| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Carmelo Sgobio, David A Kupferschmidt, Guohong Cui, Lixin Sun, Zheng Li, Huaibin Cai, David M Lovinge. Optogenetic measurement of presynaptic calcium transients using conditional genetically encoded calcium indicator expression in dopaminergic neurons. PloS one. vol 9. issue 10. 2015-12-22. PMID:25360513. |
calcium triggers dopamine release from presynaptic terminals of midbrain dopaminergic (mda) neurons in the striatum. |
2015-12-22 |
2023-08-13 |
mouse |
| Marta Garcia-Miralles, Janaky Coomaraswamy, Karina Häbig, Martin C Herzig, Natalja Funk, Frank Gillardon, Martina Maisel, Mathias Jucker, Thomas Gasser, Dagmar Galter, Saskia Bisku. No dopamine cell loss or changes in cytoskeleton function in transgenic mice expressing physiological levels of wild type or G2019S mutant LRRK2 and in human fibroblasts. PloS one. vol 10. issue 4. 2015-12-22. PMID:25830304. |
no neuronal loss or neurodegeneration was detected in midbrain dopamine neurons at the age of 12 months. |
2015-12-22 |
2023-08-13 |
mouse |
| Masayuki Matsumot. Dopamine signals and physiological origin of cognitive dysfunction in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 30. issue 4. 2015-12-21. PMID:25773863. |
the pathological hallmark of parkinson's disease (pd) is the degeneration of midbrain dopamine neurons. |
2015-12-21 |
2023-08-13 |
Not clear |
| Babita Panigrahi, Kathleen A Martin, Yi Li, Austin R Graves, Alison Vollmer, Lars Olson, Brett D Mensh, Alla Y Karpova, Joshua T Dudma. Dopamine Is Required for the Neural Representation and Control of Movement Vigor. Cell. vol 162. issue 6. 2015-12-15. PMID:26359992. |
progressive depletion of midbrain dopamine neurons (pdd) is associated with deficits in the initiation, speed, and fluidity of voluntary movement. |
2015-12-15 |
2023-08-13 |
mouse |
| Meltem Sevgi, Lionel Rigoux, Anne B Kühn, Jan Mauer, Leonhard Schilbach, Martin E Hess, Theo O J Gruendler, Markus Ullsperger, Klaas Enno Stephan, Jens C Brüning, Marc Tittgemeye. An Obesity-Predisposing Variant of the FTO Gene Regulates D2R-Dependent Reward Learning. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 36. 2015-12-14. PMID:26354923. |
in a behavioral and fmri study, we demonstrate that gene variants of fto affect dopamine (d2)-dependent midbrain brain responses to reward learning and behavioral responses associated with learning from negative outcome in humans. |
2015-12-14 |
2023-08-13 |
mouse |
| Amanda L Sharpe, Erika Varela, Lynne Bettinger, Michael J Beckstea. Methamphetamine self-administration in mice decreases GIRK channel-mediated currents in midbrain dopamine neurons. The international journal of neuropsychopharmacology. vol 18. issue 5. 2015-12-08. PMID:25522412. |
methamphetamine self-administration in mice decreases girk channel-mediated currents in midbrain dopamine neurons. |
2015-12-08 |
2023-08-13 |
mouse |
| Amanda L Sharpe, Erika Varela, Lynne Bettinger, Michael J Beckstea. Methamphetamine self-administration in mice decreases GIRK channel-mediated currents in midbrain dopamine neurons. The international journal of neuropsychopharmacology. vol 18. issue 5. 2015-12-08. PMID:25522412. |
acute methamphetamine elevates extracellular dopamine, which in the midbrain can activate d2 autoreceptors to increase a g-protein gated inwardly rectifying potassium (girk) conductance that inhibits dopamine neuron firing. |
2015-12-08 |
2023-08-13 |
mouse |
| Hanna Opiol, Ilya Pavlovski, Mateusz Michalik, Ralph E Mistlberge. Ultrasonic vocalizations in rats anticipating circadian feeding schedules. Behavioural brain research. vol 284. 2015-12-07. PMID:25677650. |
anticipatory behaviors evoked by conditioned stimuli include 50 khz ultrasonic vocalizations (usvs), a proposed behavioral correlate of positive affect and activation of midbrain dopamine pathways. |
2015-12-07 |
2023-08-13 |
rat |
| Manivannan Subramaniyan, John A Dan. Dopaminergic and cholinergic learning mechanisms in nicotine addiction. Annals of the New York Academy of Sciences. vol 1349. 2015-12-07. PMID:26301866. |
capitalizing on mechanisms that subserve natural rewards, nicotine activates midbrain dopamine neurons directly and indirectly, and nicotine causes dopamine release in very broad target areas throughout the brain, including the nac, amygdala, and hippocampus. |
2015-12-07 |
2023-08-13 |
Not clear |
| Raphaël Eddine, Sebastien Valverde, Stefania Tolu, Daniel Dautan, Audrey Hay, Carole Morel, Yihui Cui, Bertrand Lambolez, Laurent Venance, Fabio Marti, Philippe Faur. A concurrent excitation and inhibition of dopaminergic subpopulations in response to nicotine. Scientific reports. vol 5. 2015-12-01. PMID:25640814. |
midbrain dopamine (da) neurons are key players in motivation and reward processing. |
2015-12-01 |
2023-08-13 |
Not clear |
| Tertia D Purves-Tyson, Danny Boerrigter, Katherine Allen, Katerina Zavitsanou, Tim Karl, Vanezha Djunaidi, Kay L Double, Reena Desai, David J Handelsman, Cynthia Shannon Weicker. Testosterone attenuates and the selective estrogen receptor modulator, raloxifene, potentiates amphetamine-induced locomotion in male rats. Hormones and behavior. vol 70. 2015-11-13. PMID:25747465. |
our previous work suggests that increasing testosterone during adolescence may bias midbrain neurons to synthesise more dopamine. |
2015-11-13 |
2023-08-13 |
rat |
| Julie E Miller, George W Hafzalla, Zachary D Burkett, Cynthia M Fox, Stephanie A Whit. Reduced vocal variability in a zebra finch model of dopamine depletion: implications for Parkinson disease. Physiological reports. vol 3. issue 11. 2015-11-13. PMID:26564062. |
midbrain dopamine (da) modulates the activity of basal ganglia circuitry important for motor control in a variety of species. |
2015-11-13 |
2023-08-13 |
Not clear |
| Diogo Ribeiro, Rocio Laguna Goya, Geeta Ravindran, Romina Vuono, Clare L Parish, Claire Foldi, Tobias Piroth, Shanzheng Yang, Malin Parmar, Guido Nikkhah, Jens Hjerling-Leffler, Olle Lindvall, Roger A Barker, Ernest Arena. Efficient expansion and dopaminergic differentiation of human fetal ventral midbrain neural stem cells by midbrain morphogens. Neurobiology of disease. vol 49. 2015-11-10. PMID:22940632. |
human fetal midbrain tissue grafting has provided proof-of-concept for dopamine cell replacement therapy (crt) in parkinson's disease (pd). |
2015-11-10 |
2023-08-12 |
human |
| Nicolas X Tritsch, Won-Jong Oh, Chenghua Gu, Bernardo L Sabatin. Midbrain dopamine neurons sustain inhibitory transmission using plasma membrane uptake of GABA, not synthesis. eLife. vol 3. 2015-11-10. PMID:24843012. |
midbrain dopamine neurons sustain inhibitory transmission using plasma membrane uptake of gaba, not synthesis. |
2015-11-10 |
2023-08-13 |
Not clear |
| Nicolas X Tritsch, Won-Jong Oh, Chenghua Gu, Bernardo L Sabatin. Midbrain dopamine neurons sustain inhibitory transmission using plasma membrane uptake of GABA, not synthesis. eLife. vol 3. 2015-11-10. PMID:24843012. |
synaptic transmission between midbrain dopamine neurons and target neurons in the striatum is essential for the selection and reinforcement of movements. |
2015-11-10 |
2023-08-13 |
Not clear |
| Nicolas X Tritsch, Won-Jong Oh, Chenghua Gu, Bernardo L Sabatin. Midbrain dopamine neurons sustain inhibitory transmission using plasma membrane uptake of GABA, not synthesis. eLife. vol 3. 2015-11-10. PMID:24843012. |
however, the gaba synthetic enzymes gad65 and gad67 are not detected in midbrain dopamine neurons. |
2015-11-10 |
2023-08-13 |
Not clear |
| Kristal R Tucker, Ethan R Block, Edwin S Levita. Action potentials and amphetamine release antipsychotic drug from dopamine neuron synaptic VMAT vesicles. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 32. 2015-11-10. PMID:26216995. |
because many apds are dopamine (da) d2 receptor (d2r) antagonists, such a mechanism would be particularly interesting if it operated in midbrain da neurons. |
2015-11-10 |
2023-08-13 |
human |
| Elisabeth Piccart, Nicholas A Courtney, Sarah Y Branch, Christopher P Ford, Michael J Beckstea. Neurotensin Induces Presynaptic Depression of D2 Dopamine Autoreceptor-Mediated Neurotransmission in Midbrain Dopaminergic Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 31. 2015-11-05. PMID:26245975. |
neurotensin induces presynaptic depression of d2 dopamine autoreceptor-mediated neurotransmission in midbrain dopaminergic neurons. |
2015-11-05 |
2023-08-13 |
mouse |
| Elisabeth Piccart, Nicholas A Courtney, Sarah Y Branch, Christopher P Ford, Michael J Beckstea. Neurotensin Induces Presynaptic Depression of D2 Dopamine Autoreceptor-Mediated Neurotransmission in Midbrain Dopaminergic Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 31. 2015-11-05. PMID:26245975. |
application of the modulatory peptide neurotensin (nt) to midbrain dopaminergic neurons transiently increases activity by decreasing d2 dopamine autoreceptor function, yet little is known about the mechanisms that underlie long-lasting effects. |
2015-11-05 |
2023-08-13 |
mouse |
| Elisabeth Piccart, Nicholas A Courtney, Sarah Y Branch, Christopher P Ford, Michael J Beckstea. Neurotensin Induces Presynaptic Depression of D2 Dopamine Autoreceptor-Mediated Neurotransmission in Midbrain Dopaminergic Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 31. 2015-11-05. PMID:26245975. |
the current research provides a mechanism through which augmented nt release can produce a long-lasting increase in membrane excitability of midbrain dopamine neurons. |
2015-11-05 |
2023-08-13 |
mouse |