| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| John R Cirrito, Brianne M Disabato, Jessica L Restivo, Deborah K Verges, Whitney D Goebel, Anshul Sathyan, Davinder Hayreh, Gina D'Angelo, Tammie Benzinger, Hyejin Yoon, Jungsu Kim, John C Morris, Mark A Mintun, Yvette I Shelin. Serotonin signaling is associated with lower amyloid-β levels and plaques in transgenic mice and humans. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 36. 2011-11-02. PMID:21873225. |
similarly, direct infusion of serotonin into the hippocampus reduced isf aβ levels. |
2011-11-02 |
2023-08-12 |
mouse |
| Elin Sörman, Dannie Wang, Mihaly Hajos, Bernat Kocsi. Control of hippocampal theta rhythm by serotonin: role of 5-HT2c receptors. Neuropharmacology. vol 61. issue 3. 2011-10-14. PMID:21281651. |
control of hippocampal theta rhythm by serotonin: role of 5-ht2c receptors. |
2011-10-14 |
2023-08-12 |
rat |
| Martin Egeland, Jennifer Warner-Schmidt, Paul Greengard, Per Svenningsso. Co-expression of serotonin 5-HT(1B) and 5-HT(4) receptors in p11 containing cells in cerebral cortex, hippocampus, caudate-putamen and cerebellum. Neuropharmacology. vol 61. issue 3. 2011-10-14. PMID:21300076. |
co-expression of serotonin 5-ht(1b) and 5-ht(4) receptors in p11 containing cells in cerebral cortex, hippocampus, caudate-putamen and cerebellum. |
2011-10-14 |
2023-08-12 |
mouse |
| Martin Egeland, Jennifer Warner-Schmidt, Paul Greengard, Per Svenningsso. Co-expression of serotonin 5-HT(1B) and 5-HT(4) receptors in p11 containing cells in cerebral cortex, hippocampus, caudate-putamen and cerebellum. Neuropharmacology. vol 61. issue 3. 2011-10-14. PMID:21300076. |
in the present study, we examined to what extent p11 containing neurons co-expressed 5-ht(1b)r and/or 5-ht(4)r in cerebral cortex, hippocampus, cerebellum and caudate-putamen. |
2011-10-14 |
2023-08-12 |
mouse |
| Martin Egeland, Jennifer Warner-Schmidt, Paul Greengard, Per Svenningsso. Co-expression of serotonin 5-HT(1B) and 5-HT(4) receptors in p11 containing cells in cerebral cortex, hippocampus, caudate-putamen and cerebellum. Neuropharmacology. vol 61. issue 3. 2011-10-14. PMID:21300076. |
in the caudate-putamen, the hippocampal pyramidal cell layer of ca1 and the hippocampal granule cell layer of dentate gyrus, most p11 containing cells co-expressed both 5-ht(1b)r and 5-ht(4)r. in the cingulate cortex, stratum radiatum/oriens of ca1, hilus of the dentate gyrus and cerebellar cortex, many cells co-expressed p11 and 5-ht(1b)r, but not 5-ht(4)r. in the studied brain regions, few cells solely expressed p11 without any significant expression of 5-ht(1b)r or 5-ht(4)r. it can be concluded that p11 is anatomically positioned to modulate serotonin neurotransmission, via 5-ht(1b)r and 5-ht(4)r, in brain regions important for emotionality, cognition and locomotion. |
2011-10-14 |
2023-08-12 |
mouse |
| Charles A Marsden, Madeleine V King, Kevin C F Fon. Influence of social isolation in the rat on serotonergic function and memory--relevance to models of schizophrenia and the role of 5-HT₆ receptors. Neuropharmacology. vol 61. issue 3. 2011-10-14. PMID:21414329. |
there is evidence that a key effect of social isolation may be loss of neuronal plasticity combined with change in the functional state of various cortical and hippocampal neurotransmitters, including glutamate and serotonin. |
2011-10-14 |
2023-08-12 |
human |
| Wendy Adams, Maarten van den Buus. Hippocampal serotonin depletion facilitates the enhancement of prepulse inhibition by risperidone: possible role of 5-HT(2C) receptors in the dorsal hippocampus. Neuropharmacology. vol 61. issue 3. 2011-10-14. PMID:21477601. |
hippocampal serotonin depletion facilitates the enhancement of prepulse inhibition by risperidone: possible role of 5-ht(2c) receptors in the dorsal hippocampus. |
2011-10-14 |
2023-08-12 |
rat |
| Wendy Adams, Maarten van den Buus. Hippocampal serotonin depletion facilitates the enhancement of prepulse inhibition by risperidone: possible role of 5-HT(2C) receptors in the dorsal hippocampus. Neuropharmacology. vol 61. issue 3. 2011-10-14. PMID:21477601. |
the present study explored the effect of serotonin depletion (>70%) along the dorsoventral axis of the hippocampus, or of partial serotonin depletion (∼50%) in the ventral hippocampus, on ppi modulation by acute antipsychotic drug treatment. |
2011-10-14 |
2023-08-12 |
rat |
| Wendy Adams, Maarten van den Buus. Hippocampal serotonin depletion facilitates the enhancement of prepulse inhibition by risperidone: possible role of 5-HT(2C) receptors in the dorsal hippocampus. Neuropharmacology. vol 61. issue 3. 2011-10-14. PMID:21477601. |
following micro-injection of 5,7-dihydroxytryptamine, neither hippocampal serotonin depletion or partial serotonin depletion in the ventral hippocampus altered baseline ppi, startle magnitude or startle habituation. |
2011-10-14 |
2023-08-12 |
rat |
| Wendy Adams, Maarten van den Buus. Hippocampal serotonin depletion facilitates the enhancement of prepulse inhibition by risperidone: possible role of 5-HT(2C) receptors in the dorsal hippocampus. Neuropharmacology. vol 61. issue 3. 2011-10-14. PMID:21477601. |
in contrast, risperidone treatment increased ppi to a significantly greater extent in rats with hippocampal serotonin depletion, an effect which was most prominent at low prepulse intensities. |
2011-10-14 |
2023-08-12 |
rat |
| Wendy Adams, Maarten van den Buus. Hippocampal serotonin depletion facilitates the enhancement of prepulse inhibition by risperidone: possible role of 5-HT(2C) receptors in the dorsal hippocampus. Neuropharmacology. vol 61. issue 3. 2011-10-14. PMID:21477601. |
partial serotonin depletion in the ventral hippocampus did not alter ppi modulation by risperidone. |
2011-10-14 |
2023-08-12 |
rat |
| Wendy Adams, Maarten van den Buus. Hippocampal serotonin depletion facilitates the enhancement of prepulse inhibition by risperidone: possible role of 5-HT(2C) receptors in the dorsal hippocampus. Neuropharmacology. vol 61. issue 3. 2011-10-14. PMID:21477601. |
neither type of serotonergic lesion altered the densities of 5-ht(1a) or 5-ht(2a) receptors in the hippocampus; serotonin transporters or 5-ht(1a) autoreceptors on raphe cell bodies; or dopamine transporters, d(1) or d(2) receptors in forebrain regions efferent to the hippocampus and implicated in schizophrenia, such as the nucleus accumbens. |
2011-10-14 |
2023-08-12 |
rat |
| Wendy Adams, Maarten van den Buus. Hippocampal serotonin depletion facilitates the enhancement of prepulse inhibition by risperidone: possible role of 5-HT(2C) receptors in the dorsal hippocampus. Neuropharmacology. vol 61. issue 3. 2011-10-14. PMID:21477601. |
however, levels of [(3)h]mesulergine binding to 5-ht(2c) receptors were increased by approximately 70% in the dorsal hippocampus of rats with serotonin depletion in this region, while those in the ventral hippocampus were unaffected. |
2011-10-14 |
2023-08-12 |
rat |
| Wendy Adams, Maarten van den Buus. Hippocampal serotonin depletion facilitates the enhancement of prepulse inhibition by risperidone: possible role of 5-HT(2C) receptors in the dorsal hippocampus. Neuropharmacology. vol 61. issue 3. 2011-10-14. PMID:21477601. |
therefore, despite intact baseline ppi, abnormal ppi regulation in rats with >70% serotonin depletion in the hippocampus was unmasked by acute risperidone treatment. |
2011-10-14 |
2023-08-12 |
rat |
| Wendy Adams, Maarten van den Buus. Hippocampal serotonin depletion facilitates the enhancement of prepulse inhibition by risperidone: possible role of 5-HT(2C) receptors in the dorsal hippocampus. Neuropharmacology. vol 61. issue 3. 2011-10-14. PMID:21477601. |
selective upregulation of 5-ht(2c) receptors in the dorsal, but not ventral, hippocampus of these lesioned rats suggests that hippocampal 5-ht(2c) receptors vary in their adaptability to changes in serotonergic tone along the dorsoventral axis. |
2011-10-14 |
2023-08-12 |
rat |
| Wendy Adams, Maarten van den Buus. Hippocampal serotonin depletion facilitates the enhancement of prepulse inhibition by risperidone: possible role of 5-HT(2C) receptors in the dorsal hippocampus. Neuropharmacology. vol 61. issue 3. 2011-10-14. PMID:21477601. |
these findings suggest that 5-ht(2c) receptors in the dorsal hippocampus may contribute to risperidone-induced enhancement of ppi. |
2011-10-14 |
2023-08-12 |
rat |
| Thibault Renoir, Michelle S Zajac, Xin Du, Terence Y Pang, Leah Leang, Caroline Chevarin, Laurence Lanfumey, Anthony J Hanna. Sexually dimorphic serotonergic dysfunction in a mouse model of Huntington's disease and depression. PloS one. vol 6. issue 7. 2011-10-13. PMID:21760962. |
while tissue levels of serotonin were reduced in both male and female hd mice, we found that serotonin concentration and hydroxylase-2 (tph2) mrna levels were higher in the hippocampus of males compared to female animals. |
2011-10-13 |
2023-08-12 |
mouse |
| Pushpendra Singh, Md Jafurulla, Yamuna Devi Paila, Amitabha Chattopadhya. Desmosterol replaces cholesterol for ligand binding function of the serotonin(1A) receptor in solubilized hippocampal membranes: support for nonannular binding sites for cholesterol? Biochimica et biophysica acta. vol 1808. issue 10. 2011-10-13. PMID:21763272. |
desmosterol replaces cholesterol for ligand binding function of the serotonin(1a) receptor in solubilized hippocampal membranes: support for nonannular binding sites for cholesterol? |
2011-10-13 |
2023-08-12 |
Not clear |
| Pushpendra Singh, Md Jafurulla, Yamuna Devi Paila, Amitabha Chattopadhya. Desmosterol replaces cholesterol for ligand binding function of the serotonin(1A) receptor in solubilized hippocampal membranes: support for nonannular binding sites for cholesterol? Biochimica et biophysica acta. vol 1808. issue 10. 2011-10-13. PMID:21763272. |
solubilization of the hippocampal serotonin(1a) receptor by chaps is accompanied by loss of cholesterol that results in a reduction in specific agonist binding activity. |
2011-10-13 |
2023-08-12 |
Not clear |
| Pushpendra Singh, Md Jafurulla, Yamuna Devi Paila, Amitabha Chattopadhya. Desmosterol replaces cholesterol for ligand binding function of the serotonin(1A) receptor in solubilized hippocampal membranes: support for nonannular binding sites for cholesterol? Biochimica et biophysica acta. vol 1808. issue 10. 2011-10-13. PMID:21763272. |
however, these results appear to be contradictory to our earlier findings, performed by sterol manipulation utilizing methyl-β-cyclodextrin, in which we observed that replacing cholesterol with desmosterol is unable to restore specific ligand binding of the hippocampal serotonin(1a) receptor. |
2011-10-13 |
2023-08-12 |
Not clear |