| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C C Felder, R Y Kanterman, A L Ma, J Axelro. Serotonin stimulates phospholipase A2 and the release of arachidonic acid in hippocampal neurons by a type 2 serotonin receptor that is independent of inositolphospholipid hydrolysis. Proceedings of the National Academy of Sciences of the United States of America. vol 87. issue 6. 1990-04-25. PMID:2315313. |
these data suggest that 5-ht stimulated the release of arachidonic acid in hippocampal neurons through the activation of phospholipase a2, independent of the activation of phospholipase c. |
1990-04-25 |
2023-08-11 |
Not clear |
| F Boix, A Fernández Teruel, R M Escorihuela, A Tobeñ. Handling-habituation prevents the effects of diazepam and alprazolam on brain serotonin levels in rats. Behavioural brain research. vol 36. issue 3. 1990-04-16. PMID:1690010. |
in two different experiments, serotonin (5-ht) and 5-hydroxyindoleacetic acid (5-hiaa) levels were measured in rats, using hplc with electrochemical detection, in 3 brain regions (hippocampus, cerebral cortex and hypothalamus) after acute i.p. |
1990-04-16 |
2023-08-11 |
rat |
| F Boix, A Fernández Teruel, R M Escorihuela, A Tobeñ. Handling-habituation prevents the effects of diazepam and alprazolam on brain serotonin levels in rats. Behavioural brain research. vol 36. issue 3. 1990-04-16. PMID:1690010. |
results of the acute treatment alone showed a significant increase in 5-ht levels in hippocampus and cerebral cortex, and a decrease in hypothalamus, but not differences in 5-hiaa levels, for the diazepam- and alprazolam-treated groups. |
1990-04-16 |
2023-08-11 |
rat |
| M E Newman, D Drummer, B Lere. Single and combined effects of desimipramine and lithium on serotonergic receptor number and second messenger function in rat brain. The Journal of pharmacology and experimental therapeutics. vol 252. issue 2. 1990-04-16. PMID:2138225. |
dmi alone had no effect on [3h]5-ht binding but reduced [3h]ketanserin binding in cortical membranes, 5-ht-stimulated inositol phosphate (ip) formation in cortical slices and the degree of inhibition of forskolin-stimulated adenylate cyclase by 5-ht in hippocampal membranes. |
1990-04-16 |
2023-08-11 |
rat |
| M E Newman, D Drummer, B Lere. Single and combined effects of desimipramine and lithium on serotonergic receptor number and second messenger function in rat brain. The Journal of pharmacology and experimental therapeutics. vol 252. issue 2. 1990-04-16. PMID:2138225. |
li alone reduced [3h]5-ht binding and the degree of inhibition of forskolin-stimulated adenylate cyclase by 5-ht in hippocampal membranes, and also reduced [3h]ketanserin binding and 5-ht-stimulated ip formation in the cortex. |
1990-04-16 |
2023-08-11 |
rat |
| M E Newman, D Drummer, B Lere. Single and combined effects of desimipramine and lithium on serotonergic receptor number and second messenger function in rat brain. The Journal of pharmacology and experimental therapeutics. vol 252. issue 2. 1990-04-16. PMID:2138225. |
the two treatments combined in general produced effects similar to those of li alone, but the decrease in [3h]ketanserin binding in cortical membranes was significantly greater than that given by li alone, whereas the reduction in the degree of inhibition of forskolin-stimulated adenylate cyclase by 5-ht in hippocampal membranes was significantly greater than that produced by dmi alone. |
1990-04-16 |
2023-08-11 |
rat |
| W Slikker, R R Holson, S F Ali, M G Kolta, M G Paule, A C Scallet, D E McMillan, J R Bailey, J S Hong, F M Scalz. Behavioral and neurochemical effects of orally administered MDMA in the rodent and nonhuman primate. Neurotoxicology. vol 10. issue 3. 1990-04-12. PMID:2576304. |
at 2-4 wk after the last dose, no significant differences between control and treated rats were seen in emergence, hot plate response, auditory startle response or complex maze behavior even though a significant dose-related decrease (50%) in 5-ht concentration was observed in the frontal cortex and hippocampus of these rats 4 wks after the last dose. |
1990-04-12 |
2023-08-11 |
human |
| P Blier, A Serrano, B Scatto. Differential responsiveness of the rat dorsal and median raphe 5-HT systems to 5-HT1 receptor agonists and p-chloroamphetamine. Synapse (New York, N.Y.). vol 5. issue 2. 1990-04-09. PMID:2137943. |
second, 8-oh-dpat and buspirone were ten and four times, respectively, more potent in decreasing 5-ht synthesis in the frontal cortex than in the hippocampus. |
1990-04-09 |
2023-08-11 |
rat |
| J L Yakel, M B Jackso. 5-HT3 receptors mediate rapid responses in cultured hippocampus and a clonal cell line. Neuron. vol 1. issue 7. 1990-04-06. PMID:3272181. |
serotonin (5-ht) induces a large inward current accompanied by a conductance increase when applied focally to either neurons of mouse hippocampal cultures or cells of the ng108-15 clonal cell line. |
1990-04-06 |
2023-08-11 |
mouse |
| A R Gorkal, A Namasivaya. Effect of isopropanol on rat brain monoamine levels. Pharmacology & toxicology. vol 65. issue 5. 1990-03-23. PMID:2622870. |
serotonin level was increased in hypothalamus, midbrain, pons-medulla and cerebral cortex, and decreased in striatum and hippocampus. |
1990-03-23 |
2023-08-11 |
rat |
| E Meller, M Goldstein, K Bohmake. Receptor reserve for 5-hydroxytryptamine1A-mediated inhibition of serotonin synthesis: possible relationship to anxiolytic properties of 5-hydroxytryptamine1A agonists. Molecular pharmacology. vol 37. issue 2. 1990-03-21. PMID:1968223. |
the irreversible receptor antagonist n-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (eedq) was used to determine the relationship between receptor occupancy and response at central 5-hydroxytryptamine1a (5-ht1a) serotonin receptors mediating the inhibition of serotonin synthesis in rat cortex and hippocampus. |
1990-03-21 |
2023-08-11 |
rat |
| V D Petkov, S L Stancheva, L Tocuschieva, V V Petko. Changes in brain biogenic monoamines induced by the nootropic drugs adafenoxate and meclofenoxate and by citicholine (experiments on rats). General pharmacology. vol 21. issue 1. 1990-03-15. PMID:2105261. |
the effects of adafenoxate (adf), meclofenoxate (mf) and citicholine (cch) administered at a daily dose of 100 mg/kg for 7 days on the levels of noradrenaline (na), dopamine (da) and serotonin (5-ht) in the frontal cerebral cortex, striatum, hippocampus and hypothalamus of rats were studied. |
1990-03-15 |
2023-08-11 |
rat |
| V D Petkov, S L Stancheva, L Tocuschieva, V V Petko. Changes in brain biogenic monoamines induced by the nootropic drugs adafenoxate and meclofenoxate and by citicholine (experiments on rats). General pharmacology. vol 21. issue 1. 1990-03-15. PMID:2105261. |
adafenoxate increased the na level in the striatum and decreased it in the hypothalamus; it increased the da level in the cerebral cortex and hypothalamus and decreased it in the striatum; it increased the 5-ht level in the cerebral cortex and decreased it in the hippocampus. |
1990-03-15 |
2023-08-11 |
rat |
| V D Petkov, S L Stancheva, L Tocuschieva, V V Petko. Changes in brain biogenic monoamines induced by the nootropic drugs adafenoxate and meclofenoxate and by citicholine (experiments on rats). General pharmacology. vol 21. issue 1. 1990-03-15. PMID:2105261. |
meclofenoxate decreased the na level in the cerebral cortex and hypothalamus; it increased the da level in the hippocampus and hypothalamus and the 5-ht level in the cerebral cortex, striatum, hippocampus and hypothalamus. |
1990-03-15 |
2023-08-11 |
rat |
| V D Petkov, S L Stancheva, L Tocuschieva, V V Petko. Changes in brain biogenic monoamines induced by the nootropic drugs adafenoxate and meclofenoxate and by citicholine (experiments on rats). General pharmacology. vol 21. issue 1. 1990-03-15. PMID:2105261. |
citicholine increased the na level in the cerebral cortex and hypothalamus; it increased the da level in the striatum and the 5-ht level in the cerebral cortex, striatum and hippocampus. |
1990-03-15 |
2023-08-11 |
rat |
| I Hide, S Yamawak. Inactivation of presynaptic 5-HT autoreceptors by lithium in rat hippocampus. Neuroscience letters. vol 107. issue 1-3. 1990-03-14. PMID:2616042. |
inactivation of presynaptic 5-ht autoreceptors by lithium in rat hippocampus. |
1990-03-14 |
2023-08-11 |
rat |
| I Hide, S Yamawak. Inactivation of presynaptic 5-HT autoreceptors by lithium in rat hippocampus. Neuroscience letters. vol 107. issue 1-3. 1990-03-14. PMID:2616042. |
the effect of lithium ion on the electrically stimulated 5-[3h]hydroxytryptamine (5-ht) release from the rat hippocampal slices preloaded with [3h]5-ht was studied. |
1990-03-14 |
2023-08-11 |
rat |
| I Hide, S Yamawak. Inactivation of presynaptic 5-HT autoreceptors by lithium in rat hippocampus. Neuroscience letters. vol 107. issue 1-3. 1990-03-14. PMID:2616042. |
the results suggest that lithium may inhibit the regulation of 5-ht release via presynaptic 5-ht autoreceptors in rat hippocampus. |
1990-03-14 |
2023-08-11 |
rat |
| R Sh Ibragimov, N K Kerimova, R G Ragimo. [The effect of oxytocin on the activity of the brain serotoninergic systems in narcotic-dependent rats]. Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova. vol 75. issue 10. 1990-03-13. PMID:2482196. |
the oxytocin administration decreased hypothalamic and hippocampal serotonin levels. |
1990-03-13 |
2023-08-11 |
rat |
| D J Haleem, G A Kennett, G Curzo. Hippocampal 5-hydroxytryptamine synthesis is greater in female rats than in males and more decreased by the 5-HT1A agonist 8-OH-DPAT. Journal of neural transmission. General section. vol 79. issue 1-2. 1990-03-09. PMID:1688708. |
hippocampal 5-hydroxytryptamine synthesis is greater in female rats than in males and more decreased by the 5-ht1a agonist 8-oh-dpat. |
1990-03-09 |
2023-08-11 |
rat |