| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J M Barnes, N M Barnes, B Costall, J W Ironside, R J Naylo. Identification and characterisation of 5-hydroxytryptamine 3 recognition sites in human brain tissue. Journal of neurochemistry. vol 53. issue 6. 1989-12-21. PMID:2809591. |
it is concluded that [3h]zacopride selectively labels with high affinity 5-ht3 recognition sites in human amygdala and hippocampus and, if these binding domains represent 5-ht3 receptors, may provide the opportunity for 5-ht3 receptor antagonists to modify 5-ht function in the human brain. |
1989-12-21 |
2023-08-11 |
human |
| L A Hilakivi, M Ota, R G Liste. Effect of isolation on brain monoamines and the behavior of mice in tests of exploration, locomotion, anxiety and behavioral 'despair'. Pharmacology, biochemistry, and behavior. vol 33. issue 2. 1989-12-19. PMID:2479036. |
monoamine assays failed to show significant changes in the noradrenaline, dopamine, hva, 5-ht or 5-hiaa contents in the amygdala, hypothalamus, hippocampus or brain stem. |
1989-12-19 |
2023-08-11 |
mouse |
| Q Pei, T Zetterström, M Fillen. Both systemic and local administration of benzodiazepine agonists inhibit the in vivo release of 5-HT from ventral hippocampus. Neuropharmacology. vol 28. issue 10. 1989-12-13. PMID:2478921. |
both systemic and local administration of benzodiazepine agonists inhibit the in vivo release of 5-ht from ventral hippocampus. |
1989-12-13 |
2023-08-11 |
rat |
| Q Pei, T Zetterström, M Fillen. Both systemic and local administration of benzodiazepine agonists inhibit the in vivo release of 5-HT from ventral hippocampus. Neuropharmacology. vol 28. issue 10. 1989-12-13. PMID:2478921. |
the effects of benzodiazepine- and gabaa-receptor agonists and antagonists on the release and metabolism of 5-ht were measured in the ventral hippocampus of freely moving rats using microdialysis. |
1989-12-13 |
2023-08-11 |
rat |
| Q Pei, T Zetterström, M Fillen. Both systemic and local administration of benzodiazepine agonists inhibit the in vivo release of 5-HT from ventral hippocampus. Neuropharmacology. vol 28. issue 10. 1989-12-13. PMID:2478921. |
local perfusion of flurazepam through the dialysis probe also decreased the release of 5-ht in the ventral hippocampus, an effect which was completely blocked by the benzodiazepine antagonist, ro15-1788 (flumazenil). |
1989-12-13 |
2023-08-11 |
rat |
| Q Pei, T Zetterström, M Fillen. Both systemic and local administration of benzodiazepine agonists inhibit the in vivo release of 5-HT from ventral hippocampus. Neuropharmacology. vol 28. issue 10. 1989-12-13. PMID:2478921. |
none of these drugs caused significant changes in the levels of the metabolite of 5-ht, 5-hydroxyindoleacetic acid (5-hiaa) in the ventral hippocampus. |
1989-12-13 |
2023-08-11 |
rat |
| Q Pei, T Zetterström, M Fillen. Both systemic and local administration of benzodiazepine agonists inhibit the in vivo release of 5-HT from ventral hippocampus. Neuropharmacology. vol 28. issue 10. 1989-12-13. PMID:2478921. |
these results suggest that the inhibitory effect of flurazepam on the release of 5-ht is mediated by benzodiazepine/gabaa receptors in the hippocampus and that gaba exerts a tonic inhibitory effect on the release of 5-ht in the region of the brain. |
1989-12-13 |
2023-08-11 |
rat |
| S C Cheetham, Y Yamaguchi, R W Horto. [3H]5-hydroxytryptamine binding sites in postmortem human brain. Neuropharmacology. vol 28. issue 10. 1989-12-13. PMID:2530468. |
binding sites for [3h]5-hydroxytryptamine (5-ht) in postmortem human frontal cortex, hippocampus and amygdala were studied by displacement with 5-ht selective drugs. |
1989-12-13 |
2023-08-11 |
human |
| F Chaouloff, D Laude, J L Elghoz. PHysical exercise: evidence for differential consequences of tryptophan on 5-HT synthesis and metabolism in central serotonergic cell bodies and terminals. Journal of neural transmission. vol 78. issue 2. 1989-12-07. PMID:2478662. |
the aim of the present study was to investigate the effects of physical exercise (running) on serotonin (5-hydroxytryptamine, 5-ht) synthesis and metabolism in midbrain on the one hand, and in striatum and hippocampus on the other hand. |
1989-12-07 |
2023-08-11 |
rat |
| F Chaouloff, D Laude, J L Elghoz. PHysical exercise: evidence for differential consequences of tryptophan on 5-HT synthesis and metabolism in central serotonergic cell bodies and terminals. Journal of neural transmission. vol 78. issue 2. 1989-12-07. PMID:2478662. |
although running triggered a 30% increase in trp levels in the three brain regions examined, inhibition of 5-ht synthesis by nsd 1015 was found to promote increased (midbrain), unchanged (striatum) or decreased (hippocampus) 5-htp accumulation in the running situation, respectively compared to that measured in the resting situation. |
1989-12-07 |
2023-08-11 |
rat |
| F Chaouloff, D Laude, J L Elghoz. PHysical exercise: evidence for differential consequences of tryptophan on 5-HT synthesis and metabolism in central serotonergic cell bodies and terminals. Journal of neural transmission. vol 78. issue 2. 1989-12-07. PMID:2478662. |
inasmuch as running-induced elevation in trp was not associated with an increased 5-htp accumulation in the striatum and the hippocampus, the consequences of running on regional trp, 5-ht and 5-hiaa levels were analyzed in saline- and trp-injected rats. |
1989-12-07 |
2023-08-11 |
rat |
| M Martire, G Pistritto, P Prezios. Different regulation of serotonin receptors following adrenal hormone imbalance in the rat hippocampus and hypothalamus. Journal of neural transmission. vol 78. issue 2. 1989-12-07. PMID:2553860. |
different regulation of serotonin receptors following adrenal hormone imbalance in the rat hippocampus and hypothalamus. |
1989-12-07 |
2023-08-11 |
rat |
| M Martire, G Pistritto, P Prezios. Different regulation of serotonin receptors following adrenal hormone imbalance in the rat hippocampus and hypothalamus. Journal of neural transmission. vol 78. issue 2. 1989-12-07. PMID:2553860. |
adrenal influence on serotonin (5-ht) transmission in the hippocampal and hypothalamic areas was studied in adrenalectomized rats receiving or not corticosterone replacement. |
1989-12-07 |
2023-08-11 |
rat |
| M Martire, G Pistritto, P Prezios. Different regulation of serotonin receptors following adrenal hormone imbalance in the rat hippocampus and hypothalamus. Journal of neural transmission. vol 78. issue 2. 1989-12-07. PMID:2553860. |
after adrenalectomy, the 5-ht presynaptic receptors were desensitized both in hippocampus and hypothalamus: a significant increase in 5-ht 1 and 5-ht 2 receptor binding numbers took place in membranes from the hippocampus, but not in hypothalamus, while no changes in affinity of receptors to radioligands were observed in either brain area. |
1989-12-07 |
2023-08-11 |
rat |
| M Martire, G Pistritto, P Prezios. Different regulation of serotonin receptors following adrenal hormone imbalance in the rat hippocampus and hypothalamus. Journal of neural transmission. vol 78. issue 2. 1989-12-07. PMID:2553860. |
corticosterone treatment restored the adrenalectomy-impaired 5-ht autoreceptor sensitivity in hippocampus and hypothalamus and 5-ht density receptor sites in the hippocampus. |
1989-12-07 |
2023-08-11 |
rat |
| M Martire, G Pistritto, P Prezios. Different regulation of serotonin receptors following adrenal hormone imbalance in the rat hippocampus and hypothalamus. Journal of neural transmission. vol 78. issue 2. 1989-12-07. PMID:2553860. |
corticosterone seems to display a distinct tonic control on serotonin transmission in both hippocampus and hypothalamus, the diversity being due to the different roles played by the hormone in these brain regions. |
1989-12-07 |
2023-08-11 |
rat |
| A S Saratikov, L L Fisanova, T A Zamoshchina, S A Sakharov. [Contents of serotonin and 5-hydroxyindoleacetic acid in the rabbit brain after long-term administration of lithium oxybutyrate]. Biulleten' eksperimental'noi biologii i meditsiny. vol 108. issue 7. 1989-12-01. PMID:2478210. |
after 29 days lh diminished 5-ht in striatum, hippocampus, amygdala by 24, 29 and 32% and 5-hiaa--in hypothalamus by 42%. |
1989-12-01 |
2023-08-11 |
rat |
| K Ishikawa, S Shibanoki, T Kubo, M Kogure, Y Imamura, N Osawa, M Ohmura, K Mikoshib. Functional difference in monoamine transmitters in the behaviorally abnormal mouse mutant (wriggle mouse sagami). Neuroscience letters. vol 103. issue 3. 1989-11-28. PMID:2812521. |
the turnover of 5-ht was significantly higher in the cerebral cortex, hippocampus, hypothalamus, midbrain and pons-medulla of wms than of the genetic control, balb/c. |
1989-11-28 |
2023-08-11 |
mouse |
| N Yokota, S Yamawaki, H Hayakawa, R Yoshida, K Sara. [Multiple [3H]8-hydroxy-2-(di-n-propylamino)-tetralin binding sites in rat brain: modulation by GTP and cations]. Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology. vol 9. issue 2. 1989-11-27. PMID:2530729. |
5-ht agonist and antagonist biphasically displaced [3h]8-oh-dpat binding in frontocortical, hippocampal, and striatal membranes. |
1989-11-27 |
2023-08-11 |
rat |
| T Itoh, Y F Zang, S Murai, H Sait. Effects of Panax ginseng root on the vertical and horizontal motor activities and on brain monoamine-related substances in mice. Planta medica. vol 55. issue 5. 1989-11-27. PMID:2813579. |
effects of the panax ginseng root (pgr) on spontaneous motor activity (vertical and horizontal motor activities), and on monoamine-related substances (tyrosine, da, dopac, 3-mt, hva, ne, mhpg, tryptophan, 5-ht, and 5-hiaa) in discrete brain areas (cerebral cortex, hippocampus, hypothalamus, corpus striatum, limbic lobe, midbrain, cerebellum, and medulla oblongata) of ddy male mice (weighing 18-22 g) were examined using an infrared photo-cell counter and hplc with electrochemical detection. |
1989-11-27 |
2023-08-11 |
mouse |