| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vanessa Nunes-de-Souza, Ricardo Nunes-de-Souza, Robert John Rodgers, Azair Canto-de-Souz. Blockade of 5-HT(2) receptors in the periaqueductal grey matter (PAG) abolishes the anxiolytic-like effect of 5-HT(1A) receptor antagonism in the median raphe nucleus in mice. Behavioural brain research. vol 225. issue 2. 2012-01-24. PMID:21839779. |
however, while activation of 5-ht(1a) or 5-ht(2) receptors in forebrain targets such as the amygdala or hippocampus enhances anxiety-like behaviours in rodents, stimulation of both receptor subtypes in the midbrain pag markedly reduces anxiety-like behaviour. |
2012-01-24 |
2023-08-12 |
mouse |
| C Wakabayashi, Y Kiyama, H Kunugi, T Manabe, Y Iwakur. Age-dependent regulation of depression-like behaviors through modulation of adrenergic receptor α₁A subtype expression revealed by the analysis of interleukin-1 receptor antagonist knockout mice. Neuroscience. vol 192. 2012-01-18. PMID:21722710. |
although the contents of 5-ht, norepinephrine (ne), and dopamine (da), which are known to be associated with major symptoms of psychiatric disorders, were not significantly different in the hippocampus or cerebral cortex between il-1ra ko and their wild-type (wt) littermate mice, the mrna expression level of the arα(1a) subtype was significantly changed in the cerebral cortex. |
2012-01-18 |
2023-08-12 |
mouse |
| Gregory C Hadlock, Katy M Webb, Lisa M McFadden, Pei Wen Chu, Jonathan D Ellis, Scott C Allen, David M Andrenyak, Paula L Vieira-Brock, Christopher L German, Kevin M Conrad, Amanda J Hoonakker, James W Gibb, Diana G Wilkins, Glen R Hanson, Annette E Fleckenstei. 4-Methylmethcathinone (mephedrone): neuropharmacological effects of a designer stimulant of abuse. The Journal of pharmacology and experimental therapeutics. vol 339. issue 2. 2012-01-16. PMID:21810934. |
results revealed that, similar to methylenedioxymethamphetamine, methamphetamine, and methcathinone, repeated mephedrone injections (4× 10 or 25 mg/kg s.c. per injection, 2-h intervals, administered in a pattern used frequently to mimic psychostimulant "binge" treatment) cause a rapid decrease in striatal dopamine (da) and hippocampal serotonin (5-hydroxytryptamine; 5ht) transporter function. |
2012-01-16 |
2023-08-12 |
rat |
| Patricia Rojas, Norma Serrano-García, Omar N Medina-Campos, José Pedraza-Chaverri, Sven O Ogren, Carolina Roja. Antidepressant-like effect of a Ginkgo biloba extract (EGb761) in the mouse forced swimming test: role of oxidative stress. Neurochemistry international. vol 59. issue 5. 2012-01-12. PMID:21672588. |
animals were sacrificed to evaluate lipid peroxidation, different antioxidant enzyme activities, serotonin and dopamine content in midbrain, hippocampus and prefrontal cortex. |
2012-01-12 |
2023-08-12 |
mouse |
| Enrique Jiménez-Ferrer, Maribel Herrera-Ruiz, Raúl Ramírez-García, Armando Herrera-Arellano, Jaime Tortoriell. Interaction of the natural anxiolytic Galphimine-B with serotonergic drugs on dorsal hippocampus in rats. Journal of ethnopharmacology. vol 137. issue 1. 2011-12-27. PMID:21742023. |
for this reason, the objective of this work was to evaluate the pharmacological interaction between g-b with the 5-hydroxytryptamine 1a (5ht(1a)) and 5-hydroxytryptamine 2a (5ht(2a)) serotonergic receptors on ca1 neurons of hippocampus. |
2011-12-27 |
2023-08-12 |
rat |
| Yonggang Wang, Melanie Neumann, Katharina Hansen, Shuwhey M Hong, Sharon Kim, Linda J Noble-Haeusslein, Jialing Li. Fluoxetine increases hippocampal neurogenesis and induces epigenetic factors but does not improve functional recovery after traumatic brain injury. Journal of neurotrauma. vol 28. issue 2. 2011-12-22. PMID:21175261. |
the selective serotonin reuptake inhibitor fluoxetine induces hippocampal neurogenesis, stimulates maturation and synaptic plasticity of adult hippocampal neurons, and reduces motor/sensory and memory impairments in several cns disorders. |
2011-12-22 |
2023-08-12 |
mouse |
| C Nothdurfter, S Tanasic, G Rammes, R Rupprech. Modulation of ligand-gated ion channels as a novel pharmacological principle. Pharmacopsychiatry. vol 44 Suppl 1. 2011-12-19. PMID:21544743. |
electrophysiological recordings of 5-ht evoked cation currents were recorded with n1e-115 and hek-5-ht (3a) cells and hippocampal neurons. |
2011-12-19 |
2023-08-12 |
Not clear |
| Christian M Cremer, Joachim H R Lübke, Nicola Palomero-Gallagher, Karl Zille. Laminar distribution of neurotransmitter receptors in different reeler mouse brain regions. Brain structure & function. vol 216. issue 3. 2011-12-12. PMID:21442415. |
in the hippocampus, a significant decrease of gaba(b), 5-ht(1) and a'₁ receptors were observed. |
2011-12-12 |
2023-08-12 |
mouse |
| Sven Parkel, Lauri Tõntson, Ago Rinke. Millimolar Mn2+ influences agonist binding to 5-HT1A receptors by inhibiting guanosine nucleotide binding to receptor-coupled G-proteins. Neurotoxicology. vol 32. issue 1. 2011-12-09. PMID:21126535. |
in the present report we have studied the influence of mn(2+) on 5-ht(1a) receptor signaling complexes in rat brain and found that mn(2+) in millimolar concentration caused an increase of high-affinity agonist binding to rat hippocampal membranes in comparison with experiments in the presence of mg(2+), but not in rat cortical membranes and in sf9 cell membranes expressing 5-ht(1a) receptors and g(i1) heterotrimers. |
2011-12-09 |
2023-08-12 |
rat |
| Sven Parkel, Lauri Tõntson, Ago Rinke. Millimolar Mn2+ influences agonist binding to 5-HT1A receptors by inhibiting guanosine nucleotide binding to receptor-coupled G-proteins. Neurotoxicology. vol 32. issue 1. 2011-12-09. PMID:21126535. |
activation of g proteins with 30μm gtpγs turned all 5-ht(1a) receptors in these preparations into a low-affinity state for agonist binding in the presence of 1mm mg(2+), but not in the presence of 1mm mn(2+) in rat hippocampal membranes. |
2011-12-09 |
2023-08-12 |
rat |
| Yosefa Avraham, Mayer Saidian, James J Burston, Raphael Mevorach, Lia Vorobiev, Iddo Magen, Eithan Kunkes, Beatriz Borges, Aron H Lichtman, Elliot M Berr. Fish oil promotes survival and protects against cognitive decline in severely undernourished mice by normalizing satiety signals. The Journal of nutritional biochemistry. vol 22. issue 8. 2011-11-28. PMID:21109417. |
in the hippocampus, fish oil supplementation normalized 5-ht, camkk2, silent mating type information regulation 1 and brain-derived neurotrophic factor. |
2011-11-28 |
2023-08-12 |
mouse |
| Tamaki Nagata, Atsuko Nishiyama, Takako Yamato, Toshio Obata, Masahiro Aomin. Diabetes modulates ethanol-induced increase in serotonin release from rat hippocampus: an in vivo microdialysis study. Nutritional neuroscience. vol 14. issue 3. 2011-11-21. PMID:21756530. |
diabetes modulates ethanol-induced increase in serotonin release from rat hippocampus: an in vivo microdialysis study. |
2011-11-21 |
2023-08-12 |
rat |
| Tamaki Nagata, Atsuko Nishiyama, Takako Yamato, Toshio Obata, Masahiro Aomin. Diabetes modulates ethanol-induced increase in serotonin release from rat hippocampus: an in vivo microdialysis study. Nutritional neuroscience. vol 14. issue 3. 2011-11-21. PMID:21756530. |
we examined whether diabetes mellitus (dm) affects the acute ethanol (etoh)-induced increase in serotonin (5-ht) release from the rat hippocampus, and compared the findings with those obtained from non-dm rats. |
2011-11-21 |
2023-08-12 |
rat |
| Tamaki Nagata, Atsuko Nishiyama, Takako Yamato, Toshio Obata, Masahiro Aomin. Diabetes modulates ethanol-induced increase in serotonin release from rat hippocampus: an in vivo microdialysis study. Nutritional neuroscience. vol 14. issue 3. 2011-11-21. PMID:21756530. |
hippocampal 5-ht was measured by using in vivo microdialysis. |
2011-11-21 |
2023-08-12 |
rat |
| Tamaki Nagata, Atsuko Nishiyama, Takako Yamato, Toshio Obata, Masahiro Aomin. Diabetes modulates ethanol-induced increase in serotonin release from rat hippocampus: an in vivo microdialysis study. Nutritional neuroscience. vol 14. issue 3. 2011-11-21. PMID:21756530. |
experiments using various antagonists and agonists of 5-ht receptors showed that the functions of 5-ht(1b), 5-ht(2), 5-ht(3), and/or 5-ht(4) receptors in the hippocampus of dm rats differ from those in non-dm rats, suggesting that dm induces dysfunction of central neurotransmitter systems including 5-ht receptors. |
2011-11-21 |
2023-08-12 |
rat |
| Tamaki Nagata, Atsuko Nishiyama, Takako Yamato, Toshio Obata, Masahiro Aomin. Diabetes modulates ethanol-induced increase in serotonin release from rat hippocampus: an in vivo microdialysis study. Nutritional neuroscience. vol 14. issue 3. 2011-11-21. PMID:21756530. |
the present study is the first, to our knowledge, to show that dm modulated the etoh-induced 5-ht release from the hippocampus in type-1 diabetic rats. |
2011-11-21 |
2023-08-12 |
rat |
| Pieter Schipper, Amanda J Kiliaan, Judith R Homber. A mixed polyunsaturated fatty acid diet normalizes hippocampal neurogenesis and reduces anxiety in serotonin transporter knockout rats. Behavioural pharmacology. vol 22. issue 4. 2011-11-15. PMID:21606840. |
a mixed polyunsaturated fatty acid diet normalizes hippocampal neurogenesis and reduces anxiety in serotonin transporter knockout rats. |
2011-11-15 |
2023-08-12 |
human |
| Hakan Kayir, Oguzhan Yavuz, Gokhan Goktalay, Murat Yildirim, Tayfun Uzba. The relationship between baseline prepulse inhibition levels and ethanol withdrawal severity in rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 34. issue 8. 2011-11-14. PMID:20800642. |
brain tissue concentrations of dopamine, serotonin and noradrenaline in hippocampus, cortex, and striatum were measured after the 6th hour of ews testing. |
2011-11-14 |
2023-08-12 |
rat |
| E S Onaivi, R Benno, T Halpern, M Mehanovic, N Schanz, C Sanders, X Yan, H Ishiguro, Q-R Liu, A L Berzal, M P Viveros, S F Al. Consequences of cannabinoid and monoaminergic system disruption in a mouse model of autism spectrum disorders. Current neuropharmacology. vol 9. issue 1. 2011-11-10. PMID:21886592. |
in the hippocampus, striatum and frontal cortex, the levels of da and 5-ht and their metabolites were differentially altered in the btbr and c57bl/6j mice. |
2011-11-10 |
2023-08-12 |
mouse |
| Marcela Pereira, Patrícia A Dombrowski, Estela M Losso, Lea R Chioca, Cláudio Da Cunha, Roberto Andreatin. Memory impairment induced by sodium fluoride is associated with changes in brain monoamine levels. Neurotoxicity research. vol 19. issue 1. 2011-11-08. PMID:19957215. |
the results showed that naf impairs open-field habituation and increases noradrenaline (na) and serotonin (5-ht) in the striatum, hippocampus and neocortex. |
2011-11-08 |
2023-08-12 |
rat |