| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M T Lowy, J F Nash, H Y Meltze. Selective reduction of striatal type II glucocorticoid receptors in rats by 3,4-methylenedioxymethamphetamine (MDMA). European journal of pharmacology. vol 163. issue 1. 1989-08-21. PMID:2472965. |
a single 20 mg/kg dose of 3,4-methylenedioxymethamphetamine (mdma) administered to rats markedly decreased serotonin (5-ht) and 5-hydroxyindoleacetic acid (5-hiaa) levels in hippocampus, frontal cortex and striatum seven days following injection. |
1989-08-21 |
2023-08-11 |
rat |
| R Invernizzi, C Fracasso, S Caccia, A Di Clemente, S Garattini, R Samani. Effect of L-cysteine on the long-term depletion of brain indoles caused by p-chloroamphetamine and d-fenfluramine in rats. Relation to brain drug concentrations. European journal of pharmacology. vol 163. issue 1. 1989-08-21. PMID:2744095. |
significantly reduced serotonin and 5-hydroxyindoleacetic acid levels in the striatum, hippocampus and cortex, particularly in the latter areas. |
1989-08-21 |
2023-08-11 |
rat |
| O Rascol, P Dutar, Y Lamou. Involvement of a pertussis toxin-sensitive G-protein in the pharmacological properties of septo-hippocampal neurones. British journal of pharmacology. vol 96. issue 4. 1989-08-18. PMID:2500997. |
these results suggest the involvement of a pertussis toxin-sensitive g-protein in responses medicated by 5-ht and gabab-receptors but not in responses mediated by cholinoceptors and gabaa-receptors in medial septum neurones projecting into the hippocampus. |
1989-08-18 |
2023-08-11 |
rat |
| S G Bec. 5-Carboxyamidotryptamine mimics only the 5-HT elicited hyperpolarization of hippocampal pyramidal cells via 5-HT1A receptor. Neuroscience letters. vol 99. issue 1-2. 1989-08-18. PMID:2748003. |
perfusion of the rat hippocampal slice in vitro by 5-hydroxytryptamine (5-ht) elicits 3 distinct actions recorded intracellularly from pyramidal cells in area ca1: a hyperpolarization, reduction in spike train elicited afterhyperpolarization (ahp) and depolarization. |
1989-08-18 |
2023-08-11 |
rat |
| E Blomstrand, D Perrett, M Parry-Billings, E A Newsholm. Effect of sustained exercise on plasma amino acid concentrations and on 5-hydroxytryptamine metabolism in six different brain regions in the rat. Acta physiologica Scandinavica. vol 136. issue 3. 1989-08-15. PMID:2473602. |
exercise caused an increase in the levels of 5-ht and 5-hydroxyindoleacetic acid (5-hiaa) in the brain stem (14 and 44% respectively) and hypothalamus (16 and 17% respectively) and an increase in the level of 5-hiaa in the hippocampus (21%) and striatum (28%). |
1989-08-15 |
2023-08-11 |
rat |
| H P Pfister, J L Mui. Influence of exogenously administered oxytocin on central noradrenaline, dopamine and serotonin levels following psychological stress in nulliparous female rats (Rattus norvegicus). The International journal of neuroscience. vol 45. issue 3-4. 1989-08-15. PMID:2744963. |
this study was designed to examine the effects of psychological stress and oxytocin treatment (5.8 or 11.6 iu/kg) on noradrenaline, dopamine and serotonin levels in the hypothalamus, hippocampus and brainstem. |
1989-08-15 |
2023-08-11 |
rat |
| H P Pfister, J L Mui. Influence of exogenously administered oxytocin on central noradrenaline, dopamine and serotonin levels following psychological stress in nulliparous female rats (Rattus norvegicus). The International journal of neuroscience. vol 45. issue 3-4. 1989-08-15. PMID:2744963. |
furthermore, when oxytocin was administered immediately prior to unpredictable exposure to the novelty stressor, a significant increase in levels of noradrenaline in the hypothalamus and serotonin in the hippocampus and brainstem were observed. |
1989-08-15 |
2023-08-11 |
rat |
| M S Kleven, W L Woolverton, L S Seide. Evidence that both intragastric and subcutaneous administration of methylenedioxymethylamphetamine (MDMA) produce serotonin neurotoxicity in rhesus monkeys. Brain research. vol 488. issue 1-2. 1989-08-14. PMID:2472850. |
further, a significant decrease in [3h]5-ht uptake sites in the hippocampus was observed in monkeys treated with mdma by the i.g. |
1989-08-14 |
2023-08-11 |
rat |
| J C Chen, P B Crino, P W Schnepper, A C To, L Volice. Increased serotonin efflux by a partially oxidized serotonin: tryptamine-4,5-dione. The Journal of pharmacology and experimental therapeutics. vol 250. issue 1. 1989-08-11. PMID:2473186. |
in in vitro superfusion experiments, 10(-5)m 4,5-dkt significantly increased the basal 5-ht efflux from both rat hippocampal and striatal fragments. |
1989-08-11 |
2023-08-11 |
rat |
| J C Chen, P B Crino, P W Schnepper, A C To, L Volice. Increased serotonin efflux by a partially oxidized serotonin: tryptamine-4,5-dione. The Journal of pharmacology and experimental therapeutics. vol 250. issue 1. 1989-08-11. PMID:2473186. |
in in vitro incubation experiments, 10(-8) to 10(-5) m 4,5-dkt evoked 5-ht efflux from rat hippocampus in a dose-dependent fashion. |
1989-08-11 |
2023-08-11 |
rat |
| M Johnson, A A Letter, K Merchant, G R Hanson, J W Gib. Effects of 3,4-methylenedioxyamphetamine and 3,4-methylenedioxymethamphetamine isomers on central serotonergic, dopaminergic and nigral neurotensin systems of the rat. The Journal of pharmacology and experimental therapeutics. vol 244. issue 3. 1989-08-10. PMID:2472482. |
with five successive doses (3.5 mg/kg) the d-mda isomer was more potent than the l-mda in its ability to decrease the concentrations of serotonin in the frontal cortex and hippocampus. |
1989-08-10 |
2023-08-11 |
rat |
| Y Claustre, L Rouquier, B Scatto. Pharmacological characterization of serotonin-stimulated phosphoinositide turnover in brain regions of the immature rat. The Journal of pharmacology and experimental therapeutics. vol 244. issue 3. 1989-08-10. PMID:2855237. |
in the presence of licl, 5-ht caused a marked increase in total [3h]inositol phosphate levels in cortical (maximal effect + 420%, ec50 = 7 microm) and to a lesser extent in hippocampal and striatal slices prepared from the immature (8-day-old) rat; the cortical 5-ht-induced phosphoinositide response was tetrodotoxin resistant. |
1989-08-10 |
2023-08-11 |
rat |
| Y Claustre, L Rouquier, B Scatto. Pharmacological characterization of serotonin-stimulated phosphoinositide turnover in brain regions of the immature rat. The Journal of pharmacology and experimental therapeutics. vol 244. issue 3. 1989-08-10. PMID:2855237. |
a variety of 5-ht2 or mixed 5-ht1/5-ht2 agonists stimulated total [3h]inositol phosphate formation in the immature rat cortex and hippocampus with a rank order of potency [alpha(+)-methyl-5-ht greater than quipazine greater than mk 212 greater than 5-ht] which resembles their potencies at the 5-ht2 binding site. |
1989-08-10 |
2023-08-11 |
rat |
| K T Borer, R Bonna, M Kiel. Hippocampal serotonin mediates hypoactivity in dietarily obese hamsters: a possible manifestation of aging? Pharmacology, biochemistry, and behavior. vol 31. issue 4. 1989-08-01. PMID:3252281. |
hippocampal serotonin mediates hypoactivity in dietarily obese hamsters: a possible manifestation of aging? |
1989-08-01 |
2023-08-11 |
Not clear |
| K T Borer, R Bonna, M Kiel. Hippocampal serotonin mediates hypoactivity in dietarily obese hamsters: a possible manifestation of aging? Pharmacology, biochemistry, and behavior. vol 31. issue 4. 1989-08-01. PMID:3252281. |
neurotoxin led to selective deletion of serotonin in the hippocampus (77%) and parietal cortex (50%). |
1989-08-01 |
2023-08-11 |
Not clear |
| P E Potter, C E Tedford, G Kindel, I Hani. Inhibition of high affinity choline transport attenuates both cholinergic and non-cholinergic effects of ethylcholine aziridinium (AF64A). Brain research. vol 487. issue 2. 1989-07-18. PMID:2525061. |
in earlier studies, using af64a, we reported that slow infusion of 1-2 nmol of this compound into each lateral ventricle of sprague-dawley rats resulted in small, and transient decreases in noradrenaline (na) and serotonin (5-ht) levels in the hippocampus, while inducing a permanent and significant cholinergic hypofunction in the same brain region. |
1989-07-18 |
2023-08-11 |
rat |
| T Sharp, S R Bramwell, D Clark, D G Grahame-Smit. In vivo measurement of extracellular 5-hydroxytryptamine in hippocampus of the anaesthetized rat using microdialysis: changes in relation to 5-hydroxytryptaminergic neuronal activity. Journal of neurochemistry. vol 53. issue 1. 1989-07-13. PMID:2470860. |
in vivo measurement of extracellular 5-hydroxytryptamine in hippocampus of the anaesthetized rat using microdialysis: changes in relation to 5-hydroxytryptaminergic neuronal activity. |
1989-07-13 |
2023-08-11 |
rat |
| T Sharp, S R Bramwell, D Clark, D G Grahame-Smit. In vivo measurement of extracellular 5-hydroxytryptamine in hippocampus of the anaesthetized rat using microdialysis: changes in relation to 5-hydroxytryptaminergic neuronal activity. Journal of neurochemistry. vol 53. issue 1. 1989-07-13. PMID:2470860. |
the effect of manipulating the activity of central 5-hydroxytryptamine (5-ht) neurones on extracellular 5-ht in ventral hippocampus of the chloral hydrate-anaesthetized rat was studied using the brain perfusion method, microdialysis. |
1989-07-13 |
2023-08-11 |
rat |
| T Sharp, S R Bramwell, D Clark, D G Grahame-Smit. In vivo measurement of extracellular 5-hydroxytryptamine in hippocampus of the anaesthetized rat using microdialysis: changes in relation to 5-hydroxytryptaminergic neuronal activity. Journal of neurochemistry. vol 53. issue 1. 1989-07-13. PMID:2470860. |
hippocampal dialysate levels of 5-ht sharply declined over the first hour after dialysis probe implantation, but then became constant. |
1989-07-13 |
2023-08-11 |
rat |
| T Sharp, S R Bramwell, D Clark, D G Grahame-Smit. In vivo measurement of extracellular 5-hydroxytryptamine in hippocampus of the anaesthetized rat using microdialysis: changes in relation to 5-hydroxytryptaminergic neuronal activity. Journal of neurochemistry. vol 53. issue 1. 1989-07-13. PMID:2470860. |
electrical stimulation (1-ms pulse width, 300 microa, 2-20 hz) of the dorsal raphe nucleus for 20 min caused a rapid rise in hippocampal 5-ht output, which immediately declined on cessation of the stimulus and was frequency-dependent. |
1989-07-13 |
2023-08-11 |
rat |