| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G B Bissonette, M R Roesc. Development and function of the midbrain dopamine system: what we know and what we need to. Genes, brain, and behavior. vol 15. issue 1. 2016-10-20. PMID:26548362. |
while midbrain dopamine degeneration is a major focus for treatment and research, many other human disorders are impacted by abnormal dopamine, including drug addiction, autism and schizophrenia. |
2016-10-20 |
2023-08-13 |
human |
| G B Bissonette, M R Roesc. Development and function of the midbrain dopamine system: what we know and what we need to. Genes, brain, and behavior. vol 15. issue 1. 2016-10-20. PMID:26548362. |
this review will provide a brief overview of the major molecular and genetic players throughout the development of midbrain dopamine neurons and what we know about the behavioral- and disease-related implications associated with perturbations to midbrain dopamine neuron development. |
2016-10-20 |
2023-08-13 |
human |
| Ting-Yi Wang, Kiara F Bruggeman, Jessica A Kauhausen, Alexandra L Rodriguez, David R Nisbet, Clare L Paris. Functionalized composite scaffolds improve the engraftment of transplanted dopaminergic progenitors in a mouse model of Parkinson's disease. Biomaterials. vol 74. 2016-10-19. PMID:26454047. |
in vitro we confirmed the ability of the scaffolds to support ventral midbrain (vm) dopamine progenitors, and provide sustained delivery of gdnf - capable of eliciting effects on cell survival and dopaminergic axon growth. |
2016-10-19 |
2023-08-13 |
mouse |
| Ji Heon Rhim, Xiangjian Luo, Xiaoyun Xu, Dongbing Gao, Tieling Zhou, Fuhai Li, Lidong Qin, Ping Wang, Xiaofeng Xia, Stephen T C Won. A High-content screen identifies compounds promoting the neuronal differentiation and the midbrain dopamine neuron specification of human neural progenitor cells. Scientific reports. vol 5. 2016-10-19. PMID:26542303. |
a high-content screen identifies compounds promoting the neuronal differentiation and the midbrain dopamine neuron specification of human neural progenitor cells. |
2016-10-19 |
2023-08-13 |
human |
| Ji Heon Rhim, Xiangjian Luo, Xiaoyun Xu, Dongbing Gao, Tieling Zhou, Fuhai Li, Lidong Qin, Ping Wang, Xiaofeng Xia, Stephen T C Won. A High-content screen identifies compounds promoting the neuronal differentiation and the midbrain dopamine neuron specification of human neural progenitor cells. Scientific reports. vol 5. 2016-10-19. PMID:26542303. |
we carried out a high-content screen to systematically characterize known bioactive compounds, on their effects on the neuronal differentiation and the midbrain dopamine (mda) neuron specification of neural progenitor cells (npcs) derived from the ventral mesencephalon of human fetal brain. |
2016-10-19 |
2023-08-13 |
human |
| Venissa Machado, Tanja Zöller, Abdelraheim Attaai, Björn Spitta. Microglia-Mediated Neuroinflammation and Neurotrophic Factor-Induced Protection in the MPTP Mouse Model of Parkinson's Disease-Lessons from Transgenic Mice. International journal of molecular sciences. vol 17. issue 2. 2016-10-19. PMID:26821015. |
parkinson's disease (pd) is a neurodegenerative disease characterised by histopathological and biochemical manifestations such as loss of midbrain dopaminergic (da) neurons and decrease in dopamine levels accompanied by a concomitant neuroinflammatory response in the affected brain regions. |
2016-10-19 |
2023-08-13 |
mouse |
| Klas R Linderholm, Maximilian Tufvesson Alm, Markus K Larsson, Sara K Olsson, Michel Goiny, Mihaly Hajos, Sophie Erhardt, Göran Engber. Inhibition of kynurenine aminotransferase II reduces activity of midbrain dopamine neurons. Neuropharmacology. vol 102. 2016-10-07. PMID:26514401. |
inhibition of kynurenine aminotransferase ii reduces activity of midbrain dopamine neurons. |
2016-10-07 |
2023-08-13 |
Not clear |
| Dan P Covey, Jennifer M Wenzel, Joseph F Chee. Cannabinoid modulation of drug reward and the implications of marijuana legalization. Brain research. vol 1628. issue Pt A. 2016-09-27. PMID:25463025. |
presynaptic cb1 receptors control midbrain dopamine neuron activity and thereby shape phasic dopamine release in target regions, particularly the nucleus accumbens (nac). |
2016-09-27 |
2023-08-13 |
Not clear |
| William C Buchta, Arthur C Riege. Chronic cocaine disrupts mesocortical learning mechanisms. Brain research. vol 1628. issue Pt A. 2016-09-27. PMID:25704202. |
reward learning involves burst firing of midbrain dopamine neurons in response to rewards and cues predictive of reward. |
2016-09-27 |
2023-08-13 |
human |
| Nathan J Marchant, Leslie R Whitaker, Jennifer M Bossert, Brandon K Harvey, Bruce T Hope, Konstantin Kaganovsky, Sweta Adhikary, Thomas E Prisinzano, Eyal Vardy, Bryan L Roth, Yavin Shaha. Behavioral and Physiological Effects of a Novel Kappa-Opioid Receptor-Based DREADD in Rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 2. 2016-09-20. PMID:26019014. |
2, we show that salb completely inhibited tonic firing in kord-expressing putative dopamine neurons in midbrain. |
2016-09-20 |
2023-08-13 |
mouse |
| M-P Cossette, K Conover, P Shizga. The neural substrates for the rewarding and dopamine-releasing effects of medial forebrain bundle stimulation have partially discrepant frequency responses. Behavioural brain research. vol 297. 2016-09-20. PMID:26477378. |
midbrain dopamine neurons have long been implicated in the rewarding effect produced by electrical brain stimulation of the medial forebrain bundle (mfb). |
2016-09-20 |
2023-08-13 |
human |
| M-P Cossette, K Conover, P Shizga. The neural substrates for the rewarding and dopamine-releasing effects of medial forebrain bundle stimulation have partially discrepant frequency responses. Behavioural brain research. vol 297. 2016-09-20. PMID:26477378. |
this study assessed the hypothesis that midbrain dopamine neurons are in series with the directly stimulated substrate for self-stimulation of the mfb and either perform spatio-temporal integration of synaptic input from directly activated mfb fibers or relay the results of such integration to efferent stages of the reward circuitry. |
2016-09-20 |
2023-08-13 |
human |
| Carmen Cavada Martíne. [THE THALAMIC DOPAMINERGIC SYSTEM. A NOVEL SYSTEM IN THE PRIMATE BRAIN]. Anales de la Real Academia Nacional de Medicina. vol 131. issue 1. 2016-09-15. PMID:27386678. |
the origin of thalamic dopamine is multiple; it includes dopaminergic nuclei in the hypothalamus, periaqueductal gray, ventral mesencephalon and lateral parabrachial nucleus. |
2016-09-15 |
2023-08-13 |
human |
| Jessica A Kauhausen, Lachlan H Thompson, Clare L Paris. Chondroitinase improves midbrain pathway reconstruction by transplanted dopamine progenitors in Parkinsonian mice. Molecular and cellular neurosciences. vol 69. 2016-09-12. PMID:26463051. |
chondroitinase improves midbrain pathway reconstruction by transplanted dopamine progenitors in parkinsonian mice. |
2016-09-12 |
2023-08-13 |
mouse |
| Jessica A Kauhausen, Lachlan H Thompson, Clare L Paris. Chondroitinase improves midbrain pathway reconstruction by transplanted dopamine progenitors in Parkinsonian mice. Molecular and cellular neurosciences. vol 69. 2016-09-12. PMID:26463051. |
consequently, while clinical trials in parkinson's disease (pd) patients have demonstrated the capacity of fetal-derived dopamine neurons to survive, integrate and alleviate symptoms, the non-permissive host environment has contributed to the incomplete re-innervation of the target tissue by ectopic grafts, and even more noticeable, the poor reconstruction of the midbrain dopamine pathways following homotopic midbrain grafting. |
2016-09-12 |
2023-08-13 |
mouse |
| b' Giovanni Hernandez, Marie-Pierre Cossette, Peter Shizgal, Pierre-Paul Rompr\\xc3\\xa. Ventral Midbrain NMDA Receptor Blockade: From Enhanced Reward and Dopamine Inactivation. Frontiers in behavioral neuroscience. vol 10. 2016-09-12. PMID:27616984.' |
ventral midbrain nmda receptor blockade: from enhanced reward and dopamine inactivation. |
2016-09-12 |
2023-08-13 |
rat |
| b' Giovanni Hernandez, Marie-Pierre Cossette, Peter Shizgal, Pierre-Paul Rompr\\xc3\\xa. Ventral Midbrain NMDA Receptor Blockade: From Enhanced Reward and Dopamine Inactivation. Frontiers in behavioral neuroscience. vol 10. 2016-09-12. PMID:27616984.' |
glutamate stimulates ventral midbrain (vm) n-methyl-d-aspartate receptors (nmdar) to initiate dopamine (da) burst firing activity, a mode of discharge associated with enhanced da release and reward. |
2016-09-12 |
2023-08-13 |
rat |
| Emily M Rocha, Gaynor A Smith, Eric Park, Hongmei Cao, Eilish Brown, Melissa A Hayes, Jonathan Beagan, Jesse R McLean, Sarah C Izen, Eduardo Perez-Torres, Penelope J Hallett, Ole Isacso. Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons. Neurobiology of disease. vol 82. 2016-08-24. PMID:26392287. |
glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons. |
2016-08-24 |
2023-08-13 |
mouse |
| Emily M Rocha, Gaynor A Smith, Eric Park, Hongmei Cao, Eilish Brown, Melissa A Hayes, Jonathan Beagan, Jesse R McLean, Sarah C Izen, Eduardo Perez-Torres, Penelope J Hallett, Ole Isacso. Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons. Neurobiology of disease. vol 82. 2016-08-24. PMID:26392287. |
the present study tested whether increasing gcase through aav-gba1 intra-cerebral gene delivery in two pd rodent models would reduce the accumulation of α-synuclein and protect midbrain dopamine neurons from α-synuclein-mediated neuronal damage. |
2016-08-24 |
2023-08-13 |
mouse |
| Edita Navratilova, Christopher W Atcherley, Frank Porrec. Brain Circuits Encoding Reward from Pain Relief. Trends in neurosciences. vol 38. issue 11. 2016-08-24. PMID:26603560. |
we review findings from electrophysiological, neuroimaging, and behavioral studies supporting the concept that the rewarding effect of pain relief requires opioid signaling in the anterior cingulate cortex (acc), activation of midbrain dopamine neurons, and the release of dopamine in the nucleus accumbens (nac). |
2016-08-24 |
2023-08-13 |
Not clear |