| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kenichi Fukumoto, Michihiko Iijima, Shigeyuki Chak. Serotonin-1A receptor stimulation mediates effects of a metabotropic glutamate 2/3 receptor antagonist, 2S-2-amino-2-(1S,2S-2-carboxycycloprop-1-yl)-3-(xanth-9-yl)propanoic acid (LY341495), and an N-methyl-D-aspartate receptor antagonist, ketamine, in the novelty-suppressed feeding test. Psychopharmacology. vol 231. issue 11. 2014-12-29. PMID:24402133. |
ampa receptor stimulation has also been shown to mediate an increase in the extracellular level of serotonin (5-ht) in the medial prefrontal cortex by an mglu2/3 receptor antagonist in rats. |
2014-12-29 |
2023-08-12 |
rat |
| Shimako Yoshitake, Eugenia Kuteeva, Tomas Hökfelt, Françoise Mennicken, Elvar Theodorsson, Masatoshi Yamaguchi, Jan Kehr, Takashi Yoshitak. Correlation between the effects of local and intracerebroventricular infusions of galanin on 5-HT release studied by microdialysis, and distribution of galanin and galanin receptors in prefrontal cortex, ventral hippocampus, amygdala, hypothalamus, and striatum of awake rats. Synapse (New York, N.Y.). vol 68. issue 5. 2014-11-07. PMID:24430888. |
infusions of galanin on basal extracellular 5-ht levels in medial prefrontal cortex (mpfc), ca1 area of ventral hippocampus (vhpc), central amygdaloid nucleus (cea), ventromedial hypothalamic nucleus ventrolateral part (vmhvl), and ventromedial caudate putamen (cpu). |
2014-11-07 |
2023-08-12 |
rat |
| Ken-Ichi Ohta, Takanori Miki, Katsuhiko Warita, Shingo Suzuki, Takashi Kusaka, Tomiko Yakura, Jun-Qian Liu, Motoki Tamai, Yoshiki Takeuch. Prolonged maternal separation disturbs the serotonergic system during early brain development. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 33. 2014-10-10. PMID:24184298. |
hplc revealed imbalance between serotonin and 5-hydroxyindoleacetic acid in midbrain raphe nuclei, the amygdala, the hippocampus, and the medial prefrontal cortex (mpfc) on pds 7 and 14. |
2014-10-10 |
2023-08-12 |
rat |
| Noelle C Anastasio, Sonja J Stutz, Robert G Fox, Robert M Sears, Ronald B Emeson, Ralph J DiLeone, Richard T O'Neil, Latham H Fink, Dingge Li, Thomas A Green, F Gerard Moeller, Kathryn A Cunningha. Functional status of the serotonin 5-HT2C receptor (5-HT2CR) drives interlocked phenotypes that precipitate relapse-like behaviors in cocaine dependence. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 2. 2014-08-21. PMID:23939424. |
the serotonin (5-hydroxytryptamine, 5-ht) 5-ht2c receptor (5-ht2cr) within the medial prefrontal cortex (mpfc) is uniquely poised to serve as a strategic nexus to mechanistically control these behaviors. |
2014-08-21 |
2023-08-12 |
rat |
| Andrew E Arrant, Elizabeth Coburn, Jacob Jacobsen, Cynthia M Kuh. Lower anxiogenic effects of serotonin agonists are associated with lower activation of amygdala and lateral orbital cortex in adolescent male rats. Neuropharmacology. vol 73. 2014-08-13. PMID:23774134. |
increased extracellular serotonin in the medial prefrontal cortex similarly in both ages. |
2014-08-13 |
2023-08-12 |
rat |
| Yuxin He, Jia Chen, Zimei Pan, Zhou Yin. Scalp acupuncture treatment protocol for anxiety disorders: a case report. Global advances in health and medicine. vol 3. issue 4. 2014-08-08. PMID:25105075. |
the possible mechanism of action of scalp acupuncture on anxiety disorder may be related to overlapping modulatory effects on the cortical structures (orbitofrontal cortex [ofc]) and medial prefrontal cortex [mpfc]) and subcortical/limbic regions (amygdala and hippocampus), and biochemical effect of acupuncture through immunohistochemistry (norepinephrine, serotonin) performed directly to the brain tissue for anxiety disorders. |
2014-08-08 |
2023-08-13 |
Not clear |
| Francesco Cresp. In vivo oxymetric analysis of mild hypercapnia upon cerebral oxygen, temperature and blood flow: markers of mood as proposed by concomitant bupropion challenge and electrochemical analysis? Experimental brain research. vol 230. issue 4. 2014-05-27. PMID:23503770. |
here, in vivo flow-oxymetry is applied to verify relationships between cerebral oxygen tension (po2), blood flow (cbf), that are markers of brain metabolism, and temperature (t), while in vivo voltammetry is concomitantly applied in the medial prefrontal cortex of anaesthetized rats to monitor monoamine levels such as dopamine (da) and serotonin. |
2014-05-27 |
2023-08-12 |
rat |
| Alan L Pehrson, Thomas Cremers, Cecile Bétry, Marieke G C van der Hart, Laerke Jørgensen, Mathias Madsen, Nasser Haddjeri, Bjarke Ebert, Connie Sanche. Lu AA21004, a novel multimodal antidepressant, produces regionally selective increases of multiple neurotransmitters--a rat microdialysis and electrophysiology study. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 23. issue 2. 2014-04-21. PMID:22612991. |
extracellular 5-ht, ne and da levels were evaluated in the ventral hippocampus (vhc), medial prefrontal cortex (mpfc) and nucleus accumbens (nac) after acute and subchronic treatment with lu aa21004 or escitalopram. |
2014-04-21 |
2023-08-12 |
rat |
| Pedro Bekinschtein, Maria Constanza Renner, Maria Carolina Gonzalez, Noelia Weisstau. Role of medial prefrontal cortex serotonin 2A receptors in the control of retrieval of recognition memory in rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 40. 2013-11-25. PMID:24089480. |
role of medial prefrontal cortex serotonin 2a receptors in the control of retrieval of recognition memory in rats. |
2013-11-25 |
2023-08-12 |
human |
| A J D Nelson, K E Thur, C A Marsden, H J Cassada. Paradoxical effects of low dose MDMA on latent inhibition in the rat. Neuropharmacology. vol 67. 2013-11-04. PMID:23201353. |
moreover, there were small but significant reductions in 5-ht in medial prefrontal cortex (mpfc) and amygdala assayed 7 days post mdma administration (2 × 6 mg/kg, 24 h apart). |
2013-11-04 |
2023-08-12 |
rat |
| Andrew E Arrant, Hikma Jemal, Cynthia M Kuh. Adolescent male rats are less sensitive than adults to the anxiogenic and serotonin-releasing effects of fenfluramine. Neuropharmacology. vol 65. 2013-10-17. PMID:23103347. |
produced greater anxiogenic effects in adult rats in both the light/dark and elevated plus maze tests for anxiety-like behavior, and stimulated greater increases in extracellular serotonin in the adult medial prefrontal cortex (mpfc) (1, 2.5, and 10 mg/kg, i.p.). |
2013-10-17 |
2023-08-12 |
rat |
| Josefine S Witteveen, Anthonieke Middelman, Josephus A van Hulten, Gerard J M Martens, Judith R Homberg, Sharon M Kol. Lack of serotonin reuptake during brain development alters rostral raphe-prefrontal network formation. Frontiers in cellular neuroscience. vol 7. 2013-10-10. PMID:24109430. |
one of the targets of the 5-ht projection system, originating in the brainstem raphe nuclei, is the medial prefrontal cortex (mpfc), an area involved in higher cognitive functions and important in the etiology of many neurodevelopmental disorders. |
2013-10-10 |
2023-08-12 |
rat |
| Iku Tsutsui-Kimura, Yu Ohmura, Takeshi Izumi, Haruko Kumamoto, Taku Yamaguchi, Takayuki Yoshida, Mitsuhiro Yoshiok. Milnacipran enhances the control of impulsive action by activating D₁-like receptors in the infralimbic cortex. Psychopharmacology. vol 225. issue 2. 2013-06-10. PMID:22892727. |
milnacipran increases not only extracellular serotonin and noradrenaline but also dopamine specifically in the medial prefrontal cortex, which is one of the brain regions responsible for impulsive action. |
2013-06-10 |
2023-08-12 |
rat |
| C Hou, L Xue, J Feng, L Zhang, Y Wang, L Chen, T Wang, Q J Zhang, J Li. Unilateral lesion of the nigrostriatal pathway decreases the response of GABA interneurons in the dorsal raphe nucleus to 5-HT(1A) receptor stimulation in the rat. Neurochemistry international. vol 61. issue 8. 2013-05-24. PMID:23032407. |
this study examined the firing rate and pattern of electrophysiologically and chemically identified gaba interneurons in the dorsal raphe nucleus (drn), and role of 5-ht(1a) receptor agonist 8-oh-dpat and the medial prefrontal cortex (mpfc) in the firing activity in rats with 6-hydroxydopamine lesions of the substantia nigra pars compacta (snc). |
2013-05-24 |
2023-08-12 |
rat |
| Nobuo Tsuruoka, Yoshinori Beppu, Hirofumi Koda, Nobutaka Doe, Hiroshi Watanabe, Keiichi Ab. A DKP cyclo(L-Phe-L-Phe) found in chicken essence is a dual inhibitor of the serotonin transporter and acetylcholinesterase. PloS one. vol 7. issue 11. 2013-05-22. PMID:23209830. |
the dkp increased extracellular levels of the cerebral monoamines serotonin, norepinephrine, and dopamine in the medial prefrontal cortex and acetylcholine in the ventral hippocampus of freely moving rats when administered orally. |
2013-05-22 |
2023-08-12 |
mouse |
| Caroline A Browne, Gerard Clarke, Joachim Hanke, Timothy G Dinan, Herbert Schwegler, Deniz M Yilmazer-Hanke, John F Crya. Alterations in prefrontal cortical serotonin and antidepressant-like behavior in a novel C3H/HeJxDBA/2J recombinant inbred mouse strain. Behavioural brain research. vol 236. issue 1. 2013-04-23. PMID:22960457. |
significantly increased concentrations of 5-ht and its metabolite 5-hiaa were observed in the medial prefrontal cortex (mpfc) but not in the hypothalamus, striatum, hippocampus, amygdala, or midbrain of high-fss mice compared to low-fss mice. |
2013-04-23 |
2023-08-12 |
mouse |
| Florent G Revel, Claas A Meyer, Amyaouch Bradaia, Karine Jeanneau, Eleonora Calcagno, Cédric B André, Markus Haenggi, Marie-Thérèse Miss, Guido Galley, Roger D Norcross, Roberto W Invernizzi, Joseph G Wettstein, Jean-Luc Moreau, Marius C Hoene. Brain-specific overexpression of trace amine-associated receptor 1 alters monoaminergic neurotransmission and decreases sensitivity to amphetamine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 12. 2013-03-22. PMID:22763617. |
taar1 transgenic mice did not show overt behavioral abnormalities under baseline conditions, despite augmented extracellular levels of dopamine and noradrenaline in the accumbens nucleus (acb) and of serotonin in the medial prefrontal cortex. |
2013-03-22 |
2023-08-12 |
mouse |
| Cinzia Nasuti, Manuel Carloni, Donatella Fedeli, Rosita Gabbianelli, Antonio Di Stefano, Cerasa Laura Serafina, Isabel Silva, Valentina Domingues, Roberto Ciccociopp. Effects of early life permethrin exposure on spatial working memory and on monoamine levels in different brain areas of pre-senescent rats. Toxicology. vol 303. 2013-03-07. PMID:23174539. |
the predominant disturbances concern the dopamine (da) depletion in the striatum and, the serotonin (5-ht) and noradrenaline (ne) unbalance together with a hypometabolic state in the medial prefrontal cortex area. |
2013-03-07 |
2023-08-12 |
rat |
| Daniella Johansson, Aki Falk, Monica M Marcus, Torgny H Svensso. Celecoxib enhances the effect of reboxetine and fluoxetine on cortical noradrenaline and serotonin output in the rat. Progress in neuro-psychopharmacology & biological psychiatry. vol 39. issue 1. 2013-01-21. PMID:22691715. |
to examine the neurobiological underpinnings to the clinical observations, we here studied the acute effects of a combined treatment with celecoxib and reboxetine on noradrenaline and dopamine output, as well as celecoxib and fluoxetine on 5-ht output in the medial prefrontal cortex, using in vivo microdialysis in awake freely moving rats. |
2013-01-21 |
2023-08-12 |
rat |
| Xavier López-Gil, Laura Jiménez-Sánchez, Tamara Romón, Leticia Campa, Francesc Artigas, Albert Adel. Importance of inter-hemispheric prefrontal connection in the effects of non-competitive NMDA receptor antagonists. The international journal of neuropsychopharmacology. vol 15. issue 7. 2012-12-11. PMID:21733285. |
dialysis probes were implanted in the medial prefrontal cortex, and extracellular serotonin as well as behavioural stereotypies was measured after systemic administration of mk-801 and ketamine (1 mg/kg and 25 mg/kg, respectively), and unilateral and bilateral perfusion of both drugs (300 μm and 3 mm, respectively). |
2012-12-11 |
2023-08-12 |
Not clear |