| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Peng Zhong, Xiaojie Liu, Zhen Zhang, Ying Hu, Sarah J Liu, Martha Lezama-Ruiz, Milan Joksimovic, Qing-song Li. Cyclin-dependent kinase 5 in the ventral tegmental area regulates depression-related behaviors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 18. 2014-06-23. PMID:24790206. |
using the cre/loxp system to selectively delete cdk5 in the vta or in midbrain dopamine neurons in cdk5(loxp/loxp) mice, we showed that cdk5 loss of function in the vta induced anxiety- and depressive-like behaviors that were associated with decreases in th phosphorylation at ser31 and ser40 in the vta and dopamine release in its target region, the nucleus accumbens. |
2014-06-23 |
2023-08-13 |
mouse |
| Elham H A Ali, Amany H Mahmoud Elgol. Combined prenatal and postnatal butyl paraben exposure produces autism-like symptoms in offspring: comparison with valproic acid autistic model. Pharmacology, biochemistry, and behavior. vol 111. 2014-06-13. PMID:24036472. |
the offspring male rats were subjected at the last 3 days of lactation to morris water maze and three chamber sociability test then decapitated and the brain was excised and dissected to the cortex, hippocampus, cerebellum, midbrain and pons for the determination of norepinephrine, dopamine and serotonin (ne, da and 5-ht) and cortex amino acids and whole brain bdnf. |
2014-06-13 |
2023-08-12 |
rat |
| Fredrik H Sterky, Karin Pernold, Brandon K Harvey, Eva Lindqvist, Barry J Hoffer, Lars Olso. Glial cell line-derived neurotrophic factor partially ameliorates motor symptoms without slowing neurodegeneration in mice with respiratory chain-deficient dopamine neurons. Cell transplantation. vol 22. issue 9. 2014-06-09. PMID:23051605. |
degeneration of midbrain dopamine neurons causes the striatal dopamine deficiency responsible for the hallmark motor symptoms of parkinson's disease (pd). |
2014-06-09 |
2023-08-12 |
mouse |
| Fredrik H Sterky, Karin Pernold, Brandon K Harvey, Eva Lindqvist, Barry J Hoffer, Lars Olso. Glial cell line-derived neurotrophic factor partially ameliorates motor symptoms without slowing neurodegeneration in mice with respiratory chain-deficient dopamine neurons. Cell transplantation. vol 22. issue 9. 2014-06-09. PMID:23051605. |
these behavioral changes are accompanied by increased levels of dopamine in the midbrain, but not in striatum. |
2014-06-09 |
2023-08-12 |
mouse |
| Jaemin Kim, Perminder Sachdev, Kuldip Sidh. Alginate microcapsule as a 3D platform for the efficient differentiation of human embryonic stem cells to dopamine neurons. Stem cell research. vol 11. issue 3. 2014-06-07. PMID:23900167. |
we present an approach to culture and differentiate hescs into midbrain dopamine (mdda) neurons in a 3d microenvironment using alginate microcapsules for the first time. |
2014-06-07 |
2023-08-12 |
human |
| J L Badger, O Cordero-Llana, E M Hartfield, R Wade-Martin. Parkinson's disease in a dish - Using stem cells as a molecular tool. Neuropharmacology. vol 76 Pt A. 2014-06-05. PMID:24035919. |
the cardinal motor symptoms of the disease result from the loss of dopamine (da) neurons in the midbrain. |
2014-06-05 |
2023-08-12 |
human |
| Shin Hye Kim, Jin Young Jang, Miae Jang, Ki Bum Um, Sungkwon Chung, Hyun Jin Kim, Myoung Kyu Par. Homeostatic regulation mechanism of spontaneous firing determines glutamate responsiveness in the midbrain dopamine neurons. Cell calcium. vol 54. issue 4. 2014-05-27. PMID:23988034. |
homeostatic regulation mechanism of spontaneous firing determines glutamate responsiveness in the midbrain dopamine neurons. |
2014-05-27 |
2023-08-12 |
Not clear |
| Shin Hye Kim, Jin Young Jang, Miae Jang, Ki Bum Um, Sungkwon Chung, Hyun Jin Kim, Myoung Kyu Par. Homeostatic regulation mechanism of spontaneous firing determines glutamate responsiveness in the midbrain dopamine neurons. Cell calcium. vol 54. issue 4. 2014-05-27. PMID:23988034. |
autonomous tonic firing of the midbrain dopamine neuron is essential for maintenance of ambient dopamine level in the brain, in which intracellular ca2+ concentration ([ca2+]c) plays a complex but pivotal role. |
2014-05-27 |
2023-08-12 |
Not clear |
| Shin Hye Kim, Jin Young Jang, Miae Jang, Ki Bum Um, Sungkwon Chung, Hyun Jin Kim, Myoung Kyu Par. Homeostatic regulation mechanism of spontaneous firing determines glutamate responsiveness in the midbrain dopamine neurons. Cell calcium. vol 54. issue 4. 2014-05-27. PMID:23988034. |
in the midbrain dopamine neurons, we here show that spontaneous firing evoked [ca2+]c changes in a phasic manner in the dendritic region but a tonic manner in the soma. |
2014-05-27 |
2023-08-12 |
Not clear |
| Anton Ilango, Andrew J Kesner, Carl J Broker, Dong V Wang, Satoshi Ikemot. Phasic excitation of ventral tegmental dopamine neurons potentiates the initiation of conditioned approach behavior: parametric and reinforcement-schedule analyses. Frontiers in behavioral neuroscience. vol 8. 2014-05-16. PMID:24834037. |
midbrain dopamine neurons are implicated in motivation and learning. |
2014-05-16 |
2023-08-13 |
mouse |
| Stefanie Reyes, Veronica Cottam, Deniz Kirik, Kay L Double, Glenda M Hallida. Variability in neuronal expression of dopamine receptors and transporters in the substantia nigra. Movement disorders : official journal of the Movement Disorder Society. vol 28. issue 10. 2014-05-09. PMID:23674405. |
recent studies have suggested that alterations in dopamine receptors in the midbrain underlie impulsive behaviors and that more impulsive individuals, including patients with pd, exhibit increased occupancy of their midbrain dopamine receptors. |
2014-05-09 |
2023-08-12 |
human |
| Stefanie Reyes, Veronica Cottam, Deniz Kirik, Kay L Double, Glenda M Hallida. Variability in neuronal expression of dopamine receptors and transporters in the substantia nigra. Movement disorders : official journal of the Movement Disorder Society. vol 28. issue 10. 2014-05-09. PMID:23674405. |
the midbrain dopamine regions associated with impulsivity (medial nigra and ventral tegmental area [vta]) expressed less dopamine transporter on their neurons than other midbrain dopamine regions. |
2014-05-09 |
2023-08-12 |
human |
| Stefanie Reyes, Veronica Cottam, Deniz Kirik, Kay L Double, Glenda M Hallida. Variability in neuronal expression of dopamine receptors and transporters in the substantia nigra. Movement disorders : official journal of the Movement Disorder Society. vol 28. issue 10. 2014-05-09. PMID:23674405. |
the heterogeneous pattern of dopamine receptors and transporters in the human midbrain suggests that the effects of dopamine and dopamine agonists are likely to be nonuniform. |
2014-05-09 |
2023-08-12 |
human |
| Stefanie Reyes, Veronica Cottam, Deniz Kirik, Kay L Double, Glenda M Hallida. Variability in neuronal expression of dopamine receptors and transporters in the substantia nigra. Movement disorders : official journal of the Movement Disorder Society. vol 28. issue 10. 2014-05-09. PMID:23674405. |
the expression of excitatory d1 receptors on nigral dopamine neurons in midbrain regions associated with impulsivity, and their variable loss as seen in pd, may be of particular interest for impulse control. |
2014-05-09 |
2023-08-12 |
human |
| Luca Aquil. The causal role between phasic midbrain dopamine signals and learning. Frontiers in behavioral neuroscience. vol 8. 2014-05-05. PMID:24795588. |
the causal role between phasic midbrain dopamine signals and learning. |
2014-05-05 |
2023-08-13 |
Not clear |
| Shujie Wang, Yan Tan, Ju-En Zhang, Minmin Lu. Pharmacogenetic activation of midbrain dopaminergic neurons induces hyperactivity. Neuroscience bulletin. vol 29. issue 5. 2014-05-02. PMID:23516143. |
this study was carried out to directly test whether selective activation of dopamine neurons in the midbrain induces hyperactivity. |
2014-05-02 |
2023-08-12 |
mouse |
| Shujie Wang, Yan Tan, Ju-En Zhang, Minmin Lu. Pharmacogenetic activation of midbrain dopaminergic neurons induces hyperactivity. Neuroscience bulletin. vol 29. issue 5. 2014-05-02. PMID:23516143. |
a pharmacogenetic approach was used to activate midbrain dopamine neurons, and behavioral assays were conducted to determine the effects on mouse activity levels. |
2014-05-02 |
2023-08-12 |
mouse |
| Allyson K Friedman, Jessica J Walsh, Barbara Juarez, Stacy M Ku, Dipesh Chaudhury, Jing Wang, Xianting Li, David M Dietz, Nina Pan, Vincent F Vialou, Rachael L Neve, Zhenyu Yue, Ming-Hu Ha. Enhancing depression mechanisms in midbrain dopamine neurons achieves homeostatic resilience. Science (New York, N.Y.). vol 344. issue 6181. 2014-04-28. PMID:24744379. |
enhancing depression mechanisms in midbrain dopamine neurons achieves homeostatic resilience. |
2014-04-28 |
2023-08-13 |
mouse |
| Nao Chuhma, Susana Mingote, Holly Moore, Stephen Raypor. Dopamine neurons control striatal cholinergic neurons via regionally heterogeneous dopamine and glutamate signaling. Neuron. vol 81. issue 4. 2014-04-23. PMID:24559678. |
midbrain dopamine neurons fire in bursts conveying salient information. |
2014-04-23 |
2023-08-12 |
Not clear |
| Martín F Adrover, Jung Hoon Shin, Veronica A Alvare. Glutamate and dopamine transmission from midbrain dopamine neurons share similar release properties but are differentially affected by cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 9. 2014-04-22. PMID:24573277. |
glutamate and dopamine transmission from midbrain dopamine neurons share similar release properties but are differentially affected by cocaine. |
2014-04-22 |
2023-08-12 |
mouse |