| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alice Servonnet, Florence Allain, Alice Gravel-Chouinard, Giovanni Hernandez, Casey Bourdeau Caporuscio, Mathilde Legrix, Daniel Lévesque, Pierre-Paul Rompré, Anne-Noël Samah. Dopaminergic mechanisms underlying the expression of antipsychotic-induced dopamine supersensitivity in rats. Neuropharmacology. vol 197. 2021-10-14. PMID:34364897. |
finally, after discontinuing haloperidol treatment, neither increasing ventral midbrain dopamine impulse flow nor infusing d-amphetamine into the cerebral ventricles triggered the expression of already established dopamine supersensitivity, suggesting that peripheral effects are required. |
2021-10-14 |
2023-08-13 |
rat |
| Ki Bum Um, Suyun Hahn, So Woon Kim, Yoon Je Lee, Lutz Birnbaumer, Hyun Jin Kim, Myoung Kyu Par. TRPC3 and NALCN channels drive pacemaking in substantia nigra dopaminergic neurons. eLife. vol 10. 2021-10-14. PMID:34409942. |
midbrain dopamine (da) neurons are slow pacemakers that maintain extracellular da levels. |
2021-10-14 |
2023-08-13 |
mouse |
| Bernadete Negrelli, José Augusto Pochapski, Cyrus Antonio Villas-Boas, Letícia Ferreira Jessen, Mayra Aline Lopes Teixeira, Claudio Da Cunh. Evidence that haloperidol impairs learning and motivation scores in a probabilistic task by reducing the reward expectation. Behavioural brain research. vol 395. 2021-10-13. PMID:32810468. |
activation of midbrain dopamine neurons in response to positive prediction errors and reward predictive cues is proposed to "energize" reward seeking behaviors and approach responses to places where the reward is expected. |
2021-10-13 |
2023-08-13 |
rat |
| M Thiele, K S L Yuen, A V M Gerlicher, R Kalisc. A ventral striatal prediction error signal in human fear extinction learning. NeuroImage. vol 229. 2021-10-13. PMID:33460800. |
animal studies have shown that the prediction error (pe) signal that drives fear extinction learning is encoded by phasic activity of midbrain dopamine (da) neurons. |
2021-10-13 |
2023-08-13 |
human |
| Xinrong Liu, Shuya Liu, Yong Tang, Zhengjia Pu, Hong Xiao, Jieying Gao, Qi Yin, Yan Jia, Qunhua Ba. Intragastric Administration of Casein Leads to Nigrostriatal Disease Progressed Accompanied with Persistent Nigrostriatal-Intestinal Inflammation Activited and Intestinal Microbiota-Metabolic Disorders Induced in MPTP Mouse Model of Parkinson's Disease. Neurochemical research. vol 46. issue 6. 2021-10-12. PMID:33719004. |
the experimental results revealed that the mice with casein gavage after mptp treatment showed a persisted dyskinesia, the content of dopamine in striatum and the expression of th in midbrain and ileum were decreased, the expression of iba-1, cd4, il-22 in midbrain and ileum increased continuously with persisted intestinal histopathology and intestinal barrier injury. |
2021-10-12 |
2023-08-13 |
mouse |
| Michelle Kokkinou, Elaine E Irvine, David R Bonsall, Sridhar Natesan, Lisa A Wells, Mark Smith, Justyna Glegola, Eleanor J Paul, Kyoko Tossell, Mattia Veronese, Sanjay Khadayate, Nina Dedic, Seth C Hopkins, Mark A Ungless, Dominic J Withers, Oliver D Howe. Reproducing the dopamine pathophysiology of schizophrenia and approaches to ameliorate it: a translational imaging study with ketamine. Molecular psychiatry. vol 26. issue 6. 2021-10-11. PMID:32382134. |
these effects were countered by inhibition of midbrain dopamine neurons, and by activation of pv interneurons in pre-limbic cortex and ventral subiculum of the hippocampus. |
2021-10-11 |
2023-08-13 |
mouse |
| Tsui-Wen Chou, Nydia P Chang, Medha Krishnagiri, Aisha P Patel, Marissa Lindman, Juan P Angel, Po-Lun Kung, Colm Atkins, Brian P Daniel. Fibrillar α-synuclein induces neurotoxic astrocyte activation via RIP kinase signaling and NF-κB. Cell death & disease. vol 12. issue 8. 2021-10-11. PMID:34333522. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the death of midbrain dopamine neurons. |
2021-10-11 |
2023-08-13 |
human |
| Lauren Malave, Dustin R Zuelke, Santiago Uribe-Cano, Lev Starikov, Heike Rebholz, Eitan Friedman, Chuan Qin, Qin Li, Erwan Bezard, Andreas H Kottman. Dopaminergic co-transmission with sonic hedgehog inhibits abnormal involuntary movements in models of Parkinson's disease and L-Dopa induced dyskinesia. Communications biology. vol 4. issue 1. 2021-10-09. PMID:34552196. |
here we report that diminished sonic hedgehog (shh) signaling in the basal ganglia caused by the degeneration of midbrain dopamine neurons facilitates the formation and expression of lid. |
2021-10-09 |
2023-08-13 |
mouse |
| Maisha Iqbal, Sylvia Maria Leonarda Cox, Natalia Jaworska, Maria Tippler, Natalie Castellanos-Ryan, Sophie Parent, Alain Dagher, Frank Vitaro, Mara R Brendgen, Michel Boivin, Robert O Pihl, Sylvana M Côté, Richard E Tremblay, Jean R Séguin, Marco Leyto. A three-factor model of common early onset psychiatric disorders: temperament, adversity, and dopamine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2021-10-09. PMID:34625707. |
the mediating processes remain poorly understood, but three factors show some promise: adolescent externalizing traits, early life adversity, and midbrain dopamine autoreceptors. |
2021-10-09 |
2023-08-13 |
human |
| Federico G Gnazzo, Devry Mourra, Christopher A Guevara, Jeff A Beele. Chronic food restriction enhances dopamine-mediated intracranial self-stimulation. Neuroreport. vol 32. issue 13. 2021-10-07. PMID:34284450. |
using mouse genetic lines to express channelrhodopsin selectively in midbrain dopamine neurons, we demonstrate that genetically expressed channelrhodopsin can mediate optically evoked dopamine release and support self-stimulation in a lever-pressing paradigm. |
2021-10-07 |
2023-08-13 |
mouse |
| Federico G Gnazzo, Devry Mourra, Christopher A Guevara, Jeff A Beele. Chronic food restriction enhances dopamine-mediated intracranial self-stimulation. Neuroreport. vol 32. issue 13. 2021-10-07. PMID:34284450. |
using this midbrain dopamine oicss preparation, we compare acquisition and rate of pressing in ad libitum versus food restricted mice. |
2021-10-07 |
2023-08-13 |
mouse |
| Takuya Hikima, Christian R Lee, Paul Witkovsky, Julia Chesler, Konstantin Ichtchenko, Margaret E Ric. Activity-dependent somatodendritic dopamine release in the substantia nigra autoinhibits the releasing neuron. Cell reports. vol 35. issue 1. 2021-10-06. PMID:33826884. |
somatodendritic dopamine (da) release from midbrain da neurons activates d2 autoreceptors on these cells to regulate their activity. |
2021-10-06 |
2023-08-13 |
Not clear |
| Kevin Burbidge, David J Rademacher, Jessica Mattick, Stephanie Zack, Andrea Grillini, Luc Bousset, Ochan Kwon, Konrad Kubicki, Alexander Simon, Ronald Melki, Edward M Campbel. LGALS3 (galectin 3) mediates an unconventional secretion of SNCA/α-synuclein in response to lysosomal membrane damage by the autophagic-lysosomal pathway in human midbrain dopamine neurons. Autophagy. 2021-10-06. PMID:34612142. |
lgals3 (galectin 3) mediates an unconventional secretion of snca/α-synuclein in response to lysosomal membrane damage by the autophagic-lysosomal pathway in human midbrain dopamine neurons. |
2021-10-06 |
2023-08-13 |
human |
| Kevin Burbidge, David J Rademacher, Jessica Mattick, Stephanie Zack, Andrea Grillini, Luc Bousset, Ochan Kwon, Konrad Kubicki, Alexander Simon, Ronald Melki, Edward M Campbel. LGALS3 (galectin 3) mediates an unconventional secretion of SNCA/α-synuclein in response to lysosomal membrane damage by the autophagic-lysosomal pathway in human midbrain dopamine neurons. Autophagy. 2021-10-06. PMID:34612142. |
here, we use a human midbrain dopamine (mda) neuronal culture model to provide evidence in support of a cellular mechanism that explains the cell-to-cell transfer of pathological forms of snca that are observed in pd. |
2021-10-06 |
2023-08-13 |
human |
| Liza Bergkvist, Michaela E Johnson, Gabriela Mercado, Jennifer A Steiner, Lindsay Meyerdirk, Emily Schulz, Zachary Madaj, Jiyan Ma, Katelyn Becker, Yazhou Li, Patrik Brundi. An extended release GLP-1 analogue increases α-synuclein accumulation in a mouse model of prodromal Parkinson's disease. Experimental neurology. vol 341. 2021-10-04. PMID:33727096. |
one prior study has reported a protective effect of a glp-1 analogue on midbrain dopamine neurons following injection of α-syn preformed fibrils (pff) into the striatum. |
2021-10-04 |
2023-08-13 |
mouse |
| Małgorzata Kujawska, Michael Jourdes, Łukasz Witucki, Marta Karaźniewicz-Łada, Michał Szulc, Agata Górska, Przemysław Ł Mikołajczak, Pierre-Louis Teissedre, Jadwiga Jodynis-Lieber. Pomegranate Juice Ameliorates Dopamine Release and Behavioral Deficits in a Rat Model of Parkinson's Disease. Brain sciences. vol 11. issue 9. 2021-10-01. PMID:34573149. |
after this, we assessed the olfactory discrimination index (di) and vertical and horizontal activities as well as levels of dopamine and its main metabolite 3,4-dihydroxyphenylacetic acid (dopac) in the dissected midbrain of animals. |
2021-10-01 |
2023-08-13 |
rat |
| Samuel J Millard, Carrie E Bearden, Katherine H Karlsgodt, Melissa J Sharp. The prediction-error hypothesis of schizophrenia: new data point to circuit-specific changes in dopamine activity. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2021-09-30. PMID:34588607. |
recently, there has been an explosion of new research investigating how dopamine contributes to reinforcement learning, which illustrates that midbrain dopamine contributes in complex ways to reinforcement learning, not previously envisioned. |
2021-09-30 |
2023-08-13 |
Not clear |
| Iulia Zoicas, Sabine E Huber, Liubov S Kalinichenko, Erich Gulbins, Christian P Müller, Johannes Kornhube. Ceramides affect alcohol consumption and depressive-like and anxiety-like behavior in a brain region- and ceramide species-specific way in male mice. Addiction biology. vol 25. issue 6. 2021-09-28. PMID:31828921. |
our results revealed that c16, but not c8 and c20, ceramide altered alcohol drinking and emotional behavior in a brain region-specific way without altering tissue noradrenaline, dopamine, and serotonin levels in the prefrontal cortex, ventral striatum, and dorsal mesencephalon. |
2021-09-28 |
2023-08-13 |
mouse |
| Saad Latif, Muhammad Jahangeer, Dure Maknoon Razia, Mehvish Ashiq, Abdul Ghaffar, Muhammad Akram, Aicha El Allam, Abdelhakim Bouyahya, Larisa Garipova, Mohammad Ali Shariati, Muthu Thiruvengadam, Mohammad Azam Ansar. Dopamine in Parkinson's disease. Clinica chimica acta; international journal of clinical chemistry. vol 522. 2021-09-28. PMID:34389279. |
the production of dopamine (a monoamine neurotransmitter) occurs in the ventral tegmental area (vta) of the substantia nigra, specifically in the hypothalamic nucleus and midbrain. |
2021-09-28 |
2023-08-13 |
Not clear |
| Saad Latif, Muhammad Jahangeer, Dure Maknoon Razia, Mehvish Ashiq, Abdul Ghaffar, Muhammad Akram, Aicha El Allam, Abdelhakim Bouyahya, Larisa Garipova, Mohammad Ali Shariati, Muthu Thiruvengadam, Mohammad Azam Ansar. Dopamine in Parkinson's disease. Clinica chimica acta; international journal of clinical chemistry. vol 522. 2021-09-28. PMID:34389279. |
compared to other monoamines, dopamine is widely distributed in the olfactory bulb, midbrain substantia nigra, hypothalamus, vta, retina, and the periaqueductal gray area. |
2021-09-28 |
2023-08-13 |
Not clear |