| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Agnes Norbury, Masud Husai. Sensation-seeking: Dopaminergic modulation and risk for psychopathology. Behavioural brain research. vol 288. 2016-01-27. PMID:25907745. |
both high tonic dopamine levels and hyper-reactive midbrain dopaminergic responses to signals of forthcoming reward are evident in higher sensations-seekers. |
2016-01-27 |
2023-08-13 |
human |
| b' Giovanni Hernandez, Ali Khodami-Pour, Daniel L\\xc3\\xa9vesque, Pierre-Paul Rompr\\xc3\\xa. Reduction in Ventral Midbrain NMDA Receptors Reveals Two Opposite Modulatory Roles for Glutamate on Reward. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 7. 2016-01-25. PMID:25578795.' |
such opposite modulatory functions imply that different subtypes of nmdars are expressed on different ventral midbrain (vm) neurons and/or afferent inputs to dopamine neurons. |
2016-01-25 |
2023-08-13 |
Not clear |
| K H Stansfield, K N Ruby, B D Soares, J L McGlothan, X Liu, T R Guilart. Early-life lead exposure recapitulates the selective loss of parvalbumin-positive GABAergic interneurons and subcortical dopamine system hyperactivity present in schizophrenia. Translational psychiatry. vol 5. 2016-01-20. PMID:25756805. |
loss of pvgi inhibitory control to pyramidal cells alters the excitatory drive to midbrain dopamine neurons increasing subcortical dopaminergic activity. |
2016-01-20 |
2023-08-13 |
rat |
| Xi-Biao He, Mirang Kim, Seon-Young Kim, Sang-Hoon Yi, Yong-Hee Rhee, Taeho Kim, Eun-Hye Lee, Chang-Hwan Park, Shilpy Dixit, Fiona E Harrison, Sang-Hun Le. Vitamin C facilitates dopamine neuron differentiation in fetal midbrain through TET1- and JMJD3-dependent epigenetic control manner. Stem cells (Dayton, Ohio). vol 33. issue 4. 2016-01-15. PMID:25535150. |
vitamin c facilitates dopamine neuron differentiation in fetal midbrain through tet1- and jmjd3-dependent epigenetic control manner. |
2016-01-15 |
2023-08-13 |
mouse |
| Lan-Ting Lee, Hsin Chun Tsai, Mei Hung Chi, Wei Hung Chang, Kao Chin Chen, I Hui Lee, Po See Chen, Wei Jen Yao, Nan Tsing Chiu, Yen Kuang Yan. Lower availability of striatal dopamine transporter in generalized anxiety disorder: a preliminary two-ligand SPECT study. International clinical psychopharmacology. vol 30. issue 3. 2016-01-15. PMID:25647452. |
the aims of this study were to examine the availabilities of the striatal dopamine transporter (dat) and the midbrain serotonin transporter (sert) in patients with gad. |
2016-01-15 |
2023-08-13 |
human |
| Robert C Twining, Daniel S Wheeler, Amanda L Ebben, Andre J Jacobsen, Mykel A Robble, John R Mantsch, Robert A Wheele. Aversive stimuli drive drug seeking in a state of low dopamine tone. Biological psychiatry. vol 77. issue 10. 2016-01-13. PMID:25442790. |
additionally, we examined the midbrain regulation of both dopamine signaling and cocaine seeking by the stress-sensitive peptide, corticotropin releasing factor (crf). |
2016-01-13 |
2023-08-13 |
Not clear |
| Penelope J Hallett, Michela Deleidi, Arnar Astradsson, Gaynor A Smith, Oliver Cooper, Teresia M Osborn, Maria Sundberg, Michele A Moore, Eduardo Perez-Torres, Anna-Liisa Brownell, James M Schumacher, Roger D Spealman, Ole Isacso. Successful function of autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson's disease. Cell stem cell. vol 16. issue 3. 2016-01-08. PMID:25732245. |
here, we analyzed cynomolgus monkey (cm) ipsc-derived midbrain dopamine neurons for up to 2 years following autologous transplantation in a parkinson's disease (pd) model. |
2016-01-08 |
2023-08-13 |
monkey |
| Lulu Jiang, Shih-Heng Chen, Chun-Hsien Chu, Shi-Jun Wang, Esteban Oyarzabal, Belinda Wilson, Virginia Sanders, Keqin Xie, Qingshan Wang, Jau-Shyong Hon. A novel role of microglial NADPH oxidase in mediating extra-synaptic function of norepinephrine in regulating brain immune homeostasis. Glia. vol 63. issue 6. 2016-01-08. PMID:25740080. |
this piece of in vivo data prompted us to conduct a series of studies in an effort to elucidate the mechanism as to how ne affects dopamine neuron survival by using primary midbrain neuron/glia cultures. |
2016-01-08 |
2023-08-13 |
mouse |
| Michael J Bannon, Candace L Savonen, Hui Jia, Fabien Dachet, Steven D Halter, Carl J Schmidt, Leonard Lipovich, Gregory Kapato. Identification of long noncoding RNAs dysregulated in the midbrain of human cocaine abusers. Journal of neurochemistry. vol 135. issue 1. 2016-01-08. PMID:26222413. |
midbrain dopamine (da) neurons in particular mediate numerous responses to drugs of abuse. |
2016-01-08 |
2023-08-13 |
human |
| Julio Cesar Aguila, Alexandra Blak, Joris van Arensbergen, Amaia Sousa, Nerea Vázquez, Ariane Aduriz, Mayela Gayosso, Maria Paz Lopez Mato, Rakel Lopez de Maturana, Eva Hedlund, Kai-Christian Sonntag, Rosario Sanchez-Pernaut. Selection Based on FOXA2 Expression Is Not Sufficient to Enrich for Dopamine Neurons From Human Pluripotent Stem Cells. Stem cells translational medicine. vol 3. issue 9. 2016-01-06. PMID:25024431. |
inductive differentiation protocols can generate midbrain dopamine neurons but result in heterogeneous cell mixtures. |
2016-01-06 |
2023-08-13 |
human |
| Julio Cesar Aguila, Alexandra Blak, Joris van Arensbergen, Amaia Sousa, Nerea Vázquez, Ariane Aduriz, Mayela Gayosso, Maria Paz Lopez Mato, Rakel Lopez de Maturana, Eva Hedlund, Kai-Christian Sonntag, Rosario Sanchez-Pernaut. Selection Based on FOXA2 Expression Is Not Sufficient to Enrich for Dopamine Neurons From Human Pluripotent Stem Cells. Stem cells translational medicine. vol 3. issue 9. 2016-01-06. PMID:25024431. |
we then selected foxa2-positive neural progenitors from several human pluripotent stem cell lines, which demonstrated a gene expression profile typical for the ventral domain of the midbrain and floor plate, but failed to enrich for dopamine neurons. |
2016-01-06 |
2023-08-13 |
human |
| S T Masoud, L M Vecchio, Y Bergeron, M M Hossain, L T Nguyen, M K Bermejo, B Kile, T D Sotnikova, W B Siesser, R R Gainetdinov, R M Wightman, M G Caron, J R Richardson, G W Miller, A J Ramsey, M Cyr, A Salahpou. Increased expression of the dopamine transporter leads to loss of dopamine neurons, oxidative stress and l-DOPA reversible motor deficits. Neurobiology of disease. vol 74. 2016-01-06. PMID:25447236. |
we report that dopamine transporter over-expressing (dat-tg) mice display spontaneous loss of midbrain dopamine neurons that is accompanied by increases in oxidative stress markers, 5-s-cysteinyl-dopamine and 5-s-cysteinyl-dopac. |
2016-01-06 |
2023-08-13 |
mouse |
| Khalil Rouibi, Poulomee Bose, Pierre-Paul Rompré, Richard A Warre. Ventral Midbrain NTS1 Receptors Mediate Conditioned Reward Induced by the Neurotensin Analog, D-Tyr[11]neurotensin. Frontiers in neuroscience. vol 9. 2016-01-06. PMID:26733785. |
these findings suggest that (i) nt is acting on ventral midbrain nts1 receptors to induce a rewarding effect and (ii) that this psychostimulant-like effect could be due to a direct action of nt on dopamine neurons and/or an enhancement of glutamatergic inputs to non-dopamine ([formula: see text]) neurons. |
2016-01-06 |
2023-08-13 |
rat |
| Mary L Huff, Ryan T LaLumier. The rostromedial tegmental nucleus modulates behavioral inhibition following cocaine self-administration in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 4. 2016-01-05. PMID:25257212. |
recent findings suggest that the mesolimbic dopamine neurons, known to promote cocaine-seeking behavior, are strongly inhibited by a newly characterized region of the midbrain known as the rostromedial tegmental nucleus (rmtg). |
2016-01-05 |
2023-08-13 |
rat |
| Daniel A Stevens, Yunjong Lee, Ho Chul Kang, Byoung Dae Lee, Yun-Il Lee, Aaron Bower, Haisong Jiang, Sung-Ung Kang, Shaida A Andrabi, Valina L Dawson, Joo-Ho Shin, Ted M Dawso. Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 37. 2016-01-04. PMID:26324925. |
adult knockout of parkin in the ventral midbrain of mice leads to an age-dependent loss of dopamine neurons that is dependent on the accumulation of parkin interacting substrate (paris), zinc finger protein 746 (znf746), and its transcriptional repression of pgc-1α. |
2016-01-04 |
2023-08-13 |
mouse |
| Tam Duong, Jaetaek Kim, H Earl Ruley, Daewoong J. Cell-permeable parkin proteins suppress Parkinson disease-associated phenotypes in cultured cells and animals. PloS one. vol 9. issue 7. 2016-01-01. PMID:25019626. |
these included enhanced survival and dopamine expression in cultured cath.a and sh-sy5y neuronal cells; and protection against mptp-induced damage in mice, notably preservation of tyrosine hydroxylase-positive cells with enhanced dopamine expression in the striatum and midbrain, and preservation of gross motor function. |
2016-01-01 |
2023-08-13 |
mouse |
| Richard Brandon Goertz, Matthew J Wanat, Jorge A Gomez, Zeliene J Brown, Paul E M Phillips, Carlos A Paladin. Cocaine increases dopaminergic neuron and motor activity via midbrain α1 adrenergic signaling. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 5. 2015-12-31. PMID:25374094. |
here, we demonstrate that the rapid elevation in dopamine levels and motor activity elicited by cocaine involves α1 receptor activation within the ventral midbrain. |
2015-12-31 |
2023-08-13 |
rat |
| E Dragicevic, J Schiemann, B Lis. Dopamine midbrain neurons in health and Parkinson's disease: emerging roles of voltage-gated calcium channels and ATP-sensitive potassium channels. Neuroscience. vol 284. 2015-12-30. PMID:25450964. |
dopamine midbrain neurons in health and parkinson's disease: emerging roles of voltage-gated calcium channels and atp-sensitive potassium channels. |
2015-12-30 |
2023-08-13 |
Not clear |
| E Dragicevic, J Schiemann, B Lis. Dopamine midbrain neurons in health and Parkinson's disease: emerging roles of voltage-gated calcium channels and ATP-sensitive potassium channels. Neuroscience. vol 284. 2015-12-30. PMID:25450964. |
dopamine (da) releasing midbrain neurons are essential for multiple brain functions, such as voluntary movement, working memory, emotion and cognition. |
2015-12-30 |
2023-08-13 |
Not clear |
| Jian Yuan, Zhi-nian Lei, Xi Wang, Yong-Jian Deng, Dong-Bo Che. Interaction between Oc-1 and Lmx1a promotes ventral midbrain dopamine neural stem cells differentiation into dopamine neurons. Brain research. vol 1608. 2015-12-24. PMID:25747864. |
interaction between oc-1 and lmx1a promotes ventral midbrain dopamine neural stem cells differentiation into dopamine neurons. |
2015-12-24 |
2023-08-13 |
Not clear |