| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Idaira Oliva, Matthew J Wana. Ventral Tegmental Area Afferents and Drug-Dependent Behaviors. Frontiers in psychiatry. vol 7. 2016-03-25. PMID:27014097. |
preclinical studies demonstrate that the acquisition and expression of many drug-dependent behaviors involves the ventral tegmental area (vta), a midbrain structure comprised of dopamine, gaba, and glutamate neurons. |
2016-03-25 |
2023-08-13 |
Not clear |
| U Keber, M Klietz, T Carlsson, W H Oertel, E Weihe, M K-H Schäfer, G U Höglinger, C Depboyl. Striatal tyrosine hydroxylase-positive neurons are associated with L-DOPA-induced dyskinesia in hemiparkinsonian mice. Neuroscience. vol 298. 2016-03-21. PMID:25892702. |
we have focused on the expression of striatal tyrosine hydroxylase-positive (th+) neurons, which are capable of producing either l-dopa or dopamine (da) in target areas of ventral midbrain daergic neurons. |
2016-03-21 |
2023-08-13 |
mouse |
| Karin Nordenankar, Casey J A Smith-Anttila, Nadine Schweizer, Thomas Viereckel, Carolina Birgner, Jana Mejia-Toiber, Marisela Morales, Richardson N Leao, Åsa Wallén-Mackenzi. Increased hippocampal excitability and impaired spatial memory function in mice lacking VGLUT2 selectively in neurons defined by tyrosine hydroxylase promoter activity. Brain structure & function. vol 220. issue 4. 2016-03-18. PMID:24802380. |
three populations of neurons expressing the vesicular glutamate transporter 2 (vglut2) were recently described in the a10 area of the mouse midbrain, of which two populations were shown to express the gene encoding, the rate-limiting enzyme for catecholamine synthesis, tyrosine hydroxylase (th).one of these populations ("th-vglut2 class1") also expressed the dopamine transporter (dat) gene while one did not ("th-vglut2 class2"), and the remaining population did not express th at all ("vglut2-only"). |
2016-03-18 |
2023-08-13 |
mouse |
| Zev B Rosen, Stephanie Cheung, Steven A Siegelbau. Midbrain dopamine neurons bidirectionally regulate CA3-CA1 synaptic drive. Nature neuroscience. vol 18. issue 12. 2016-03-14. PMID:26523642. |
midbrain dopamine neurons bidirectionally regulate ca3-ca1 synaptic drive. |
2016-03-14 |
2023-08-13 |
Not clear |
| Claudia Sagheddu, Miriam Meli. Individual differences and vulnerability to drug addiction: a focus on the endocannabinoid system. CNS & neurological disorders drug targets. vol 14. issue 4. 2016-02-23. PMID:25714966. |
this phenomenon, which is phylogenetically preserved, appears to be a compensatory change to increased impulse activity of midbrain dopamine neurons. |
2016-02-23 |
2023-08-13 |
Not clear |
| José A Larrauri, Dennis A Burke, Brandon J Hall, Edward D Levi. Role of nicotinic receptors in the lateral habenula in the attenuation of amphetamine-induced prepulse inhibition deficits of the acoustic startle response in rats. Psychopharmacology. vol 232. issue 16. 2016-02-23. PMID:25912180. |
a high concentration of nicotinic receptors is found in the lateral habenula (lhb), an epithalamic structure with efferent projections to brain regions involved in the modulation of ppi, which has been shown to regulate the activity of midbrain dopamine neurons. |
2016-02-23 |
2023-08-13 |
rat |
| Stephan Steidl, Kevin Veverk. Optogenetic excitation of LDTg axons in the VTA reinforces operant responding in rats. Brain research. vol 1614. 2016-02-22. PMID:25911581. |
the laterodorsal tegmental nucleus (ldtg) importantly contributes to regulating firing activity of midbrain dopamine neurons and forebrain dopamine levels. |
2016-02-22 |
2023-08-13 |
rat |
| Marcus Lira Brandão, Amanda Ribeiro de Oliveira, Sangu Muthuraju, Ana Caroline Colombo, Viviane Mitsuko Saito, Teddy Talbo. Dual role of dopamine D(2)-like receptors in the mediation of conditioned and unconditioned fear. FEBS letters. vol 589. issue 22. 2016-02-15. PMID:25783771. |
dopamine d2 receptor inhibition in the terminal fields of the mesolimbic dopamine system generally causes anxiolytic-like effects, whereas the activity of midbrain substrates of unconditioned fear are enhanced by d2 receptor antagonists, suggesting that d2 receptor-mediated mechanisms play opposing roles in fear/anxiety processes, depending on the brain region under study. |
2016-02-15 |
2023-08-13 |
rat |
| Marcus Lira Brandão, Amanda Ribeiro de Oliveira, Sangu Muthuraju, Ana Caroline Colombo, Viviane Mitsuko Saito, Teddy Talbo. Dual role of dopamine D(2)-like receptors in the mediation of conditioned and unconditioned fear. FEBS letters. vol 589. issue 22. 2016-02-15. PMID:25783771. |
dopamine appears to mediate conditioned fear by acting at rostral levels of the brain and regulate unconditioned fear at the midbrain level, likely by reducing the sensorimotor gating of aversive events. |
2016-02-15 |
2023-08-13 |
rat |
| Emmanouil Metzakopian, Kamal Bouhali, Matías Alvarez-Saavedra, Jeffrey A Whitsett, David J Picketts, Siew-Lan An. Genome-wide characterisation of Foxa1 binding sites reveals several mechanisms for regulating neuronal differentiation in midbrain dopamine cells. Development (Cambridge, England). vol 142. issue 7. 2016-02-13. PMID:25804738. |
genome-wide characterisation of foxa1 binding sites reveals several mechanisms for regulating neuronal differentiation in midbrain dopamine cells. |
2016-02-13 |
2023-08-13 |
mouse |
| Emmanouil Metzakopian, Kamal Bouhali, Matías Alvarez-Saavedra, Jeffrey A Whitsett, David J Picketts, Siew-Lan An. Genome-wide characterisation of Foxa1 binding sites reveals several mechanisms for regulating neuronal differentiation in midbrain dopamine cells. Development (Cambridge, England). vol 142. issue 7. 2016-02-13. PMID:25804738. |
midbrain dopamine neuronal progenitors develop into heterogeneous subgroups of neurons, such as substantia nigra pars compacta, ventral tegmental area and retrorubal field, that regulate motor control, motivated and addictive behaviours. |
2016-02-13 |
2023-08-13 |
mouse |
| Emmanouil Metzakopian, Kamal Bouhali, Matías Alvarez-Saavedra, Jeffrey A Whitsett, David J Picketts, Siew-Lan An. Genome-wide characterisation of Foxa1 binding sites reveals several mechanisms for regulating neuronal differentiation in midbrain dopamine cells. Development (Cambridge, England). vol 142. issue 7. 2016-02-13. PMID:25804738. |
the development of midbrain dopamine neurons has been extensively studied, and these studies indicate that complex cross-regulatory interactions between extrinsic and intrinsic molecules regulate a precise temporal and spatial programme of neurogenesis in midbrain dopamine progenitors. |
2016-02-13 |
2023-08-13 |
mouse |
| Emmanouil Metzakopian, Kamal Bouhali, Matías Alvarez-Saavedra, Jeffrey A Whitsett, David J Picketts, Siew-Lan An. Genome-wide characterisation of Foxa1 binding sites reveals several mechanisms for regulating neuronal differentiation in midbrain dopamine cells. Development (Cambridge, England). vol 142. issue 7. 2016-02-13. PMID:25804738. |
our genome-wide foxa1-bound cis-regulatory sequences from chip-seq and foxa1/2 candidate target genes from rna-seq analyses of embryonic midbrain dopamine cells also provide an excellent resource for probing mechanistic insights into gene regulatory networks involved in the differentiation of midbrain dopamine neurons. |
2016-02-13 |
2023-08-13 |
mouse |
| Ronald Keiflin, Patricia H Jana. Dopamine Prediction Errors in Reward Learning and Addiction: From Theory to Neural Circuitry. Neuron. vol 88. issue 2. 2016-02-10. PMID:26494275. |
midbrain dopamine (da) neurons are proposed to signal reward prediction error (rpe), a fundamental parameter in associative learning models. |
2016-02-10 |
2023-08-13 |
Not clear |
| A M Morales, M Kohno, C L Robertson, A C Dean, M A Mandelkern, E D Londo. Gray-matter volume, midbrain dopamine D2/D3 receptors and drug craving in methamphetamine users. Molecular psychiatry. vol 20. issue 6. 2016-02-09. PMID:25896164. |
gray-matter volume, midbrain dopamine d2/d3 receptors and drug craving in methamphetamine users. |
2016-02-09 |
2023-08-13 |
human |
| A M Morales, M Kohno, C L Robertson, A C Dean, M A Mandelkern, E D Londo. Gray-matter volume, midbrain dopamine D2/D3 receptors and drug craving in methamphetamine users. Molecular psychiatry. vol 20. issue 6. 2016-02-09. PMID:25896164. |
despite evidence suggesting that midbrain dopamine receptors influence amphetamine-induced dopamine release and that dopamine is involved in methamphetamine-induced neurotoxicity, associations between dopamine receptors and gray-matter volume have been unexplored in methamphetamine users. |
2016-02-09 |
2023-08-13 |
human |
| A M Morales, M Kohno, C L Robertson, A C Dean, M A Mandelkern, E D Londo. Midbrain dopamine D2/D3 receptor availability and drug craving are associated with mesocorticolimbic gray matter volume in methamphetamine users. Molecular psychiatry. vol 20. issue 6. 2016-02-09. PMID:25993553. |
midbrain dopamine d2/d3 receptor availability and drug craving are associated with mesocorticolimbic gray matter volume in methamphetamine users. |
2016-02-09 |
2023-08-13 |
Not clear |
| Sybren F de Kloet, Huibert D Mansvelder, Taco J De Vrie. Cholinergic modulation of dopamine pathways through nicotinic acetylcholine receptors. Biochemical pharmacology. vol 97. issue 4. 2016-02-09. PMID:26208783. |
profound modulatory cholinergic input from the pedunculopontine and laterodorsal tegmentum to dopaminergic midbrain nuclei as well as local cholinergic interneuron projections to dopamine neuron axons in the striatum may play a major role in the effects of nicotine. |
2016-02-09 |
2023-08-13 |
Not clear |
| Timothy J Collier, D Eugene Redmond, Kathy Steece-Collier, Jack W Lipton, Fredric P Manfredsso. Is Alpha-Synuclein Loss-of-Function a Contributor to Parkinsonian Pathology? Evidence from Non-human Primates. Frontiers in neuroscience. vol 10. 2016-02-09. PMID:26858591. |
accumulation of alpha-synuclein (α-syn) in lewy bodies and neurites of midbrain dopamine neurons is diagnostic for parkinson's disease (pd), leading to the proposal that pd is a toxic gain-of-function synucleinopathy. |
2016-02-09 |
2023-08-13 |
Not clear |
| Alexander A Nevue, Cameron J Elde, David J Perkel, Christine V Portfor. Dopaminergic Input to the Inferior Colliculus in Mice. Frontiers in neuroanatomy. vol 9. 2016-02-02. PMID:26834578. |
the principal auditory midbrain nucleus, the inferior colliculus (ic), is a likely location for dopaminergic modulation of auditory processing because it contains dopamine receptors and nerve terminals immunoreactive for tyrosine hydroxylase (th), the rate-limiting enzyme in dopamine synthesis. |
2016-02-02 |
2023-08-13 |
mouse |