| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alessandro Fiorenzano, Edoardo Sozzi, Marcella Birtele, Janko Kajtez, Jessica Giacomoni, Fredrik Nilsson, Andreas Bruzelius, Yogita Sharma, Yu Zhang, Bengt Mattsson, Jenny Emnéus, Daniella Rylander Ottosson, Petter Storm, Malin Parma. Single-cell transcriptomics captures features of human midbrain development and dopamine neuron diversity in brain organoids. Nature communications. vol 12. issue 1. 2021-12-16. PMID:34911939. |
using single cell rna sequencing, we identify the presence of three molecularly distinct subtypes of human dopamine neurons with high similarity to those in developing and adult human midbrain. |
2021-12-16 |
2023-08-13 |
human |
| Päivi Lindholm, Mart Saarm. Cerebral dopamine neurotrophic factor protects and repairs dopamine neurons by novel mechanism. Molecular psychiatry. 2021-12-15. PMID:34907395. |
midbrain dopamine neurons deteriorate in parkinson's disease (pd) that is a progressive neurodegenerative movement disorder. |
2021-12-15 |
2023-08-13 |
mouse |
| Allen P F Chen, Lu Chen, Thomas A Kim, Qiaojie Xion. Integrating the Roles of Midbrain Dopamine Circuits in Behavior and Neuropsychiatric Disease. Biomedicines. vol 9. issue 6. 2021-12-11. PMID:34200134. |
integrating the roles of midbrain dopamine circuits in behavior and neuropsychiatric disease. |
2021-12-11 |
2023-08-13 |
Not clear |
| Lianwei Mu, Xiaojie Liu, Hao Yu, Mengming Hu, Vladislav Friedman, Thomas J Kelly, Li Zhao, Qing-Song Li. Ibudilast attenuates cocaine self-administration and prime- and cue-induced reinstatement of cocaine seeking in rats. Neuropharmacology. vol 201. 2021-12-11. PMID:34626665. |
to investigate potential mechanisms for ibudilast-induced attenuation of cocaine self-administration, we recorded from ventral tegmental area (vta) dopamine neurons in ex vivo midbrain slices prepared from rats that had undergone saline and cocaine self-administration. |
2021-12-11 |
2023-08-13 |
rat |
| Su Hyoun Lee, Sungyeon Jung, Yun Ju Lee, Minju Hyun, Kwang Chul Chun. FBXO7 triggers caspase 8-mediated proteolysis of the transcription factor FOXO4 and exacerbates neuronal cytotoxicity. The Journal of biological chemistry. vol 297. issue 6. 2021-12-11. PMID:34800438. |
parkinson's disease (pd) is characterized by the progressive loss of midbrain dopamine neurons in the substantia nigra. |
2021-12-11 |
2023-08-13 |
Not clear |
| Przemysław Cieśla. Glutamate receptors in the dopamine system – function and role in reinforcement learning Postepy biochemii. vol 67. issue 3. 2021-12-11. PMID:34894387. |
glutamate receptors in the dopamine system – function and role in reinforcement learning midbrain dopamine neurons along with the major target of their projections, dopaminoceptive neurons in striatum, regulate reinforcement learning and motivation. |
2021-12-11 |
2023-08-13 |
mouse |
| Mathieu Di Miceli, Adesina Omoloye, Benjamin Gronie. Characterisation of methylphenidate-induced excitation in midbrain dopamine neurons, an electrophysiological study in the rat brain. Progress in neuro-psychopharmacology & biological psychiatry. vol 112. 2021-12-10. PMID:34339759. |
characterisation of methylphenidate-induced excitation in midbrain dopamine neurons, an electrophysiological study in the rat brain. |
2021-12-10 |
2023-08-13 |
rat |
| Harry J Stewardson, Thomas D Sambroo. Reward prediction error in the ERP following unconditioned aversive stimuli. Scientific reports. vol 11. issue 1. 2021-12-10. PMID:34620955. |
midbrain dopamine neurons, believed to compute reward prediction errors, generate this signal in response to both conditioned and unconditioned stimuli, as predicted by temporal difference learning. |
2021-12-10 |
2023-08-13 |
human |
| Vasilios Pallikaras, Francis Carter, David Natanael Velazquez-Martinez, Andreas Arvanitogiannis, Peter Shizga. The trade-off between pulse duration and power in optical excitation of midbrain dopamine neurons approximates Bloch's law. Behavioural brain research. vol 419. 2021-12-10. PMID:34864162. |
the trade-off between pulse duration and power in optical excitation of midbrain dopamine neurons approximates bloch's law. |
2021-12-10 |
2023-08-13 |
human |
| Katarína Tiklová, Linda Gillberg, Nikolaos Volakakis, Hilda Lundén-Miguel, Lina Dahl, Geidy E Serrano, Charles H Adler, Thomas G Beach, Thomas Perlman. Disease Duration Influences Gene Expression in Neuromelanin-Positive Cells From Parkinson's Disease Patients. Frontiers in molecular neuroscience. vol 14. 2021-12-07. PMID:34867188. |
major symptoms in parkinson's disease (pd) are caused by the degeneration of midbrain dopamine (mda) neurons within the substantia nigra. |
2021-12-07 |
2023-08-13 |
Not clear |
| Theodoros Tsetsenis, Julia K Badyna, Julianne A Wilson, Xiaowen Zhang, Elizabeth N Krizman, Manivannan Subramaniyan, Kechun Yang, Steven A Thomas, John A Dan. Midbrain dopaminergic innervation of the hippocampus is sufficient to modulate formation of aversive memories. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 40. 2021-12-06. PMID:34580198. |
using optogenetic manipulations and mutant mice to control dopamine transmission in the hippocampus, we show that midbrain dopamine potently modulates aversive memory formation during encoding of contextual fear. |
2021-12-06 |
2023-08-13 |
mouse |
| Theodoros Tsetsenis, Julia K Badyna, Julianne A Wilson, Xiaowen Zhang, Elizabeth N Krizman, Manivannan Subramaniyan, Kechun Yang, Steven A Thomas, John A Dan. Midbrain dopaminergic innervation of the hippocampus is sufficient to modulate formation of aversive memories. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 40. 2021-12-06. PMID:34580198. |
our findings identify a cluster of midbrain dopamine neurons that innervate the hippocampus and show that the midbrain dopamine neuromodulation in the dorsal hippocampus is sufficient to maintain aversive memory formation. |
2021-12-06 |
2023-08-13 |
mouse |
| Gian Pietro Serra, Adriane Guillaumin, Sylvie Dumas, Bianca Vlcek, Åsa Wallén-Mackenzi. Midbrain Dopamine Neurons Defined by TrpV1 Modulate Psychomotor Behavior. Frontiers in neural circuits. vol 15. 2021-12-04. PMID:34858142. |
midbrain dopamine neurons defined by trpv1 modulate psychomotor behavior. |
2021-12-04 |
2023-08-13 |
Not clear |
| Nathan D Winters, Gaurav Bedse, Anastasia A Astafyev, Toni A Patrick, Megan Altemus, Amanda J Morgan, Snigdha Mukerjee, Keenan D Johnson, Vikrant R Mahajan, Md Jashim Uddin, Philip J Kingsley, Samuel W Centanni, Cody A Siciliano, David C Samuels, Lawrence J Marnett, Danny G Winder, Sachin Pate. Targeting diacylglycerol lipase reduces alcohol consumption in preclinical models. The Journal of clinical investigation. 2021-12-03. PMID:34292886. |
lastly, dagl inhibition also prevented ethanol-induced suppression of gabaergic transmission onto midbrain dopamine neurons, providing mechanistic insight into how dagl inhibition could affect alcohol reward. |
2021-12-03 |
2023-08-13 |
mouse |
| Zhijun Diao, Li Yao, Qiangqiang Cheng, Meilin Wu, Yuanyuan Di, Zhaoqiang Qian, Chunling Wei, Yingxun Liu, Yingfang Tian, Wei Re. Correction to: Involvement of Midbrain Dopamine Neuron Activity in Negative Reinforcement Learning in Mice. Molecular neurobiology. vol 58. issue 12. 2021-12-03. PMID:34674100. |
correction to: involvement of midbrain dopamine neuron activity in negative reinforcement learning in mice. |
2021-12-03 |
2023-08-13 |
mouse |
| Zhijun Diao, Li Yao, Qiangqiang Cheng, Meilin Wu, Yuanyuan Di, Zhaoqiang Qian, Chunling Wei, Yingxun Liu, Yingfang Tian, Wei Re. Involvement of Midbrain Dopamine Neuron Activity in Negative Reinforcement Learning in Mice. Molecular neurobiology. vol 58. issue 11. 2021-12-02. PMID:34387814. |
involvement of midbrain dopamine neuron activity in negative reinforcement learning in mice. |
2021-12-02 |
2023-08-13 |
mouse |
| Fatemeh Shaerzadeh, Leah Phan, Douglas Miller, Maxwell Dacquel, William Hachmeister, Carissa Hansen, Alexandra Bechtle, Duan Tu, Maia Martcheva, Thomas C Foster, Ashok Kumar, Wolfgang J Streit, Habibeh Khoshboue. Microglia senescence occurs in both substantia nigra and ventral tegmental area. Glia. vol 68. issue 11. 2021-11-30. PMID:32275335. |
during aging humans lose midbrain dopamine neurons, but not all dopamine regions exhibit vulnerability to neurodegeneration. |
2021-11-30 |
2023-08-13 |
mouse |
| D Halperin, A Stavsky, R Kadir, M Drabkin, O Wormser, Y Yogev, V Dolgin, R Proskorovski-Ohayon, Y Perez, H Nudelman, O Stoler, B Rotblat, T Lifschytz, A Lotan, G Meiri, D Gitler, O S Bir. CDH2 mutation affecting N-cadherin function causes attention-deficit hyperactivity disorder in humans and mice. Nature communications. vol 12. issue 1. 2021-11-30. PMID:34702855. |
specific downstream molecular pathways were affected in both the ventral midbrain and prefrontal cortex, with reduced tyrosine hydroxylase expression and dopamine levels. |
2021-11-30 |
2023-08-13 |
mouse |
| Anna Maria Lavezz. Altered Development of Mesencephalic Dopaminergic Neurons in SIDS: New Insights into Understanding Sudden Infant Death Pathogenesis. Biomedicines. vol 9. issue 11. 2021-11-30. PMID:34829763. |
dopaminergic structures in midbrain sections of a large series of sudden infant deaths (36 sids and 26 controls) were identified using polyclonal rabbit antibodies against tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis, and the dopamine transporter, a membrane protein specifically expressed in dopaminergic cells. |
2021-11-30 |
2023-08-13 |
human |
| Denis Burdako. Subsecond Ensemble Dynamics of Orexin Neurons Link Sensation and Action. Frontiers of neurology and neuroscience. vol 45. 2021-11-29. PMID:34052808. |
these findings establish orexin neurons as rapid and strong sensorimotor controllers that are in many ways operationally similar to classic subcortical movement controllers, such as midbrain dopamine neurons. |
2021-11-29 |
2023-08-13 |
Not clear |