |
midbrain dopamine (da) neurons are involved in the processing of rewards and reward-predicting stimuli, possibly analogous to reinforcement learning reward prediction errors. |
2021-07-27 |
2023-08-13 |
rat |
| Julio Aguila, Shangli Cheng, Nigel Kee, Ming Cao, Menghan Wang, Qiaolin Deng, Eva Hedlun. Spatial RNA Sequencing Identifies Robust Markers of Vulnerable and Resistant Human Midbrain Dopamine Neurons and Their Expression in Parkinson's Disease. Frontiers in molecular neuroscience. vol 14. 2021-07-27. PMID:34305528. |
spatial rna sequencing identifies robust markers of vulnerable and resistant human midbrain dopamine neurons and their expression in parkinson's disease. |
2021-07-27 |
2023-08-13 |
human |
| Christian U von Linstow, Merritt DeLano-Taylor, Jeffrey H Kordower, Patrik Brundi. Does Developmental Variability in the Number of Midbrain Dopamine Neurons Affect Individual Risk for Sporadic Parkinson's Disease? Journal of Parkinson's disease. vol 10. issue 2. 2021-07-26. PMID:31958098. |
does developmental variability in the number of midbrain dopamine neurons affect individual risk for sporadic parkinson's disease? |
2021-07-26 |
2023-08-13 |
Not clear |
| Maho Asami, Yuji Suzuki, Fumio Sakan. Dopamine and the phosphorylated dopamine transporter are increased in the diacylglycerol kinase η-knockout mouse brain. FEBS letters. vol 595. issue 9. 2021-07-23. PMID:33599293. |
here, we found that dgkη knockout markedly increased dopamine (da) levels in the midbrain (da-producing region, 2.8-fold) and cerebral cortex (da projection region, 1.2-fold). |
2021-07-23 |
2023-08-13 |
mouse |
| Jun Wang, Jie Li, Qian Yang, Ya-Kai Xie, Ya-Lan Wen, Zhen-Zhong Xu, Yulong Li, Tianle Xu, Zhi-Ying Wu, Shumin Duan, Han X. Basal forebrain mediates prosocial behavior via disinhibition of midbrain dopamine neurons. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 7. 2021-07-22. PMID:33563763. |
basal forebrain mediates prosocial behavior via disinhibition of midbrain dopamine neurons. |
2021-07-22 |
2023-08-13 |
Not clear |
| Jun Wang, Jie Li, Qian Yang, Ya-Kai Xie, Ya-Lan Wen, Zhen-Zhong Xu, Yulong Li, Tianle Xu, Zhi-Ying Wu, Shumin Duan, Han X. Basal forebrain mediates prosocial behavior via disinhibition of midbrain dopamine neurons. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 7. 2021-07-22. PMID:33563763. |
here we identify a causal role of the basal forebrain (bf) in the control of prosocial behavior via inhibitory projections that disinhibit the midbrain ventral tegmental area (vta) dopamine (da) neurons. |
2021-07-22 |
2023-08-13 |
Not clear |
| Daniel Eskenazi, Lauren Malave, Susana Mingote, Leora Yetnikoff, Samira Ztaou, Vlad Velicu, Stephen Rayport, Nao Chuhm. Dopamine Neurons That Cotransmit Glutamate, From Synapses to Circuits to Behavior. Frontiers in neural circuits. vol 15. 2021-07-16. PMID:34093138. |
this review article encompasses the current body of evidence investigating the functions of dopamine neurons of the ventral midbrain that cotransmit glutamate. |
2021-07-16 |
2023-08-13 |
Not clear |
| Hajime Shiotani, Muneaki Miyata, Takeshi Kameyama, Kenji Mandai, Miwako Yamasaki, Masahiko Watanabe, Kiyohito Mizutani, Yoshimi Taka. Nectin-2α is localized at cholinergic neuron dendrites and regulates synapse formation in the medial habenula. The Journal of comparative neurology. vol 529. issue 2. 2021-07-13. PMID:32452538. |
the medial habenula (mhb) receives afferents from the triangular septum and the medial septal complex, projects efferents to the interpeduncular nucleus (ipn) in the midbrain to regulate dopamine and serotonin levels, and is implicated in stress, depression, memory, and nicotine withdrawal syndrome. |
2021-07-13 |
2023-08-13 |
Not clear |
| Anil Joshi, Fanny Faivre, Susanne Eva la Fleur, Michel Barro. Midbrain and Lateral Nucleus Accumbens Dopamine Depletion Affects Free-choice High-fat high-sugar Diet Preference in Male Rats. Neuroscience. vol 467. 2021-07-12. PMID:34048800. |
midbrain and lateral nucleus accumbens dopamine depletion affects free-choice high-fat high-sugar diet preference in male rats. |
2021-07-12 |
2023-08-13 |
rat |