| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M A Gongwer, J M Murphy, W J McBride, L Lumeng, T K L. Regional brain contents of serotonin, dopamine and their metabolites in the selectively bred high- and low-alcohol drinking lines of rats. Alcohol (Fayetteville, N.Y.). vol 6. issue 4. 1989-10-03. PMID:2475142. |
compared with the lad line, the contents of 5-ht and/or 5-hydroxyindoleacetic acid were approximately 10-20% (p less than 0.05) lower in several brain regions of the had line (cerebral cortex, striatum, nucleus accumbens, septal nuclei, hippocampus and hypothalamus). |
1989-10-03 |
2023-08-11 |
rat |
| T Mizuta, T Segaw. Chronic effects of imipramine and lithium on 5-HT receptor subtypes in rat frontal cortex, hippocampus and choroid plexus: quantitative receptor autoradiographic analysis. Japanese journal of pharmacology. vol 50. issue 3. 1989-09-20. PMID:2761132. |
the effects of chronic treatment with imipramine or lithium on serotonin (5-ht) receptor subtypes were analyzed in the frontal cortex, hippocampus and choroid plexus of rat brain by quantitative receptor autoradiographic procedures, using radioligands [3h]-5-ht, [3h]-8-hydroxy-2-(di-n-propylamino)tetralin ([3h]-8-oh-dpat), [125i]-iodocyanopindolol ([125i]-cyp), [3h]-mesulergine and [125i]-7-amino-8-iodo-ketanserin ([125i]-ketanserin) or [3h]-spiperone. |
1989-09-20 |
2023-08-11 |
rat |
| M Bugge, F Bengtsson, H Hall, I Wedel, A Nobin, B Jeppsson, P Herli. Serotonin receptors in the brain following total hepatectomy in rats treated with branched-chain amino acids. JPEN. Journal of parenteral and enteral nutrition. vol 13. issue 3. 1989-09-15. PMID:2474682. |
serotonin receptors (5-ht1 and 5-ht2) were investigated in the cortex and hippocampus by radioligand binding studies using 3h-serotonin for analysis of 5-ht1-receptors and 3h-ketanserin for analysis of 5-ht2-receptors. |
1989-09-15 |
2023-08-11 |
rat |
| P H Hutson, G S Sarna, M T O'Connell, G Curzo. Hippocampal 5-HT synthesis and release in vivo is decreased by infusion of 8-OHDPAT into the nucleus raphe dorsalis. Neuroscience letters. vol 100. issue 1-3. 1989-09-15. PMID:2474776. |
hippocampal 5-ht synthesis and release in vivo is decreased by infusion of 8-ohdpat into the nucleus raphe dorsalis. |
1989-09-15 |
2023-08-11 |
Not clear |
| P H Hutson, G S Sarna, M T O'Connell, G Curzo. Hippocampal 5-HT synthesis and release in vivo is decreased by infusion of 8-OHDPAT into the nucleus raphe dorsalis. Neuroscience letters. vol 100. issue 1-3. 1989-09-15. PMID:2474776. |
infusion of the serotonin-1a (5-ht1a) agonist, 8-hydroxy-2-di(n-propylamino)tetralin (8-ohdpat) (0.5, 1.0 and 2.0 micrograms) into the dorsal raphe, decreased extracellular 5-ht as measured by dialysis in the ventral hippocampus and also decreased 5-ht synthesis in both the hippocampus and the rest of the brain as measured by 5-hydroxytryptophan (5-htp) accumulation following decarboxylase inhibition by nsd 1015. |
1989-09-15 |
2023-08-11 |
Not clear |
| G B Baker, G P Reynold. Biogenic amines and their metabolites in Alzheimer's disease: noradrenaline, 5-hydroxytryptamine and 5-hydroxyindole-3-acetic acid depleted in hippocampus but not in substantia innominata. Neuroscience letters. vol 100. issue 1-3. 1989-09-15. PMID:2474777. |
biogenic amines and their metabolites in alzheimer's disease: noradrenaline, 5-hydroxytryptamine and 5-hydroxyindole-3-acetic acid depleted in hippocampus but not in substantia innominata. |
1989-09-15 |
2023-08-11 |
human |
| G B Baker, G P Reynold. Biogenic amines and their metabolites in Alzheimer's disease: noradrenaline, 5-hydroxytryptamine and 5-hydroxyindole-3-acetic acid depleted in hippocampus but not in substantia innominata. Neuroscience letters. vol 100. issue 1-3. 1989-09-15. PMID:2474777. |
the following monoamine transmitters and related neurochemicals were analyzed in hippocampus and substantia innominata from postmortem brain tissue of subjects with senile dementia of the alzheimer's type (sdat): tryptophan (tp), 5-hydroxytryptamine (5-ht), 5-hydroxyindole-3-acetic acid (5-hiaa), noradrenaline (na), dopamine (da) and homovanillic acid (hva). |
1989-09-15 |
2023-08-11 |
human |
| G B Baker, G P Reynold. Biogenic amines and their metabolites in Alzheimer's disease: noradrenaline, 5-hydroxytryptamine and 5-hydroxyindole-3-acetic acid depleted in hippocampus but not in substantia innominata. Neuroscience letters. vol 100. issue 1-3. 1989-09-15. PMID:2474777. |
while hippocampal 5-ht, 5-hiaa and na concentrations were markedly reduced in sdat patients relative to normals, the substantia innominata concentrations of these three were not significantly different between controls and sdat patients, emphasizing the importance of detailed regional analyses when conducting neurochemical studies in sdat. |
1989-09-15 |
2023-08-11 |
human |
| Y Nagai, S Narumi, M Kakihana, N Yamazaki, A Nagaoka, Y Nagaw. Effects of idebenone on metabolism of monoamines and cyclic AMP formation in rats. Archives of gerontology and geriatrics. vol 8. issue 3. 1989-09-14. PMID:2475075. |
), administered 24 h after the treatment with pcpa, accelerated the pcpa-induced 5-ht decreased in the hippocampus, diencephalon and brain stem in a dose-dependent manner. |
1989-09-14 |
2023-08-11 |
rat |
| Y Nagai, S Narumi, M Kakihana, N Yamazaki, A Nagaoka, Y Nagaw. Effects of idebenone on metabolism of monoamines and cyclic AMP formation in rats. Archives of gerontology and geriatrics. vol 8. issue 3. 1989-09-14. PMID:2475075. |
stimulated the release of 5-ht in the dorsal hippocampus as determined by in vivo differential pulse voltammetry. |
1989-09-14 |
2023-08-11 |
rat |
| Y Nagai, S Narumi, M Kakihana, N Yamazaki, A Nagaoka, Y Nagaw. Effects of idebenone on metabolism of monoamines and cyclic AMP formation in rats. Archives of gerontology and geriatrics. vol 8. issue 3. 1989-09-14. PMID:2475075. |
idebenone, like p-chloroamphetamine (pca), stimulated 5-ht release from slices of hippocampus and diencephalon, and the formation of cyclic amp in a concentration-dependent manner in rat diencephalon slice. |
1989-09-14 |
2023-08-11 |
rat |
| Y Nagai, S Narumi, M Kakihana, N Yamazaki, A Nagaoka, Y Nagaw. Effects of idebenone on metabolism of monoamines and cyclic AMP formation in rats. Archives of gerontology and geriatrics. vol 8. issue 3. 1989-09-14. PMID:2475075. |
idebenone slightly and pca markedly inhibited 5-ht uptake into hippocampus slices. |
1989-09-14 |
2023-08-11 |
rat |
| Y Nagai, S Narumi, M Kakihana, N Yamazaki, A Nagaoka, Y Nagaw. Effects of idebenone on metabolism of monoamines and cyclic AMP formation in rats. Archives of gerontology and geriatrics. vol 8. issue 3. 1989-09-14. PMID:2475075. |
the mechanism of the 5-ht releasing actions of idebenone in the hippocampal slices may be mediated through endogenous calcium. |
1989-09-14 |
2023-08-11 |
rat |
| Y Nagai, S Narumi, M Kakihana, N Yamazaki, A Nagaoka, Y Nagaw. Effects of idebenone on metabolism of monoamines and cyclic AMP formation in rats. Archives of gerontology and geriatrics. vol 8. issue 3. 1989-09-14. PMID:2475075. |
these results suggest that idebenone has an enhancing effect on the turnover of 5-ht in the hippocampus, diencephalon, and brain stem of rats. |
1989-09-14 |
2023-08-11 |
rat |
| D L Commins, R A Shaughnessy, K J Axt, G Vosmer, L S Seide. Variability among brain regions in the specificity of 6-hydroxydopamine (6-OHDA)-induced lesions. Journal of neural transmission. vol 77. issue 2-3. 1989-09-11. PMID:2503586. |
unexpectedly, however, the two highest doses of 6-ohda significantly decreased 5-ht levels in the hippocampus and increased 5-ht levels in the striatum. |
1989-09-11 |
2023-08-11 |
rat |
| R Nakov, E Habermann, G Hertting, S Wurster, C Allgaie. Effects of botulinum A toxin on presynaptic modulation of evoked transmitter release. European journal of pharmacology. vol 164. issue 1. 1989-09-07. PMID:2568939. |
rabbit hippocampal slices prelabelled with [3h]noradrenaline ([3h]na), [3h]5-hydroxytryptamine ([3h]5-ht) or [3h]choline were superfused with physiological medium and were stimulated electrically during superfusion. |
1989-09-07 |
2023-08-11 |
rabbit |
| A L Markowska, W S Stone, D K Ingram, J Reynolds, P E Gold, L H Conti, M J Pontecorvo, G L Wenk, D S Olto. Individual differences in aging: behavioral and neurobiological correlates. Neurobiology of aging. vol 10. issue 1. 1989-08-31. PMID:2569170. |
the following neurotransmitter markers were examined: choline acetyltransferase; the density of nicotinic, benzodiazepine and glutamine receptors in the cortex and caudate nucleus; endogenous levels of norepinephrine, dopamine, and serotonin in the cortex and hippocampus. |
1989-08-31 |
2023-08-11 |
rat |
| M E Otero-Losada, M C Rubi. Acute changes in 5-HT metabolism after S-adenosyl-L-methionine administration. General pharmacology. vol 20. issue 4. 1989-08-29. PMID:2473938. |
one hour after sam injection 5-ht biosynthesis was increased in the corpus striatum (55%), the hippocampus (3-fold) (82% 2 hr after sam injection) and decreased in the olfactory bulbs (34%). |
1989-08-29 |
2023-08-11 |
rat |
| M E Otero-Losada, M C Rubi. Acute changes in 5-HT metabolism after S-adenosyl-L-methionine administration. General pharmacology. vol 20. issue 4. 1989-08-29. PMID:2473938. |
5-ht levels were: (a) increased in the corpus striatum (39%), the hippocampus (44%) and the frontal cortex (27%), and oppositely reduced in the olfactory bulbs (47%) 1 hr after sam injection; (b) increased in the hippocampus (39%) and reduced in the olfactory bulbs (35%) 1.5 hr after sam injection; (c) increased in the hippocampus (25%) 2 hr after sam injection. |
1989-08-29 |
2023-08-11 |
rat |
| M Gobbi, C Taddei, T Mennin. In-vivo (+)-[3H]fenfluramine binding to rat brain: biochemical and autoradiographic studies. The Journal of pharmacy and pharmacology. vol 41. issue 4. 1989-08-25. PMID:2568465. |
the regional distribution of (+)-[3h]fenfluramine specific binding sites (hypothalamus greater than striatum = cortex greater than brainstem greater than hippocampus greater than cerebellum) closely parallels the regional distribution of 5-hydroxytryptamine uptake. |
1989-08-25 |
2023-08-11 |
rat |