| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jingzhong Zhang, Sebastian Götz, Daniela M Vogt Weisenhorn, Antonio Simeone, Wolfgang Wurst, Nilima Prakas. A WNT1-regulated developmental gene cascade prevents dopaminergic neurodegeneration in adult En1(+/-) mice. Neurobiology of disease. vol 82. 2016-08-19. PMID:26049140. |
the protracted and age-dependent degeneration of dopamine (da)-producing neurons of the substantia nigra pars compacta (snc) and ventral tegmental area (vta) in the mammalian midbrain is a hallmark of human parkinson's disease (pd) and of certain genetic mouse models of pd, such as mice heterozygous for the homeodomain transcription factor engrailed 1 (en1(+/-) mice). |
2016-08-19 |
2023-08-13 |
mouse |
| Christina Poetschke, Elena Dragicevic, Johanna Duda, Julia Benkert, Antonios Dougalis, Roberta DeZio, Terrance P Snutch, Joerg Striessnig, Birgit Lis. Compensatory T-type Ca2+ channel activity alters D2-autoreceptor responses of Substantia nigra dopamine neurons from Cav1.3 L-type Ca2+ channel KO mice. Scientific reports. vol 5. 2016-08-19. PMID:26381090. |
the preferential degeneration of substantia nigra dopamine midbrain neurons (sn da) causes the motor-symptoms of parkinson's disease (pd). |
2016-08-19 |
2023-08-13 |
mouse |
| Weidong Le, Lifen Zhang, Wenjie Xie, Song Li, John A Dan. Pitx3 deficiency produces decreased dopamine signaling and induces motor deficits in Pitx3(-/-) mice. Neurobiology of aging. vol 36. issue 12. 2016-08-15. PMID:26363812. |
midbrain dopamine (da) neurons are involved in cognition, control of motor activity, and emotion-related behaviors. |
2016-08-15 |
2023-08-13 |
mouse |
| Miae Jang, Ki Bum Um, Jinyoung Jang, Hyun Jin Kim, Hana Cho, Sungkwon Chung, Myoung Kyu Par. Coexistence of glutamatergic spine synapses and shaft synapses in substantia nigra dopamine neurons. Scientific reports. vol 5. 2016-08-15. PMID:26435058. |
therefore, we provide the first evidence that the midbrain dopamine neurons have two morphologically and functionally distinct types of glutamatergic synapses, spine synapses and shaft synapses, on the same dendrite. |
2016-08-15 |
2023-08-13 |
mouse |
| Miae Jang, Ki Bum Um, Jinyoung Jang, Hyun Jin Kim, Hana Cho, Sungkwon Chung, Myoung Kyu Par. Coexistence of glutamatergic spine synapses and shaft synapses in substantia nigra dopamine neurons. Scientific reports. vol 5. 2016-08-15. PMID:26435058. |
this peculiar organization could be a new basis for unraveling many physiological and pathological functions of the midbrain dopamine neurons. |
2016-08-15 |
2023-08-13 |
mouse |
| Catherine Jensen Peña, Frances A Champagn. Neonatal overexpression of estrogen receptor-α alters midbrain dopamine neuron development and reverses the effects of low maternal care in female offspring. Developmental neurobiology. vol 75. issue 10. 2016-08-10. PMID:25044746. |
neonatal overexpression of estrogen receptor-α alters midbrain dopamine neuron development and reverses the effects of low maternal care in female offspring. |
2016-08-10 |
2023-08-13 |
rat |
| Abigail G Schindler, Marta E Soden, Larry S Zweifel, Jeremy J Clar. Reversal of Alcohol-Induced Dysregulation in Dopamine Network Dynamics May Rescue Maladaptive Decision-making. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 13. 2016-08-08. PMID:27030756. |
indeed, we find that increased phasic dopamine signaling after adolescent alcohol use is attributable to a midbrain circuit, including the input from the pedunculopontine tegmentum to the vta. |
2016-08-08 |
2023-08-13 |
rat |
| Garry Cooper, Efrat Lasser-Katz, Alon Simchovitz, Ronit Sharon, Hermona Soreq, D James Surmeier, Joshua A Goldber. Functional segregation of voltage-activated calcium channels in motoneurons of the dorsal motor nucleus of the vagus. Journal of neurophysiology. vol 114. issue 3. 2016-08-04. PMID:26156385. |
in experimental pd models, treatment with isradipine, the dihydropyridine with the highest affinity to cav1.3 channels, prevents subthreshold calcium influx via cav1.3 channels into midbrain dopamine neurons and protects them from mos. |
2016-08-04 |
2023-08-13 |
Not clear |
| R W Morris, T D Purves-Tyson, C Shannon Weickert, D Rothmond, R Lenroot, T W Weicker. Testosterone and reward prediction-errors in healthy men and men with schizophrenia. Schizophrenia research. vol 168. issue 3. 2016-08-03. PMID:26232868. |
to determine if testosterone can have a direct effect on dopamine neurons, we also localized and measured androgen receptors in human midbrain with immunohistochemistry and quantitative pcr. |
2016-08-03 |
2023-08-13 |
human |
| R W Morris, T D Purves-Tyson, C Shannon Weickert, D Rothmond, R Lenroot, T W Weicker. Testosterone and reward prediction-errors in healthy men and men with schizophrenia. Schizophrenia research. vol 168. issue 3. 2016-08-03. PMID:26232868. |
we also identified midbrain dopamine neurons that were androgen receptor immunoreactive, and found that androgen receptor (ar) mrna was positively correlated with tyrosine hydroxylase (th) mrna in human male substantia nigra. |
2016-08-03 |
2023-08-13 |
human |
| R W Morris, T D Purves-Tyson, C Shannon Weickert, D Rothmond, R Lenroot, T W Weicker. Testosterone and reward prediction-errors in healthy men and men with schizophrenia. Schizophrenia research. vol 168. issue 3. 2016-08-03. PMID:26232868. |
the results suggest that sex steroid receptors can potentially influence midbrain dopamine biosynthesis, and higher levels of serum testosterone are linked to better discrimination of motivationally-relevant signals in the ventral striatum, putatively by modulation of the dopamine biosynthesis pathway via ar ligand binding. |
2016-08-03 |
2023-08-13 |
human |
| Sean James Fallon, Katrijn Smulders, Rianne A Esselink, Bart P van de Warrenburg, Bastiaan R Bloem, Roshan Cool. Differential optimal dopamine levels for set-shifting and working memory in Parkinson's disease. Neuropsychologia. vol 77. 2016-08-03. PMID:26239947. |
however, despite the uniformity of midbrain dopamine depletion only some patients experience cognitive impairment. |
2016-08-03 |
2023-08-13 |
human |
| Kun Ma, Hao-Yu Wu, Bo Zhang, Xi He, Bai-Xiang L. Neurotoxicity effects of atrazine-induced SH-SY5Y human dopaminergic neuroblastoma cells via microglial activation. Molecular bioSystems. vol 11. issue 11. 2016-08-01. PMID:26256823. |
however, atr is neurotoxic; it reduces dopamine levels in the substantia nigra and corpus striatum in the midbrain, affects the absorption of synaptic vesicles and synaptic bodies, and interferes with dopamine storage and uptake in synaptic vesicles, leading to neurodegenerative disorders. |
2016-08-01 |
2023-08-13 |
human |
| Zuxin Chen, Paul J Kenn. Running on Empty: Leptin Signaling in VTA Regulates Reward from Physical Activity. Cell metabolism. vol 22. issue 4. 2016-08-01. PMID:26445509. |
(2015) show that disruption of leptin-regulated stat3 signaling in midbrain dopamine neurons increases the rewarding effects of running in mice, which could explain the "high" experienced by endurance runners. |
2016-08-01 |
2023-08-13 |
mouse |
| Dan Lindholm, Johanna Mäkelä, Valentina Di Liberto, Giuseppa Mudò, Natale Belluardo, Ove Eriksson, Mart Saarm. Current disease modifying approaches to treat Parkinson's disease. Cellular and molecular life sciences : CMLS. vol 73. issue 7. 2016-07-28. PMID:26616211. |
parkinson's disease (pd is a progressive neurological disorder characterized by the degeneration and death of midbrain dopamine and non-dopamine neurons in the brain leading to motor dysfunctions and other symptoms, which seriously influence the quality of life of pd patients. |
2016-07-28 |
2023-08-13 |
Not clear |
| Elizabeth S Smith, Phillip Fabian, Alek Rosenthal, Amine Kaddour-Djebbar, Hongjoo J Le. The roles of central amygdala D1 and D2 receptors on attentional performance in a five-choice task. Behavioral neuroscience. vol 129. issue 5. 2016-07-26. PMID:26214208. |
emerging evidence suggests that the connections between the cea and the midbrain dopamine areas are important for attentional processing. |
2016-07-26 |
2023-08-13 |
rat |
| Judith Mylius, Max F K Happel, Alexander G Gorkin, Ying Huang, Henning Scheich, Michael Brosc. Fast transmission from the dopaminergic ventral midbrain to the sensory cortex of awake primates. Brain structure & function. vol 220. issue 6. 2016-07-25. PMID:25084746. |
thus, we speculate that the dopaminergic ventral midbrain exerts a temporally precise, phasic influence on sensory cortex using fast-acting non-dopaminergic transmitters and that their effects are modulated by dopamine on a longer timescale. |
2016-07-25 |
2023-08-13 |
monkey |
| Joseph R Mazzulli, Friederike Zunke, Ole Isacson, Lorenz Studer, Dimitri Krain. α-Synuclein-induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 7. 2016-07-22. PMID:26839413. |
here, we find that α-syn accumulation reduced lysosomal degradation capacity in human midbrain dopamine models of synucleinopathies through disrupting hydrolase trafficking. |
2016-07-22 |
2023-08-13 |
human |
| Philipp Schwartenbeck, Thomas H B FitzGerald, Christoph Mathys, Ray Dolan, Karl Fristo. The Dopaminergic Midbrain Encodes the Expected Certainty about Desired Outcomes. Cerebral cortex (New York, N.Y. : 1991). vol 25. issue 10. 2016-07-20. PMID:25056572. |
furthermore, midbrain activity, encompassing dopamine projection neurons, was accurately predicted by trial-by-trial variations in model-based estimates of precision. |
2016-07-20 |
2023-08-13 |
human |
| Mia Apuschkin, Sara Stilling, Troels Rahbek-Clemmensen, Gunnar Sørensen, Guillaume Fortin, Freja Herborg Hansen, Jacob Eriksen, Louis-Eric Trudeau, Kristoffer Egerod, Ulrik Gether, Mattias Rickha. A novel dopamine transporter transgenic mouse line for identification and purification of midbrain dopaminergic neurons reveals midbrain heterogeneity. The European journal of neuroscience. vol 42. issue 7. 2016-07-20. PMID:26286107. |
a novel dopamine transporter transgenic mouse line for identification and purification of midbrain dopaminergic neurons reveals midbrain heterogeneity. |
2016-07-20 |
2023-08-13 |
mouse |