| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dong-Oh Seo, Samuel C Funderburk, Dionnet L Bhatti, Laura E Motard, Dillan Newbold, Kasey S Girven, Jordan G McCall, Michael Krashes, Dennis R Sparta, Michael R Brucha. A GABAergic Projection from the Centromedial Nuclei of the Amygdala to Ventromedial Prefrontal Cortex Modulates Reward Behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 42. 2017-07-24. PMID:27798138. |
it is widely accepted that the midbrain dopamine (da) neurons are critical for the reward-related behaviors. |
2017-07-24 |
2023-08-13 |
Not clear |
| Ji Hoon Yoo, Vivien Zell, Johnathan Wu, Cindy Punta, Nivedita Ramajayam, Xinyi Shen, Lauren Faget, Varoth Lilascharoen, Byung Kook Lim, Thomas S Hnask. Activation of Pedunculopontine Glutamate Neurons Is Reinforcing. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 1. 2017-07-24. PMID:28053028. |
dopamine transmission from midbrain ventral tegmental area (vta) neurons underlies behavioral processes related to motivation and drug addiction. |
2017-07-24 |
2023-08-13 |
mouse |
| P Leon Brown, Heather Palacorolla, Dana Brady, Katelyn Riegger, Greg I Elmer, Paul D Shepar. Habenula-Induced Inhibition of Midbrain Dopamine Neurons Is Diminished by Lesions of the Rostromedial Tegmental Nucleus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 1. 2017-07-24. PMID:28053043. |
habenula-induced inhibition of midbrain dopamine neurons is diminished by lesions of the rostromedial tegmental nucleus. |
2017-07-24 |
2023-08-13 |
rat |
| P Leon Brown, Heather Palacorolla, Dana Brady, Katelyn Riegger, Greg I Elmer, Paul D Shepar. Habenula-Induced Inhibition of Midbrain Dopamine Neurons Is Diminished by Lesions of the Rostromedial Tegmental Nucleus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 1. 2017-07-24. PMID:28053043. |
functional changes associated with tonic and phasic activation of the lhb are often attributed to a corresponding inhibition of midbrain dopamine (da) neurons. |
2017-07-24 |
2023-08-13 |
rat |
| Megan E Fox, Maria A Mikhailova, Caroline E Bass, Pavel Takmakov, Raul R Gainetdinov, Evgeny A Budygin, R Mark Wightma. Cross-hemispheric dopamine projections have functional significance. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 25. 2017-07-17. PMID:27298371. |
in the freely moving animals, simultaneous bilateral measurements revealed that dopamine release synchronizes between hemispheres and intact, contralateral projections can release dopamine in the midbrain of 6-hydroxydopamine-lesioned rats. |
2017-07-17 |
2023-08-13 |
rat |
| Johanna Duda, Christina Pötschke, Birgit Lis. Converging roles of ion channels, calcium, metabolic stress, and activity pattern of Substantia nigra dopaminergic neurons in health and Parkinson's disease. Journal of neurochemistry. vol 139 Suppl 1. 2017-07-14. PMID:26865375. |
sn da neurons release dopamine from their axonal terminals within the dorsal striatum, and also from their cell bodies and dendrites within the midbrain in a calcium- and activity-dependent manner. |
2017-07-14 |
2023-08-13 |
Not clear |
| Dianne P Figlewic. Expression of receptors for insulin and leptin in the ventral tegmental area/substantia nigra (VTA/SN) of the rat: Historical perspective. Brain research. vol 1645. 2017-07-13. PMID:26731335. |
thus, these major metabolic hormones have effects on synaptic and cell signaling function of the midbrain dopamine neurons, across a range of concentrations that reflect physiologic (fasting vs. fed) and pathophysiologic (diabetes) circumstances. |
2017-07-13 |
2023-08-13 |
rat |
| Vasiliki Mitsi, Venetia Zachario. Modulation of pain, nociception, and analgesia by the brain reward center. Neuroscience. vol 338. 2017-07-11. PMID:27189881. |
the midbrain dopamine center comprises a key network for reward, salience, motivation, and mood. |
2017-07-11 |
2023-08-13 |
Not clear |
| Vasiliki Mitsi, Venetia Zachario. Modulation of pain, nociception, and analgesia by the brain reward center. Neuroscience. vol 338. 2017-07-11. PMID:27189881. |
evidence from various clinical and preclinical settings points to the midbrain dopamine circuit as an important modulator of pain perception and pain-induced anxiety and depression. |
2017-07-11 |
2023-08-13 |
Not clear |
| Ke-Zhong Shen, Yan-Na Wu, Adam C Munhall, Steven W Johnso. AMP kinase regulates ligand-gated K-ATP channels in substantia nigra dopamine neurons. Neuroscience. vol 330. 2017-07-11. PMID:27267246. |
we used patch pipettes to record currents and potentials to investigate effects of ampk on k-atp currents in substantia nigra compacta (snc) dopamine neurons in slices of rat midbrain. |
2017-07-11 |
2023-08-13 |
rat |
| Joseph R Mazzulli, Friederike Zunke, Taiji Tsunemi, Nicholas J Toker, Sohee Jeon, Lena F Burbulla, Samarjit Patnaik, Ellen Sidransky, Juan J Marugan, Carolyn M Sue, Dimitri Krain. Activation of β-Glucocerebrosidase Reduces Pathological α-Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 29. 2017-07-11. PMID:27445146. |
using induced pluripotent stem cell (ipsc)-derived human midbrain dopamine (da) neurons from synucleinopathy patients with different pd-linked mutations, we find that a non-inhibitory small molecule modulator of gcase specifically enhanced activity within lysosomal compartments. |
2017-07-11 |
2023-08-13 |
human |
| A V Kulikov, E Y Bazhenova, E A Kulikova, D V Fursenko, L I Trapezova, E E Terenina, P Mormede, N K Popova, O V Trapezo. Interplay between aggression, brain monoamines and fur color mutation in the American mink. Genes, brain, and behavior. vol 15. issue 8. 2017-06-28. PMID:27489198. |
significant interaction effects were found between the hedlund mutation and aggressive behavior on serotonin metabolism in the substantia nigra (p < 0.001), dopamine level in the midbrain (p < 0.01) and its metabolism in the striatum (p < 0.05). |
2017-06-28 |
2023-08-13 |
Not clear |
| Katsuo Kimura, Ken-Ichi Inoue, Yoshiyuki Kuroiwa, Fumiaki Tanaka, Masahiko Takad. Propagated but Topologically Distributed Forebrain Neurons Expressing Alpha-Synuclein in Aged Macaques. PloS one. vol 11. issue 11. 2017-06-26. PMID:27861638. |
it was found that the occurrence of α-syn-positive neurons proceeded topologically based on the midbrain dopamine pathways arising from the substantia nigra and the ventral tegmental area where they were primarily observed. |
2017-06-26 |
2023-08-13 |
human |
| Kymry T Jones, Catherine Woods, Juan Zhen, Tamara Antonio, Kenneth D Carr, Maarten E A Reit. Effects of diet and insulin on dopamine transporter activity and expression in rat caudate-putamen, nucleus accumbens, and midbrain. Journal of neurochemistry. vol 140. issue 5. 2017-06-23. PMID:27973691. |
effects of diet and insulin on dopamine transporter activity and expression in rat caudate-putamen, nucleus accumbens, and midbrain. |
2017-06-23 |
2023-08-13 |
rat |
| Kymry T Jones, Catherine Woods, Juan Zhen, Tamara Antonio, Kenneth D Carr, Maarten E A Reit. Effects of diet and insulin on dopamine transporter activity and expression in rat caudate-putamen, nucleus accumbens, and midbrain. Journal of neurochemistry. vol 140. issue 5. 2017-06-23. PMID:27973691. |
in this study, we examined diet effects on expression and function of the dopamine transporter (dat) in caudate-putamen (cpu), nucleus accumbens (nac), and midbrain regions. |
2017-06-23 |
2023-08-13 |
rat |
| Kymry T Jones, Catherine Woods, Juan Zhen, Tamara Antonio, Kenneth D Carr, Maarten E A Reit. Effects of diet and insulin on dopamine transporter activity and expression in rat caudate-putamen, nucleus accumbens, and midbrain. Journal of neurochemistry. vol 140. issue 5. 2017-06-23. PMID:27973691. |
dopamine (da) uptake by cpu, nac or midbrain synapto(neuro)somes was measured in vitro with rotating disk electrode voltammetry or with [ |
2017-06-23 |
2023-08-13 |
rat |
| Douglas A Grow, DeNard V Simmons, Jorge A Gomez, Matthew J Wanat, John R McCarrey, Carlos A Paladini, Christopher S Navar. Differentiation and Characterization of Dopaminergic Neurons From Baboon Induced Pluripotent Stem Cells. Stem cells translational medicine. vol 5. issue 9. 2017-06-22. PMID:27343168. |
we confirmed that bipsc-derived dopaminergic neurons resemble those found in the human midbrain based on cell type-specific expression of dopamine markers th and girk2. |
2017-06-22 |
2023-08-13 |
human |
| Rao Fu, Xing Chen, Wanhong Zuo, Jing Li, Seungwoo Kang, Li-Hua Zhou, Allan Siegel, Alex Bekker, Jiang-Hong Y. Ablation of μ opioid receptor-expressing GABA neurons in rostromedial tegmental nucleus increases ethanol consumption and regulates ethanol-related behaviors. Neuropharmacology. vol 107. 2017-06-21. PMID:26921770. |
the rmtg contains mostly gabaergic neurons, sends a dense inhibitory projection to dopamine neurons in the midbrain, and is rich with μ-opioid receptors (mor). |
2017-06-21 |
2023-08-13 |
rat |
| Chi Wang Ip, Ioannis U Isaias, Burak B Kusche-Tekin, Dennis Klein, Janos Groh, Aet O'Leary, Susanne Knorr, Takahiro Higuchi, James B Koprich, Jonathan M Brotchie, Klaus V Toyka, Andreas Reif, Jens Volkman. Tor1a+/- mice develop dystonia-like movements via a striatal dopaminergic dysregulation triggered by peripheral nerve injury. Acta neuropathologica communications. vol 4. issue 1. 2017-06-21. PMID:27716431. |
western blot analysis was performed for dopamine transporter (dat), d1 and d2 receptors from striatal and quantitative rt-pcr analysis for dat from midbrain dissections. |
2017-06-21 |
2023-08-13 |
mouse |
| Li-Ping Liang, Jie Huang, Ruth Fulton, Jennifer N Pearson-Smith, Brian J Day, Manisha Pate. Pre-clinical therapeutic development of a series of metalloporphyrins for Parkinson's disease. Toxicology and applied pharmacology. vol 326. 2017-06-06. PMID:28400118. |
all of these compounds protected against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-induced neurotoxicity, including dopamine depletion in the striatum, dopaminergic neuronal loss in the substantial nigra, and increased oxidative/nitrative stress indices (glutathione disulfide and 3-nitrotyrosine) in the ventral midbrain of the mice without inhibiting mptp metabolism. |
2017-06-06 |
2023-08-13 |
mouse |