| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R D Creech, Q Li, G A Carrasco, L D Van de Kar, N A Mum. Estradiol induces partial desensitization of serotonin 1A receptor signaling in the paraventricular nucleus of the hypothalamus and alters expression and interaction of RGSZ1 and Gαz. Neuropharmacology. vol 62. issue 5-6. 2012-07-23. PMID:22251927. |
a 55 kd membrane-associate rgsz1 protein was greatly increased in the pvn and rest of the hypothalamus and moderately increased in the dorsal hippocampus and amygdala after eb treatment as well as after an acute dose of a 5-ht(1a) receptor agonist. |
2012-07-23 |
2023-08-12 |
Not clear |
| P Panther, S Nullmeier, H Dobrowolny, H Schwegler, R Wol. CPB-K mice a mouse model of schizophrenia? Differences in dopaminergic, serotonergic and behavioral markers compared to BALB/cJ mice. Behavioural brain research. vol 230. issue 1. 2012-07-23. PMID:22454846. |
our results can be summarized as follows: compared to balb/cj, cpb-k mice showed:(1) significantly reduced traveling distance and number of contacts in social interaction test, (2) differences in the number of serotonin transporter-immunoreactive neurons and volume of raphe nuclei and a lower serotonergic fiber density in the ventral and dorsal hippocampal subfields ca1 and ca3, (3) no alterations of dopaminergic markers like neuron number, neuron density and volume in subregions of substantia nigra and ventral tegmental area, but a significantly higher dopaminergic fiber density in the dorsal hippocampus, the ventral hippocampus of ca1 and gyrus dentatus, (4) no significant differences in serotonergic and dopaminergic fiber densities in the amygdala.based on our results and previous studies, cpb-k mice compared to balb/cj may serve as an important model to understand the interaction of the serotonergic and dopaminergic system and their impact on sensorimotor gating and cognitive function as related to neuropsychiatric disorders like schizophrenia. |
2012-07-23 |
2023-08-12 |
mouse |
| Simon Trent, Tommaso Cassano, Gaurav Bedse, Obah A Ojarikre, Trevor Humby, William Davie. Altered serotonergic function may partially account for behavioral endophenotypes in steroid sulfatase-deficient mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 5. 2012-07-20. PMID:22189290. |
high performance liquid chromatography analysis of monoamine levels in wild type and 39,x(y)*o brain tissue regions (the frontal cortex, striatum, thalamus, hippocampus, and cerebellum) revealed significantly higher levels of 5-hydroxytryptamine (5-ht) in the striatum and hippocampus of 39,x(y)*o mice. |
2012-07-20 |
2023-08-12 |
mouse |
| Simon Trent, Tommaso Cassano, Gaurav Bedse, Obah A Ojarikre, Trevor Humby, William Davie. Altered serotonergic function may partially account for behavioral endophenotypes in steroid sulfatase-deficient mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 5. 2012-07-20. PMID:22189290. |
significant correlations between hippocampal 5-ht levels and pr performance, and between striatal 5-ht levels and locomotor activity strongly implicate regionally-specific perturbations of the 5-ht system as a neurobiological candidate for behavioral differences between 40,xy and 39,x(y)*o mice. |
2012-07-20 |
2023-08-12 |
mouse |
| Isabella Peruga, Silvia Hartwig, Doron Merkler, Jan Thöne, Bernhard Hovemann, Georg Juckel, Ralf Gold, Ralf A Linke. Endogenous ciliary neurotrophic factor modulates anxiety and depressive-like behavior. Behavioural brain research. vol 229. issue 2. 2012-07-17. PMID:22266927. |
in the hippocampus of 20 weeks old, but not 10 weeks old, cntf -/- mice, these changes correlated with a loss of parvalbumin immunoreactive gabaergic interneurons and a reduction of serotonin levels as well as 5-ht receptor 1a expression. |
2012-07-17 |
2023-08-12 |
mouse |
| Blanca Erika Gutiérrez-Guzmán, J Jesús Hernández-Pérez, Miguel Ángel López-Vázquez, Cesar Soria Fregozo, Miguel Ángel Guevara, María Esther Olvera-Corté. Serotonin depletion of supramammillary/posterior hypothalamus nuclei produces place learning deficiencies and alters the concomitant hippocampal theta activity in rats. European journal of pharmacology. vol 682. issue 1-3. 2012-07-17. PMID:22387092. |
serotonin depletion of supramammillary/posterior hypothalamus nuclei produces place learning deficiencies and alters the concomitant hippocampal theta activity in rats. |
2012-07-17 |
2023-08-12 |
rat |
| Blanca Erika Gutiérrez-Guzmán, J Jesús Hernández-Pérez, Miguel Ángel López-Vázquez, Cesar Soria Fregozo, Miguel Ángel Guevara, María Esther Olvera-Corté. Serotonin depletion of supramammillary/posterior hypothalamus nuclei produces place learning deficiencies and alters the concomitant hippocampal theta activity in rats. European journal of pharmacology. vol 682. issue 1-3. 2012-07-17. PMID:22387092. |
the participation of the sumn in place learning and modulation of hippocampal theta activity were recently shown; thus, we questioned whether serotonin acting on sumn/phn could modulate place learning ability and concurrent hippocampal theta activity. |
2012-07-17 |
2023-08-12 |
rat |
| Blanca Erika Gutiérrez-Guzmán, J Jesús Hernández-Pérez, Miguel Ángel López-Vázquez, Cesar Soria Fregozo, Miguel Ángel Guevara, María Esther Olvera-Corté. Serotonin depletion of supramammillary/posterior hypothalamus nuclei produces place learning deficiencies and alters the concomitant hippocampal theta activity in rats. European journal of pharmacology. vol 682. issue 1-3. 2012-07-17. PMID:22387092. |
we conclude that serotonin can regulate the hippocampal theta activity acting on the sumn/phn relay of the sas and that the influence of 5-ht in these nuclei is required for the learning-related changes in hippocampal theta activity that underlie the successful resolution of the morris water maze task. |
2012-07-17 |
2023-08-12 |
rat |
| M A Santini, A B Klein, M El-Sayed, C Ratner, G M Knudsen, J D Mikkelsen, S Azna. Novelty-induced activity-regulated cytoskeletal-associated protein (Arc) expression in frontal cortex requires serotonin 2A receptor activation. Neuroscience. vol 190. 2012-07-05. PMID:21664256. |
pretreatment with 5-ht(2a)r antagonist ketanserin did not repress the arc induction in hippocampus, indicating that the involvement of 5-ht(2a)r in this response is restricted to the fc. |
2012-07-05 |
2023-08-12 |
mouse |
| K Tokarski, M Kusek, G Hes. 5-HT7 receptors modulate GABAergic transmission in rat hippocampal CA1 area. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 62. issue 5. 2012-06-25. PMID:22204801. |
the effects of the activation of serotonin-7 (5-ht(7)) receptors were investigated in the ca1 area pyramidal cells and stratum radiatum fast spiking gabaergic interneurons of rat hippocampal slices. |
2012-06-25 |
2023-08-12 |
rat |
| Yu-Lung Lin, Shu-Yi Lin, Sabrina Wan. Prenatal lipopolysaccharide exposure increases anxiety-like behaviors and enhances stress-induced corticosterone responses in adult rats. Brain, behavior, and immunity. vol 26. issue 3. 2012-06-22. PMID:22198119. |
dopamine (da) in the nucleus accumbens and serotonin (5-ht) in the medial prefrontal cortex and the hippocampus were significantly reduced in lps rats. |
2012-06-22 |
2023-08-12 |
rat |
| Yu-Lung Lin, Shu-Yi Lin, Sabrina Wan. Prenatal lipopolysaccharide exposure increases anxiety-like behaviors and enhances stress-induced corticosterone responses in adult rats. Brain, behavior, and immunity. vol 26. issue 3. 2012-06-22. PMID:22198119. |
their glucocorticoid receptors in the dorsal hippocampus and the 5-ht(1a) receptors in the dorsal and ventral hippocampus were also reduced. |
2012-06-22 |
2023-08-12 |
rat |
| Yu-Lung Lin, Shu-Yi Lin, Sabrina Wan. Prenatal lipopolysaccharide exposure increases anxiety-like behaviors and enhances stress-induced corticosterone responses in adult rats. Brain, behavior, and immunity. vol 26. issue 3. 2012-06-22. PMID:22198119. |
in addition, chronic but not acute fluoxetine treatment reversed the behavioral changes and increased hippocampal 5-ht(1a) receptor expression. |
2012-06-22 |
2023-08-12 |
rat |
| Ghulam Abbas, Sabira Naqvi, Ahsana Da. Comparison of monoamine reuptake inhibitors for the immobility time and serotonin levels in the hippocampus and plasma of sub-chronically forced swim stressed rats. Pakistan journal of pharmaceutical sciences. vol 25. issue 2. 2012-06-11. PMID:22459475. |
comparison of monoamine reuptake inhibitors for the immobility time and serotonin levels in the hippocampus and plasma of sub-chronically forced swim stressed rats. |
2012-06-11 |
2023-08-12 |
rat |
| Ghulam Abbas, Sabira Naqvi, Ahsana Da. Comparison of monoamine reuptake inhibitors for the immobility time and serotonin levels in the hippocampus and plasma of sub-chronically forced swim stressed rats. Pakistan journal of pharmaceutical sciences. vol 25. issue 2. 2012-06-11. PMID:22459475. |
in the hippocampus of rats, the imipramine treatment caused significant elevation of 5-hydroxytryptamine (5-ht) whereas, the fluoxetine and venlafaxine elicited significant increase in 5-hydroxyindoleacetic acid (5-hiaa) levels. |
2012-06-11 |
2023-08-12 |
rat |
| S L Diaz, S Doly, N Narboux-Nême, S Fernández, P Mazot, S M Banas, K Boutourlinsky, I Moutkine, A Belmer, A Roumier, L Maroteau. 5-HT(2B) receptors are required for serotonin-selective antidepressant actions. Molecular psychiatry. vol 17. issue 2. 2012-06-04. PMID:22158014. |
moreover, the observation that (i) this receptor is expressed by raphe serotonergic neurons, (ii) the ssri-induced increase in hippocampal extracellular serotonin concentration is strongly reduced in the absence of functional 5-ht(2b) receptors and (iii) a selective 5-ht(2b) agonist mimics ssri responses, supports a positive regulation of serotonergic neurons by 5-ht(2b) receptors. |
2012-06-04 |
2023-08-12 |
Not clear |
| Y Xu, C Zhang, R Wang, S S Govindarajan, P A Barish, M M Vernon, C Fu, A P Acharya, L Chen, E Boykin, J Yu, J Pan, J M O'Donnell, W O Ogl. Corticosterone induced morphological changes of hippocampal and amygdaloid cell lines are dependent on 5-HT7 receptor related signal pathway. Neuroscience. vol 182. 2012-05-31. PMID:21371532. |
we now show that 5-ht(7) receptor mrna levels were significantly upregulated in ht-22 cells, but downregulated in ar-5 cells by exposure to a physiologically relevant level of cort (50 μm) for 24 h, which was later confirmed by primary hippocampal and amygdaloid neuron cultures. |
2012-05-31 |
2023-08-12 |
Not clear |
| Y Xu, C Zhang, R Wang, S S Govindarajan, P A Barish, M M Vernon, C Fu, A P Acharya, L Chen, E Boykin, J Yu, J Pan, J M O'Donnell, W O Ogl. Corticosterone induced morphological changes of hippocampal and amygdaloid cell lines are dependent on 5-HT7 receptor related signal pathway. Neuroscience. vol 182. 2012-05-31. PMID:21371532. |
these observed results support the hypothesis that 5-ht may differentially modulate neuronal morphology in the hippocampus and amygdala depending on the expression levels of the 5-ht receptor subtypes during stress hormone insults. |
2012-05-31 |
2023-08-12 |
Not clear |
| J L Barr, G L Forste. Serotonergic neurotransmission in the ventral hippocampus is enhanced by corticosterone and altered by chronic amphetamine treatment. Neuroscience. vol 182. 2012-05-31. PMID:21420472. |
extracellular serotonin in the ventral hippocampus was increased by corticosterone in drug naive rats, and this corticosterone-induced serotonin augmentation was blocked by the glucocorticoid receptor antagonist mifepristone. |
2012-05-31 |
2023-08-12 |
rat |
| J L Barr, G L Forste. Serotonergic neurotransmission in the ventral hippocampus is enhanced by corticosterone and altered by chronic amphetamine treatment. Neuroscience. vol 182. 2012-05-31. PMID:21420472. |
together, our results suggest that chronic amphetamine exposure reduces serotonergic neurotransmission, in part via alterations to glucocorticoid receptor-facilitation of serotonin release in the rat ventral hippocampus. |
2012-05-31 |
2023-08-12 |
rat |