| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Cole, D R Weinberger, V S Mattay, X Cheng, A W Toga, P M Thompson, G Powell-Smith, S Cohen-Woods, A Simmons, P McGuffin, C H Y F. No effect of 5HTTLPR or BDNF Val66Met polymorphism on hippocampal morphology in major depression. Genes, brain, and behavior. vol 10. issue 7. 2012-02-22. PMID:21692988. |
imaging genetics studies have investigated the influence of the serotonin transporter-linked polymorphic region (5httlpr) and brain-derived neurotrophic factor (bdnf) val66met polymorphism on the hippocampus in healthy individuals and patients with depression (mdd). |
2012-02-22 |
2023-08-12 |
Not clear |
| Li-ping Chen, Yan Sun, Fa-wei Wang, Dong-mei Duan, Ya-zhuo H. [Effect of Shuyusan on neuropeptide Y and serotonin expression in the hippocampal neurons of rats with chronic mild unpredictable stress-induced depression]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 31. issue 1. 2012-02-13. PMID:21269971. |
[effect of shuyusan on neuropeptide y and serotonin expression in the hippocampal neurons of rats with chronic mild unpredictable stress-induced depression]. |
2012-02-13 |
2023-08-12 |
rat |
| Li-ping Chen, Yan Sun, Fa-wei Wang, Dong-mei Duan, Ya-zhuo H. [Effect of Shuyusan on neuropeptide Y and serotonin expression in the hippocampal neurons of rats with chronic mild unpredictable stress-induced depression]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 31. issue 1. 2012-02-13. PMID:21269971. |
to investigate the effect of shuyusan decoction on neuropeptide y (npy) and serotonin (5-ht) expression in the hippocampus and plasma of rats with chronic mild unpredictable stressors depression. |
2012-02-13 |
2023-08-12 |
rat |
| Darakhshan J Halee. Behavioral deficits and exaggerated feedback control over raphe-hippocampal serotonin neurotransmission in restrained rats. Pharmacological reports : PR. vol 63. issue 4. 2012-02-10. PMID:22001976. |
serotonin (5-hydroxytryptamine, 5-ht), acting via the hippocampus, is thought to be critical for the neuroadaptation that alleviates the adverse effects of stress on emotion and behavior. |
2012-02-10 |
2023-08-12 |
rat |
| Darakhshan J Halee. Behavioral deficits and exaggerated feedback control over raphe-hippocampal serotonin neurotransmission in restrained rats. Pharmacological reports : PR. vol 63. issue 4. 2012-02-10. PMID:22001976. |
acute exposure to 2 h of restraint stress increased 5-ht metabolism in the cortex and raphe region but had no such effect in the hippocampus. |
2012-02-10 |
2023-08-12 |
rat |
| Darakhshan J Halee. Behavioral deficits and exaggerated feedback control over raphe-hippocampal serotonin neurotransmission in restrained rats. Pharmacological reports : PR. vol 63. issue 4. 2012-02-10. PMID:22001976. |
animals sacrificed 24 h after termination of the stress period exhibited a decrease in the concentration of 5-ht and its metabolite 5-hydroxyindoleacetic acid (5-hiaa) in the hippocampus but not in the cortex and raphe. |
2012-02-10 |
2023-08-12 |
rat |
| Darakhshan J Halee. Behavioral deficits and exaggerated feedback control over raphe-hippocampal serotonin neurotransmission in restrained rats. Pharmacological reports : PR. vol 63. issue 4. 2012-02-10. PMID:22001976. |
8-hydroxy-2-di-n-propylaminotetralin (8-oh-dpat) injected at doses of 0.125, 0.25 and 0.5 mg/kg decreased 5-ht metabolism in the raphe, cortex and hippocampus of restrained and unrestrained animals, and the decreases in the raphe and hippocampus, but not those in the cortex, were greater in restrained than unrestrained animals. |
2012-02-10 |
2023-08-12 |
rat |
| Ouissame Mnie-Filali, Céline Faure, Laura Lambás-Señas, Mostafa El Mansari, Hassina Belblidia, Elise Gondard, Adeline Etiévant, Hélène Scarna, Anne Didier, Anne Berod, Pierre Blier, Nasser Haddjer. Pharmacological blockade of 5-HT7 receptors as a putative fast acting antidepressant strategy. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 6. 2012-02-09. PMID:21326194. |
in contrast with fluoxetine, a 1-week treatment with sb-269970 did not alter 5-ht firing activity but desensitized cell body 5-ht autoreceptors, enhanced the hippocampal cell proliferation, and counteracted the depressive-like behavior in olfactory bulbectomized rats. |
2012-02-09 |
2023-08-12 |
rat |
| Paulina Rok-Bujko, Paweł Krząścik, Janusz Szyndler, Wojciech Kostowski, Roman Stefańsk. The influence of neonatal serotonin depletion on emotional and exploratory behaviours in rats. Behavioural brain research. vol 226. issue 1. 2012-02-09. PMID:21893103. |
biochemical analysis of 5,7-dht-treated rats revealed a significant decrease in the concentration of 5-ht and its metabolite in the frontal cortex, hippocampus and striatum, with a decreased dopamine level in striatum. |
2012-02-09 |
2023-08-12 |
rat |
| Yi-Qun Wang, Zhi-Cai Tu, Xing-Yuan Xu, Rui Li, Wei-Min Qu, Yoshihiro Urade, Zhi-Li Huan. Acute administration of fluoxetine normalizes rapid eye movement sleep abnormality, but not depressive behaviors in olfactory bulbectomized rats. Journal of neurochemistry. vol 120. issue 2. 2012-02-09. PMID:22035172. |
neurochemistry studies revealed that acute administration of fluoxetine increased serotonin (5-ht) levels in the hippocampus, thalamus, and midbrain and decreased levels of the 5-ht metabolite 5-hydroxyindoleacetic acid (5-hiaa). |
2012-02-09 |
2023-08-12 |
rat |
| Sairam Krishnamurthy, Debapriya Garabadu, Nagannathahalli Ranga Reddy, Keerikkattil P Jo. Risperidone in ultra low dose protects against stress in the rodent cold restraint model by modulating stress pathways. Neurochemical research. vol 36. issue 10. 2012-02-08. PMID:21660590. |
uld caused dose and brain region (hippocampus, prefrontal cortex and striatum) specific changes to stress-induced perturbations of serotonin, dopamine and its metabolites indicating modulation of brain monoaminergic system (bms). |
2012-02-08 |
2023-08-12 |
rat |
| Marlies Oostland, Jim Sellmeijer, Johannes A van Hoof. Transient expression of functional serotonin 5-HT3 receptors by glutamatergic granule cells in the early postnatal mouse cerebellum. The Journal of physiology. vol 589. issue Pt 20. 2012-02-07. PMID:21878518. |
the serotonin 5-ht(3) receptor is the only ligand-gated ion channel activated by serotonin and is expressed by gabaergic interneurons in many brain regions, including the cortex, amygdala and hippocampus. |
2012-02-07 |
2023-08-12 |
mouse |
| Sarah J Texel, Simonetta Camandola, Bruce Ladenheim, Sarah M Rothman, Mohamed R Mughal, Erica L Unger, Jean Lud Cadet, Mark P Mattso. Ceruloplasmin deficiency results in an anxiety phenotype involving deficits in hippocampal iron, serotonin, and BDNF. Journal of neurochemistry. vol 120. issue 1. 2012-02-06. PMID:22035068. |
ceruloplasmin deficiency results in an anxiety phenotype involving deficits in hippocampal iron, serotonin, and bdnf. |
2012-02-06 |
2023-08-12 |
mouse |
| Sarah J Texel, Simonetta Camandola, Bruce Ladenheim, Sarah M Rothman, Mohamed R Mughal, Erica L Unger, Jean Lud Cadet, Mark P Mattso. Ceruloplasmin deficiency results in an anxiety phenotype involving deficits in hippocampal iron, serotonin, and BDNF. Journal of neurochemistry. vol 120. issue 1. 2012-02-06. PMID:22035068. |
previous studies provided evidence that anxiety disorders and long-standing stress are associated with reductions in levels of serotonin (5ht) and brain-derived neurotrophic factor (bdnf) in the hippocampus. |
2012-02-06 |
2023-08-12 |
mouse |
| Sarah J Texel, Simonetta Camandola, Bruce Ladenheim, Sarah M Rothman, Mohamed R Mughal, Erica L Unger, Jean Lud Cadet, Mark P Mattso. Ceruloplasmin deficiency results in an anxiety phenotype involving deficits in hippocampal iron, serotonin, and BDNF. Journal of neurochemistry. vol 120. issue 1. 2012-02-06. PMID:22035068. |
we found that levels of 5ht and norepinephrine (ne), and the expression of bdnf and its receptor trkb, are significantly reduced in the hippocampus of cpko mice. |
2012-02-06 |
2023-08-12 |
mouse |
| Sarah J Texel, Simonetta Camandola, Bruce Ladenheim, Sarah M Rothman, Mohamed R Mughal, Erica L Unger, Jean Lud Cadet, Mark P Mattso. Ceruloplasmin deficiency results in an anxiety phenotype involving deficits in hippocampal iron, serotonin, and BDNF. Journal of neurochemistry. vol 120. issue 1. 2012-02-06. PMID:22035068. |
thus, cp deficiency causes an anxiety phenotype by a mechanism that involves decreased levels of iron, 5ht, ne, and bdnf in the hippocampus. |
2012-02-06 |
2023-08-12 |
mouse |
| Koilmani Emmanuvel Rajan, Hemant K Singh, Arunagiri Parkavi, Prisila Dulcy Charle. Attenuation of 1-(m-chlorophenyl)-biguanide induced hippocampus-dependent memory impairment by a standardised extract of Bacopa monniera (BESEB CDRI-08). Neurochemical research. vol 36. issue 11. 2012-01-27. PMID:21735137. |
wistar rat pups received a single dose of beseb cdri-08 during postnatal days 15-29 showed higher latency during hippocampal-dependent learning accompanied with enhanced 5ht(3a) receptor expression, serotonin and acetylcholine levels in hippocampus. |
2012-01-27 |
2023-08-12 |
rat |
| Yinyin Xia, Shuqun Cheng, Junlin He, Xueqing Liu, Yan Tang, Haiyan Yuan, Lijun He, Tao Lu, Baijie Tu, Yingxiong Wan. Effects of subchronic exposure to benzo[a]pyrene (B[a]P) on learning and memory, and neurotransmitters in male Sprague-Dawley rat. Neurotoxicology. vol 32. issue 2. 2012-01-25. PMID:21216261. |
endogenous monoamine levels, norepinephrine (ne), adrenaline (a), dopamine (da) and 5-hydroxytryptamine (5-ht) and their selected metabolites dihydroxyphenylacetic acid (dopac) and 5-hydroxyindoleacetic acid (5-hiaa) in hippocampus were measured using high performance liquid chromatography (hplc). |
2012-01-25 |
2023-08-12 |
rat |
| Yinyin Xia, Shuqun Cheng, Junlin He, Xueqing Liu, Yan Tang, Haiyan Yuan, Lijun He, Tao Lu, Baijie Tu, Yingxiong Wan. Effects of subchronic exposure to benzo[a]pyrene (B[a]P) on learning and memory, and neurotransmitters in male Sprague-Dawley rat. Neurotoxicology. vol 32. issue 2. 2012-01-25. PMID:21216261. |
b[a]p at both doses, 2.5 and 6.25 mg/kg, increased ne, da, dopac and 5-ht content in the hippocampus. |
2012-01-25 |
2023-08-12 |
rat |
| Vanessa Nunes-de-Souza, Ricardo Nunes-de-Souza, Robert John Rodgers, Azair Canto-de-Souz. Blockade of 5-HT(2) receptors in the periaqueductal grey matter (PAG) abolishes the anxiolytic-like effect of 5-HT(1A) receptor antagonism in the median raphe nucleus in mice. Behavioural brain research. vol 225. issue 2. 2012-01-24. PMID:21839779. |
in this context, it is known that blockade of 5-ht(1a) somatodendritic autoreceptors in the midbrain raphe nuclei increases the firing rate of these neurons, disinhibiting 5-ht release in postsynaptic target areas such as amygdala, hippocampus and periaqueductal grey matter (pag). |
2012-01-24 |
2023-08-12 |
mouse |