| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Na Yu, Carmen C Canavie. A Mathematical Model of a Midbrain Dopamine Neuron Identifies Two Slow Variables Likely Responsible for Bursts Evoked by SK Channel Antagonists and Terminated by Depolarization Block. Journal of mathematical neuroscience. vol 5. 2015-04-08. PMID:25852980. |
midbrain dopamine neurons exhibit a novel type of bursting that we call "inverted square wave bursting" when exposed to ca(2+)-activated small conductance (sk) k(+) channel blockers in vitro. |
2015-04-08 |
2023-08-13 |
Not clear |
| Li Li, Junping Cao, Suming Zhang, Cunjin Wang, Jinfeng Wang, Ge Song, Hongjun Wang, Licai Zhan. NCAM signaling mediates the effects of GDNF on chronic morphine-induced neuroadaptations. Journal of molecular neuroscience : MN. vol 53. issue 4. 2015-04-06. PMID:24399412. |
glial cell line-derived neurotrophic factor (gdnf) is a potent neurotrophic factor for midbrain dopamine (da) neurons, while the da neurons in the ventral tegmental area (vta) is a crucial part of the neural circuits associated with drug addiction. |
2015-04-06 |
2023-08-12 |
rat |
| Na Yu, Kristal R Tucker, Edwin S Levitan, Paul D Shepard, Carmen C Canavie. Implications of cellular models of dopamine neurons for schizophrenia. Progress in molecular biology and translational science. vol 123. 2015-04-02. PMID:24560140. |
midbrain dopamine neurons are pacemakers in vitro, but in vivo they fire less regularly and occasionally in bursts that can lead to a temporary cessation in firing produced by depolarization block. |
2015-04-02 |
2023-08-12 |
Not clear |
| Yan Sun, Yan-Shu Li, Jun-Wei Yang, Jia Yu, Yan-Ping Wu, Bai-Xiang L. Exposure to atrazine during gestation and lactation periods: toxicity effects on dopaminergic neurons in offspring by downregulation of Nurr1 and VMAT2. International journal of molecular sciences. vol 15. issue 2. 2015-03-30. PMID:24552878. |
dopamine (da) content was examined in striatum samples by hplc-fl; the mrna expressions of tyrosine hydroxylase (th), orphan nuclear hormone (nurr1), dopamine transporter (dat), and vesicular monoamine transporter 2 (vmat2) in the ventral midbrain samples were examined by fluorescence pcr when the offspring reached one year of age. |
2015-03-30 |
2023-08-12 |
rat |
| Stephan Lammel, Elizabeth E Steinberg, Csaba Földy, Nicholas R Wall, Kevin Beier, Liqun Luo, Robert C Malenk. Diversity of transgenic mouse models for selective targeting of midbrain dopamine neurons. Neuron. vol 85. issue 2. 2015-03-24. PMID:25611513. |
diversity of transgenic mouse models for selective targeting of midbrain dopamine neurons. |
2015-03-24 |
2023-08-13 |
mouse |
| Serge Guerreiro, Clélia Florence, Erwann Rousseau, Sabah Hamadat, Etienne C Hirsch, Patrick P Miche. The sleep-modulating peptide orexin-B protects midbrain dopamine neurons from degeneration, alone or in cooperation with nicotine. Molecular pharmacology. vol 87. issue 3. 2015-03-20. PMID:25552485. |
the sleep-modulating peptide orexin-b protects midbrain dopamine neurons from degeneration, alone or in cooperation with nicotine. |
2015-03-20 |
2023-08-13 |
rat |
| Serge Guerreiro, Clélia Florence, Erwann Rousseau, Sabah Hamadat, Etienne C Hirsch, Patrick P Miche. The sleep-modulating peptide orexin-B protects midbrain dopamine neurons from degeneration, alone or in cooperation with nicotine. Molecular pharmacology. vol 87. issue 3. 2015-03-20. PMID:25552485. |
to determine whether orexinergic hypothalamic peptides can influence the survival of brainstem dopamine (da) neurons, we used a model system of rat midbrain cultures in which da neurons degenerate spontaneously and progressively as they mature. |
2015-03-20 |
2023-08-13 |
rat |
| Minho Moon, Inhye Jeong, Chun-Hyung Kim, Jihong Kim, Paula K J Lee, Inhee Mook-Jung, Pierre Leblanc, Kwang-Soo Ki. Correlation between orphan nuclear receptor Nurr1 expression and amyloid deposition in 5XFAD mice, an animal model of Alzheimer's disease. Journal of neurochemistry. vol 132. issue 2. 2015-03-16. PMID:25156412. |
the functional roles of the orphan nuclear receptor, nurr1, have been extensively studied and well established in the development and survival of midbrain dopamine neurons. |
2015-03-16 |
2023-08-13 |
mouse |
| Oren Griffiths, Robyn Langdon, Mike E Le Pelley, Max Colthear. Delusions and prediction error: re-examining the behavioural evidence for disrupted error signalling in delusion formation. Cognitive neuropsychiatry. vol 19. issue 5. 2015-03-12. PMID:24702287. |
there is now significant evidence that prediction error signalling is mediated by dopamine in the midbrain, and that dopamine dysfunction is implicated in people experiencing psychotic symptoms, including delusions. |
2015-03-12 |
2023-08-13 |
Not clear |
| Barry J Everit. Neural and psychological mechanisms underlying compulsive drug seeking habits and drug memories--indications for novel treatments of addiction. The European journal of neuroscience. vol 40. issue 1. 2015-03-03. PMID:24935353. |
data are reviewed that indicate these transitions from use to abuse to addiction depend upon shifts from ventral to dorsal striatal control over behaviour, mediated in part by serial connectivity between the striatum and midbrain dopamine systems. |
2015-03-03 |
2023-08-13 |
Not clear |
| Michael J Bannon, Magen M Johnson, Sharon K Michelhaugh, Zachary J Hartley, Steven D Halter, James A David, Gregory Kapatos, Carl J Schmid. A molecular profile of cocaine abuse includes the differential expression of genes that regulate transcription, chromatin, and dopamine cell phenotype. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 9. 2015-03-02. PMID:24642598. |
the key contributions of midbrain dopamine (da)-synthesizing neurons throughout the addiction process provide a compelling rationale for determining the drug-induced molecular changes that occur in these cells. |
2015-03-02 |
2023-08-12 |
human |
| Jinyoung Jang, Ki Bum Um, Miae Jang, Shin Hye Kim, Hana Cho, Sungkwon Chung, Hyun Jin Kim, Myoung Kyu Par. Balance between the proximal dendritic compartment and the soma determines spontaneous firing rate in midbrain dopamine neurons. The Journal of physiology. vol 592. issue 13. 2015-02-21. PMID:24756642. |
balance between the proximal dendritic compartment and the soma determines spontaneous firing rate in midbrain dopamine neurons. |
2015-02-21 |
2023-08-13 |
rat |
| Jinyoung Jang, Ki Bum Um, Miae Jang, Shin Hye Kim, Hana Cho, Sungkwon Chung, Hyun Jin Kim, Myoung Kyu Par. Balance between the proximal dendritic compartment and the soma determines spontaneous firing rate in midbrain dopamine neurons. The Journal of physiology. vol 592. issue 13. 2015-02-21. PMID:24756642. |
midbrain dopamine (da) neurons are slow intrinsic pacemakers that require the elaborate composition of many ion channels in the somatodendritic compartments. |
2015-02-21 |
2023-08-13 |
rat |
| James G Green. Causes and consequences of degeneration of the dorsal motor nucleus of the vagus nerve in Parkinson's disease. Antioxidants & redox signaling. vol 21. issue 4. 2015-02-20. PMID:24597973. |
parkinson's disease (pd) is no longer considered merely a movement disorder caused by degeneration of dopamine neurons in the midbrain. |
2015-02-20 |
2023-08-12 |
Not clear |
| Stéphanie Bissonnette, Sophie Muratot, Nathalie Vernoux, François Bezeau, Frédéric Calon, Sébastien S Hébert, Pershia Samad. The effect of striatal pre-enkephalin overexpression in the basal ganglia of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. The European journal of neuroscience. vol 40. issue 2. 2015-02-20. PMID:24750443. |
the midbrain dopamine (da) cell death underlying parkinson's disease (pd) is associated with upregulation of pre-enkephalin (penk) in striatopallidal neurons. |
2015-02-20 |
2023-08-13 |
mouse |
| Kaustuv Saha, Danielle Sambo, Ben D Richardson, Landon M Lin, Brittany Butler, Laura Villarroel, Habibeh Khoshboue. Intracellular methamphetamine prevents the dopamine-induced enhancement of neuronal firing. The Journal of biological chemistry. vol 289. issue 32. 2015-02-19. PMID:24962577. |
we further examined the unique mechanisms by which amphetamine and methamphetamine regulate dat function and dopamine neurotransmission; in the present study we examined the impact of extracellular and intracellular amphetamine and methamphetamine on the spontaneous firing of cultured midbrain dopaminergic neurons and isolated dat-mediated current. |
2015-02-19 |
2023-08-13 |
Not clear |
| Erin S Calipari, Haiguo Sun, Khalil Eldeeb, Deborah J Luessen, Xin Feng, Allyn C Howlett, Sara R Jones, Rong Che. Amphetamine self-administration attenuates dopamine D2 autoreceptor function. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 8. 2015-02-12. PMID:24513972. |
dopamine d2 autoreceptors located on the midbrain dopaminergic neurons modulate dopamine (da) neuron firing, da release, and da synthesis through a negative-feedback mechanism. |
2015-02-12 |
2023-08-12 |
Not clear |
| Yanshu Li, Yan Sun, Junwei Yang, Yanping Wu, Jia Yu, Baixiang L. Age-dependent dopaminergic dysfunction following fetal exposure to atrazine in SD rats. Environmental toxicology and pharmacology. vol 37. issue 3. 2015-01-29. PMID:24863964. |
the mrna and protein expression of orphan nuclear hormone (nurr1), tyrosine hydroxylase(th), vesicular monoaminetransporter 2 (vmat2), dopamine transporter (dat), monoamine (mao), and catechol-o-methyl transferase (comt) in the midbrain were examined by fluorescence pcr and western blot when the offspring reached six-month old or one year old .when measured 6 months post-treatment, the level of da and expression of nurr1, vmat2, dat and th were reduced in the striatum and substantia nigra, respectively. |
2015-01-29 |
2023-08-13 |
human |
| Amandine Berthet, Elyssa B Margolis, Jue Zhang, Ivy Hsieh, Jiasheng Zhang, Thomas S Hnasko, Jawad Ahmad, Robert H Edwards, Hiromi Sesaki, Eric J Huang, Ken Nakamur. Loss of mitochondrial fission depletes axonal mitochondria in midbrain dopamine neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 43. 2015-01-23. PMID:25339743. |
loss of mitochondrial fission depletes axonal mitochondria in midbrain dopamine neurons. |
2015-01-23 |
2023-08-13 |
mouse |
| Xiao-Gang Gong, Hong-Mei Sun, Yi Zhang, Shu-Jing Zhang, Yu-Shan Gao, Jing Feng, Jing-Hong Hu, Cong Gai, Zhen-Yu Guo, Hong Xu, Ling M. Da-bu-yin-wan and qian-zheng-san to neuroprotect the mouse model of Parkinson's disease. Evidence-based complementary and alternative medicine : eCAM. vol 2014. 2015-01-22. PMID:25610480. |
it was observed that dbyw and/or qzs served to ameliorate mptp-induced behavioral impairment and prevent the loss of substantia nigra dopamine neurons, as well as increase atp level in the midbrain tissue and downregulate sur1 expression at mrna and protein levels with no marked influence on kir6.2. |
2015-01-22 |
2023-08-13 |
mouse |