| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ali Azargoonjahrom. Serotonin enhances neurogenesis biomarkers, hippocampal volumes, and cognitive functions in Alzheimer's disease. Molecular brain. vol 17. issue 1. 2024-12-19. PMID:39696587. |
serotonin enhances neurogenesis biomarkers, hippocampal volumes, and cognitive functions in alzheimer's disease. |
2024-12-19 |
2024-12-21 |
human |
| Ali Azargoonjahrom. Serotonin enhances neurogenesis biomarkers, hippocampal volumes, and cognitive functions in Alzheimer's disease. Molecular brain. vol 17. issue 1. 2024-12-19. PMID:39696587. |
this study aimed to investigate the influence of serotonin on brain structure and hippocampal volumes in relation to cognitive functions in ad, as well as its link with biomarkers like cntf, fgf-4, bmp-6, and mmp-1. |
2024-12-19 |
2024-12-21 |
human |
| Ali Azargoonjahrom. Serotonin enhances neurogenesis biomarkers, hippocampal volumes, and cognitive functions in Alzheimer's disease. Molecular brain. vol 17. issue 1. 2024-12-19. PMID:39696587. |
the analysis found a positive correlation between serotonin levels and total brain (r = 0.229, p = 0.023) and hippocampal volumes (right: r = 0.186, p = 0.032; left: r = 0.210, p = 0.023), even after fdr adjustment. |
2024-12-19 |
2024-12-21 |
human |
| Johann Emilio Gonzales Embang, Ying Hui Valerie Tan, Yu Xuan Ng, Gerard Jude Ponce Loyola, Lik-Wei Wong, Yuqing Guo, Yanhong Don. Role of sleep and neurochemical biomarkers in synaptic plasticity related to neurological and psychiatric disorders: A scoping review. Journal of neurochemistry. vol 169. issue 1. 2024-12-15. PMID:39676063. |
slow-wave and rapid-eye movement sleep, sleep spindles, sleep cycle disruption, k-complex(kc) density, hippocampal seeg, bdnf, il-6, inos mrna expression, plasma serotonin, csf aβ-42, t-tau and p-tau proteins, and serum cortisol revealed associations with cognitive dysfunction. |
2024-12-15 |
2024-12-21 |
Not clear |
| Xiaoqian He, Ziying Lai, Xueyan Wang, Jingjing Li, Guangbing Duan, Junwen Wang, Zhao Qin, Shuchang Xu, Ying Huan. Role of 5-hydroxytryptamine type 3 receptors in aerobic exercise-induced improvement of memory and hippocampal synaptic plasticity. Neural regeneration research. 2024-12-12. PMID:39665807. |
role of 5-hydroxytryptamine type 3 receptors in aerobic exercise-induced improvement of memory and hippocampal synaptic plasticity. |
2024-12-12 |
2024-12-14 |
mouse |
| Xiaoqian He, Ziying Lai, Xueyan Wang, Jingjing Li, Guangbing Duan, Junwen Wang, Zhao Qin, Shuchang Xu, Ying Huan. Role of 5-hydroxytryptamine type 3 receptors in aerobic exercise-induced improvement of memory and hippocampal synaptic plasticity. Neural regeneration research. 2024-12-12. PMID:39665807. |
5-hydroxytryptamine type 3 receptors are necessary for exercise-induced hippocampal neurogenesis. |
2024-12-12 |
2024-12-14 |
mouse |
| Xiaoqian He, Ziying Lai, Xueyan Wang, Jingjing Li, Guangbing Duan, Junwen Wang, Zhao Qin, Shuchang Xu, Ying Huan. Role of 5-hydroxytryptamine type 3 receptors in aerobic exercise-induced improvement of memory and hippocampal synaptic plasticity. Neural regeneration research. 2024-12-12. PMID:39665807. |
some antipsychotic drugs with 5-hydroxytryptamine type 3 receptor antagonistic properties may impede the amelioration of cognitive impairment and hippocampal plasticity induced by exercise. |
2024-12-12 |
2024-12-14 |
mouse |
| Xiaoqian He, Ziying Lai, Xueyan Wang, Jingjing Li, Guangbing Duan, Junwen Wang, Zhao Qin, Shuchang Xu, Ying Huan. Role of 5-hydroxytryptamine type 3 receptors in aerobic exercise-induced improvement of memory and hippocampal synaptic plasticity. Neural regeneration research. 2024-12-12. PMID:39665807. |
while 5-hydroxytryptamine type 3 receptors did not affect baseline neurogenesis in the hippocampal dentate gyrus, 5-hydroxytryptamine type 3 receptors were required for aerobic exercise-induced neurogenesis and astrocyte proliferation in this region. |
2024-12-12 |
2024-12-14 |
mouse |
| Xiaoqian He, Ziying Lai, Xueyan Wang, Jingjing Li, Guangbing Duan, Junwen Wang, Zhao Qin, Shuchang Xu, Ying Huan. Role of 5-hydroxytryptamine type 3 receptors in aerobic exercise-induced improvement of memory and hippocampal synaptic plasticity. Neural regeneration research. 2024-12-12. PMID:39665807. |
in addition, 5-hydroxytryptamine type 3 receptors were crucial for maintaining long-term potentiation in the ca1, dentate gyrus, and ca3 regions of the hippocampus. |
2024-12-12 |
2024-12-14 |
mouse |
| Xiaoqian He, Ziying Lai, Xueyan Wang, Jingjing Li, Guangbing Duan, Junwen Wang, Zhao Qin, Shuchang Xu, Ying Huan. Role of 5-hydroxytryptamine type 3 receptors in aerobic exercise-induced improvement of memory and hippocampal synaptic plasticity. Neural regeneration research. 2024-12-12. PMID:39665807. |
the long-term potentiation changes induced by aerobic exercise in sub-regions of the hippocampus were heterogeneous: 5-hydroxytryptamine type 3 receptors were essential for aerobic exercise to enhance long-term potentiation in the ca3, but not the ca1 or dentate gyrus, regions of the hippocampus. |
2024-12-12 |
2024-12-14 |
mouse |
| Xiaoqian He, Ziying Lai, Xueyan Wang, Jingjing Li, Guangbing Duan, Junwen Wang, Zhao Qin, Shuchang Xu, Ying Huan. Role of 5-hydroxytryptamine type 3 receptors in aerobic exercise-induced improvement of memory and hippocampal synaptic plasticity. Neural regeneration research. 2024-12-12. PMID:39665807. |
furthermore, aerobic exercise up-regulated 5-hydroxytryptamine type 3 receptor expression and increased brain-derived neurotrophic factor release in the hippocampus in a 5-hydroxytryptamine type 3 receptor-dependent manner. |
2024-12-12 |
2024-12-14 |
mouse |
| Xiaoqian He, Ziying Lai, Xueyan Wang, Jingjing Li, Guangbing Duan, Junwen Wang, Zhao Qin, Shuchang Xu, Ying Huan. Role of 5-hydroxytryptamine type 3 receptors in aerobic exercise-induced improvement of memory and hippocampal synaptic plasticity. Neural regeneration research. 2024-12-12. PMID:39665807. |
these results suggest that aerobic exercise increases hippocampal dentate gyrus neurogenesis and astrocyte proliferation via the up-regulation of 5-hydroxytryptamine type 3 receptors, leading to more brain-derived neurotrophic factor production and release from these cells, which results in long-term potentiation facilitation in the hippocampal ca3 region and help improve memory. |
2024-12-12 |
2024-12-14 |
mouse |
| Hariom, Prerna Kumari, Sushma Chaturvedi, Sonika Shrivastav, Sushma Maratha, Vaibhav Wali. Caffeic acid differentially modulates behavior and neurochemicals in chronic unpredictable mild stress and dexamethasone induced models of depression. Pharmacology, biochemistry, and behavior. 2024-12-07. PMID:39644931. |
hippocampus was dissected and was used for the neurochemical assays including 5-ht (serotonin), glutamate, nitrite and gamma-aminobutyric acid (gaba). |
2024-12-07 |
2024-12-10 |
mouse |
| Hariom, Prerna Kumari, Sushma Chaturvedi, Sonika Shrivastav, Sushma Maratha, Vaibhav Wali. Caffeic acid differentially modulates behavior and neurochemicals in chronic unpredictable mild stress and dexamethasone induced models of depression. Pharmacology, biochemistry, and behavior. 2024-12-07. PMID:39644931. |
ca (50 mg/kg) evoked anxiogenic reactions in cums model by increasing the hippocampal nitrite and glutamate level while ca (50 mg/kg) exerted anxiolysis in dexa model by reducing the level of 5-ht. |
2024-12-07 |
2024-12-10 |
mouse |
| Kristian H Reveles Jensen, Vibeke H Dam, Kristin Köhler-Forsberg, Brice Ozenne, Dea S Stenbæk, Melanie Ganz, Patrick MacDonald Fisher, Vibe Gedsoe Frokjaer, Gitte M Knudsen, Martin Balslev Jørgense. Changes in hippocampal volume, 5-HT Journal of psychiatric research. vol 181. 2024-12-01. PMID:39616866. |
changes in hippocampal volume, 5-ht serotonin reuptake inhibitors have been reported to increase hippocampal volume and improve memory function in patients with major depressive disorder (mdd). |
2024-12-01 |
2024-12-06 |
Not clear |
| Ahmed S Al-Shami, Medhat Haroun, Amina E Essawy, Nermine Moussa, Heba-Tallah Abd Elrahim Abd Elkade. Early-life bisphenol A exposure causes detrimental age-related changes in anxiety, depression, learning, and memory in juvenile and adult male rats: Involvement of NMDAR/PSD-95-PTEN/AKT signaling pathway. Neurotoxicology. 2024-12-01. PMID:39617347. |
notably, neurotransmitter levels such as dopamine, serotonin, and gamma-aminobutyric acid, levels of postsynaptic density protein 95 and camp response element-binding protein, as well as mrna levels of n-methyl-d-aspartate receptor subunits, fluctuated between reduction and elevation in the pfc and hippocampus. |
2024-12-01 |
2024-12-06 |
rat |
| Maria Kuznetsova, Carey Wilson, Lesley Cheng, Terence Pang, Shanshan Li, Blaine Roberts, Larissa C Lago, Harvey Tran, Andrew F Hill, Anthony J Hannan, Thibault Renoi. Serotonergic-dependent effects of exercise and elevated stress hormone on small non-coding RNA transcriptomics and proteomics in a mouse model of affective disorders. Neuropharmacology. 2024-11-29. PMID:39613253. |
using the serotonin transporter (5-htt) knockout (ko) mouse model of depression/anxiety, this study aimed to compare the effects of voluntary exercise (ex) versus chronic treatment with the stress hormone (ct), corticosterone, on hippocampal mirna transcriptome and proteome in five comparison groups: wt-sh vs. ko-sh; wt-sh vs. wt-ex; ko-sh vs. ko-ex; wt-sh vs. wt-ct; ko-sh vs. ko-ct. we hypothesized that treatment with stress hormone will result in mirna and proteomics changes observed in genetic model of depression, while exercise will have beneficial effects similar to antidepressant treatment. |
2024-11-29 |
2024-12-02 |
mouse |
| D Kunčická, N Cmarková, S Ondráčková, D Kačer, D Rodriguez, K Valeš, J Svoboda, H Brožka, A Stuchlí. Serotonin and Effort-Based Decision-Making: Dissociating Behavioral Effects of 8-OH-DPAT and PCPA. Physiological research. vol 73. issue 5. 2024-11-19. PMID:39560195. |
next, homovanillic acid and 5-hydroxyindoleacetic acid, metabolites of dopamine and serotonin, respectively, were quantified in the rats' prefrontal cortex, striatum, and hippocampus. |
2024-11-19 |
2024-11-22 |
rat |
| D Kunčická, N Cmarková, S Ondráčková, D Kačer, D Rodriguez, K Valeš, J Svoboda, H Brožka, A Stuchlí. Serotonin and Effort-Based Decision-Making: Dissociating Behavioral Effects of 8-OH-DPAT and PCPA. Physiological research. vol 73. issue 5. 2024-11-19. PMID:39560195. |
our findings suggest that the overall reduction of serotonin levels alone does not affect effort-based decision-making and highlights the possible role of the hippocampus and the 5-ht1a receptor in this cognitive process. |
2024-11-19 |
2024-11-22 |
rat |
| Bin Zhang, Chen Yang, Yuxiao Zheng, Xinliang Li, Xingguo Wang, Li Yuehu. Integration of pharmacochemistry, pharmacodynamics and metabolomics to reveal active ingredients and mechanism of Nan Bao detox capsule alleviating methamphetamine addiction. Addiction biology. vol 29. issue 11. 2024-11-11. PMID:39526639. |
nbdc significantly attenuated meth-induced behavioural anomalies and modulated neurotransmitter levels, notably increasing brain da and serotonin (5-ht) content with concomitant upregulation of d1 dopamine receptor (drd1) and 5-ht1a receptor (5-ht1ar) expression, ameliorating hippocampal pathology. |
2024-11-11 |
2024-11-17 |
rat |