| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Muramatsu, S Chaki, C Usuki-ito, S Otom. Attenuation of serotonin-suppressed [3H]acetylcholine release by tetrahydroaminoacridine and dendrotoxin: interaction with minaprine binding site. Research communications in chemical pathology and pharmacology. vol 68. issue 2. 1990-07-16. PMID:2353129. |
5-hydroxytryptamine (5-ht) inhibited k(+)-induced [3h]acetylcholine ([3h]ach) release from rat hippocampal slices dose-dependently. |
1990-07-16 |
2023-08-11 |
rat |
| M Muramatsu, S Chaki, C Usuki-ito, S Otom. Attenuation of serotonin-suppressed [3H]acetylcholine release by tetrahydroaminoacridine and dendrotoxin: interaction with minaprine binding site. Research communications in chemical pathology and pharmacology. vol 68. issue 2. 1990-07-16. PMID:2353129. |
a neurotoxin isolated from the venom of dendroaspis snake, dendrotoxin (dtx), also attenuated the 5-ht inhibited [3h]ach release from hippocampal slices dose-dependently at doses of more than 3 x 10(-7) g/ml (about 42 nm). |
1990-07-16 |
2023-08-11 |
rat |
| M Koulu, J Lappalainen, J Hietala, B Sjöhol. Effects of chronic administration of ondansetron (GR38032F), a selective 5-HT3 receptor antagonist, on monoamine metabolism in mesolimbic and nigrostriatal dopaminergic neurons and on striatal D2-receptor binding. Psychopharmacology. vol 101. issue 2. 1990-07-12. PMID:2140903. |
ondansetron did not change 5-ht metabolism in the nucleus raphé dorsalis, amygdala, hippocampus or in habenula. |
1990-07-12 |
2023-08-11 |
Not clear |
| M Briley, P Chopin, C More. Effect of serotonergic lesion on "anxious" behaviour measured in the elevated plus-maze test in the rat. Psychopharmacology. vol 101. issue 2. 1990-07-12. PMID:2140904. |
twenty-four hours later, the rats were killed and serotonin levels and [3h]paroxetine binding measured in cortical and hippocampal membranes. |
1990-07-12 |
2023-08-11 |
rat |
| M Briley, P Chopin, C More. Effect of serotonergic lesion on "anxious" behaviour measured in the elevated plus-maze test in the rat. Psychopharmacology. vol 101. issue 2. 1990-07-12. PMID:2140904. |
the lesion destroyed 81% of the serotonergic innervation in the cortex and 99% in the hippocampus as determined by endogenous serotonin levels. |
1990-07-12 |
2023-08-11 |
rat |
| M P Johnson, D E Nichol. Comparative serotonin neurotoxicity of the stereoisomers of fenfluramine and norfenfluramine. Pharmacology, biochemistry, and behavior. vol 36. issue 1. 1990-07-11. PMID:2140899. |
with the exception of hippocampal 5-ht levels following d-fenfluramine treatment, there was a decrease in all the serotonergic markers assayed, following treatment with the d-enantiomers of fenfluramine and norfenfluramine. |
1990-07-11 |
2023-08-11 |
rat |
| K J Axt, L S Seide. alpha-Methyl-p-tyrosine partially attenuates p-chloroamphetamine-induced 5-hydroxytryptamine depletions in the rat brain. Pharmacology, biochemistry, and behavior. vol 35. issue 4. 1990-07-02. PMID:1971723. |
amt reduced the pca-induced 5-ht depletions in the striatum and to a lesser extent in the hippocampus. |
1990-07-02 |
2023-08-11 |
rat |
| S Hjorth, T Sharp, Y Li. cis-(+)-8-OH-1-CH3-DPAT, (+)ALK-3, a novel stereoselective pharmacological probe for characterizing 5-HT release-controlling 5-HT1A autoreceptors. An in vivo brain microdialysis study. Naunyn-Schmiedeberg's archives of pharmacology. vol 341. issue 3. 1990-06-27. PMID:1692973. |
the cis-1-methylated 8-oh-dpat analogue (+)alk-3 was comparable to the parent compound in reducing the 5-ht output from rat ventral hippocampus. |
1990-06-27 |
2023-08-11 |
rat |
| S Hjorth, T Sharp, Y Li. cis-(+)-8-OH-1-CH3-DPAT, (+)ALK-3, a novel stereoselective pharmacological probe for characterizing 5-HT release-controlling 5-HT1A autoreceptors. An in vivo brain microdialysis study. Naunyn-Schmiedeberg's archives of pharmacology. vol 341. issue 3. 1990-06-27. PMID:1692973. |
pretreatment with (-)pindolol (8 mg/kg s.c.), which has high affinity for 5-ht1a radioligand binding sites, blocked the reduction of hippocampal 5-ht release induced by a submaximally effective dose of (+)alk-3. |
1990-06-27 |
2023-08-11 |
rat |
| S Hjorth, T Sharp, Y Li. cis-(+)-8-OH-1-CH3-DPAT, (+)ALK-3, a novel stereoselective pharmacological probe for characterizing 5-HT release-controlling 5-HT1A autoreceptors. An in vivo brain microdialysis study. Naunyn-Schmiedeberg's archives of pharmacology. vol 341. issue 3. 1990-06-27. PMID:1692973. |
in summary, the data indicate that (+)alk-3, like 8-oh-dpat, is a very potent 5-ht receptor agonist which inhibits terminal 5-ht release in rat hippocampus, probably via activation of somatodendritic 5-ht1a autoreceptors. |
1990-06-27 |
2023-08-11 |
rat |
| M Raiteri, M Marchi, G Maura, G Bonann. Presynaptic regulation of acetylcholine release in the CNS. Cell biology international reports. vol 13. issue 12. 1990-06-25. PMID:2699834. |
in this chapter we report on our recent results concerning the regulation of the release of ach by ach itself, 5-ht and gaba in the rat hippocampus. |
1990-06-25 |
2023-08-11 |
rat |
| F C Zhou, E C Azmiti. Neurotrophic factor for serotonergic neurons prevents degeneration of grafted raphe neurons in the cerebellum. Brain research. vol 507. issue 2. 1990-06-20. PMID:1692500. |
earlier studies in this laboratory have shown that partial serotonergic (5-ht) deafferentation from the hippocampus induced a homotypic sprouting. |
1990-06-20 |
2023-08-11 |
Not clear |
| F C Zhou, E C Azmiti. Neurotrophic factor for serotonergic neurons prevents degeneration of grafted raphe neurons in the cerebellum. Brain research. vol 507. issue 2. 1990-06-20. PMID:1692500. |
the 5-ht-denervated hippocampus was further found to be a favorable environment for the growth of grafted 5-ht, but not for norepinephrinergic neurons. |
1990-06-20 |
2023-08-11 |
Not clear |
| F C Zhou, E C Azmiti. Neurotrophic factor for serotonergic neurons prevents degeneration of grafted raphe neurons in the cerebellum. Brain research. vol 507. issue 2. 1990-06-20. PMID:1692500. |
these results indicate that (a) the supernatant in the 5-ht-denervated hippocampus contains a potent neurotrophic factor to 5-ht neurons (b) which can either directly or indirectly also support non-5-ht raphe neurons, and (c) possibly an inhibitory factor is present which is detrimental to 5-ht neurons in high concentration. |
1990-06-20 |
2023-08-11 |
Not clear |
| J St Popova, V V Petko. Changes in 5-HT1 receptors in different brain structures of rats with isolation syndrome. General pharmacology. vol 21. issue 2. 1990-06-07. PMID:2332142. |
binding studies with [3h]5-ht showed that the affinity (kd) of 5-ht1 receptors in the frontal cortex, striatum, hippocampus and hypothalamus of isolated aggressive rats was significantly decreased as compared to that in grouped rats. |
1990-06-07 |
2023-08-11 |
rat |
| W J McBride, J M Murphy, L Lumeng, T K L. Serotonin, dopamine and GABA involvement in alcohol drinking of selectively bred rats. Alcohol (Fayetteville, N.Y.). vol 7. issue 3. 1990-06-05. PMID:2184832. |
neurochemical data indicate that high alcohol-seeking behavior (when compared with data from rats with low alcohol-seeking characteristics) is associated with: a) lower (10-20%; p less than 0.05) contents of 5-ht in certain limbic regions (e.g., nucleus accumbens, frontal cortex, hypothalamus and hippocampus); b) a lower (10-15%; p less than 0.05) content of da in the nucleus accumbens; c) higher (20-35%; p less than 0.05) densities of 5-ht1a binding sites in some limbic regions (e.g., medial nucleus accumbens, medial prefrontal cortex and ventral hippocampus); and d) a greater (20-50%) density of gaba axon terminals in the nucleus accumbens. |
1990-06-05 |
2023-08-11 |
rat |
| I Kusumi, M Mikuni, Y Kuroda, K Takahash. Subchronic administration of para-chlorophenylalanine enhances serotonin-stimulated phosphoinositide hydrolysis in rat hippocampal slices. Journal of neural transmission. General section. vol 80. issue 3. 1990-06-04. PMID:2158796. |
serotonin (5-ht) caused a dose-dependent accumulation of inositol monophosphate (ip-1) in rat hippocampal slices (maximal effect + 172%, ec50 = 630 nm) in the presence of licl. |
1990-06-04 |
2023-08-11 |
rat |
| I Kusumi, M Mikuni, Y Kuroda, K Takahash. Subchronic administration of para-chlorophenylalanine enhances serotonin-stimulated phosphoinositide hydrolysis in rat hippocampal slices. Journal of neural transmission. General section. vol 80. issue 3. 1990-06-04. PMID:2158796. |
10-day treatment with para-chlorophenyl-alanine (pcpa), a 5-ht synthesis inhibitor, resulted in a significant increase (maximal effect + 225%, ec50 = 580 nm) in 5-ht-stimulated ip-1 accumulation with no substantial change in ec50 value, which suggest that subchronic treatment with pcpa enhances the 5-ht-mediated pi hydrolysis in rat hippocampus. |
1990-06-04 |
2023-08-11 |
rat |
| M Sega. Developmental changes in serotonin actions in rat hippocampus. Brain research. Developmental brain research. vol 52. issue 1-2. 1990-06-04. PMID:2331792. |
developmental changes in serotonin actions in rat hippocampus. |
1990-06-04 |
2023-08-11 |
rat |
| T Sharp, L I Backus, S Hjorth, S R Bramwell, D G Grahame-Smit. Further investigation of the in vivo pharmacological properties of the putative 5-HT1A antagonist, BMY 7378. European journal of pharmacology. vol 176. issue 3. 1990-05-31. PMID:1970304. |
in contrast to its apparent 5-ht1a antagonist properties in the behavioural experiments, bmy 7378 caused a marked and dose-dependent (0.01-1.0 mg/kg s.c.) decrease of 5-ht release in ventral hippocampus of the anaesthetized rat as detected by brain microdialysis. |
1990-05-31 |
2023-08-11 |
rat |