| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shaletha Holmes, Meharvan Singh, Chang Su, Rebecca L Cunningha. Effects of Oxidative Stress and Testosterone on Pro-Inflammatory Signaling in a Female Rat Dopaminergic Neuronal Cell Line. Endocrinology. vol 157. issue 7. 2017-06-05. PMID:27167771. |
these pathological markers can contribute to the loss of dopamine neurons in the midbrain. |
2017-06-05 |
2023-08-13 |
rat |
| Pınar Kanlikilicer, Die Zhang, Andrei Dragomir, Yasemin M Akay, Metin Aka. Gene expression profiling of midbrain dopamine neurons upon gestational nicotine exposure. Medical & biological engineering & computing. vol 55. issue 3. 2017-06-05. PMID:27255453. |
gene expression profiling of midbrain dopamine neurons upon gestational nicotine exposure. |
2017-06-05 |
2023-08-13 |
Not clear |
| Gael Le Douaron, Laurent Ferrié, Julia E Sepulveda-Diaz, Majid Amar, Abha Harfouche, Blandine Séon-Méniel, Rita Raisman-Vozari, Patrick P Michel, Bruno Figadèr. New 6-Aminoquinoxaline Derivatives with Neuroprotective Effect on Dopaminergic Neurons in Cellular and Animal Parkinson Disease Models. Journal of medicinal chemistry. vol 59. issue 13. 2017-05-29. PMID:27341519. |
parkinson's disease (pd) is a neurodegenerative disorder of aging characterized by motor symptoms that result from the loss of midbrain dopamine neurons and the disruption of dopamine-mediated neurotransmission. |
2017-05-29 |
2023-08-13 |
mouse |
| Benjamin Weismüller, Christian Bellebau. Expectancy affects the feedback-related negativity (FRN) for delayed feedback in probabilistic learning. Psychophysiology. vol 53. issue 11. 2017-05-17. PMID:27565454. |
prediction error signals coded by midbrain dopamine (da) neurons are projected to the basal ganglia and anterior cingulate cortex (acc). |
2017-05-17 |
2023-08-13 |
human |
| Marija Fjodorova, Eduardo M Torres, Stephen B Dunnet. Transplantation site influences the phenotypic differentiation of dopamine neurons in ventral mesencephalic grafts in Parkinsonian rats. Experimental neurology. vol 291. 2017-05-16. PMID:28131726. |
foetal midbrain progenitors have been shown to survive, give rise to different classes of dopamine neurons and integrate into the host brain alleviating parkinsonian symptoms following transplantation in patients and animal models of the disease. |
2017-05-16 |
2023-08-13 |
rat |
| Marija Fjodorova, Eduardo M Torres, Stephen B Dunnet. Transplantation site influences the phenotypic differentiation of dopamine neurons in ventral mesencephalic grafts in Parkinsonian rats. Experimental neurology. vol 291. 2017-05-16. PMID:28131726. |
dopamine neuron subpopulations in the midbrain, namely a9 and a10, can be identified anatomically based on cell morphology and ascending axonal projections. |
2017-05-16 |
2023-08-13 |
rat |
| Marija Fjodorova, Eduardo M Torres, Stephen B Dunnet. Transplantation site influences the phenotypic differentiation of dopamine neurons in ventral mesencephalic grafts in Parkinsonian rats. Experimental neurology. vol 291. 2017-05-16. PMID:28131726. |
g protein-gated inwardly rectifying potassium channel girk2 and the calcium binding protein calbindin are the two best available histochemical markers currently used to label (with some overlap) a9- and a10-like dopamine neuron subtypes, respectively, in tyrosine hydroxylase expressing neurons both in the midbrain and grafts. |
2017-05-16 |
2023-08-13 |
rat |
| Marija Fjodorova, Eduardo M Torres, Stephen B Dunnet. Transplantation site influences the phenotypic differentiation of dopamine neurons in ventral mesencephalic grafts in Parkinsonian rats. Experimental neurology. vol 291. 2017-05-16. PMID:28131726. |
here we used rat foetal midbrain progenitors at two developmental stages corresponding to a peak in either a9 or a10 neurogenesis and examined their commitment to respective dopaminergic phenotypes by grafting cells into different forebrain regions that contain targets of either nigral a9 dopamine innervation (dorsal striatum), ventral tegmental area a10 dopamine innervation (nucleus accumbens and prefrontal cortex), or only sparse dopamine but rich noradrenaline innervation (hippocampus). |
2017-05-16 |
2023-08-13 |
rat |
| Marija Fjodorova, Eduardo M Torres, Stephen B Dunnet. Transplantation site influences the phenotypic differentiation of dopamine neurons in ventral mesencephalic grafts in Parkinsonian rats. Experimental neurology. vol 291. 2017-05-16. PMID:28131726. |
these novel findings suggest that dopamine progenitors use targets of a9/a10 innervation in the transplantation site to complete maturation and the efficacy of foetal cell replacement therapy in patients may be improved by deriving midbrain tissue at earlier developmental stages than in current practice. |
2017-05-16 |
2023-08-13 |
rat |
| Dibyadeep Datta, Dominique Arion, Kaitlyn M Roman, David W Volk, David A Lewi. Altered Expression of ARP2/3 Complex Signaling Pathway Genes in Prefrontal Layer 3 Pyramidal Cells in Schizophrenia. The American journal of psychiatry. vol 174. issue 2. 2017-05-01. PMID:27523502. |
these findings may be related via excitatory projections from the dlpfc to the ventral mesencephalon, the location of dopamine cells projecting to the striatum. |
2017-05-01 |
2023-08-13 |
mouse |
| Janusz W Błaszczy. Nigrostriatal interaction in the aging brain: new therapeutic target for Parkinson's disease. Acta neurobiologiae experimentalis. vol 77. issue 1. 2017-04-14. PMID:28379221. |
research results gathered to date support the hypothesis that the motor symptoms of the disease result from the gradual loss of midbrain dopamine neurons residing in the substantia nigra pars compacta (snpc). |
2017-04-14 |
2023-08-13 |
Not clear |
| J Martí-Clú. Natural apoptosis in developing mice dopamine midbrain neurons and vermal Purkinje cells. Folia neuropathologica. vol 54. issue 2. 2017-04-13. PMID:27543775. |
natural apoptosis in developing mice dopamine midbrain neurons and vermal purkinje cells. |
2017-04-13 |
2023-08-13 |
mouse |
| Parisa Farzanehfa. Towards a Better Treatment Option for Parkinson's Disease: A Review of Adult Neurogenesis. Neurochemical research. vol 41. issue 12. 2017-03-15. PMID:27613619. |
the motor symptoms of parkinson's disease (pd) are caused by degeneration of dopamine (da) neurons in the substantia nigra pars compacta (snc) of midbrain. |
2017-03-15 |
2023-08-13 |
Not clear |
| Veronne de Vrind, Jacqueline Scuvée-Moreau, Guillaume Drion, Cyrine Hmaied, Fabian Philippart, Dominique Engel, Vincent Seuti. Interactions between calcium channels and SK channels in midbrain dopamine neurons and their impact on pacemaker regularity: Contrasting roles of N- and L-type channels. European journal of pharmacology. vol 788. 2017-03-10. PMID:27364758. |
interactions between calcium channels and sk channels in midbrain dopamine neurons and their impact on pacemaker regularity: contrasting roles of n- and l-type channels. |
2017-03-10 |
2023-08-13 |
rat |
| N S Corral-Frías, D A Pizzagalli, J M Carré, L J Michalski, Y S Nikolova, R H Perlis, J Fagerness, M R Lee, E Drabant Conley, T M Lancaster, S Haddad, A Wolf, J W Smoller, A R Hariri, R Bogda. COMT Val(158) Met genotype is associated with reward learning: a replication study and meta-analysis. Genes, brain, and behavior. vol 15. issue 5. 2017-02-06. PMID:27138112. |
a common functional polymorphism within the catechol-o-methyl transferase gene (comt; rs4680, val(158) met) has been linked to reward learning, where homozygosity for the met allele (linked to heightened prefrontal dopamine function and decreased dopamine synthesis in the midbrain) has been associated with relatively increased reward learning. |
2017-02-06 |
2023-08-13 |
human |
| Masayuki Matsumot. [Multiple Dopamine Signals and Their Contributions to Reinforcement Learning]. Brain and nerve = Shinkei kenkyu no shinpo. vol 68. issue 10. 2017-01-27. PMID:27703101. |
midbrain dopamine neurons are activated by reward and sensory cue that predicts reward. |
2017-01-27 |
2023-08-13 |
Not clear |
| Rowan P Orme, Charlotte Middleditch, Lauren Waite, Rosemary A Fricke. The Role of Vitamin D₃ in the Development and Neuroprotection of Midbrain Dopamine Neurons. Vitamins and hormones. vol 100. 2017-01-18. PMID:26827956. |
the role of vitamin d₃ in the development and neuroprotection of midbrain dopamine neurons. |
2017-01-18 |
2023-08-13 |
Not clear |
| Annalisa Pinna, Francesco Napolitano, Barbara Pelosi, Anna Di Maio, Jadwiga Wardas, Maria Antonietta Casu, Giulia Costa, Sara Migliarini, Paolo Calabresi, Massimo Pasqualetti, Micaela Morelli, Alessandro Usiell. The Small GTP-Binding Protein Rhes Influences Nigrostriatal-Dependent Motor Behavior During Aging. Movement disorders : official journal of the Movement Disorder Society. vol 31. issue 4. 2017-01-17. PMID:26853527. |
here we aimed to evaluate: (1) rhes mrna expression in mouse midbrain, (2) the effect of rhes deletion on the number of dopamine neurons, (3) nigrostriatal-sensitive behavior during aging in knockout mice. |
2017-01-17 |
2023-08-13 |
mouse |
| Jie Dong, Song Li, Jing-Lin Mo, Huai-Bin Cai, Wei-Dong L. Nurr1-Based Therapies for Parkinson's Disease. CNS neuroscience & therapeutics. vol 22. issue 5. 2017-01-16. PMID:27012974. |
previous studies have documented that orphan nuclear receptor nurr1 (also known as nr4a2) plays important roles in the midbrain dopamine (da) neuron development, differentiation, and survival. |
2017-01-16 |
2023-08-13 |
Not clear |
| Rao Fu, Wanhong Zuo, Danielle Gregor, Jing Li, Dennis Grech, Jiang-Hong Y. Pharmacological Manipulation of the Rostromedial Tegmental Nucleus Changes Voluntary and Operant Ethanol Self-Administration in Rats. Alcoholism, clinical and experimental research. vol 40. issue 3. 2017-01-11. PMID:26876382. |
it is also a major source of inhibitory gabaergic inputs to the midbrain dopamine neurons. |
2017-01-11 |
2023-08-13 |
rat |