| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Clare L Parish, Lachlan H Thompso. Modulating Wnt signaling to improve cell replacement therapy for Parkinson's disease. Journal of molecular cell biology. vol 6. issue 1. 2014-08-21. PMID:24334258. |
with a greater understanding of failure in prior clinical trials, increased knowledge of midbrain dopamine development (now including wnts), and the development of pluripotent stem cell technologies, we are better equipped than ever to re-address a number of these challenges. |
2014-08-21 |
2023-08-12 |
Not clear |
| Angela Anderegg, Hsin-Pin Lin, Jun-An Chen, Giuliana Caronia-Brown, Natalya Cherepanova, Beth Yun, Milan Joksimovic, Jason Rock, Brian D Harfe, Randy Johnson, Rajeshwar Awatraman. An Lmx1b-miR135a2 regulatory circuit modulates Wnt1/Wnt signaling and determines the size of the midbrain dopaminergic progenitor pool. PLoS genetics. vol 9. issue 12. 2014-08-20. PMID:24348261. |
conditional gain of function studies reveal that lmx1b promotes wnt1/wnt signaling, and thereby increases midbrain size and dopamine progenitor allocation. |
2014-08-20 |
2023-08-12 |
Not clear |
| Angela Anderegg, Hsin-Pin Lin, Jun-An Chen, Giuliana Caronia-Brown, Natalya Cherepanova, Beth Yun, Milan Joksimovic, Jason Rock, Brian D Harfe, Randy Johnson, Rajeshwar Awatraman. An Lmx1b-miR135a2 regulatory circuit modulates Wnt1/Wnt signaling and determines the size of the midbrain dopaminergic progenitor pool. PLoS genetics. vol 9. issue 12. 2014-08-20. PMID:24348261. |
we posit that microrna modulation of the lmx1b/wnt axis in the early midbrain/isthmus could determine midbrain size and allocation of dopamine progenitors. |
2014-08-20 |
2023-08-12 |
Not clear |
| Yanhong Zhou, Sharon K Michelhaugh, Carl J Schmidt, Jun S Liu, Michael J Bannon, Zhicheng Li. Ventral midbrain correlation between genetic variation and expression of the dopamine transporter gene in cocaine-abusing versus non-abusing subjects. Addiction biology. vol 19. issue 1. 2014-08-18. PMID:22026501. |
ventral midbrain correlation between genetic variation and expression of the dopamine transporter gene in cocaine-abusing versus non-abusing subjects. |
2014-08-18 |
2023-08-12 |
human |
| Martin Sarter, Roger L Albin, Aaron Kucinski, Cindy Lusti. Where attention falls: Increased risk of falls from the converging impact of cortical cholinergic and midbrain dopamine loss on striatal function. Experimental neurology. vol 257. 2014-08-13. PMID:24805070. |
where attention falls: increased risk of falls from the converging impact of cortical cholinergic and midbrain dopamine loss on striatal function. |
2014-08-13 |
2023-08-13 |
Not clear |
| Christoph Straub, Nicolas X Tritsch, Nellwyn A Hagan, Chenghua Gu, Bernardo L Sabatin. Multiphasic modulation of cholinergic interneurons by nigrostriatal afferents. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 25. 2014-08-12. PMID:24948810. |
the motor and learning functions of the striatum are critically dependent on synaptic transmission from midbrain dopamine neurons and striatal cholinergic interneurons (cins). |
2014-08-12 |
2023-08-13 |
mouse |
| Christoph Straub, Nicolas X Tritsch, Nellwyn A Hagan, Chenghua Gu, Bernardo L Sabatin. Multiphasic modulation of cholinergic interneurons by nigrostriatal afferents. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 25. 2014-08-12. PMID:24948810. |
whereas midbrain dopamine neurons respond to salient stimuli with a brief burst of activity, cins exhibit a distinct pause in firing that is often followed by a period of increased excitability. |
2014-08-12 |
2023-08-13 |
mouse |
| Christoph Straub, Nicolas X Tritsch, Nellwyn A Hagan, Chenghua Gu, Bernardo L Sabatin. Multiphasic modulation of cholinergic interneurons by nigrostriatal afferents. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 25. 2014-08-12. PMID:24948810. |
these findings imply that, in addition to their direct effects on striatal projection neurons, midbrain dopamine neurons indirectly modulate striatal output by dynamically controlling cholinergic tone. |
2014-08-12 |
2023-08-13 |
mouse |
| Nicholas A Courtney, Christopher P For. The timing of dopamine- and noradrenaline-mediated transmission reflects underlying differences in the extent of spillover and pooling. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 22. 2014-08-05. PMID:24872568. |
incorporating the results into a model simulating extracellular diffusion predicted that the functional range of noradrenaline diffusion was nearly fivefold greater in the locus ceruleus than dopamine in the midbrain. |
2014-08-05 |
2023-08-13 |
mouse |
| Síle M Griffin, Mark R Pickard, Rowan P Orme, Clive P Hawkins, Rosemary A Fricke. Nicotinamide promotes neuronal differentiation of mouse embryonic stem cells in vitro. Neuroreport. vol 24. issue 18. 2014-07-31. PMID:24257250. |
future work will focus on evaluating the effect of nicotinamide on the differentiation of midbrain dopamine neurons, towards a therapy for parkinson's disease. |
2014-07-31 |
2023-08-12 |
mouse |
| Christian L Roth, Anke Hinney, Ellen A Schur, Clinton T Elfers, Thomas Reineh. Association analyses for dopamine receptor gene polymorphisms and weight status in a longitudinal analysis in obese children before and after lifestyle intervention. BMC pediatrics. vol 13. 2014-07-31. PMID:24283216. |
dopamine receptors are involved in midbrain reward circuit activation. |
2014-07-31 |
2023-08-12 |
Not clear |
| Sally J Vogel, Gregory P Strauss, Daniel N Alle. Using negative feedback to guide behavior: impairments on the first 4 cards of the Wisconsin Card Sorting Test predict negative symptoms of schizophrenia. Schizophrenia research. vol 151. issue 1-3. 2014-07-29. PMID:24210530. |
these learning deficits are thought to arise from abnormalities in midbrain dopamine activity. |
2014-07-29 |
2023-08-12 |
human |
| Mickael Decressac, Nikolaos Volakakis, Anders Björklund, Thomas Perlman. NURR1 in Parkinson disease--from pathogenesis to therapeutic potential. Nature reviews. Neurology. vol 9. issue 11. 2014-07-28. PMID:24126627. |
in parkinson disease (pd), affected midbrain dopamine (da) neurons lose specific dopaminergic properties before the neurons die. |
2014-07-28 |
2023-08-12 |
Not clear |
| D Eugene Redmond, Caleb R S McEntire, Joseph P Kingsbery, Csaba Leranth, John D Elsworth, Kimberly B Bjugstad, Robert H Roth, Richard J Samulski, John R Slade. Comparison of fetal mesencephalic grafts, AAV-delivered GDNF, and both combined in an MPTP-induced nonhuman primate Parkinson's model. Molecular therapy : the journal of the American Society of Gene Therapy. vol 21. issue 12. 2014-07-25. PMID:23913185. |
we combined viral vector delivery of human glial-derived neurotrophic factor (gdnf) with the grafting of dopamine (da) precursor cells from fetal ventral mesencephalon (vm) to determine whether these strategies would improve the anti-parkinson's effects in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-treated monkeys, an animal model for parkinson's disease (pd). |
2014-07-25 |
2023-08-12 |
human |
| Navneet Khurana, Asmita Gajbhiy. Ameliorative effect of Sida cordifolia in rotenone induced oxidative stress model of Parkinson's disease. Neurotoxicology. vol 39. 2014-07-23. PMID:23994302. |
the rotenone induced decrease of dopamine level in the midbrain region of rats was also attenuated by co-treatment of aesc-100mg/kg and afsc-100mg/kg. |
2014-07-23 |
2023-08-12 |
rat |
| Mats I Ekstrand, Alexander R Nectow, Zachary A Knight, Kaamashri N Latcha, Lisa E Pomeranz, Jeffrey M Friedma. Molecular profiling of neurons based on connectivity. Cell. vol 157. issue 5. 2014-07-23. PMID:24855954. |
we then used an aav to selectively profile midbrain dopamine neurons projecting to the nucleus accumbens. |
2014-07-23 |
2023-08-13 |
Not clear |
| Sooyoung Chung, Eun Jeong Lee, Seongsik Yun, Han Kyoung Choe, Seong-Beom Park, Hyo Jin Son, Kwang-Soo Kim, Dean E Dluzen, Inah Lee, Onyou Hwang, Gi Hoon Son, Kyungjin Ki. Impact of circadian nuclear receptor REV-ERBα on midbrain dopamine production and mood regulation. Cell. vol 157. issue 4. 2014-07-15. PMID:24813609. |
impact of circadian nuclear receptor rev-erbα on midbrain dopamine production and mood regulation. |
2014-07-15 |
2023-08-13 |
mouse |
| Sooyoung Chung, Eun Jeong Lee, Seongsik Yun, Han Kyoung Choe, Seong-Beom Park, Hyo Jin Son, Kwang-Soo Kim, Dean E Dluzen, Inah Lee, Onyou Hwang, Gi Hoon Son, Kyungjin Ki. Impact of circadian nuclear receptor REV-ERBα on midbrain dopamine production and mood regulation. Cell. vol 157. issue 4. 2014-07-15. PMID:24813609. |
here, we show that the circadian nuclear receptor rev-erbα, which is associated with bipolar disorder, impacts midbrain dopamine production and mood-related behavior in mice. |
2014-07-15 |
2023-08-13 |
mouse |
| Weidong L. Role of iron in UPS impairment model of Parkinson's disease. Parkinsonism & related disorders. vol 20 Suppl 1. 2014-07-11. PMID:24262171. |
our studies have shown that injection of the proteasome inhibitor lactacystin in the substantia nigra (sn) of rodents causes significant loss of dopamine (da) neurons and induces intracellular inclusion body formation, which is accompanied by excessive iron accumulation in the midbrain. |
2014-07-11 |
2023-08-12 |
Not clear |
| Hui-Hsing Hung, Wei-Pang Huang, Chien-Yuan Pa. Dopamine- and zinc-induced autophagosome formation facilitates PC12 cell survival. Cell biology and toxicology. vol 29. issue 6. 2014-07-07. PMID:24077806. |
primary embryonic midbrain neurons expressing egfp-lc3 also displayed a significant increase in the number of fluorescent aggregates in cells upon treatment with dopamine or zn2+. |
2014-07-07 |
2023-08-12 |
Not clear |