| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chun-Hyung Kim, Baek-Soo Han, Jisook Moon, Deog-Joong Kim, Joon Shin, Sreekanth Rajan, Quoc Toan Nguyen, Mijin Sohn, Won-Gon Kim, Minjoon Han, Inhye Jeong, Kyoung-Shim Kim, Eun-Hye Lee, Yupeng Tu, Jacqueline L Naffin-Olivos, Chang-Hwan Park, Dagmar Ringe, Ho Sup Yoon, Gregory A Petsko, Kwang-Soo Ki. Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 28. 2015-10-30. PMID:26124091. |
parkinson's disease (pd), primarily caused by selective degeneration of midbrain dopamine (mda) neurons, is the most prevalent movement disorder, affecting 1-2% of the global population over the age of 65. |
2015-10-30 |
2023-08-13 |
rat |
| Kevin T Beier, Elizabeth E Steinberg, Katherine E DeLoach, Stanley Xie, Kazunari Miyamichi, Lindsay Schwarz, Xiaojing J Gao, Eric J Kremer, Robert C Malenka, Liqun Lu. Circuit Architecture of VTA Dopamine Neurons Revealed by Systematic Input-Output Mapping. Cell. vol 162. issue 3. 2015-10-28. PMID:26232228. |
dopamine (da) neurons in the midbrain ventral tegmental area (vta) integrate complex inputs to encode multiple signals that influence motivated behaviors via diverse projections. |
2015-10-28 |
2023-08-13 |
Not clear |
| Talia N Lerner, Carrie Shilyansky, Thomas J Davidson, Kathryn E Evans, Kevin T Beier, Kelly A Zalocusky, Ailey K Crow, Robert C Malenka, Liqun Luo, Raju Tomer, Karl Deisserot. Intact-Brain Analyses Reveal Distinct Information Carried by SNc Dopamine Subcircuits. Cell. vol 162. issue 3. 2015-10-28. PMID:26232229. |
recent progress in understanding the diversity of midbrain dopamine neurons has highlighted the importance--and the challenges--of defining mammalian neuronal cell types. |
2015-10-28 |
2023-08-13 |
Not clear |
| Jae-Ick Kim, Subhashree Ganesan, Sarah X Luo, Yu-Wei Wu, Esther Park, Eric J Huang, Lu Chen, Jun B Din. Aldehyde dehydrogenase 1a1 mediates a GABA synthesis pathway in midbrain dopaminergic neurons. Science (New York, N.Y.). vol 350. issue 6256. 2015-10-28. PMID:26430123. |
midbrain dopamine neurons are an essential component of the basal ganglia circuitry, playing key roles in the control of fine movement and reward. |
2015-10-28 |
2023-08-13 |
Not clear |
| Jae-Ick Kim, Subhashree Ganesan, Sarah X Luo, Yu-Wei Wu, Esther Park, Eric J Huang, Lu Chen, Jun B Din. Aldehyde dehydrogenase 1a1 mediates a GABA synthesis pathway in midbrain dopaminergic neurons. Science (New York, N.Y.). vol 350. issue 6256. 2015-10-28. PMID:26430123. |
these findings provide insights into the functional role of gaba co-release in midbrain dopamine neurons, which may be essential for reward-based behavior and addiction. |
2015-10-28 |
2023-08-13 |
Not clear |
| Amanda Laque, Sangho Yu, Emily Qualls-Creekmore, Sarah Gettys, Candice Schwartzenburg, Kelly Bui, Christopher Rhodes, Hans-Rudolf Berthoud, Christopher D Morrison, Brenda K Richards, Heike Münzber. Leptin modulates nutrient reward via inhibitory galanin action on orexin neurons. Molecular metabolism. vol 4. issue 10. 2015-10-27. PMID:26500842. |
food reward requires stimulation of midbrain dopamine neurons and is modulated by central leptin action, but the exact central mechanisms remain unclear. |
2015-10-27 |
2023-08-13 |
Not clear |
| Jeung Hee An, Dong-Kug Choi, Kwon-Jai Lee, Jeong-Woo Cho. Surface-enhanced Raman spectroscopy detection of dopamine by DNA Targeting amplification assay in Parkisons's model. Biosensors & bioelectronics. vol 67. 2015-10-26. PMID:25465795. |
at 7 and 21 days after the last administration of mptp, dopamine was found by western blot analysis to have decreased in the midbrain by 37.44% and 92.95%, respectively. |
2015-10-26 |
2023-08-13 |
mouse |
| Jeung Hee An, Dong-Kug Choi, Kwon-Jai Lee, Jeong-Woo Cho. Surface-enhanced Raman spectroscopy detection of dopamine by DNA Targeting amplification assay in Parkisons's model. Biosensors & bioelectronics. vol 67. 2015-10-26. PMID:25465795. |
our results demonstrate that the concentration of dopamine in midbrain and striatum of mptp-treated mice can be easily detected using the bio-barcode assay, which is a rapid, high-throughput screening tool for detecting neurotransmitters. |
2015-10-26 |
2023-08-13 |
mouse |
| Daniel G Dillon, Isabelle M Rosso, Pia Pechtel, William D S Killgore, Scott L Rauch, Diego A Pizzagall. Peril and pleasure: an rdoc-inspired examination of threat responses and reward processing in anxiety and depression. Depression and anxiety. vol 31. issue 3. 2015-10-23. PMID:24151118. |
the mechanisms underlying such effects are unclear, but the fourth section reviews new optogenetic data in rodents indicating that gabaergic inhibition of midbrain dopamine neurons, driven by activation of the habenula, may play a fundamental role in stress-induced anhedonia. |
2015-10-23 |
2023-08-12 |
Not clear |
| Gregory P Strauss, James A Waltz, James M Gol. A review of reward processing and motivational impairment in schizophrenia. Schizophrenia bulletin. vol 40 Suppl 2. 2015-10-23. PMID:24375459. |
aberrant cortical-striatal interactions may be involved with multiple reward processing abnormalities, including: (1) dopamine-mediated basal ganglia systems that support reinforcement learning and the ability to predict cues that lead to rewarding outcomes; (2) orbitofrontal cortex-driven deficits in generating, updating, and maintaining value representations; (3) aberrant effort-value computations, which may be mediated by disrupted anterior cingulate cortex and midbrain dopamine functioning; and (4) altered activation of the prefrontal cortex, which is important for generating exploratory behaviors in environments where reward outcomes are uncertain. |
2015-10-23 |
2023-08-12 |
Not clear |
| Mansour A Al-Hazm. Patulin in apple juice and its risk assessments on albino mice. Toxicology and industrial health. vol 30. issue 6. 2015-10-19. PMID:23012343. |
the potential maximal changes in norepinephrine, dopamine and serotonin5-hydroxytryptamine levels attained in cortex, hypothalamus, striatum, hippocampus, midbrain and pons and medulla were assessed. |
2015-10-19 |
2023-08-12 |
mouse |
| Haigang Gu, Roman M Lazarenko, Dmitry Koktysh, Lorraine Iacovitti, Qi Zhan. A Stem Cell-Derived Platform for Studying Single Synaptic Vesicles in Dopaminergic Synapses. Stem cells translational medicine. vol 4. issue 8. 2015-10-16. PMID:26025981. |
we report a more efficient procedure to reliably generate dopamine neurons from embryonic stem cells, and it yields more dopamine neurons with more dopaminergic axon projections than midbrain culture does. |
2015-10-16 |
2023-08-13 |
Not clear |
| Haigang Gu, Roman M Lazarenko, Dmitry Koktysh, Lorraine Iacovitti, Qi Zhan. A Stem Cell-Derived Platform for Studying Single Synaptic Vesicles in Dopaminergic Synapses. Stem cells translational medicine. vol 4. issue 8. 2015-10-16. PMID:26025981. |
using a collection of functional measurements, we show that stem cell-derived dopamine neurons are indistinguishable from those in midbrain culture. |
2015-10-16 |
2023-08-13 |
Not clear |
| Bryan B Gore, Marta E Soden, Larry S Zweife. Visualization of plasticity in fear-evoked calcium signals in midbrain dopamine neurons. Learning & memory (Cold Spring Harbor, N.Y.). vol 21. issue 11. 2015-10-13. PMID:25320348. |
visualization of plasticity in fear-evoked calcium signals in midbrain dopamine neurons. |
2015-10-13 |
2023-08-13 |
Not clear |
| Wei-Xing Pan, Joshua T Dudma. A Specific Component of the Evoked Potential Mirrors Phasic Dopamine Neuron Activity during Conditioning. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 29. 2015-10-07. PMID:26203140. |
midbrain dopamine (da) neurons are thought to be a critical node in the circuitry that mediates reward learning. |
2015-10-07 |
2023-08-13 |
mouse |
| Silvio Peluso, Anna De Rosa, Antonella Antenora, Maria Lieto, Chiara Criscuolo, Fabrizio Barbieri, Sabina Pappatà, Giuseppe De Michel. Efficacy of dopamine agonist treatment in delayed-onset parkinsonism due to midbrain hemorrhage. Parkinsonism & related disorders. vol 21. issue 2. 2015-09-30. PMID:25483721. |
efficacy of dopamine agonist treatment in delayed-onset parkinsonism due to midbrain hemorrhage. |
2015-09-30 |
2023-08-13 |
Not clear |
| Mi-Sun Lim, Mi-Yoon Chang, Sang-Mi Kim, Sang-Hoon Yi, Haeyoung Suh-Kim, Sung Jun Jung, Min Jung Kim, Jin Hyuk Kim, Yong-Sung Lee, Soo Young Lee, Dong-Wook Kim, Sang-Hun Lee, Chang-Hwan Par. Generation of Dopamine Neurons from Rodent Fibroblasts through the Expandable Neural Precursor Cell Stage. The Journal of biological chemistry. vol 290. issue 28. 2015-09-29. PMID:26023233. |
specifically, overexpression of nurr1 and foxa2, transcription factors specific for midbrain dopamine neuron development, drove inpcs to yield mature midbrain dopamine neurons equipped with presynaptic da neuronal functions. |
2015-09-29 |
2023-08-13 |
mouse |
| Andrew D Steele, Ralph E Mistlberge. Activity is a slave to many masters. eLife. vol 4. 2015-09-22. PMID:25675211. |
dopamine neurons in the midbrain have a central role in generating cycles of biological activity with periods as short as 4 hours and as long as 100 hours. |
2015-09-22 |
2023-08-13 |
Not clear |
| Ian D Blum, Lei Zhu, Luc Moquin, Maia V Kokoeva, Alain Gratton, Bruno Giros, Kai-Florian Storc. A highly tunable dopaminergic oscillator generates ultradian rhythms of behavioral arousal. eLife. vol 3. 2015-09-21. PMID:25546305. |
period lengthening also results from chemogenetic activation of midbrain dopamine neurons and psychostimulant treatment, while the antipsychotic haloperidol has the opposite effect. |
2015-09-21 |
2023-08-13 |
mouse |
| S Sütt, A Altpere, R Reimets, T Visnapuu, M Loomets, S Raud, T Salum, R Mahlapuu, C Kairane, M Zilmer, E Vasa. Wfs1-deficient animals have brain-region-specific changes of Na+, K+-ATPase activity and mRNA expression of α1 and β1 subunits. Journal of neuroscience research. vol 93. issue 3. 2015-09-10. PMID:25385034. |
in the temporal lobe, an increase in the activity of the na-pump is probably related to increased anxiety established in wfs1-deficient mice, whereas the blunted dopamine function in the forebrain of wfs1-deficient mice may be associated with a decrease of na-pump activity in the dorsal and ventral striatum and in the midbrain after exposure to the epm. |
2015-09-10 |
2023-08-13 |
mouse |