| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Benjamin M Seitz, Ivy B Hoang, Lauren E DiFazio, Aaron P Blaisdell, Melissa J Sharp. Dopamine errors drive excitatory and inhibitory components of backward conditioning in an outcome-specific manner. Current biology : CB. 2022-06-25. PMID:35752165. |
for over two decades, phasic activity in midbrain dopamine neurons was considered synonymous with the prediction error in temporal-difference reinforcement learning. |
2022-06-25 |
2023-08-14 |
Not clear |
| Kenan Steidel, Marina C Ruppert, Andrea Greuel, Masoud Tahmasian, Franziska Maier, Jochen Hammes, Thilo van Eimeren, Lars Timmermann, Marc Tittgemeyer, Alexander Drzezga, David J Pedrosa, Carsten Egger. Longitudinal trimodal imaging of midbrain-associated network degeneration in Parkinson's disease. NPJ Parkinson's disease. vol 8. issue 1. 2022-06-22. PMID:35732679. |
here, we applied a trimodal imaging protocol combining 18f-fluorodeoxyglucose (fdg)- and 18f-fluoro-l-dopa- (fdopa)-pet with resting-state functional mri to assess longitudinal changes in midbrain metabolism, striatal dopamine depletion and striatocortical dysconnectivity in 17 well-characterized pd patients. |
2022-06-22 |
2023-08-14 |
human |
| Arjun Patel, Catherine A Olang, Gregory Lewis, Kesava Mandalaneni, Nikhilesh Anand, Vasavi Rakesh Gorantl. An Overview of Parkinson's Disease: Curcumin as a Possible Alternative Treatment. Cureus. vol 14. issue 5. 2022-06-20. PMID:35719816. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra of the midbrain and basal ganglia, followed by dopamine deficiency in the brain. |
2022-06-20 |
2023-08-14 |
Not clear |
| Saptarsi Mitra, Sumela Basu, Omprakash Singh, Abhinav Srivastava, Praful S Singr. Calcium-binding proteins typify the dopaminergic neuronal subtypes in the ventral tegmental area of zebra finch, Taeniopygia guttata. The Journal of comparative neurology. 2022-06-18. PMID:35715989. |
calcium-binding proteins (cbps) regulate neuronal function in midbrain dopamine (da)-ergic neurons in mammals by buffering and sensing the intracellular ca |
2022-06-18 |
2023-08-14 |
Not clear |
| Matthew J Reid, Maria Rogdaki, Lucia Dutan, Bjørn Hanger, Kaarin Sabad, Roland Nagy, Dwaipayan Adhya, Simon Baron-Cohen, Grainne McAlonan, Jack Price, Anthony C Vernon, Oliver D Howes, Deepak P Srivastav. Cell line specific alterations in genes associated with dopamine metabolism and signaling in midbrain dopaminergic neurons derived from 22q11.2 deletion carriers with elevated dopamine synthesis capacity. Schizophrenia research. 2022-06-14. PMID:35701280. |
cell line specific alterations in genes associated with dopamine metabolism and signaling in midbrain dopaminergic neurons derived from 22q11.2 deletion carriers with elevated dopamine synthesis capacity. |
2022-06-14 |
2023-08-14 |
Not clear |
| Alessandro Fiorenzano, Edoardo Sozzi, Marcella Birtele, Janko Kajtez, Jessica Giacomoni, Fredrik Nilsson, Andreas Bruzelius, Yogita Sharma, Yu Zhang, Bengt Mattsson, Jenny Emnéus, Daniella Rylander Ottosson, Petter Storm, Malin Parma. Author Correction: Single-cell transcriptomics captures features of human midbrain development and dopamine neuron diversity in brain organoids. Nature communications. vol 13. issue 1. 2022-06-08. PMID:35676291. |
author correction: single-cell transcriptomics captures features of human midbrain development and dopamine neuron diversity in brain organoids. |
2022-06-08 |
2023-08-14 |
human |
| J S Witteveen, S R Loopstok, L Luque Ballesteros, A Boonstra, N H M van Bakel, W H P van Boekel, G J M Martens, J E Visser, S M Kol. HGprt deficiency disrupts dopaminergic circuit development in a genetic mouse model of Lesch-Nyhan disease. Cellular and molecular life sciences : CMLS. vol 79. issue 6. 2022-06-06. PMID:35660973. |
it has been known for decades that lnd is associated with dysfunction of midbrain dopamine neurons, without overt structural brain abnormalities. |
2022-06-06 |
2023-08-14 |
mouse |
| J S Witteveen, S R Loopstok, L Luque Ballesteros, A Boonstra, N H M van Bakel, W H P van Boekel, G J M Martens, J E Visser, S M Kol. HGprt deficiency disrupts dopaminergic circuit development in a genetic mouse model of Lesch-Nyhan disease. Cellular and molecular life sciences : CMLS. vol 79. issue 6. 2022-06-06. PMID:35660973. |
in the current study, hgprt deficiency causes specific neurodevelopmental abnormalities in mice during embryogenesis, particularly affecting proliferation and migration of developing midbrain dopamine (mda) neurons. |
2022-06-06 |
2023-08-14 |
mouse |
| Aurore Tourville, David Akbar, Olga Corti, Jochen H M Prehn, Ronald Melki, Stéphane Hunot, Patrick P Miche. Modelling α-Synuclein Aggregation and Neurodegeneration with Fibril Seeds in Primary Cultures of Mouse Dopaminergic Neurons. Cells. vol 11. issue 10. 2022-05-28. PMID:35626675. |
to model α-synuclein (αs) aggregation and neurodegeneration in parkinson's disease (pd), we established cultures of mouse midbrain dopamine (da) neurons and chronically exposed them to fibrils 91 (f91) generated from recombinant human αs. |
2022-05-28 |
2023-08-13 |
mouse |
| Hailan Liu, Xing Cai, Yanlin He, Yong X. Hyperactivity of a midbrain dopamine to 5-HT circuit causes anorexia. Journal of molecular cell biology. 2022-05-25. PMID:35612989. |
hyperactivity of a midbrain dopamine to 5-ht circuit causes anorexia. |
2022-05-25 |
2023-08-13 |
Not clear |
| Mayank Patel, Shamsher Sing. Apigenin Attenuates Functional and Structural Alterations via Targeting NF-kB/Nrf2 Signaling Pathway in LPS-Induced Parkinsonism in Experimental Rats : Apigenin Attenuates LPS-Induced Parkinsonism in Experimental Rats. Neurotoxicity research. 2022-05-24. PMID:35608813. |
parkinson's disease (pd) is a progressive hypokinetic movement disorder caused by selective degeneration of dopaminergic neurons in striatum and dopamine deficiency in a region of the midbrain. |
2022-05-24 |
2023-08-13 |
rat |
| Niamh Moriarty, Jessica A Kauhausen, Chiara Pavan, Cameron Pj Hunt, Isabelle R de Luzy, Vanessa Penna, Charlotte M Ermine, Lachlan H Thompson, Clare L Paris. Understanding the influence of target acquisition on survival, integration and phenotypic maturation of dopamine neurons within stem cell-derived neural grafts in a Parkinson's disease model. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-05-24. PMID:35610045. |
vm progenitors were grafted into female mice with 6ohda-lesions of host midbrain dopamine neurons, with some animals also receiving intrastriatal quinolinic acid injections to ablate medium spiny neurons (msn) - the a9 neuron primary target. |
2022-05-24 |
2023-08-13 |
mouse |
| Iro Boura, Kallol Ray Chaudhur. Coronavirus Disease 2019 and Related Parkinsonism: The Clinical Evidence Thus Far. Movement disorders clinical practice. 2022-05-23. PMID:35601258. |
this theory is further augmented by reports of a pathogenic effect of the severe acute respiratory syndrome coronavirus-2 (sars-cov-2) on the central nervous system with specific impact on the dopaminergic pathway, as well as the possibility of the virus to selectively bind to angiotensin-converting enzyme-2 (ace-2); these molecules are expressed abundantly in the midbrain dopamine neurons and, are likely involved in several cellular mechanisms cited in parkinson's disease (pd) pathophysiology. |
2022-05-23 |
2023-08-13 |
Not clear |
| Mengjiao Chen, Fangqing Liu, Longying Wen, Xia H. Nonlinear relationship between CAN current and Cognitive neurodynamics. vol 16. issue 3. 2022-05-23. PMID:35603052. |
nonlinear relationship between can current and bursting of midbrain dopamine (da) neurons is believed to represent an important reward signal that instructs and reinforces goal-directed behaviors. |
2022-05-23 |
2023-08-13 |
Not clear |
| Francesca Montarolo, Serena Martire, Francesco Chiara, Sarah Allegra, Silvia De Francia, Eriola Hoxha, Filippo Tempia, Marco Alfonso Capobianco, Antonio Bertolott. NURR1-deficient mice have age- and sex-specific behavioral phenotypes. Journal of neuroscience research. 2022-05-20. PMID:35593070. |
the transcription factor nurr1 is essential to the generation and maintenance of midbrain dopaminergic (mda) neurons and its deregulation is involved in the development of dopamine (da)-associated brain disorders, such as parkinson's disease (pd). |
2022-05-20 |
2023-08-13 |
mouse |
| Anthony S Ferranti, Tazeen Ishmam, Isaiah C Swann, Jennifer Du, Janet Mariadoss, Lindsley W Craig, Jerri M Rook, Peter J Conn, Daniel J Foste. CB2 Receptor Potentiation Mediates Antipsychotic-like Efficacy in Mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35553978. |
recent preclinical literature indicates that cb2 is expressed on numerous neuronal subtypes including midbrain dopamine neurons projecting to the striatum. |
2022-05-13 |
2023-08-13 |
mouse |
| Tetsuo Ono, Kodai Hino, Tomoko Kimura, Yasuhiro Uchimura, Takashi Ashihara, Takako Higa, Hideto Kojima, Takashi Murakami, Jun Udagaw. Excessive folic acid intake combined with undernutrition during gestation alters offspring behavior and brain monoamine profiles. Congenital anomalies. 2022-05-09. PMID:35531602. |
these behavioral changes were accompanied by reduced dopamine in the prefrontal cortex (pfc), norepinephrine in the amygdala, and 5-hydroxytryptamine (5-ht) in the dorsal midbrain (dm), pfc, and amygdala where 5-ht neurons project from the dm. |
2022-05-09 |
2023-08-13 |
Not clear |
| Guilian Tian, May Hui, Desiree Macchia, Pieter Derdeyn, Alexandra Rogers, Elizabeth Hubbard, Chengfeng Liu, Jose J Vasquez, Lara Taniguchi, Katrina Bartas, Sean Carroll, Kevin T Beie. An extended amygdala-midbrain circuit controlling cocaine withdrawal-induced anxiety and reinstatement. Cell reports. vol 39. issue 5. 2022-05-04. PMID:35508124. |
although midbrain dopamine (da) circuits are central to motivated behaviors, our knowledge of how experience modifies these circuits to facilitate subsequent behavioral adaptations is limited. |
2022-05-04 |
2023-08-13 |
Not clear |
| Xing Cai, Hailan Liu, Bing Feng, Meng Yu, Yang He, Hesong Liu, Chen Liang, Yongjie Yang, Longlong Tu, Nan Zhang, Lina Wang, Na Yin, Junying Han, Zili Yan, Chunmei Wang, Pingwen Xu, Qi Wu, Qingchun Tong, Yanlin He, Yong X. A D2 to D1 shift in dopaminergic inputs to midbrain 5-HT neurons causes anorexia in mice. Nature neuroscience. 2022-05-02. PMID:35501380. |
midbrain dopamine (da) and serotonin (5-ht) neurons regulate motivated behaviors, including feeding, but less is known about how these circuits may interact. |
2022-05-02 |
2023-08-13 |
mouse |
| Justin Buck, Matthew T C Manion, Wenyu Zhang, Erica R Glasper, Kuan Hong Wan. Comparative anatomical analysis of dopamine systems in Mus musculus and Peromyscus californicus. Brain structure & function. 2022-05-02. PMID:35501609. |
in contrast, major interspecies differences from m. musculus are found in the ventral midbrain and striatum of p. californicus, including the expansion of midbrain dopamine neurons into the ventral substantia nigra and the presence of an internal capsule-like white matter tract that demarcates a dorsomedial area from the rest of the striatum. |
2022-05-02 |
2023-08-13 |
mouse |