| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Brandon J Henderson, Teagan R Wall, Beverley M Henley, Charlene H Kim, Weston A Nichols, Ruin Moaddel, Cheng Xiao, Henry A Leste. Menthol Alone Upregulates Midbrain nAChRs, Alters nAChR Subtype Stoichiometry, Alters Dopamine Neuron Firing Frequency, and Prevents Nicotine Reward. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 10. 2016-07-19. PMID:26961950. |
menthol alone upregulates midbrain nachrs, alters nachr subtype stoichiometry, alters dopamine neuron firing frequency, and prevents nicotine reward. |
2016-07-19 |
2023-08-13 |
mouse |
| Doris Tomas, Augustinus H Prijanto, Emma L Burrows, Anthony J Hannan, Malcolm K Horne, Tim D Auman. Environmental modulations of the number of midbrain dopamine neurons in adult mice. Journal of visualized experiments : JoVE. issue 95. 2016-07-18. PMID:25650697. |
environmental modulations of the number of midbrain dopamine neurons in adult mice. |
2016-07-18 |
2023-08-13 |
mouse |
| Doris Tomas, Augustinus H Prijanto, Emma L Burrows, Anthony J Hannan, Malcolm K Horne, Tim D Auman. Environmental modulations of the number of midbrain dopamine neurons in adult mice. Journal of visualized experiments : JoVE. issue 95. 2016-07-18. PMID:25650697. |
two environmental manipulations are described which increase or decrease the number of tyrosine hydroxylase immunopositive (th+, the rate-limiting enzyme in dopamine (da) synthesis) neurons in the adult mouse midbrain. |
2016-07-18 |
2023-08-13 |
mouse |
| Qiaoqiao Yang, Shuxi Liu, Min Yin, Yanqing Yin, Guomin Zhou, Jiawei Zho. Ebf2 is required for development of dopamine neurons in the midbrain periaqueductal gray matter of mouse. Developmental neurobiology. vol 75. issue 11. 2016-07-12. PMID:25762221. |
ebf2 is required for development of dopamine neurons in the midbrain periaqueductal gray matter of mouse. |
2016-07-12 |
2023-08-13 |
mouse |
| Fernando Caravaggio, Margaret Hahn, Shinichiro Nakajima, Philip Gerretsen, Gary Remington, Ariel Graff-Guerrer. Reduced insulin-receptor mediated modulation of striatal dopamine release by basal insulin as a possible contributing factor to hyperdopaminergia in schizophrenia. Medical hypotheses. vol 85. issue 4. 2016-07-12. PMID:26118462. |
studies in animals have demonstrated that insulin receptors are expressed on midbrain dopamine neurons, and that insulin from the periphery acts on these receptors to modify dopamine transmission in the striatum. |
2016-07-12 |
2023-08-13 |
Not clear |
| Fernando Caravaggio, Margaret Hahn, Shinichiro Nakajima, Philip Gerretsen, Gary Remington, Ariel Graff-Guerrer. Reduced insulin-receptor mediated modulation of striatal dopamine release by basal insulin as a possible contributing factor to hyperdopaminergia in schizophrenia. Medical hypotheses. vol 85. issue 4. 2016-07-12. PMID:26118462. |
collectively, these data suggest that midbrain insulin receptor functioning may be abnormal in persons with schizophrenia, resulting in reduced insulin-mediated regulation of dopamine transmission in the striatum. |
2016-07-12 |
2023-08-13 |
Not clear |
| Fernando Caravaggio, Margaret Hahn, Shinichiro Nakajima, Philip Gerretsen, Gary Remington, Ariel Graff-Guerrer. Reduced insulin-receptor mediated modulation of striatal dopamine release by basal insulin as a possible contributing factor to hyperdopaminergia in schizophrenia. Medical hypotheses. vol 85. issue 4. 2016-07-12. PMID:26118462. |
we hypothesize that, (i) insulin receptor expression and/or function is reduced in midbrain dopamine neurons in persons with schizophrenia, (ii) basal insulin should reduce dopaminergic transmission in the striatum via these receptors, and (iii) this modulation of dopaminergic transmission by basal insulin is reduced in the brains of persons with schizophrenia. |
2016-07-12 |
2023-08-13 |
Not clear |
| Navid Nouri, Meera J Patel, Milan Joksimovic, Jean-Francois Poulin, Angela Anderegg, M Mark Taketo, Yong-Chao Ma, Rajeshwar Awatraman. Excessive Wnt/beta-catenin signaling promotes midbrain floor plate neurogenesis, but results in vacillating dopamine progenitors. Molecular and cellular neurosciences. vol 68. 2016-07-11. PMID:26164566. |
excessive wnt/beta-catenin signaling promotes midbrain floor plate neurogenesis, but results in vacillating dopamine progenitors. |
2016-07-11 |
2023-08-13 |
Not clear |
| Huikun Wang, Tyler Treadway, Daniel P Covey, Joseph F Cheer, Carl R Lupic. Cocaine-Induced Endocannabinoid Mobilization in the Ventral Tegmental Area. Cell reports. vol 12. issue 12. 2016-07-06. PMID:26365195. |
endogenous cannabinoids (ecb) are lipid molecules released from midbrain dopamine (da) neurons that modulate cocaine's effects through poorly understood mechanisms. |
2016-07-06 |
2023-08-13 |
rat |
| Debashis Dutta, Kochupurackal P Mohanakuma. Tea and Parkinson's disease: Constituents of tea synergize with antiparkinsonian drugs to provide better therapeutic benefits. Neurochemistry international. vol 89. 2016-07-04. PMID:26271432. |
pd syndromes result from excessive loss of dopamine from the forebrain striatal region, due to dopaminergic neuronal death in the midbrain substantia nigra pars compacta. |
2016-07-04 |
2023-08-13 |
Not clear |
| William Menegas, Joseph F Bergan, Sachie K Ogawa, Yoh Isogai, Kannan Umadevi Venkataraju, Pavel Osten, Naoshige Uchida, Mitsuko Watabe-Uchid. Dopamine neurons projecting to the posterior striatum form an anatomically distinct subclass. eLife. vol 4. 2016-07-01. PMID:26322384. |
combining rabies-virus tracing, optical clearing (clarity), and whole-brain light-sheet imaging, we mapped the monosynaptic inputs to midbrain dopamine neurons projecting to different targets (different parts of the striatum, cortex, amygdala, etc) in mice. |
2016-07-01 |
2023-08-13 |
mouse |
| William Menegas, Joseph F Bergan, Sachie K Ogawa, Yoh Isogai, Kannan Umadevi Venkataraju, Pavel Osten, Naoshige Uchida, Mitsuko Watabe-Uchid. Dopamine neurons projecting to the posterior striatum form an anatomically distinct subclass. eLife. vol 4. 2016-07-01. PMID:26322384. |
these results lay a foundation for understanding the input/output structure of the midbrain dopamine circuit and demonstrate that dopamine neurons projecting to the posterior striatum constitute a unique class of dopamine neurons regulated by different inputs. |
2016-07-01 |
2023-08-13 |
mouse |
| Stephanie C Gantz, Brooks G Robinson, David C Buck, James R Bunzow, Rachael L Neve, John T Williams, Kim A Nev. Distinct regulation of dopamine D2S and D2L autoreceptor signaling by calcium. eLife. vol 4. 2016-06-28. PMID:26308580. |
two isoforms of the d2 receptor, d2s and d2l, are expressed in midbrain dopamine neurons. |
2016-06-28 |
2023-08-13 |
mouse |
| J L Rodríguez, I Ares, V Castellano, M Martínez, M R Martínez-Larrañaga, A Anadón, M A Martíne. Effects of exposure to pyrethroid cyfluthrin on serotonin and dopamine levels in brain regions of male rats. Environmental research. vol 146. 2016-06-27. PMID:26826775. |
after last dose of cyfluthrin, dopamine (da) and serotonin (5-ht) and its metabolites levels were determined in brain regions hypothalamus, midbrain, hippocampus, striatum and prefrontal cortex by hplc. |
2016-06-27 |
2023-08-13 |
rat |
| David S Wheeler, Suzanne M Underhill, Donna B Stolz, Geoffrey H Murdoch, Edda Thiels, Guillermo Romero, Susan G Amar. Amphetamine activates Rho GTPase signaling to mediate dopamine transporter internalization and acute behavioral effects of amphetamine. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 51. 2016-06-07. PMID:26553986. |
this effect, which can be observed in transfected cells, cultured dopamine neurons, and midbrain slices, is mediated by activation of the small gtpase rhoa. |
2016-06-07 |
2023-08-13 |
mouse |
| Bettina Mai, Susanne Sommer, Wolfgang Haube. Dopamine D1/D2 Receptor Activity in the Nucleus Accumbens Core But Not in the Nucleus Accumbens Shell and Orbitofrontal Cortex Modulates Risk-Based Decision Making. The international journal of neuropsychopharmacology. vol 18. issue 10. 2016-06-01. PMID:25908669. |
it is well known that brain dopamine (da) signals support risk-based decision making; however, the specific terminal regions of midbrain da neurons through which da signals mediate risk-based decision making are unknown. |
2016-06-01 |
2023-08-13 |
Not clear |
| E Kärkkäinen, L Yavich, P O Miettinen, H Tanil. Opposing effects of APP/PS1 and TrkB.T1 genotypes on midbrain dopamine neurons and stimulated dopamine release in vivo. Brain research. vol 1622. 2016-06-01. PMID:26168899. |
opposing effects of app/ps1 and trkb.t1 genotypes on midbrain dopamine neurons and stimulated dopamine release in vivo. |
2016-06-01 |
2023-08-13 |
mouse |
| Guoxiang Liu, Carmelo Sgobio, Xinglong Gu, Lixin Sun, Xian Lin, Jia Yu, Loukia Parisiadou, Chengsong Xie, Namratha Sastry, Jinhui Ding, Kelly M Lohr, Gary W Miller, Yolanda Mateo, David M Lovinger, Huaibin Ca. Selective expression of Parkinson's disease-related Leucine-rich repeat kinase 2 G2019S missense mutation in midbrain dopaminergic neurons impairs dopamine release and dopaminergic gene expression. Human molecular genetics. vol 24. issue 18. 2016-05-31. PMID:26123485. |
selective expression of parkinson's disease-related leucine-rich repeat kinase 2 g2019s missense mutation in midbrain dopaminergic neurons impairs dopamine release and dopaminergic gene expression. |
2016-05-31 |
2023-08-13 |
mouse |
| Tomás R Guilarte, Kalynda K Gonzale. Manganese-Induced Parkinsonism Is Not Idiopathic Parkinson's Disease: Environmental and Genetic Evidence. Toxicological sciences : an official journal of the Society of Toxicology. vol 146. issue 2. 2016-05-31. PMID:26220508. |
in fact, the most successful parkinsonian drug treatment, the dopamine precursor levodopa, is ineffective in alleviating mn-induced motor symptoms, implying that parkinsonism in mn-exposed individuals may not be linked to midbrain dopaminergic neuron cell loss. |
2016-05-31 |
2023-08-13 |
human |
| Benjamin T Saunders, Jocelyn M Richard, Patricia H Jana. Contemporary approaches to neural circuit manipulation and mapping: focus on reward and addiction. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 370. issue 1677. 2016-05-31. PMID:26240425. |
here we discuss contemporary approaches for understanding reward and addiction, with a focus on midbrain dopamine and cortico-striato-pallidal circuits. |
2016-05-31 |
2023-08-13 |
Not clear |