| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jochen Winterer, A Vanessa Stempel, Tamar Dugladze, Csaba Földy, Nino Maziashvili, Aleksandar R Zivkovic, Josef Priller, Ivan Soltesz, Tengis Gloveli, Dietmar Schmit. Cell-type-specific modulation of feedback inhibition by serotonin in the hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 23. 2011-09-01. PMID:21653851. |
midbrain raphe nuclei provide strong serotonergic projections to the hippocampus, in which serotonin (5-ht) exerts differential effects mediated by multiple 5-ht receptor subtypes. |
2011-09-01 |
2023-08-12 |
rat |
| Jochen Winterer, A Vanessa Stempel, Tamar Dugladze, Csaba Földy, Nino Maziashvili, Aleksandar R Zivkovic, Josef Priller, Ivan Soltesz, Tengis Gloveli, Dietmar Schmit. Cell-type-specific modulation of feedback inhibition by serotonin in the hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 23. 2011-09-01. PMID:21653851. |
here we show that serotonin via 5-ht(1b) heteroreceptors substantially reduces synaptic excitation of cholecystokinin-expressing interneurons in area ca1 of the rat hippocampus, in contrast to parvalbumin-expressing basket cells. |
2011-09-01 |
2023-08-12 |
rat |
| Fanny Mochel, Brandon Durant, Alexandra Durr, Raphael Schiffman. Altered dopamine and serotonin metabolism in motorically asymptomatic R6/2 mice. PloS one. vol 6. issue 3. 2011-08-25. PMID:21483838. |
in the striatum, hippocampus and frontal cortex of 4, 8 and 12-week-old r6/2 mice, serotonin and its metabolite 5-hydroxyindoleacetic acid were significantly decreased in association with a decreased turnover of serotonin. |
2011-08-25 |
2023-08-12 |
mouse |
| Jantarima Charoenphandhu, Jarinthorn Teerapornpuntakit, Amporn Nuntapornsak, Nateetip Krishnamra, Narattaphol Charoenphandh. Anxiety-like behaviors and expression of SERT and TPH in the dorsal raphé of estrogen- and fluoxetine-treated ovariectomized rats. Pharmacology, biochemistry, and behavior. vol 98. issue 4. 2011-08-24. PMID:21382399. |
furthermore, e2 and e2+flx similarly upregulated the mrna expression of serotonin reuptake transporter (sert) and tryptophan hydroxylase-2 in the dorsal raphé of ovx rats, while having no effect on sert expression in the frontal cortex, hippocampus, septum, amygdala and periaqueductal gray. |
2011-08-24 |
2023-08-12 |
rat |
| Chia-Ying Chuang, Yeu-Ching Shi, He-Pei You, Yi-Hiyuan Lo, Tzu-Ming Pa. Antidepressant effect of GABA-rich monascus-fermented product on forced swimming rat model. Journal of agricultural and food chemistry. vol 59. issue 7. 2011-08-17. PMID:21375324. |
moreover, gaba might recover the level of monoamines norepinephrine, dopamine (da), and 5-hydroxytryptamine (5-ht) in hippocampus and normalize the turnover ratio of 5-ht and da in hippocampus and amygdala. |
2011-08-17 |
2023-08-12 |
rat |
| Harumasa Takano, Hiroshi Ito, Hidehiko Takahashi, Ryosuke Arakawa, Masaki Okumura, Fumitoshi Kodaka, Tatsui Otsuka, Motoichiro Kato, Tetsuya Suhar. Serotonergic neurotransmission in the living human brain: a positron emission tomography study using [¹¹C]dasb and [¹¹C]WAY100635 in young healthy men. Synapse (New York, N.Y.). vol 65. issue 7. 2011-08-16. PMID:21484882. |
in contrast, the highest binding to 5-ht(1a) receptors was seen in the hippocampal regions, insula, neocortical regions, and dorsal raphe nucleus, and very low binding was found in the thalamus and basal ganglia. |
2011-08-16 |
2023-08-12 |
human |
| Hideki Miura, Yu Ando, Yukihiro Noda, Kenichi Isobe, Norio Ozak. Long-lasting effects of inescapable-predator stress on brain tryptophan metabolism and the behavior of juvenile mice. Stress (Amsterdam, Netherlands). vol 14. issue 3. 2011-08-05. PMID:21294659. |
behavior on an elevated plus-maze, and trp, kyn, and 5-ht levels in the prefrontal cortex, hippocampus, amygdala, and dorsal raphe nuclei were measured 1 and 4 weeks after stress exposure. |
2011-08-05 |
2023-08-12 |
mouse |
| Matthew R Skelton, Tori L Schaefer, Devon L Graham, Ton J Degrauw, Joseph F Clark, Michael T Williams, Charles V Vorhee. Creatine transporter (CrT; Slc6a8) knockout mice as a model of human CrT deficiency. PloS one. vol 6. issue 1. 2011-08-02. PMID:21249153. |
crt(⁻/y) mice had increased serotonin and 5-hydroxyindole acetic acid in the hippocampus and prefrontal cortex. |
2011-08-02 |
2023-08-12 |
mouse |
| Björn H Schott, Constanze I Seidenbecher, Sylvia Richter, Torsten Wüstenberg, Grazyna Debska-Vielhaber, Heike Schubert, Hans-Jochen Heinze, Alan Richardson-Klavehn, Emrah Düze. Genetic variation of the serotonin 2a receptor affects hippocampal novelty processing in humans. PloS one. vol 6. issue 1. 2011-08-02. PMID:21267461. |
genetic variation of the serotonin 2a receptor affects hippocampal novelty processing in humans. |
2011-08-02 |
2023-08-12 |
human |
| Raffaella Morini, Boris Mlinar, Gilda Baccini, Renato Corradett. Enhanced hippocampal long-term potentiation following repeated MDMA treatment in Dark-Agouti rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 21. issue 1. 2011-07-20. PMID:20727723. |
one week after neurotoxic mdma treatment in vivo (12.5mg/kg i.p., once a week, per three weeks), serotonergic deficit was evident in hippocampal slices as 56.3% reduction in 5-ht content (p=0.04) and as 68.4% reduction in the effect of endogenous 5-ht release on synaptic neurotransmission (p<0.01). |
2011-07-20 |
2023-08-12 |
rat |
| Michael T Klein, Małgorzata Dukat, Richard A Glennon, Milt Teitle. Toward selective drug development for the human 5-hydroxytryptamine 1E receptor: a comparison of 5-hydroxytryptamine 1E and 1F receptor structure-affinity relationships. The Journal of pharmacology and experimental therapeutics. vol 337. issue 3. 2011-07-19. PMID:21422162. |
the 5-hydroxytryptamine (5-ht) 1e receptor is highly expressed in the human frontal cortex and hippocampus, and this distribution suggests the function of 5-ht(1e) receptors might be linked to memory. |
2011-07-19 |
2023-08-12 |
human |
| Beryl Koener, Stéphanie Goursaud, Morgane Van De Stadt, André-Guilhem Calas, Anne P Jeanjean, Jean-Marie Maloteaux, Emmanuel Herman. Pharmacological blockade of dopamine D2 receptors by aripiprazole is not associated with striatal sensitization. Naunyn-Schmiedeberg's archives of pharmacology. vol 383. issue 1. 2011-07-15. PMID:21061116. |
hence, in additional experiments, aripiprazole was found to efficiently promote [³⁵s]gtpγs binding in hippocampal membranes through the activation of 5-ht(₁a) receptors. |
2011-07-15 |
2023-08-12 |
rat |
| Friederike Klempin, Harish Babu, Davide De Pietri Tonelli, Edson Alarcon, Klaus Fabel, Gerd Kemperman. Oppositional effects of serotonin receptors 5-HT1a, 2, and 2c in the regulation of adult hippocampal neurogenesis. Frontiers in molecular neuroscience. vol 3. 2011-07-14. PMID:20721314. |
oppositional effects of serotonin receptors 5-ht1a, 2, and 2c in the regulation of adult hippocampal neurogenesis. |
2011-07-14 |
2023-08-12 |
Not clear |
| Friederike Klempin, Harish Babu, Davide De Pietri Tonelli, Edson Alarcon, Klaus Fabel, Gerd Kemperman. Oppositional effects of serotonin receptors 5-HT1a, 2, and 2c in the regulation of adult hippocampal neurogenesis. Frontiers in molecular neuroscience. vol 3. 2011-07-14. PMID:20721314. |
serotonin (5-ht) appears to play a major role in controlling adult hippocampal neurogenesis and thereby it is relevant for theories linking failing adult neurogenesis to the pathogenesis of major depression and the mechanisms of action of antidepressants. |
2011-07-14 |
2023-08-12 |
Not clear |
| A V Kulikov, M A Tikhonova, E A Kulikova, T M Khomenko, D V Korchagina, K P Volcho, H F Salachutdinov, N K Popov. [Effect of new potential psychotropic drug, 8-(trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine hydrochloride, on the expression of serotonin-related genes in mouse brain]. Molekuliarnaia biologiia. vol 45. issue 2. 2011-07-08. PMID:21634115. |
tx-2153 significantly reduced m-rna level of 5-ht(1a) receptor and maoa genes in the midbrain without any effect on expression of these genes in the frontal cortex and hippocampus. |
2011-07-08 |
2023-08-12 |
mouse |
| H Jovanovic, A Perski, H Berglund, I Savi. Chronic stress is linked to 5-HT(1A) receptor changes and functional disintegration of the limbic networks. NeuroImage. vol 55. issue 3. 2011-06-28. PMID:21211567. |
they also displayed a reduced 5-ht(1a) receptor bp in the anterior cingulate (acc), the insular-cortex, and the hippocampus. |
2011-06-28 |
2023-08-12 |
human |
| H Jovanovic, A Perski, H Berglund, I Savi. Chronic stress is linked to 5-HT(1A) receptor changes and functional disintegration of the limbic networks. NeuroImage. vol 55. issue 3. 2011-06-28. PMID:21211567. |
the degree of reported stress was inversely correlated with activation of acc, and the 5-ht(1a) receptor bp in the amygdala and hippocampus. |
2011-06-28 |
2023-08-12 |
human |
| Alessandro Barbon, Cesare Orlandi, Luca La Via, Luca Caracciolo, Daniela Tardito, Laura Musazzi, Alessandra Mallei, Massimo Gennarelli, Giorgio Racagni, Maurizio Popoli, Sergio Barlat. Antidepressant treatments change 5-HT2C receptor mRNA expression in rat prefrontal/frontal cortex and hippocampus. Neuropsychobiology. vol 63. issue 3. 2011-06-21. PMID:21228608. |
we analyzed the time course of 5-ht2c receptor (5-htr2c) mrna expression during antidepressant treatment in the prefrontal/frontal cortex (p/fc) and in the hippocampus (hc) of rats chronically treated with fluoxetine (a selective serotonin reuptake inhibitor) and reboxetine (a selective noradrenaline reuptake inhibitor). |
2011-06-21 |
2023-08-12 |
rat |
| Jamie L Scholl, Kenneth J Renner, Gina L Forster, Shanaz Tejani-But. Central monoamine levels differ between rat strains used in studies of depressive behavior. Brain research. vol 1355. 2011-06-20. PMID:20696147. |
interestingly, wis rats showed reduced levels of the 5-ht metabolite 5-hydroxyindoleacetic acid (5-hiaa) in several regions including the prefrontal cortex, subregions of the hippocampus and subregions of the hypothalamus, suggesting decreased 5-ht turnover when compared to both wky and sd rats. |
2011-06-20 |
2023-08-12 |
rat |
| Thomas Mueggler, Florence Razoux, Holger Russig, Anna Buehler, Tamara B Franklin, Christof Baltes, Isabelle M Mansuy, Markus Rudi. Mapping of CBV changes in 5-HT(1A) terminal fields by functional MRI in the mouse brain. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 21. issue 4. 2011-06-15. PMID:20656461. |
we show that administration of the 5-ht(1a) receptor agonist 8-oh-dpat prompts a dose-dependent reduction in local cerebral blood volume (cbv) in brain areas rich in neurons expressing post-synaptic 5-ht(1a) receptor, including the prefrontal cortex, hippocampus and amygdalar nuclei. |
2011-06-15 |
2023-08-12 |
mouse |