| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M S Kleven, L S Seide. D-, L- and DL-fenfluramine cause long-lasting depletions of serotonin in rat brain. Brain research. vol 505. issue 2. 1990-01-30. PMID:2598057. |
d-fenfluramine (1.6-12.5 mg/kg), l-fenfluramine (1.6-25 mg/kg), and dl-fenfluramine (1.6-25 mg/kg) injected s.c. twice daily for 4 consecutive days produced dose-related depletions of serotonin (5-ht) levels in somatosensory cortex, striatum, hypothalamus, and hippocampus of rats (n = 5-8/group) sacrificed two weeks after the last injection. |
1990-01-30 |
2023-08-11 |
rat |
| L A Matsuda, G R Hanson, J W Gib. Neurochemical effects of amphetamine metabolites on central dopaminergic and serotonergic systems. The Journal of pharmacology and experimental therapeutics. vol 251. issue 3. 1990-01-30. PMID:2600821. |
in contrast, only hypothalamic and hippocampal serotonin stores were altered significantly in rats treated with p-oha systemically. |
1990-01-30 |
2023-08-11 |
rat |
| E Domański, F Przekop, L Chomicka, A Ostrowsk. Effect of stress on the course of oestrous cycle and the release of luteinizing hormone; the role of endorphin in these processes. Acta physiologica Polonica. vol 40. issue 1. 1990-01-26. PMID:2532447. |
footshocking in rats induced significant decrease in 5-ht concentrations in the fronto-parietal brain cortex, hippocampus, striatum, medial basal hypothalamus and the preoptic-anterior hypothalamic area. |
1990-01-26 |
2023-08-11 |
rat |
| b' F Radja, G Daval, M B Emerit, M C Gallissot, M Hamon, D Verg\\xc3\\xa. Selective irreversible blockade of 5-hydroxytryptamine1A and 5-hydroxytryptamine1C receptor binding sites in the rat brain by 8-MeO-2\'-chloro-PAT: a quantitative autoradiographic study. Neuroscience. vol 31. issue 3. 1990-01-25. PMID:2531850.' |
a marked reduction (-50% to -75%) of [3h]8-oh-dpat and [125i]bh-8-meo-n-pat specific binding to 5-hydroxytryptamine1a sites in the hippocampus (ca1 area) and the dorsal raphe nucleus, and of [3h]5-hydroxytryptamine specific binding to 5-hydroxytryptamine1c sites in the choroid plexus was found in sections exposed to 1 microm 8-meo-2'-chloro-pat and then washed extensively. |
1990-01-25 |
2023-08-11 |
rat |
| T Sharp, S R Bramwell, S Hjorth, D G Grahame-Smit. Pharmacological characterization of 8-OH-DPAT-induced inhibition of rat hippocampal 5-HT release in vivo as measured by microdialysis. British journal of pharmacology. vol 98. issue 3. 1990-01-25. PMID:2574066. |
pharmacological characterization of 8-oh-dpat-induced inhibition of rat hippocampal 5-ht release in vivo as measured by microdialysis. |
1990-01-25 |
2023-08-11 |
rat |
| T Sharp, S R Bramwell, S Hjorth, D G Grahame-Smit. Pharmacological characterization of 8-OH-DPAT-induced inhibition of rat hippocampal 5-HT release in vivo as measured by microdialysis. British journal of pharmacology. vol 98. issue 3. 1990-01-25. PMID:2574066. |
we have previously found that the putative 5-ht1a agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-oh-dpat) decreases hippocampal 5-hydroxytryptamine (5-ht) release in the anaesthetized rat, as measured by brain microdialysis. |
1990-01-25 |
2023-08-11 |
rat |
| T Sharp, S R Bramwell, S Hjorth, D G Grahame-Smit. Pharmacological characterization of 8-OH-DPAT-induced inhibition of rat hippocampal 5-HT release in vivo as measured by microdialysis. British journal of pharmacology. vol 98. issue 3. 1990-01-25. PMID:2574066. |
we conclude from these data that the decrease of hippocampal 5-ht output induced by 8-ohdpat does not involve 5-ht2, 5-ht3, adrenoceptors or dopamine d2-receptors and that activation of a 5-ht1 class of receptor seems probable. |
1990-01-25 |
2023-08-11 |
rat |
| K T Finnegan, J J Skratt, I Irwin, J W Langsto. The N-methyl-D-aspartate (NMDA) receptor antagonist, dextrorphan, prevents the neurotoxic effects of 3,4-methylenedioxymethamphetamine (MDMA) in rats. Neuroscience letters. vol 105. issue 3. 1990-01-25. PMID:2574428. |
rats were treated with mdma, dextrorphan, or the combination of mdma and increasing doses of dextrorphan, and then killed 10 days later for the assay of serotonin and dopamine in the striatum, hippocampus, and cortex. |
1990-01-25 |
2023-08-11 |
rat |
| A M Di Giulio, B Tenconi, R La Croix, P Mantegazza, M P Abbracchio, F Cattabeni, A Gori. Denervation and hyperinnervation in the nervous system of diabetic animals. II. Monoaminergic and peptidergic alterations in the diabetic encephalopathy. Journal of neuroscience research. vol 24. issue 3. 1990-01-22. PMID:2480454. |
in the hippocampus, there is a reduction of serotonin content. |
1990-01-22 |
2023-08-11 |
rat |
| J Buelke-Sam, S F Ali, G L Kimmel, W Slikker, G D Newport, J R Harmo. Postnatal function following prenatal reserpine exposure in rats: neurobehavioral toxicity. Neurotoxicology and teratology. vol 11. issue 5. 1990-01-17. PMID:2593990. |
however, hippocampal 5-ht and 5-ht receptor binding were significantly reduced only in females. |
1990-01-17 |
2023-08-11 |
rat |
| M Johnson, G R Hanson, J W Gib. Characterization of acute N-ethyl-3,4-methylenedioxyamphetamine (MDE) action on the central serotonergic system. Biochemical pharmacology. vol 38. issue 23. 1990-01-16. PMID:2480796. |
within 1 hr after administration of mde (10 mg/kg), the concentration of 5-hydroxytryptamine (5-ht) and the activity of tryptophan hydroxylase (tph) had declined significantly in the hippocampus but returned to control within 12 hr. |
1990-01-16 |
2023-08-11 |
Not clear |
| F Bolanos, G Fillio. Minaprine antagonises the serotonergic inhibitory effect of trifluoromethylphenylpiperazine (TFMPP) on acetylcholine release. European journal of pharmacology. vol 168. issue 1. 1990-01-11. PMID:2583235. |
the serotonin agonist, m-trifluoromethylphenylpiperazine (tfmpp), inhibited the k+-evoked release of [3h]acetylcholine ([3h]ach) from rat hippocampal synaptosomes. |
1990-01-11 |
2023-08-11 |
rat |
| S C Cheetham, M R Crompton, C Czudek, R W Horton, C L Katona, G P Reynold. Serotonin concentrations and turnover in brains of depressed suicides. Brain research. vol 502. issue 2. 1990-01-08. PMID:2479456. |
5-ht, 5-hiaa and 5-ht turnover did not differ significantly between the total, drug-free and antidepressant-treated suicides and controls in frontal and temporal cortex, caudate and hippocampus. |
1990-01-08 |
2023-08-11 |
human |
| M Segal, E C Azmitia, P M Whitaker-Azmiti. Physiological effects of selective 5-HT1a and 5-HT1b ligands in rat hippocampus: comparison to 5-HT. Brain research. vol 502. issue 1. 1990-01-04. PMID:2531014. |
physiological effects of selective 5-ht1a and 5-ht1b ligands in rat hippocampus: comparison to 5-ht. |
1990-01-04 |
2023-08-11 |
rat |
| M Segal, E C Azmitia, P M Whitaker-Azmiti. Physiological effects of selective 5-HT1a and 5-HT1b ligands in rat hippocampus: comparison to 5-HT. Brain research. vol 502. issue 1. 1990-01-04. PMID:2531014. |
the responses of ca1 neurons to topical application of serotonin (5-ht) and selective 5-ht1a and 5-ht1b agonists were examined with intracellular recording in the hippocampal slice. |
1990-01-04 |
2023-08-11 |
rat |
| M Segal, E C Azmitia, P M Whitaker-Azmiti. Physiological effects of selective 5-HT1a and 5-HT1b ligands in rat hippocampus: comparison to 5-HT. Brain research. vol 502. issue 1. 1990-01-04. PMID:2531014. |
it is suggested that the physiological response to 5-ht in the rat hippocampus is mediated by a 5-ht1a receptor. |
1990-01-04 |
2023-08-11 |
rat |
| M Segal, E C Azmitia, P M Whitaker-Azmiti. Physiological effects of selective 5-HT1a and 5-HT1b ligands in rat hippocampus: comparison to 5-HT. Brain research. vol 502. issue 1. 1990-01-04. PMID:2531014. |
the currently available 5-ht1a ligands show a low agonist potential and a high antagonist action towards the responses of hippocampal neurons to 5-ht. |
1990-01-04 |
2023-08-11 |
rat |
| M R Pranzatelli, Y Y Huang, A M Dollison, M Stanle. Brainstem serotonergic hyperinnervation modifies behavioral supersensitivity to 5-hydroxytryptophan in the rat. Brain research. Developmental brain research. vol 50. issue 1. 1990-01-04. PMID:2582610. |
after 14 weeks, 5-ht was selectively depleted (-43 to -92%) in hippocampus, spinal cord, and frontal cortex, and differences between i.c. |
1990-01-04 |
2023-08-11 |
rat |
| J L Muir, H P Pfiste. Psychological stress and oxytocin treatment during pregnancy affect central norepinephrine, dopamine and serotonin in lactating rats. The International journal of neuroscience. vol 48. issue 3-4. 1990-01-04. PMID:2583934. |
the aim of these experiments was to investigate the effects of psychological stress and oxytocin treatment on levels of norepinephrine, dopamine and serotonin in the hypothalamus, hippocampus, striatum, midbrain and brainstem of lactating females. |
1990-01-04 |
2023-08-11 |
rat |
| J L Muir, H P Pfiste. Psychological stress and oxytocin treatment during pregnancy affect central norepinephrine, dopamine and serotonin in lactating rats. The International journal of neuroscience. vol 48. issue 3-4. 1990-01-04. PMID:2583934. |
furthermore, a marked reduction in serotonin levels in the hypothalamus, hippocampus, midbrain and brainstem was observed as a result of oxytocin treatment on both day 6 and day 21 postpartum. |
1990-01-04 |
2023-08-11 |
rat |