| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A C Meyer, D B Horton, N M Neugebauer, T E Wooters, J R Nickell, L P Dwoskin, M T Bard. Tetrabenazine inhibition of monoamine uptake and methamphetamine behavioral effects: locomotor activity, drug discrimination and self-administration. Neuropharmacology. vol 61. issue 4. 2012-05-25. PMID:21669212. |
effects of tbz on function of the dopamine transporter (dat) and serotonin transporter (sert) in striatal and hippocampal synaptosomes, respectively, and on vmat2 function in isolated striatal synaptic vesicles were determined. |
2012-05-25 |
2023-08-12 |
rat |
| M Roche, D M Kerr, S P Hunt, J P Kell. Neurokinin-1 receptor deletion modulates behavioural and neurochemical alterations in an animal model of depression. Behavioural brain research. vol 228. issue 1. 2012-05-24. PMID:22155476. |
although nk1 receptor knockout (nk1-/-) mice did not exhibit altered behavioural responding in the open field test, noradrenaline levels were enhanced in the frontal cortex, amygdala and hippocampus, as were serotonin levels in the frontal cortex. |
2012-05-24 |
2023-08-12 |
mouse |
| Linlin Zhen, Jiejin Zhu, Xin Zhao, Wu Huang, Yiran An, Shan Li, Xia Du, Mengmeng Lin, Qiandong Wang, Ying Xu, Jianchun Pa. The antidepressant-like effect of fisetin involves the serotonergic and noradrenergic system. Behavioural brain research. vol 228. issue 2. 2012-05-23. PMID:22197297. |
moreover, neurochemical assays showed that fisetin produced an increase in serotonin and noradrenaline levels in the frontal cortex and hippocampus. |
2012-05-23 |
2023-08-12 |
mouse |
| Olaf Schulte-Herbrüggen, Miriam A Vogt, Heide Hörtnagl, Peter Gass, Rainer Hellwe. Pramipexole is active in depression tests and modulates monoaminergic transmission, but not brain levels of BDNF in mice. European journal of pharmacology. vol 677. issue 1-3. 2012-05-17. PMID:22206815. |
in a second experiment dosages of pramipexole shown to be effective were used and candidate brain regions including hippocampus, frontal cortex and striatum were analyzed for levels of 5-hydroxytryptamine (5-ht), noradrenaline and dopamine and their metabolites as well as brain-derived neurotrophic factor (bdnf) to investigate possible neurochemical correlates of behavioral changes. |
2012-05-17 |
2023-08-12 |
mouse |
| Sung-Jin An, Duk-Soo Ki. Alterations in serotonin receptors and transporter immunoreactivities in the hippocampus in the rat unilateral hypoxic-induced epilepsy model. Cellular and molecular neurobiology. vol 31. issue 8. 2012-05-14. PMID:21681557. |
alterations in serotonin receptors and transporter immunoreactivities in the hippocampus in the rat unilateral hypoxic-induced epilepsy model. |
2012-05-14 |
2023-08-12 |
rat |
| Sung-Jin An, Duk-Soo Ki. Alterations in serotonin receptors and transporter immunoreactivities in the hippocampus in the rat unilateral hypoxic-induced epilepsy model. Cellular and molecular neurobiology. vol 31. issue 8. 2012-05-14. PMID:21681557. |
to elucidate the roles of serotonin (5-hydroxytryptamine [5-ht]) in an epileptogenic insult, we investigated the changes in 5-ht receptors and serotonin transporter (5-htt) immunoreactivities within the lesioned and contralateral hippocampus following unilateral hypoxic-ischemia. |
2012-05-14 |
2023-08-12 |
rat |
| Sung-Jin An, Duk-Soo Ki. Alterations in serotonin receptors and transporter immunoreactivities in the hippocampus in the rat unilateral hypoxic-induced epilepsy model. Cellular and molecular neurobiology. vol 31. issue 8. 2012-05-14. PMID:21681557. |
during epileptogenic periods following hypoxic-ischemia, both 5-ht(1a) and 5ht(1b) receptor immunoreactivities were decreased within the lesioned and the non-lesioned hippocampus. |
2012-05-14 |
2023-08-12 |
rat |
| Paolo Tucci, Maria Grazia Morgese, Marilena Colaianna, Margherita Zotti, Stefania Schiavone, Vincenzo Cuomo, Luigia Trabac. Neurochemical consequence of steroid abuse: stanozolol-induced monoaminergic changes. Steroids. vol 77. issue 3. 2012-05-11. PMID:22197661. |
twenty-four hours after last injection, changes of dopamine (da) and relative metabolite levels, homovanilic acid (hva) and 3,4-dihydroxy phenylacetic acid (dopac), serotonin (5-ht) and its metabolite levels, 5-hydroxy indolacetic acid (5-hiaa), and noradrenaline (na) amount were investigated in prefrontal cortex (pfc), nucleus accumbens (nac), striatum (str) and hippocampus (hipp). |
2012-05-11 |
2023-08-12 |
rat |
| Zacharias Kohl, Beate Winner, Kiren Ubhi, Edward Rockenstein, Michael Mante, Martina Münch, Carolee Barlow, Todd Carter, Eliezer Masliah, Jürgen Winkle. Fluoxetine rescues impaired hippocampal neurogenesis in a transgenic A53T synuclein mouse model. The European journal of neuroscience. vol 35. issue 1. 2012-05-07. PMID:22211740. |
the present study explored if impaired hippocampal neurogenesis in the a53t transgenic animal model of pd may be restored by chronic oral application of the selective serotonin reuptake inhibitor (ssri) fluoxetine. |
2012-05-07 |
2023-08-12 |
mouse |
| Pushpendra Singh, Amitabha Chattopadhya. Removal of sphingomyelin headgroup inhibits the ligand binding function of hippocampal serotonin1A receptors. Biochemical and biophysical research communications. vol 419. issue 2. 2012-05-07. PMID:22342718. |
in this work, we explored the ligand binding function of the hippocampal serotonin(1a) receptor upon hydrolyzing sphingomyelin to ceramide and phosphocholine using sphingomyelinase. |
2012-05-07 |
2023-08-12 |
Not clear |
| Pushpendra Singh, Amitabha Chattopadhya. Removal of sphingomyelin headgroup inhibits the ligand binding function of hippocampal serotonin1A receptors. Biochemical and biophysical research communications. vol 419. issue 2. 2012-05-07. PMID:22342718. |
we show here that specific agonist binding to serotonin(1a) receptors in native hippocampal membranes is considerably reduced upon sphingomyelinase treatment. |
2012-05-07 |
2023-08-12 |
Not clear |
| Shiho Arakawa, Yukihiko Shirayama, Yuko Fujita, Tamaki Ishima, Mao Horio, Katsumasa Muneoka, Masaomi Iyo, Kenji Hashimot. Minocycline produced antidepressant-like effects on the learned helplessness rats with alterations in levels of monoamine in the amygdala and no changes in BDNF levels in the hippocampus at baseline. Pharmacology, biochemistry, and behavior. vol 100. issue 3. 2012-05-04. PMID:21967886. |
lh rats showed significantly higher serotonin turnover in the orbitofrontal cortex and lower levels of brain-derived neurotrophic factor (bdnf) in the hippocampus than control rats. |
2012-05-04 |
2023-08-12 |
rat |
| A Mørk, A Pehrson, L T Brennum, S Møller Nielsen, H Zhong, A B Lassen, S Miller, L Westrich, N J Boyle, C Sánchez, C W Fischer, N Liebenberg, G Wegener, C Bundgaard, S Hogg, B Bang-Andersen, T Bryan Stensbø. Pharmacological effects of Lu AA21004: a novel multimodal compound for the treatment of major depressive disorder. The Journal of pharmacology and experimental therapeutics. vol 340. issue 3. 2012-05-04. PMID:22171087. |
in rat microdialysis experiments, lu aa21004 (2.5-10.0 mg/kg s.c.) increased extracellular 5-ht, dopamine, and noradrenaline in the medial prefrontal cortex and ventral hippocampus. |
2012-05-04 |
2023-08-12 |
human |
| A Mørk, A Pehrson, L T Brennum, S Møller Nielsen, H Zhong, A B Lassen, S Miller, L Westrich, N J Boyle, C Sánchez, C W Fischer, N Liebenberg, G Wegener, C Bundgaard, S Hogg, B Bang-Andersen, T Bryan Stensbø. Pharmacological effects of Lu AA21004: a novel multimodal compound for the treatment of major depressive disorder. The Journal of pharmacology and experimental therapeutics. vol 340. issue 3. 2012-05-04. PMID:22171087. |
lu aa21004 (5 mg/kg per day for 3 days; minipump subcutaneously), corresponding to 41% rsert occupancy, significantly increased extracellular 5-ht in the ventral hippocampus. |
2012-05-04 |
2023-08-12 |
human |
| Paulina Kołomańska, Edyta Wyszogrodzka, Paulina Rok-Bujko, Paweł Krząścik, Wojciech Kostowski, Magdalena Zaniewska, Małgorzata Filip, Roman Stefańsk. Neonatal serotonin (5-HT) depletion does not disrupt prepulse inhibition of the startle response in rats. Pharmacological reports : PR. vol 63. issue 5. 2012-05-01. PMID:22180349. |
despite a severe and permanent decrease (80-100%) in hippocampal, prefrontal and striatal 5-ht levels, treatment with 5,7-dht caused no disruption of ppi. |
2012-05-01 |
2023-08-12 |
rat |
| Thomas M Tzschentke, Joost H A Folgering, Gunnar Flik, Jean De Vr. Tapentadol increases levels of noradrenaline in the rat spinal cord as measured by in vivo microdialysis. Neuroscience letters. vol 507. issue 2. 2012-04-26. PMID:22197547. |
we showed previously that tapentadol, in contrast to morphine, elevates levels of noradrenaline, but not serotonin, in the ventral hippocampus of rats. |
2012-04-26 |
2023-08-12 |
rat |
| Agata Kiss, Ana Márcia Delattre, Sofia I R Pereira, Ruither G Carolino, Raphael E Szawka, Janete A Anselmo-Franci, Sílvio M Zanata, Anete C Ferra. 17β-estradiol replacement in young, adult and middle-aged female ovariectomized rats promotes improvement of spatial reference memory and an antidepressant effect and alters monoamines and BDNF levels in memory- and depression-related brain areas. Behavioural brain research. vol 227. issue 1. 2012-04-23. PMID:22085882. |
neurochemical evaluations indicated that 17β-estradiol treatment was able to increase serotonin turnover rate in the hippocampus of adult rats. |
2012-04-23 |
2023-08-12 |
rat |
| Fritz Kobe, Daria Guseva, Thomas P Jensen, Alexander Wirth, Ute Renner, Dietmar Hess, Michael Müller, Lucian Medrihan, Weiqi Zhang, Mingyue Zhang, Katharina Braun, Sören Westerholz, Andreas Herzog, Konstantin Radyushkin, Ahmed El-Kordi, Hannelore Ehrenreich, Diethelm W Richter, Dmitri A Rusakov, Evgeni Ponimaski. 5-HT7R/G12 signaling regulates neuronal morphology and function in an age-dependent manner. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 9. 2012-04-20. PMID:22378867. |
here we report that activation of the serotonin 5-ht(7) receptor promotes synaptogenesis and enhances synaptic activity in hippocampal neurons at early postnatal stages. |
2012-04-20 |
2023-08-12 |
mouse |
| Fritz Kobe, Daria Guseva, Thomas P Jensen, Alexander Wirth, Ute Renner, Dietmar Hess, Michael Müller, Lucian Medrihan, Weiqi Zhang, Mingyue Zhang, Katharina Braun, Sören Westerholz, Andreas Herzog, Konstantin Radyushkin, Ahmed El-Kordi, Hannelore Ehrenreich, Diethelm W Richter, Dmitri A Rusakov, Evgeni Ponimaski. 5-HT7R/G12 signaling regulates neuronal morphology and function in an age-dependent manner. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 9. 2012-04-20. PMID:22378867. |
in organotypic preparations from the hippocampus of juvenile mice, stimulation of 5-ht(7)r/g(12) signaling potentiates formation of dendritic spines, increases neuronal excitability, and modulates synaptic plasticity. |
2012-04-20 |
2023-08-12 |
mouse |
| Fritz Kobe, Daria Guseva, Thomas P Jensen, Alexander Wirth, Ute Renner, Dietmar Hess, Michael Müller, Lucian Medrihan, Weiqi Zhang, Mingyue Zhang, Katharina Braun, Sören Westerholz, Andreas Herzog, Konstantin Radyushkin, Ahmed El-Kordi, Hannelore Ehrenreich, Diethelm W Richter, Dmitri A Rusakov, Evgeni Ponimaski. 5-HT7R/G12 signaling regulates neuronal morphology and function in an age-dependent manner. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 9. 2012-04-20. PMID:22378867. |
moreover, inhibition of 5-ht(7) receptor had no effect on synaptic plasticity in hippocampus of adult animals. |
2012-04-20 |
2023-08-12 |
mouse |