| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F C Zhou, E C Azmiti. Neurotrophic factor for serotonergic neurons prevents degeneration of grafted raphe neurons in the cerebellum. Brain research. vol 507. issue 2. 1990-06-20. PMID:1692500. |
the 5-ht-denervated hippocampus was further found to be a favorable environment for the growth of grafted 5-ht, but not for norepinephrinergic neurons. |
1990-06-20 |
2023-08-11 |
Not clear |
| F C Zhou, E C Azmiti. Neurotrophic factor for serotonergic neurons prevents degeneration of grafted raphe neurons in the cerebellum. Brain research. vol 507. issue 2. 1990-06-20. PMID:1692500. |
these results indicate that (a) the supernatant in the 5-ht-denervated hippocampus contains a potent neurotrophic factor to 5-ht neurons (b) which can either directly or indirectly also support non-5-ht raphe neurons, and (c) possibly an inhibitory factor is present which is detrimental to 5-ht neurons in high concentration. |
1990-06-20 |
2023-08-11 |
Not clear |
| J St Popova, V V Petko. Changes in 5-HT1 receptors in different brain structures of rats with isolation syndrome. General pharmacology. vol 21. issue 2. 1990-06-07. PMID:2332142. |
binding studies with [3h]5-ht showed that the affinity (kd) of 5-ht1 receptors in the frontal cortex, striatum, hippocampus and hypothalamus of isolated aggressive rats was significantly decreased as compared to that in grouped rats. |
1990-06-07 |
2023-08-11 |
rat |
| W J McBride, J M Murphy, L Lumeng, T K L. Serotonin, dopamine and GABA involvement in alcohol drinking of selectively bred rats. Alcohol (Fayetteville, N.Y.). vol 7. issue 3. 1990-06-05. PMID:2184832. |
neurochemical data indicate that high alcohol-seeking behavior (when compared with data from rats with low alcohol-seeking characteristics) is associated with: a) lower (10-20%; p less than 0.05) contents of 5-ht in certain limbic regions (e.g., nucleus accumbens, frontal cortex, hypothalamus and hippocampus); b) a lower (10-15%; p less than 0.05) content of da in the nucleus accumbens; c) higher (20-35%; p less than 0.05) densities of 5-ht1a binding sites in some limbic regions (e.g., medial nucleus accumbens, medial prefrontal cortex and ventral hippocampus); and d) a greater (20-50%) density of gaba axon terminals in the nucleus accumbens. |
1990-06-05 |
2023-08-11 |
rat |
| I Kusumi, M Mikuni, Y Kuroda, K Takahash. Subchronic administration of para-chlorophenylalanine enhances serotonin-stimulated phosphoinositide hydrolysis in rat hippocampal slices. Journal of neural transmission. General section. vol 80. issue 3. 1990-06-04. PMID:2158796. |
serotonin (5-ht) caused a dose-dependent accumulation of inositol monophosphate (ip-1) in rat hippocampal slices (maximal effect + 172%, ec50 = 630 nm) in the presence of licl. |
1990-06-04 |
2023-08-11 |
rat |
| I Kusumi, M Mikuni, Y Kuroda, K Takahash. Subchronic administration of para-chlorophenylalanine enhances serotonin-stimulated phosphoinositide hydrolysis in rat hippocampal slices. Journal of neural transmission. General section. vol 80. issue 3. 1990-06-04. PMID:2158796. |
10-day treatment with para-chlorophenyl-alanine (pcpa), a 5-ht synthesis inhibitor, resulted in a significant increase (maximal effect + 225%, ec50 = 580 nm) in 5-ht-stimulated ip-1 accumulation with no substantial change in ec50 value, which suggest that subchronic treatment with pcpa enhances the 5-ht-mediated pi hydrolysis in rat hippocampus. |
1990-06-04 |
2023-08-11 |
rat |
| M Sega. Developmental changes in serotonin actions in rat hippocampus. Brain research. Developmental brain research. vol 52. issue 1-2. 1990-06-04. PMID:2331792. |
developmental changes in serotonin actions in rat hippocampus. |
1990-06-04 |
2023-08-11 |
rat |
| T Sharp, L I Backus, S Hjorth, S R Bramwell, D G Grahame-Smit. Further investigation of the in vivo pharmacological properties of the putative 5-HT1A antagonist, BMY 7378. European journal of pharmacology. vol 176. issue 3. 1990-05-31. PMID:1970304. |
in contrast to its apparent 5-ht1a antagonist properties in the behavioural experiments, bmy 7378 caused a marked and dose-dependent (0.01-1.0 mg/kg s.c.) decrease of 5-ht release in ventral hippocampus of the anaesthetized rat as detected by brain microdialysis. |
1990-05-31 |
2023-08-11 |
rat |
| L G Larsson, L Rényi, S B Ross, B Svensson, K Angeby-Mölle. Different effects on the responses of functional pre- and postsynaptic 5-HT1A receptors by repeated treatment of rats with the 5-HT1A receptor agonist 8-OH-DPAT. Neuropharmacology. vol 29. issue 2. 1990-05-30. PMID:1691832. |
one presynaptic response examined was the 8-oh-dpat-induced decrease in the concentration of 5-hydroxyindoleacetic acid (5-hiaa), that indicates a decrease in turnover of 5-ht, due to stimulation of 5-ht receptors on the cell bodies and measured as the ratio of 5-hiaa to 5-ht in the hippocampus, hypothalamus and medulla oblongata. |
1990-05-30 |
2023-08-11 |
rat |
| L G Larsson, L Rényi, S B Ross, B Svensson, K Angeby-Mölle. Different effects on the responses of functional pre- and postsynaptic 5-HT1A receptors by repeated treatment of rats with the 5-HT1A receptor agonist 8-OH-DPAT. Neuropharmacology. vol 29. issue 2. 1990-05-30. PMID:1691832. |
another presynaptic response was the 8-oh-dpat-induced decrease in the accumulation of 5-hydroxytryptophan (5-htp) in the hippocampus and hypothalamus, after inhibition of l-aromatic amino acid decarboxylase by 3-hydroxybenzylhydrazine (nsd 1015), that is due to stimulation of autoreceptors on the 5-ht cell bodies. |
1990-05-30 |
2023-08-11 |
rat |
| R Zaczek, G Battaglia, S Culp, N M Appel, J F Contrera, E B De Souz. Effects of repeated fenfluramine administration on indices of monoamine function in rat brain: pharmacokinetic, dose response, regional specificity and time course data. The Journal of pharmacology and experimental therapeutics. vol 253. issue 1. 1990-05-30. PMID:2329498. |
high-dose (24 mg/kg) fenfluramine administration led to larger decreases in 5-ht markers in neocortex, striatum and hippocampus than in hypothalamus, brain stem and spinal cord. |
1990-05-30 |
2023-08-11 |
rat |
| R Zaczek, G Battaglia, S Culp, N M Appel, J F Contrera, E B De Souz. Effects of repeated fenfluramine administration on indices of monoamine function in rat brain: pharmacokinetic, dose response, regional specificity and time course data. The Journal of pharmacology and experimental therapeutics. vol 253. issue 1. 1990-05-30. PMID:2329498. |
following 80% to 90% reductions of the 5-ht markers in neocortex and hippocampus at 18 hr after drug treatment, 5-ht and 5-hydroxyindoleacetic acid returned to control levels by 4 and 16 weeks, respectively, but 5-ht uptake sites initially recovered more slowly, with a 25% reduction still evident at 8 months. |
1990-05-30 |
2023-08-11 |
rat |
| M Joëls, C M Pennartz, H Sijbesma, J Schippe. Eltoprazine suppresses hyperpolarizing responses to serotonin in rat hippocampus. The Journal of pharmacology and experimental therapeutics. vol 253. issue 1. 1990-05-30. PMID:2329512. |
eltoprazine suppresses hyperpolarizing responses to serotonin in rat hippocampus. |
1990-05-30 |
2023-08-11 |
rat |
| M Joëls, C M Pennartz, H Sijbesma, J Schippe. Eltoprazine suppresses hyperpolarizing responses to serotonin in rat hippocampus. The Journal of pharmacology and experimental therapeutics. vol 253. issue 1. 1990-05-30. PMID:2329512. |
our data, added to the previously demonstrated high affinity of eltoprazine for 5ht1 sites, suggest that in the hippocampal cornus ammoni-1 area eltoprazine acts as a partial 5ht1 agonist with a relatively low intrinsic activity but a considerable potency to suppress hyperpolarizing responses to 5ht. |
1990-05-30 |
2023-08-11 |
rat |
| S Stancheva, P Kunov. Effect of adafenoxate on different rat brain structures monoamine oxidase activity in vitro. Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology. vol 94. issue 1. 1990-05-30. PMID:2576744. |
the effect of the nootropic drug adafenoxate on monoamine oxidase (mao) activity in rat brain cortex, striatum, hypothalamus and hippocampus has been studied using the following substrates: tyramine (total mao), serotonin (mao a) and beta-phenylethylamine (mao b). |
1990-05-30 |
2023-08-11 |
rat |
| E Kempf, J Kempf, A Ebe. Alcohol withdrawal-induced changes in brain biogenic amines in mice: influence of the genotype. Neurochemical research. vol 15. issue 1. 1990-05-24. PMID:2325826. |
alterations in striatal and hippocampal dopamine (da) and serotonin (5ht) activities were investigated in two inbred strains of mice (c57b1 and balb/c) after 3 withdrawal periods following 5 months chronic ethanol administration. |
1990-05-24 |
2023-08-11 |
mouse |
| E Kempf, J Kempf, A Ebe. Alcohol withdrawal-induced changes in brain biogenic amines in mice: influence of the genotype. Neurochemical research. vol 15. issue 1. 1990-05-24. PMID:2325826. |
strain dependency has also been noted for hippocampal serotonin neurotransmission, since only balb/c mice showed a progressive decrease in 5ht levels. |
1990-05-24 |
2023-08-11 |
mouse |
| S Oleskevich, L Descarrie. Quantified distribution of the serotonin innervation in adult rat hippocampus. Neuroscience. vol 34. issue 1. 1990-05-21. PMID:2325849. |
quantified distribution of the serotonin innervation in adult rat hippocampus. |
1990-05-21 |
2023-08-11 |
rat |
| S Oleskevich, L Descarrie. Quantified distribution of the serotonin innervation in adult rat hippocampus. Neuroscience. vol 34. issue 1. 1990-05-21. PMID:2325849. |
to quantify the serotonin innervation in adult rat hippocampus, serotonin axon terminals (varicosities) were uptake-labeled for light microscope radioautography in whole hemisphere slices incubated with 1 microm [3h]serotonin. |
1990-05-21 |
2023-08-11 |
rat |
| S Oleskevich, L Descarrie. Quantified distribution of the serotonin innervation in adult rat hippocampus. Neuroscience. vol 34. issue 1. 1990-05-21. PMID:2325849. |
the overall density of hippocampal serotonin innervation was thus evaluated at 2.7 x 10(6) varicosities per mm3, and appeared significantly higher in subiculum (3.6 x 10(6)) and ammon's horn (3.1 x 10(6)) than in dentate gyrus (2.2 x 10(6)). |
1990-05-21 |
2023-08-11 |
rat |